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EP0964922A4 - Procedes permettant l'optimisation d'une therapie genique grace a un rearrangement et une selection recursifs de sequences - Google Patents

Procedes permettant l'optimisation d'une therapie genique grace a un rearrangement et une selection recursifs de sequences

Info

Publication number
EP0964922A4
EP0964922A4 EP97943600A EP97943600A EP0964922A4 EP 0964922 A4 EP0964922 A4 EP 0964922A4 EP 97943600 A EP97943600 A EP 97943600A EP 97943600 A EP97943600 A EP 97943600A EP 0964922 A4 EP0964922 A4 EP 0964922A4
Authority
EP
European Patent Office
Prior art keywords
optimization
selection
methods
gene therapy
recursive sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97943600A
Other languages
German (de)
English (en)
Other versions
EP0964922A1 (fr
Inventor
Willem P C Stemmer
Frederick C Christians
Shi-Kau Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maxygen Inc
Original Assignee
Maxygen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxygen Inc filed Critical Maxygen Inc
Publication of EP0964922A1 publication Critical patent/EP0964922A1/fr
Publication of EP0964922A4 publication Critical patent/EP0964922A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/14011—Details ssDNA Bacteriophages
    • C12N2795/14111—Inoviridae
    • C12N2795/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2795/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Ecology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP97943600A 1996-09-27 1997-09-26 Procedes permettant l'optimisation d'une therapie genique grace a un rearrangement et une selection recursifs de sequences Withdrawn EP0964922A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72266096A 1996-09-27 1996-09-27
US3774296P 1996-09-27 1996-09-27
US37742P 1996-09-27
PCT/US1997/017300 WO1998013487A1 (fr) 1996-09-27 1997-09-26 Procedes permettant l'optimisation d'une therapie genique grace a un rearrangement et une selection recursifs de sequences
US722660 2000-11-28

Publications (2)

Publication Number Publication Date
EP0964922A1 EP0964922A1 (fr) 1999-12-22
EP0964922A4 true EP0964922A4 (fr) 2000-10-25

Family

ID=26714441

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97943600A Withdrawn EP0964922A4 (fr) 1996-09-27 1997-09-26 Procedes permettant l'optimisation d'une therapie genique grace a un rearrangement et une selection recursifs de sequences

Country Status (5)

Country Link
EP (1) EP0964922A4 (fr)
JP (1) JP2001504325A (fr)
AU (1) AU4503797A (fr)
CA (1) CA2266423A1 (fr)
WO (1) WO1998013487A1 (fr)

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US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
WO2000053744A2 (fr) * 1999-03-09 2000-09-14 Diversa Corporation Selection finale d'une evolution dirigee
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
ATE334225T1 (de) 1997-01-17 2006-08-15 Maxygen Inc Evolution prokaryotischer ganzer zellen durch rekursive sequenzrekombination
US6602677B1 (en) * 1997-09-19 2003-08-05 Promega Corporation Thermostable luciferases and methods of production
AU1124499A (en) 1997-10-28 1999-05-17 Maxygen, Inc. Human papillomavirus vectors
EP1030861A4 (fr) 1997-10-31 2001-09-05 Maxygen Inc Modification du tropisme viral et de la diversite d'especes hote par recombinaison du genome viral
US6468745B1 (en) 1998-01-16 2002-10-22 Large Scale Biology Corporation Method for expressing a library of nucleic acid sequence variants and selecting desired traits
US6426185B1 (en) 1998-01-16 2002-07-30 Large Scale Biology Corporation Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
US6303848B1 (en) 1998-01-16 2001-10-16 Large Scale Biology Corporation Method for conferring herbicide, pest, or disease resistance in plant hosts
BR9910174A (pt) 1998-05-01 2001-03-06 Maxygen Inc Processo para se obter um gene recombinante otimizado de resistência à praga, biblioteca, e, processo para se obter um organismo que seja patogênico a uma praga de vegetal
EP1090024A2 (fr) 1998-06-17 2001-04-11 Maxygen, Inc. Technique de production de polynucleotides aux caracteristiques souhaitees
US6605430B1 (en) 1998-08-12 2003-08-12 Maxygen, Inc. DNA shuffling of monooxygenase genes for production of industrial chemicals
EP1119616A2 (fr) 1998-10-07 2001-08-01 Maxygen, Inc. Rearrangement d'adn pour produire des acides nucleiques de detoxication contre les mycotoxines
GB9823468D0 (en) 1998-10-28 1998-12-23 Secr Defence Novel enzyme
WO2000028018A1 (fr) 1998-11-10 2000-05-18 Maxygen, Inc. Adp-glucose pyrophosphorylase modifiee pour l'amelioration et l'optimisation de phenotypes vegetaux
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
EP1108783A3 (fr) 1999-01-19 2001-09-05 Maxygen, Inc. Recombinaisons d'acides nucléiques guidées par des oligonucléotides
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
KR20010102069A (ko) 1999-02-11 2001-11-15 추후제출 고효율 질량 분석
US6531316B1 (en) 1999-03-05 2003-03-11 Maxyag, Inc. Encryption of traits using split gene sequences and engineered genetic elements
DE60031126T2 (de) 1999-08-12 2007-02-08 Pfizer Products Inc., Groton Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen
US7430477B2 (en) 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
GB9925161D0 (en) 1999-10-26 1999-12-22 Secr Defence Novel enzyme
US6686515B1 (en) 1999-11-23 2004-02-03 Maxygen, Inc. Homologous recombination in plants
WO2001038513A2 (fr) * 1999-11-23 2001-05-31 Maxygen, Inc. Techniques de brassage de genes de virus et d'agrobacteries, de plasmides, et de genomes permettant d'ameliorer une transformation de plante
US7115712B1 (en) 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
AU2001234980A1 (en) 2000-02-09 2001-08-20 Genvec, Inc. Methods of preparing and using a viral vector library
CN1247784C (zh) 2000-02-09 2006-03-29 巴斯福股份公司 新延伸酶基因以及制备多不饱和脂肪酸的方法
AU2001287273A1 (en) * 2000-03-24 2001-10-08 Maxygen, Inc. Methods for modulating cellular and organismal phenotypes
CN1328144A (zh) * 2000-06-12 2001-12-26 上海博德基因开发有限公司 一种新的多肽——甲基化－dna－蛋白－半胱氨酸甲基转移酶10和编码这种多肽的多核苷酸
AU2001272978A1 (en) 2000-06-23 2002-01-08 Maxygen, Inc. Novel co-stimulatory molecules
EP1297146A2 (fr) 2000-06-23 2003-04-02 Maxygen, Inc. Nouveaux promoteurs chimeres
US6858422B2 (en) 2000-07-13 2005-02-22 Codexis, Inc. Lipase genes
US7879540B1 (en) 2000-08-24 2011-02-01 Promega Corporation Synthetic nucleic acid molecule compositions and methods of preparation
IL154596A0 (en) 2000-08-25 2003-09-17 Basf Plant Science Gmbh Plant polynucleotides encoding novel prenyl proteases
AU2004260931B9 (en) 2003-04-29 2012-01-19 E.I. Du Pont De Nemours And Company Novel glyphosate-N-acetyltransferase (GAT) genes
GB0107510D0 (en) 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
US7647184B2 (en) 2001-08-27 2010-01-12 Hanall Pharmaceuticals, Co. Ltd High throughput directed evolution by rational mutagenesis
US20030129203A1 (en) * 2001-08-27 2003-07-10 Nautilus Biotech S.A. Mutant recombinant adeno-associated viruses
DE60332358D1 (de) 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
PL1673457T3 (pl) 2003-08-25 2011-12-30 Amyra Biotech Ag Nowe białka grzybów oraz kodujące je kwasy nukleinowe
WO2005085431A2 (fr) * 2004-03-02 2005-09-15 Epfl Ecole Polytechnique Federale De Lausanne Mutants de o6-alkylguanine-adn alkyltransferase
CA2734624A1 (fr) 2004-06-09 2005-12-29 Pioneer Hi-Bred International, Inc. Peptides de transit vers des plastes
US7728118B2 (en) 2004-09-17 2010-06-01 Promega Corporation Synthetic nucleic acid molecule compositions and methods of preparation
US8715988B2 (en) 2005-03-28 2014-05-06 California Institute Of Technology Alkane oxidation by modified hydroxylases
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
AU2009248931A1 (en) 2008-05-23 2009-11-26 E. I. Du Pont De Nemours And Company Novel DGAT genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
ES2706899T3 (es) 2008-09-26 2019-04-01 Tocagen Inc Vectores de terapia génica y citosina desaminasas
CA2770854A1 (fr) 2009-08-20 2011-02-24 Pioneer Hi-Bred International, Inc. Expression fonctionnelle d'un transporteur de nitrate de levure brasse (ynt1) chez le mais pour ameliorer l'absorption du nitrate dans un environnement pauvre en nitrate
BR112012016290A2 (pt) 2009-12-31 2015-09-01 Pioneer Hi Bred Int Ácido nucléico isolado ou recombinante, cassete de expressão, célula hospedeira não humana, planta e semente transgênica, variante de polipeptídeo oxox isolado ou recombinante, método de modulação do nível de proteina oxalato oxidase (oxox) em uma planta ou célula vegetal, método para aumentar a resistência de uma planta a um patógeno, planta resistente a patógeno, método para identificar variantes oxox com atividade de oxox mantida ou aumentada, método para gerar uma planta que tem resistência aumentada a uma patógeno
BR112013003224A2 (pt) 2010-08-13 2016-06-07 Pioneer Hi Bred Int "construto de promotor quimérico, cassete de expressão, vetor de expressão, método de obtenção de uma planta, método para regular a expressão de um polinucleotídeo de interesse, polinucleotídeo, método para expressar um polinucleotídeo de interesse"
CA2872096A1 (fr) 2012-05-04 2013-11-07 E. I. Du Pont De Nemours And Company Compositions et procedes comprenant des sequences ayant une activite de meganuclease
CA2905595A1 (fr) 2013-03-14 2014-09-25 Pioneer Hi-Bred International, Inc. Compositions ayant une activite de dicamba decarboxylase et procedes d'utilisation
CA2904537A1 (fr) 2013-03-14 2014-09-25 Pioneer Hi-Bred International, Inc. Compositions ayant une activite de decarboxylase de dicamba et leurs procedes d'utilisation
US9732373B2 (en) 2014-09-11 2017-08-15 Promega Corporation Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
EP4087932A4 (fr) 2020-01-10 2024-01-17 The Regents of the University of California Plateforme biosynthétique pour la production d'acide olivétolique et d'analogues d'acide olivétolique

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035957A1 (fr) * 1996-03-25 1997-10-02 Maxygen, Inc. Absorption d'adn cellulaire par recombinaison recursive de sequences

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035957A1 (fr) * 1996-03-25 1997-10-02 Maxygen, Inc. Absorption d'adn cellulaire par recombinaison recursive de sequences

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9813487A1 *

Also Published As

Publication number Publication date
AU4503797A (en) 1998-04-17
EP0964922A1 (fr) 1999-12-22
CA2266423A1 (fr) 1998-04-02
JP2001504325A (ja) 2001-04-03
WO1998013487A1 (fr) 1998-04-02

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Legal Events

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