EP0977567A4 - Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment - Google Patents

Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Info

Publication number: EP0977567A4
Authority: EP; European Patent Office
Prior art keywords: compounds; treatment; methods; compositions containing; carbapenem antibacterial
Prior art date: 1996-09-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP97943428A

Other languages

German (de)

French (fr)

Other versions

EP0977567A1 (en

Inventor

Lovji D Cama

Robert R Wilkening

Ronald W Ratcliffe

Timothy A Blizzard

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-13

Filing date

1997-09-09

Publication date

2000-02-09

1997-01-27 Priority claimed from GBGB9701605.9A external-priority patent/GB9701605D0/en

1997-09-09 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2000-02-09 Publication of EP0977567A1 publication Critical patent/EP0977567A1/en

2000-02-09 Publication of EP0977567A4 publication Critical patent/EP0977567A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

EP97943428A 1996-09-13 1997-09-09 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment Withdrawn EP0977567A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US2618296P	1996-09-13	1996-09-13
US26182P		1996-09-13
GBGB9701605.9A GB9701605D0 (en)	1997-01-27	1997-01-27	Carbapenham antibacterial compounds compositions containing such compounds and methods of treatment
GB9701605		1997-01-27
PCT/US1997/016786 WO1998010761A1 (en)	1996-09-13	1997-09-09	Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Publications (2)

Publication Number	Publication Date
EP0977567A1 EP0977567A1 (en)	2000-02-09
EP0977567A4 true EP0977567A4 (en)	2000-02-09

Family

ID=26310862

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP97943428A Withdrawn EP0977567A4 (en)	1996-09-13	1997-09-09	Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Country Status (5)

Country	Link
EP (1)	EP0977567A4 (en)
JP (1)	JP2002515882A (en)
AU (1)	AU4490597A (en)
CA (1)	CA2264605A1 (en)
WO (1)	WO1998010761A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1027352A4 (en) *	1997-10-23	2001-09-19	Merck & Co Inc	Carbapenem antibacterial compounds, compositions and methods of treatment
US7378427B2 (en)	2004-06-18	2008-05-27	Wyeth	Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5192758A (en) *	1992-02-28	1993-03-09	Merck & Co., Inc.	2-biphenyl-carbapenem antibacterial agents
US5451579A (en) *	1994-02-15	1995-09-19	Merck & Co., Inc.	1-β-methyl-carbapenem, compositions containing same and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5578722A (en) *	1994-03-29	1996-11-26	Sumitomo Pharmaceuticals Co., Ltd.	Process for preparing carbapenem compounds

1997
- 1997-09-09 WO PCT/US1997/016786 patent/WO1998010761A1/en not_active Application Discontinuation
- 1997-09-09 JP JP51401598A patent/JP2002515882A/en active Pending
- 1997-09-09 EP EP97943428A patent/EP0977567A4/en not_active Withdrawn
- 1997-09-09 CA CA002264605A patent/CA2264605A1/en not_active Abandoned
- 1997-09-09 AU AU44905/97A patent/AU4490597A/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5192758A (en) *	1992-02-28	1993-03-09	Merck & Co., Inc.	2-biphenyl-carbapenem antibacterial agents
US5451579A (en) *	1994-02-15	1995-09-19	Merck & Co., Inc.	1-β-methyl-carbapenem, compositions containing same and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9810761A1 *

Also Published As

Publication number	Publication date
AU4490597A (en)	1998-04-02
WO1998010761A1 (en)	1998-03-19
EP0977567A1 (en)	2000-02-09
JP2002515882A (en)	2002-05-28
CA2264605A1 (en)	1998-03-19

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Legal Events

Date	Code	Title	Description
1999-12-23	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2000-02-09	17P	Request for examination filed	Effective date: 19990413
2000-02-09	A4	Supplementary search report drawn up and despatched	Effective date: 19991019
2000-02-09	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
2001-09-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2001-11-14	18D	Application deemed to be withdrawn	Effective date: 20010403