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EP0700684A3 - Composition contenant un concentré d'un complexe de la prothrombine et au minimum un composé supplémentaire qui active la coagulation, en tant qu'antidote des anticoagulants sanguins - Google Patents

Composition contenant un concentré d'un complexe de la prothrombine et au minimum un composé supplémentaire qui active la coagulation, en tant qu'antidote des anticoagulants sanguins Download PDF

Info

Publication number
EP0700684A3
EP0700684A3 EP95112570A EP95112570A EP0700684A3 EP 0700684 A3 EP0700684 A3 EP 0700684A3 EP 95112570 A EP95112570 A EP 95112570A EP 95112570 A EP95112570 A EP 95112570A EP 0700684 A3 EP0700684 A3 EP 0700684A3
Authority
EP
European Patent Office
Prior art keywords
prothrombincomplex
antidote
anticoagulants
coagulation
activates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95112570A
Other languages
German (de)
English (en)
Other versions
EP0700684A2 (fr
Inventor
Juergen Dr Roemisch
Karl-Heinz Dr Diehl
Hans-Arnold Stoehr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of EP0700684A2 publication Critical patent/EP0700684A2/fr
Publication of EP0700684A3 publication Critical patent/EP0700684A3/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/366—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP95112570A 1994-08-26 1995-08-10 Composition contenant un concentré d'un complexe de la prothrombine et au minimum un composé supplémentaire qui active la coagulation, en tant qu'antidote des anticoagulants sanguins Withdrawn EP0700684A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4430205 1994-08-26
DE4430205A DE4430205A1 (de) 1994-08-26 1994-08-26 Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung

Publications (2)

Publication Number Publication Date
EP0700684A2 EP0700684A2 (fr) 1996-03-13
EP0700684A3 true EP0700684A3 (fr) 1997-01-08

Family

ID=6526564

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95112570A Withdrawn EP0700684A3 (fr) 1994-08-26 1995-08-10 Composition contenant un concentré d'un complexe de la prothrombine et au minimum un composé supplémentaire qui active la coagulation, en tant qu'antidote des anticoagulants sanguins

Country Status (8)

Country Link
EP (1) EP0700684A3 (fr)
JP (1) JP3859176B2 (fr)
KR (1) KR960006938A (fr)
AU (1) AU3025795A (fr)
CA (1) CA2156991A1 (fr)
DE (1) DE4430205A1 (fr)
IL (1) IL115058A0 (fr)
ZA (1) ZA957139B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4437544A1 (de) * 1994-10-20 1996-04-25 Behringwerke Ag Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika
AT404673B (de) * 1996-03-20 1999-01-25 Immuno Ag Pharmazeutisches präparat zur behandlung von blutgerinnungsstörungen
EP0796623B1 (fr) * 1996-03-20 2005-05-25 Baxter Aktiengesellschaft Préparation pharmaceutique pour le traitement des maladies de la coagulation sanguine
DE19710190A1 (de) * 1997-03-12 1998-09-17 Immuno Ag Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung
AT409334B (de) * 1997-09-19 2002-07-25 Immuno Ag Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren
AT407484B (de) 1997-11-12 2001-03-26 Bio Prod & Bio Eng Ag Arzneimittel zur förderung der wundheilung
AU2003242430A1 (en) * 2002-05-23 2003-12-12 Chugai Seiyaku Kabushiki Kaisha Agent neutralizint tissue factor inhibitor and agent neutralizing activated blood coagulation factor viii preparation
ATE428440T1 (de) * 2002-07-23 2009-05-15 Bio & Bio Licensing Sa Thrombingenerierfähige und thrombinhaltige pharmazeutische wirkstoffzubereitungen und arzneimittel
EP1523327A1 (fr) 2002-07-23 2005-04-20 Bio-Products & Bio-Engineering Aktiengesellschaft Preparations de principes actifs pharmaceutiques et medicaments generant ou contenant de la thrombine
EP1935429A1 (fr) 2006-12-22 2008-06-25 CSL Behring GmbH Utilisation thérapeutique synergique de concentrés de complexe prothrombinique avec des concentrés de FVIII
KR102271404B1 (ko) 2007-09-28 2021-07-02 포톨라 파마슈티컬스, 인코포레이티드 인자 Ｘａ 저해제에 대한 안티도트 및 그것을 사용하는 방법
DE102008032361A1 (de) 2008-07-10 2010-01-21 Csl Behring Gmbh Der Einsatz von Faktor VIII und vWF bzw. vWF-enthaltenden Konzentraten zur Therapie der durch Thrombocyten-Inhibitoren induzierte Koagulopathie
AU2009314153B2 (en) * 2008-11-14 2015-09-17 Alexion Pharmaceuticals, Inc. Antidotes for factor Xa inhibitors and methods of using the same in combination with blood coagulating agents
EP3121271B1 (fr) 2009-03-30 2019-07-24 Portola Pharmaceuticals, Inc. Antidotes pour inhibiteurs du facteur xa et procédés d'utilisation associes
US20140128732A1 (en) 2012-11-06 2014-05-08 Cross Bay Medical, Inc. Biopsy and sonography method and apparatus for assessing bodily cavities
FR3000895B1 (fr) 2013-01-11 2017-02-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Sa Utilisation d'antidotes d'inhibiteurs de la coagulation indiques dans la prevention ou le traitement de pathologies thromboemboliques
DK2796145T3 (da) 2013-04-22 2018-01-29 Csl Ltd Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro
WO2016019145A1 (fr) * 2014-07-31 2016-02-04 Haemonetics Corporation Détection et classification d'un anticoagulant à l'aide d'un test de coagulation

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2902657A1 (de) * 1978-01-25 1979-07-26 Birger Blombaeck Verfahren zur herstellung von den gerinnungsfaktor ii, v oder viii oder deren gemische enthaltenden konzentraten oder von den faktoren vii, ix, x, xi oder xii oder den gemischen freiem plasma
WO1981002105A1 (fr) * 1980-01-28 1981-08-06 Baxter Travenol Lab Compositions therapeutiques et procede de fabrication et d'utilisation de celles-ci
US4455301A (en) * 1980-02-26 1984-06-19 Cutter Laboratories, Inc. Antihemophilic factor concentrate
EP0367713A1 (fr) * 1988-10-06 1990-05-09 Ciba-Geigy Ag Antidote pour anticoagulants de sang à base de facteur VIII
EP0416983A1 (fr) * 1989-09-05 1991-03-13 Centre Regional De Transfusion Sanguine De Lille Procédé de préparation de concentré du complexe Facteur VIII-facteur von Willebrand de la coagulation sanguine à partir de plasma total
DE4203965A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Antidot fuer hirudin und synthetische thrombininhibitoren
WO1994011527A1 (fr) * 1992-11-12 1994-05-26 Sheldon Goldstein Dispositif et procede d'essais de coagulation multiples
WO1995026750A1 (fr) * 1994-03-31 1995-10-12 Pharmacia Ab Formulation pharmaceutique servant a effectuer l'administration sous-cutanee, intramusculaire ou intradermique du facteur viii ou du facteur ix
EP0680764A2 (fr) * 1994-05-06 1995-11-08 IMMUNO Aktiengesellschaft Préparation stable pour le traitement des anomalies de la coagulation du sang comprenant un facteur de coagulation activé et des vésicules lipidiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3098289A (en) 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
US5240913A (en) 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2902657A1 (de) * 1978-01-25 1979-07-26 Birger Blombaeck Verfahren zur herstellung von den gerinnungsfaktor ii, v oder viii oder deren gemische enthaltenden konzentraten oder von den faktoren vii, ix, x, xi oder xii oder den gemischen freiem plasma
WO1981002105A1 (fr) * 1980-01-28 1981-08-06 Baxter Travenol Lab Compositions therapeutiques et procede de fabrication et d'utilisation de celles-ci
US4455301A (en) * 1980-02-26 1984-06-19 Cutter Laboratories, Inc. Antihemophilic factor concentrate
EP0367713A1 (fr) * 1988-10-06 1990-05-09 Ciba-Geigy Ag Antidote pour anticoagulants de sang à base de facteur VIII
EP0416983A1 (fr) * 1989-09-05 1991-03-13 Centre Regional De Transfusion Sanguine De Lille Procédé de préparation de concentré du complexe Facteur VIII-facteur von Willebrand de la coagulation sanguine à partir de plasma total
DE4203965A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Antidot fuer hirudin und synthetische thrombininhibitoren
WO1994011527A1 (fr) * 1992-11-12 1994-05-26 Sheldon Goldstein Dispositif et procede d'essais de coagulation multiples
WO1995026750A1 (fr) * 1994-03-31 1995-10-12 Pharmacia Ab Formulation pharmaceutique servant a effectuer l'administration sous-cutanee, intramusculaire ou intradermique du facteur viii ou du facteur ix
EP0680764A2 (fr) * 1994-05-06 1995-11-08 IMMUNO Aktiengesellschaft Préparation stable pour le traitement des anomalies de la coagulation du sang comprenant un facteur de coagulation activé et des vésicules lipidiques

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
D. MENACHE: "Prothrombin complex concentrates: clinical use", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 370, 1981, pages 747 - 56, XP002015681 *
DIEHL ET AL: "Investigation of activated prothrombin complex concentrate as potential hirudin antidote animal models", HAEMOSTASIS, vol. 25, 1 July 1995 (1995-07-01), pages 182 - 92, XP000566529 *
ELODI ET AL: "Activation of clotting factors in prothrombin complex concentrates as demonstrated by clotting assays for factor IXa and Xa", THROMBOSIS RESEARCH, vol. 12, no. 5, 1978, pages 797 - 807, XP002015682 *
TABERNER ET AL: "Comparison of prothrombin complex concentrate and vitamin K1 in oral anticoagulant reversal", BRITISH MEDICAL JOURNAL, vol. 2, no. 6027, 1976, pages 83 - 5, XP000565916 *
W. MUNTEAN: "Purified complex of factor VIII coagulant moiety and phospholipid: high factor VIII coagulant activity in factor VIII inhibitor plasma", WIENER KLINISCHE WOCHENSCHRIFT, vol. 96, no. 22, 1984, pages 829 - 32, XP002015680 *

Also Published As

Publication number Publication date
CA2156991A1 (fr) 1996-02-27
ZA957139B (en) 1996-03-26
AU3025795A (en) 1996-04-04
JP3859176B2 (ja) 2006-12-20
KR960006938A (ko) 1996-03-22
EP0700684A2 (fr) 1996-03-13
IL115058A0 (en) 1995-12-08
DE4430205A1 (de) 1996-02-29
JPH0859504A (ja) 1996-03-05

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