EP1017383A4 - Thrombininhibitoren - Google Patents

Thrombininhibitoren

Info

Publication number: EP1017383A4
Authority: EP; European Patent Office
Prior art keywords: thrombin inhibitors; thrombin; inhibitors
Prior art date: 1997-09-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP98947119A

Other languages

English (en)

French (fr)

Other versions

EP1017383A1 (de

Inventor

Craig Coburn

Joseph P Vacca

Peter D Williams

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-23

Filing date

1998-09-18

Publication date

2001-11-28

1998-04-15 Priority claimed from GBGB9807941.1A external-priority patent/GB9807941D0/en

1998-09-18 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2000-07-12 Publication of EP1017383A1 publication Critical patent/EP1017383A1/de

2001-11-28 Publication of EP1017383A4 publication Critical patent/EP1017383A4/de

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP98947119A 1997-09-23 1998-09-18 Thrombininhibitoren Withdrawn EP1017383A4 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US5980197P	1997-09-23	1997-09-23
US59801P		1997-09-23
GB9807941		1998-04-15
GBGB9807941.1A GB9807941D0 (en)	1998-04-15	1998-04-15	Thrombin inhibitors
PCT/US1998/019471 WO1999015169A1 (en)	1997-09-23	1998-09-18	Thrombin inhibitors

Publications (2)

Publication Number	Publication Date
EP1017383A1 EP1017383A1 (de)	2000-07-12
EP1017383A4 true EP1017383A4 (de)	2001-11-28

Family

ID=26313472

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP98947119A Withdrawn EP1017383A4 (de)	1997-09-23	1998-09-18	Thrombininhibitoren

Country Status (5)

Country	Link
EP (1)	EP1017383A4 (de)
JP (1)	JP2001517623A (de)
AU (1)	AU740447B2 (de)
CA (1)	CA2301614A1 (de)
WO (1)	WO1999015169A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6239132B1 (en)	1999-04-23	2001-05-29	Merck & Co., Inc.	Thrombin inhibitors
WO2000074682A1 (en)	1999-06-04	2000-12-14	Merck & Co., Inc.	Thrombin inhibitors
FR2795072B1 (fr) *	1999-06-15	2001-07-27	Adir	Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0507577D0 (en)	2005-04-14	2005-05-18	Novartis Ag	Organic compounds
MA54133B1 (fr)	2018-03-08	2022-01-31	Incyte Corp	Composés d'aminopyrazine diol utilisés comme inhibiteurs de pi3k-y
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996019483A1 (en) *	1994-12-22	1996-06-27	Biochem Pharma Inc.	Low molecular weight bicyclic thrombin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW263498B (de) *	1993-11-10	1995-11-21	Takeda Pharm Industry Co Ltd

1998
- 1998-09-18 CA CA002301614A patent/CA2301614A1/en not_active Abandoned
- 1998-09-18 AU AU93973/98A patent/AU740447B2/en not_active Ceased
- 1998-09-18 EP EP98947119A patent/EP1017383A4/de not_active Withdrawn
- 1998-09-18 WO PCT/US1998/019471 patent/WO1999015169A1/en not_active Application Discontinuation
- 1998-09-18 JP JP2000512538A patent/JP2001517623A/ja not_active Withdrawn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996019483A1 (en) *	1994-12-22	1996-06-27	Biochem Pharma Inc.	Low molecular weight bicyclic thrombin inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OKAYAMA T ET AL: "LACTAM-CONFORMATIONALLY RESTRICTED ANALOGS OF NALPHA-ARYLSULFONYL ARGININE AMIDE: DESIGN, SYNTHESIS AND INHIBITORY ACTIVITY TOWARD THROMBIN AND RELATED ENZYMES", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 43, no. 10, October 1995 (1995-10-01), pages 1683 - 1691, XP000942057, ISSN: 0009-2363 *
See also references of WO9915169A1 *

Also Published As

Publication number	Publication date
EP1017383A1 (de)	2000-07-12
WO1999015169A1 (en)	1999-04-01
AU9397398A (en)	1999-04-12
CA2301614A1 (en)	1999-04-01
JP2001517623A (ja)	2001-10-09
AU740447B2 (en)	2001-11-01

Publication	Publication Date	Title
EP0969840A4 (de)	2001-02-28	Thrombin inhibitoren
EP1124822A4 (de)	2002-04-03	Thrombin inhibitoren
EP0971891A4 (de)	2000-04-19	Thrombin-inhibitoren
ZA98376B (en)	1998-07-23	Sulfamide-metalloprotease inhibitors
EP0927035A4 (de)	2002-11-13	Thrombin inhibitoren
EP0820453A4 (de)	2001-08-29	Thrombin-inhibitoren
IL131661A0 (en)	2001-01-28	Protease inhibitors
EP1017393A4 (de)	2002-01-23	Pyrazinon thrombininhibitoren
GB2321641B (en)	2001-04-04	Sulfamide-metalloprotease inhibitors
IL127751A0 (en)	1999-10-28	Thrombin inhibitors
IL132088A0 (en)	2001-03-19	Protease inhibitors
EP0983228A4 (de)	2002-08-07	Proteaseinhibitoren
IL132629A0 (en)	2001-03-19	Protease inhibitors
EP1117660A4 (de)	2002-01-09	Thrombin-inhibitoren
IL136139A0 (en)	2001-05-20	Thrombin inhibitors
GB9613718D0 (en)	1996-08-28	Thrombin inhibitors
EP1015438A4 (de)	2000-11-08	Protease inhibitoren
IL121474A0 (en)	1998-02-08	Thrombin inhibitors
EP1017383A4 (de)	2001-11-28	Thrombininhibitoren
EP1039907A4 (de)	2001-09-19	Thrombin hemmer
EP0975612A4 (de)	2001-06-13	Proteaseinhibitoren
EP1027333A4 (de)	2000-11-08	Thrombin-inhibitoren
GB9704209D0 (en)	1997-04-16	Thrombin inhibitors
GB9716872D0 (en)	1997-10-15	Thrombin Inhibitors
GB9624319D0 (en)	1997-01-08	Thrombin inhibitors

Legal Events

Date	Code	Title	Description
2000-05-26	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2000-07-12	17P	Request for examination filed	Effective date: 20000425
2000-07-12	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
2000-07-12	AX	Request for extension of the european patent	Free format text: AL PAYMENT 20000425;LT PAYMENT 20000425;LV PAYMENT 20000425;MK PAYMENT 20000425;RO PAYMENT 20000425;SI PAYMENT 20000425
2001-11-28	A4	Supplementary search report drawn up and despatched	Effective date: 20011016
2001-11-28	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
2001-11-28	RIC1	Information provided on ipc code assigned before grant	Free format text: 7C 07K 5/06 A, 7A 61K 31/435 B, 7C 07D 471/04 B
2004-08-20	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2004-10-06	18D	Application deemed to be withdrawn	Effective date: 20040331