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EP0706399A4 - Compositions and process for removing bile salts - Google Patents

Compositions and process for removing bile salts

Info

Publication number
EP0706399A4
EP0706399A4 EP94919283A EP94919283A EP0706399A4 EP 0706399 A4 EP0706399 A4 EP 0706399A4 EP 94919283 A EP94919283 A EP 94919283A EP 94919283 A EP94919283 A EP 94919283A EP 0706399 A4 EP0706399 A4 EP 0706399A4
Authority
EP
European Patent Office
Prior art keywords
compositions
bile salts
removing bile
salts
bile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94919283A
Other languages
German (de)
French (fr)
Other versions
EP0706399A1 (en
Inventor
W Harry Mandeville Iii
Stephen Randall Holmes-Farley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geltex Pharmaceuticals Inc
Original Assignee
Geltex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geltex Pharmaceuticals Inc filed Critical Geltex Pharmaceuticals Inc
Publication of EP0706399A1 publication Critical patent/EP0706399A1/en
Publication of EP0706399A4 publication Critical patent/EP0706399A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
EP94919283A 1993-06-02 1994-05-27 Compositions and process for removing bile salts Withdrawn EP0706399A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7156493A 1993-06-02 1993-06-02
US71564 1993-06-02
PCT/US1994/006042 WO1994027620A1 (en) 1993-06-02 1994-05-27 Compositions and process for removing bile salts

Publications (2)

Publication Number Publication Date
EP0706399A1 EP0706399A1 (en) 1996-04-17
EP0706399A4 true EP0706399A4 (en) 1998-08-12

Family

ID=22102137

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94919283A Withdrawn EP0706399A4 (en) 1993-06-02 1994-05-27 Compositions and process for removing bile salts

Country Status (4)

Country Link
EP (1) EP0706399A4 (en)
JP (1) JPH09500368A (en)
AU (1) AU7047994A (en)
WO (1) WO1994027620A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5487888A (en) 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
FR2757866B1 (en) * 1996-12-30 2004-12-17 Catalyse POLYMERS COMPRISING QUATERNARY AMMONIUM GROUPS, THEIR USE FOR THE MANUFACTURE OF AN ANTIBACTERIAL PROPERTY MATERIAL AND THEIR PREPARATION METHODS
US5925379A (en) * 1997-03-27 1999-07-20 Geltex Pharmaceuticals, Inc. Interpenetrating polymer networks for sequestration of bile acids
US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
US6190649B1 (en) 1999-04-23 2001-02-20 Geltex Pharmaceuticals, Inc. Polyether-based bile acid sequestrants
IL147361A0 (en) * 1999-07-14 2002-08-14 Geltex Pharma Inc Fat-binding polymers, optionally combined with lipase inhibitors
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
MXPA03009562A (en) * 2001-04-18 2004-02-12 Genzyme Corp Methods of treating syndrome x with aliphatic polyamines.
JPWO2005092349A1 (en) 2004-03-26 2008-02-07 田辺三菱製薬株式会社 Insulin resistance improving agent
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
CA2620406A1 (en) 2005-09-02 2007-03-08 Genzyme Corporation Method for removing phosphate and polymer used therefore
AU2006292672B2 (en) 2005-09-15 2012-04-19 Genzyme Corporation Sachet formulation for amine polymers
DE102006007564A1 (en) * 2006-02-16 2007-08-30 Röhm Gmbh Nanoscale superparamagnetic poly (meth) acrylate polymers
WO2007145308A1 (en) 2006-06-16 2007-12-21 Mitsubishi Tanabe Pharma Corporation Agent for prevention and/or treatment of glomerulopathy
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
MA41202A (en) 2014-12-18 2017-10-24 Genzyme Corp CROSS-LINKED POLYDIALLYMINE COPOLYMERS FOR THE TREATMENT OF TYPE 2 DIABETES

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3308020A (en) * 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
ES2006782A6 (en) * 1987-07-15 1989-05-16 Garcia Alonso Julio Anionic ion exchange resin prepn.
EP0373852A2 (en) * 1988-12-13 1990-06-20 Smith Kline & French Laboratories Limited Compounds
JPH059234A (en) * 1991-06-28 1993-01-19 Chuichi Hirayama Pyrogen-adsorbing substance

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953406A (en) * 1973-01-26 1976-04-27 California Institute Of Technology Water-insoluble, swellable polyurethanes
JPS57142920A (en) * 1981-03-02 1982-09-03 Mitsubishi Petrochem Co Ltd Cholesterol depressant
US4557930A (en) * 1982-01-18 1985-12-10 Mitsubishi Petrochemical Co., Ltd. Anticholesteremic anion exchange resins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3308020A (en) * 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
ES2006782A6 (en) * 1987-07-15 1989-05-16 Garcia Alonso Julio Anionic ion exchange resin prepn.
EP0373852A2 (en) * 1988-12-13 1990-06-20 Smith Kline & French Laboratories Limited Compounds
JPH059234A (en) * 1991-06-28 1993-01-19 Chuichi Hirayama Pyrogen-adsorbing substance

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 114, no. 12, 25 March 1991, Columbus, Ohio, US; abstract no. 109016, XP002065385 *
PATENT ABSTRACTS OF JAPAN vol. 017, no. 274 (C - 1064) 27 May 1993 (1993-05-27) *
See also references of WO9427620A1 *

Also Published As

Publication number Publication date
WO1994027620A1 (en) 1994-12-08
EP0706399A1 (en) 1996-04-17
JPH09500368A (en) 1997-01-14
AU7047994A (en) 1994-12-20

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19960130

A4 Supplementary search report drawn up and despatched
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18D Application deemed to be withdrawn

Effective date: 20010903