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EP0699201A4 - SUBSTITUTED METHYLENEDIOXY 3',4':6,7]INDOLIZINO- 1,2--i(b)]QUINOLINONES - Google Patents

SUBSTITUTED METHYLENEDIOXY 3',4':6,7]INDOLIZINO- 1,2--i(b)]QUINOLINONES

Info

Publication number
EP0699201A4
EP0699201A4 EP19940915450 EP94915450A EP0699201A4 EP 0699201 A4 EP0699201 A4 EP 0699201A4 EP 19940915450 EP19940915450 EP 19940915450 EP 94915450 A EP94915450 A EP 94915450A EP 0699201 A4 EP0699201 A4 EP 0699201A4
Authority
EP
European Patent Office
Prior art keywords
quinolinones
indolizino
substituted methylenedioxy
methylenedioxy
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19940915450
Other languages
German (de)
French (fr)
Other versions
EP0699201A1 (en
Inventor
William Dennis Kingsbury
Israil Pendrak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0699201A4 publication Critical patent/EP0699201A4/en
Publication of EP0699201A1 publication Critical patent/EP0699201A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP94915450A 1993-05-03 1994-05-03 SUBSTITUTED METHYLENEDIOXY 3',4':6,7]INDOLIZINO- 1,2-$i(b)]QUINOLINONES Withdrawn EP0699201A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5713393A 1993-05-03 1993-05-03
US57133 1993-05-03
US21365794A 1994-03-15 1994-03-15
US213657 1994-03-15
PCT/US1994/004866 WO1994025465A1 (en) 1993-05-03 1994-05-03 SUBSTITUTED METHYLENEDIOXY[3',4':6,7]INDOLIZINO-[1,2-b]QUINOLINONES

Publications (2)

Publication Number Publication Date
EP0699201A4 true EP0699201A4 (en) 1996-01-22
EP0699201A1 EP0699201A1 (en) 1996-03-06

Family

ID=26736111

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94915450A Withdrawn EP0699201A1 (en) 1993-05-03 1994-05-03 SUBSTITUTED METHYLENEDIOXY 3',4':6,7]INDOLIZINO- 1,2-$i(b)]QUINOLINONES

Country Status (7)

Country Link
EP (1) EP0699201A1 (en)
JP (1) JPH08509742A (en)
AU (1) AU684777B2 (en)
CA (1) CA2161980A1 (en)
MX (1) MX9403275A (en)
NZ (1) NZ266094A (en)
WO (1) WO1994025465A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883255A (en) * 1990-10-31 1999-03-16 Smithkline Beecham Corporation Substituted indolizino 1,2-b!quinolinones

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0540099A1 (en) * 1991-10-29 1993-05-05 Glaxo Wellcome Inc. Water soluble camptothecin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829793B2 (en) * 1975-02-07 1983-06-24 日本ケミフア （株） Process for producing 7-alkoxycarbonyl-8-methylindolizino[1,2-b]quinolin-9(11H)-one
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
CA1332413C (en) * 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US5225404A (en) * 1989-11-06 1993-07-06 New York University Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
JPH06502642A (en) * 1990-10-31 1994-03-24 スミスクライン・ビーチャム・コーポレイション Substituted indolizino[1,2-b]quinolinone
JPH05191297A (en) * 1992-01-10 1993-07-30 Fujitsu Ltd Serial/parallel conversion circuit

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0540099A1 (en) * 1991-10-29 1993-05-05 Glaxo Wellcome Inc. Water soluble camptothecin derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9425465A1 *

Also Published As

Publication number Publication date
EP0699201A1 (en) 1996-03-06
NZ266094A (en) 1997-10-24
CA2161980A1 (en) 1994-11-10
AU6670494A (en) 1994-11-21
WO1994025465A1 (en) 1994-11-10
AU684777B2 (en) 1998-01-08
MX9403275A (en) 1995-01-31
JPH08509742A (en) 1996-10-15

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