[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EP0888375A4 - NOVEL DISINTEGRIN-METALLOPROTEASE AND METHODS OF USE - Google Patents

NOVEL DISINTEGRIN-METALLOPROTEASE AND METHODS OF USE

Info

Publication number
EP0888375A4
EP0888375A4 EP97908799A EP97908799A EP0888375A4 EP 0888375 A4 EP0888375 A4 EP 0888375A4 EP 97908799 A EP97908799 A EP 97908799A EP 97908799 A EP97908799 A EP 97908799A EP 0888375 A4 EP0888375 A4 EP 0888375A4
Authority
EP
European Patent Office
Prior art keywords
metalloprotease
methods
novel disintegrin
disintegrin
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97908799A
Other languages
German (de)
French (fr)
Other versions
EP0888375A1 (en
Inventor
Michael Howard Tindal
Tariq Haqqi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Procter and Gamble Co
Original Assignee
Case Western Reserve University
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University, Procter and Gamble Co filed Critical Case Western Reserve University
Publication of EP0888375A1 publication Critical patent/EP0888375A1/en
Publication of EP0888375A4 publication Critical patent/EP0888375A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489Metalloendopeptidases (3.4.24)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486Metalloendopeptidases (3.4.24)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
EP97908799A 1996-03-01 1997-02-28 NOVEL DISINTEGRIN-METALLOPROTEASE AND METHODS OF USE Withdrawn EP0888375A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1267996P 1996-03-01 1996-03-01
US12679P 1996-03-01
PCT/US1997/003217 WO1997031931A1 (en) 1996-03-01 1997-02-28 A novel disintegrin metalloprotease and methods of use

Publications (2)

Publication Number Publication Date
EP0888375A1 EP0888375A1 (en) 1999-01-07
EP0888375A4 true EP0888375A4 (en) 2001-04-11

Family

ID=21756171

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97908799A Withdrawn EP0888375A4 (en) 1996-03-01 1997-02-28 NOVEL DISINTEGRIN-METALLOPROTEASE AND METHODS OF USE

Country Status (8)

Country Link
EP (1) EP0888375A4 (en)
JP (1) JPH11506023A (en)
KR (1) KR19990087444A (en)
AU (1) AU2061797A (en)
CA (1) CA2247827A1 (en)
NO (1) NO983984L (en)
NZ (1) NZ331844A (en)
WO (1) WO1997031931A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255064B1 (en) 1996-03-01 2001-07-03 The Procter & Gamble Company Disintegrin metalloprotease and its use
CA2263883C (en) * 1996-08-29 2003-07-08 The Regents Of The University Of California Kuz, a novel family of metalloproteases
JP2001514494A (en) * 1997-02-25 2001-09-11 ザ プロクター アンド ギャンブル カンパニー Use of novel disintegrin metalloproteases, variants, fragments, etc.
US6436629B1 (en) 2000-10-27 2002-08-20 The Regents Of The University Of California Modulating angiogenesis
US6294368B1 (en) * 2001-03-22 2001-09-25 Applera Corporation Isolated human metalloprotease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
PL371525A1 (en) * 2002-01-31 2005-06-27 Wyeth Aggrecanase molecules

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008933A1 (en) * 1996-08-29 1998-03-05 The Regents Of The University Of California Kuz, a novel family of metalloproteases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008933A1 (en) * 1996-08-29 1998-03-05 The Regents Of The University Of California Kuz, a novel family of metalloproteases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHANTRY A ET AL: "A NOVEL METALLOPROTEINASE ASSOCIATED WITH BRAIN MYELIN MEMBRANES ISOLATION AND CHARACTERIZATION", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 264, no. 36, 1989, pages 21603 - 21607, XP002158712, ISSN: 0021-9258 *
HOWARD L ET AL: "MOLECULAR CLONING OF MADM: A CATALYTICALLY ACTIVE MAMMALIAN", BIOCHEMICAL JOURNAL,GB,PORTLAND PRESS, LONDON, vol. 317, no. 1, 1 July 1996 (1996-07-01), pages 45 - 50, XP002046451, ISSN: 0264-6021 *
See also references of WO9731931A1 *

Also Published As

Publication number Publication date
WO1997031931A1 (en) 1997-09-04
AU2061797A (en) 1997-09-16
NO983984L (en) 1998-11-02
KR19990087444A (en) 1999-12-27
CA2247827A1 (en) 1997-09-04
JPH11506023A (en) 1999-06-02
EP0888375A1 (en) 1999-01-07
NZ331844A (en) 2000-06-23
NO983984D0 (en) 1998-08-28

Similar Documents

Publication Publication Date Title
EP0880356A4 (en) ANTIMICROBIAL PEPTIDES AND METHODS OF USE THEREOF
EP1037911A4 (en) ANTI-PATHOGENIC SYSTEM AND METHODS OF USE
LU91437I2 (en) "dabigatran-etexilate and its salts - particularly dabigatran-etexilate-mesilate (PRADAXA)"
EP1018987A4 (en) NEOCARTILAGE AND ITS METHODS OF USE
EP0996632A4 (en) ANGIOSTATIN FRAGMENTS AND THEIR METHOD OF USE
ID18623A (en) NAFTIRIDIN'S DEMONS
NO963814D0 (en) Inhibitor of the 265 proteolytic complex and 205 proteasome contained therein
EP1019043A4 (en) GLYCOGENE SYNTHETASE KINASE-3 INHIBITORS AND METHODS OF IDENTIFYING AND USING THOSE INHIBITORS
EP0934287A4 (en) HETEROCYCLIC ESTERS AND AMIDES
NO995247L (en) Use of equipment in a well system
EP0960191A4 (en) COMPOSITIONS AND METHODS FOR THE USE OF DEFENSIN
DE69501493D1 (en) Removal of moisture and passivation of surfaces
FR2726906B1 (en) INSTRUMENT OF INDICATION
ID17440A (en) PEPTIDA'S DEMONSTRATIONS
EP0888267A4 (en) NOVEL PYRUVATE COMPOUNDS AND METHODS OF USE
ID16037A (en) PEPTIDA'S DEMONSTRATIONS
FR2754179B1 (en) NOVEL HORMONONAL COMPOSITION AND ITS USE
EP0836611A4 (en) SEQUENCES FOR THE PRODUCTION OF 2,4-DIACETYLPHLOROGLUCINOL AND METHODS OF USE
EP0888375A4 (en) NOVEL DISINTEGRIN-METALLOPROTEASE AND METHODS OF USE
EP0935654A4 (en) FIBROBLAST GROWTH FACTOR (FHF-3) APPROVED FACTOR 3 AND METHODS OF USE
DE59604570D1 (en) Fluorinated biphenylcyclohexanes and liquid crystalline medium
EP1263935A4 (en) SCYTONEMINE AND METHODS OF USE
FR2777291B1 (en) NOVEL MEMBRANE METALLOPROTEASE NEP II AND ITS USE FOR THE SCREENING OF INHIBITORS USEFUL IN THERAPY
EP1070141A4 (en) IMMEDIATE EARLY GENES AND METHODS OF USE
FR2723701B3 (en) USE OF A GRANULATOR AND CORRESPONDING GRANULATOR

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19980925

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20010223

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20020629