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EP0880357A4 - Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis - Google Patents

Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis

Info

Publication number
EP0880357A4
EP0880357A4 EP96919234A EP96919234A EP0880357A4 EP 0880357 A4 EP0880357 A4 EP 0880357A4 EP 96919234 A EP96919234 A EP 96919234A EP 96919234 A EP96919234 A EP 96919234A EP 0880357 A4 EP0880357 A4 EP 0880357A4
Authority
EP
European Patent Office
Prior art keywords
peptidomimetics
peptides
synthesis
amino acids
ring closing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96919234A
Other languages
German (de)
French (fr)
Other versions
EP0880357A1 (en
Inventor
Robert H Grubbs
J Scott Miller
Helen E Blackwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of EP0880357A1 publication Critical patent/EP0880357A1/en
Publication of EP0880357A4 publication Critical patent/EP0880357A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP96919234A 1996-01-17 1996-06-07 Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis Withdrawn EP0880357A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1017096P 1996-01-17 1996-01-17
US10170P 1996-01-17
PCT/US1996/009591 WO1997026002A1 (en) 1996-01-17 1996-06-07 Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis

Publications (2)

Publication Number Publication Date
EP0880357A1 EP0880357A1 (en) 1998-12-02
EP0880357A4 true EP0880357A4 (en) 1999-05-12

Family

ID=21744291

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96919234A Withdrawn EP0880357A4 (en) 1996-01-17 1996-06-07 Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis

Country Status (3)

Country Link
EP (1) EP0880357A4 (en)
AU (1) AU6162996A (en)
WO (1) WO1997026002A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US6582726B1 (en) * 2000-06-21 2003-06-24 Smithkline Beecham Corporation Cross linked solid supports for solid phase synthesis
AU8833701A (en) * 2000-08-19 2002-03-04 Univ Florida Functionalized polymers
US8710178B2 (en) 2006-10-18 2014-04-29 Lincoln University Macrocyclic cysteine protease inhibitors and compositions thereof
CN101730708B (en) 2007-03-28 2013-09-18 哈佛大学校长及研究员协会 Stitched polypeptides
CN104961795A (en) 2008-09-22 2015-10-07 爱勒让治疗公司 Methods for preparing purified polypeptide compositions
KR102104762B1 (en) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 Peptidomimetic macrocycles
CN108929375A (en) 2011-10-18 2018-12-04 爱勒让治疗公司 Peptidomimetic macrocyclic compound
US8927500B2 (en) 2012-02-15 2015-01-06 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN108912211A (en) 2012-02-15 2018-11-30 爱勒让治疗公司 Triazole crosslinking and thioether crosslinking peptidomimetic macrocyclic compound
SG11201503052RA (en) 2012-11-01 2015-05-28 Aileron Therapeutics Inc Disubstituted amino acids and methods of preparation and use thereof
JP6568515B2 (en) 2013-03-13 2019-08-28 プレジデント アンド フェローズ オブ ハーバード カレッジ Stapled and stitched polypeptides and uses thereof
JP2016523241A (en) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ Stabilized polypeptide insulin receptor modulators
US10533039B2 (en) 2014-05-21 2020-01-14 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
BR112017005736A2 (en) 2014-09-24 2017-12-12 Aileron Therapeutics Inc peptidomimetic macrocycles and formulations thereof
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2020023502A1 (en) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US11584956B2 (en) * 2018-12-21 2023-02-21 Microsoft Technology Licensing, Llc Selectively controllable cleavable linkers
US20200384434A1 (en) 2019-06-07 2020-12-10 Microsoft Technology Licensing, Llc Reversing bias in polymer synthesis electrode array
US11896945B2 (en) 2019-10-09 2024-02-13 Microsoft Technology Licensing, Llc High surface area coatings for solid-phase synthesis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
SCOTT J.MILLER ET AL.: "Synthesis of Conformationally Restricted Amino Acids and Peptides Employing Olefin Metathesis", J.AM.CHEM.SOC., vol. 117, 1995, pages 5855 - 6, XP002093028 *
SCOTT.J.MILLER ET AL: "Catalytic Ring-Closing Metathesis of Dienes: Application to the Synthesis of Eight-Membered Rings", J.AM.CHEM.SOC, vol. 117, 1995, pages 2108 - 9, XP002093029 *
See also references of WO9726002A1 *
THOMAS D.CLERK ET AL.: "Supramolecular Design by Covalent Capture. Design of a Peptide cylinder via Hydrogen-Bond-Promoted Intermolecular Olefin Metathesis", J.AM.CHEM.SOC., vol. 117, 1995, pages 12364 - 5, XP002093030 *

Also Published As

Publication number Publication date
EP0880357A1 (en) 1998-12-02
AU6162996A (en) 1997-08-11
WO1997026002A1 (en) 1997-07-24

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Legal Events

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