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EP1069895A4 - Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof - Google Patents

Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof

Info

Publication number
EP1069895A4
EP1069895A4 EP99913956A EP99913956A EP1069895A4 EP 1069895 A4 EP1069895 A4 EP 1069895A4 EP 99913956 A EP99913956 A EP 99913956A EP 99913956 A EP99913956 A EP 99913956A EP 1069895 A4 EP1069895 A4 EP 1069895A4
Authority
EP
European Patent Office
Prior art keywords
compositions containing
inhibit apoptosis
lysophosphatidic acids
containing lysophosphatidic
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99913956A
Other languages
German (de)
French (fr)
Other versions
EP1069895A2 (en
Inventor
John G Goddard
Donald H Picker
Samuil R Umansky
Steven Price
Jacobus C H M Wijkmans
Edward Andrew Boyd
Anthony David Baxter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LXR Biotechnology Inc
Original Assignee
LXR Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LXR Biotechnology Inc filed Critical LXR Biotechnology Inc
Publication of EP1069895A2 publication Critical patent/EP1069895A2/en
Publication of EP1069895A4 publication Critical patent/EP1069895A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP99913956A 1998-03-18 1999-03-17 Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof Withdrawn EP1069895A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7837598P 1998-03-18 1998-03-18
US78375P 1998-03-18
PCT/US1999/005943 WO1999047101A2 (en) 1998-03-18 1999-03-17 Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof

Publications (2)

Publication Number Publication Date
EP1069895A2 EP1069895A2 (en) 2001-01-24
EP1069895A4 true EP1069895A4 (en) 2002-07-31

Family

ID=22143648

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99913956A Withdrawn EP1069895A4 (en) 1998-03-18 1999-03-17 Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof

Country Status (3)

Country Link
EP (1) EP1069895A4 (en)
AU (1) AU3191599A (en)
WO (1) WO1999047101A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495532B1 (en) 1997-03-19 2002-12-17 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US6380177B1 (en) 1999-06-25 2002-04-30 Atairgin Technologies, Inc. LPA analogs as agonists of the Edg2 LPA receptor
WO2001012838A2 (en) * 1999-08-18 2001-02-22 Atairgin Technologies, Inc. Compounds which modulate the activity of an lpa receptor
AU6595900A (en) 1999-08-18 2001-03-13 Kyowa Hakko Kogyo Co. Ltd. Hair growth stimulants
EP1248628A4 (en) * 1999-12-14 2004-08-04 Sky High Llc Phospholipid compositions as anti-inflammation agents
US6492334B1 (en) 1999-12-30 2002-12-10 Robert James Generale Tri-compound analgesic for treating inflammation and pain
AU4926301A (en) * 2000-03-17 2001-10-03 Univ Tennessee Res Corp Lpa receptor agonists and antagonists and methods of use
US20030130237A1 (en) * 2000-03-17 2003-07-10 Miller Duane D. LPA receptor agonists and antagonists and methods of use
CA2371398A1 (en) * 2001-02-16 2002-08-16 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent
JP4815063B2 (en) * 2001-04-13 2011-11-16 きみ子 室伏 Drugs for promoting the proliferation, differentiation and / or survival of glial cells containing cyclic phosphatidic acid
JP4836345B2 (en) * 2001-04-13 2011-12-14 きみ子 室伏 Neuronal survival promoter containing cyclic phosphatidic acid derivative
JP4162927B2 (en) 2002-06-11 2008-10-08 きみ子 室伏 Carbacyclic phosphatidic acid derivatives
EP2481743B1 (en) * 2003-10-09 2017-03-22 University Of Tennessee Research Foundation LPA receptor agonists and antagonists and methods of use
EP1750722A4 (en) * 2004-05-06 2010-03-10 Univ Virginia Novel lysophosphatidic acid receptor selective antagonists
DK1906972T3 (en) * 2005-07-19 2013-12-16 Univ Tennessee Res Foundation LPA2 receptor agonist for the treatment of diarrhea
US20100137258A1 (en) * 2007-08-01 2010-06-03 Francine Acher Thiophosphi(o)nic acid derivatives and their therapeutical applications

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4504409A (en) * 1981-12-16 1985-03-12 Kao Corporation Emulsifying composition
JPH05311200A (en) * 1992-05-13 1993-11-22 Sanyo Chem Ind Ltd Alkaline detergent
WO1995020967A1 (en) * 1994-02-04 1995-08-10 Cell Therapeutics, Inc. Composition for wound healing, neuron growth and vascularization
US5624672A (en) * 1993-11-30 1997-04-29 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
WO1998041213A1 (en) * 1997-03-19 1998-09-24 Lxr Biotechnology Inc. Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
WO1999008514A1 (en) * 1997-08-20 1999-02-25 Lxr Biotechnology, Inc. Compositions containing polyethylene glycol and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS492266B1 (en) * 1970-06-06 1974-01-19
JPS57167364A (en) * 1981-04-07 1982-10-15 Sankin Kogyo Kk Adhesive for hard tissue of human body
JPS5810559A (en) * 1981-07-10 1983-01-21 Ajinomoto Co Inc Preparation of alpha-chloro-beta-thiosulfo-propionic acid ester salt
JPS63265972A (en) * 1987-04-24 1988-11-02 Denki Kagaku Kogyo Kk Modified vinyl chloride resin solution
US4938961A (en) 1989-04-28 1990-07-03 Geoffrey Collins Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia
US6071528A (en) * 1997-02-19 2000-06-06 Ultradent Products, Inc. Adhesive antimicrobial and/or reparative dentin stimulating dental compositions and methods for forming and using such compositions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4504409A (en) * 1981-12-16 1985-03-12 Kao Corporation Emulsifying composition
JPH05311200A (en) * 1992-05-13 1993-11-22 Sanyo Chem Ind Ltd Alkaline detergent
US5624672A (en) * 1993-11-30 1997-04-29 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
US5635187A (en) * 1993-11-30 1997-06-03 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
WO1995020967A1 (en) * 1994-02-04 1995-08-10 Cell Therapeutics, Inc. Composition for wound healing, neuron growth and vascularization
WO1998041213A1 (en) * 1997-03-19 1998-09-24 Lxr Biotechnology Inc. Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
WO1999008514A1 (en) * 1997-08-20 1999-02-25 Lxr Biotechnology, Inc. Compositions containing polyethylene glycol and uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DANG QUOC QUAN ET AL: "Synthesis and identification of bis (diacylglycero) phosphoric acid and bis (monoacylglycero) phosphoric acid", LIPIDS (1982), 17(11), 798-802, XP001022836 *
HOLBROOK, P. G. ET AL: "Bis(monoacylglycero)phosphate from PC12 cells, a phospholipid that can comigrate with phosphatidic acid: molecular species analysis by fast atom bombardment mass spectrometry", BIOCHIM. BIOPHYS. ACTA (1992), 1125(3), 330-4, XP001022857 *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 128 (C - 1174) 2 March 1994 (1994-03-02) *
QUOC QUAN DANG ET AL: "Synthesis and stereochemical study of some biologically relevant phosphoglycerides: dicarboxylic phosphatidylcholines and bis(diacylglycero)phosphoric acids", PHOSPHORUS SULFUR (1983), 18(1-2-3), 377-80, XP001022829 *
QUOC QUAN DANG ET AL: "Synthesis of labeled stereoisomers of bis(diacylglycero)phosphates and lyso derivatives", BIOCHIM. BIOPHYS. ACTA (1985), 834(1), 124-9, XP001022491 *
See also references of WO9947101A2 *

Also Published As

Publication number Publication date
AU3191599A (en) 1999-10-11
EP1069895A2 (en) 2001-01-24
WO1999047101A2 (en) 1999-09-23
WO1999047101A3 (en) 1999-11-25

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Legal Events

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