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EP0666752A4 - Therapeutic microemulsions. - Google Patents

Therapeutic microemulsions.

Info

Publication number
EP0666752A4
EP0666752A4 EP93923933A EP93923933A EP0666752A4 EP 0666752 A4 EP0666752 A4 EP 0666752A4 EP 93923933 A EP93923933 A EP 93923933A EP 93923933 A EP93923933 A EP 93923933A EP 0666752 A4 EP0666752 A4 EP 0666752A4
Authority
EP
European Patent Office
Prior art keywords
microemulsions
therapeutic
therapeutic microemulsions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93923933A
Other languages
German (de)
French (fr)
Other versions
EP0666752A1 (en
Inventor
Panayiotis Peri Constantinides
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0666752A1 publication Critical patent/EP0666752A1/en
Publication of EP0666752A4 publication Critical patent/EP0666752A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
EP93923933A 1992-10-16 1993-10-15 Therapeutic microemulsions. Withdrawn EP0666752A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96295792A 1992-10-16 1992-10-16
US962957 1992-10-16
PCT/US1993/009963 WO1994008605A1 (en) 1992-10-16 1993-10-15 Therapeutic microemulsions

Publications (2)

Publication Number Publication Date
EP0666752A1 EP0666752A1 (en) 1995-08-16
EP0666752A4 true EP0666752A4 (en) 1996-09-11

Family

ID=25506555

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93923933A Withdrawn EP0666752A4 (en) 1992-10-16 1993-10-15 Therapeutic microemulsions.

Country Status (3)

Country Link
EP (1) EP0666752A4 (en)
JP (1) JPH08502492A (en)
WO (1) WO1994008605A1 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688761A (en) * 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
IE921212A1 (en) * 1991-04-19 1992-10-21 Affinity Biotech Inc Convertible microemulsion formulations
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ATE223231T1 (en) * 1993-04-19 2002-09-15 Inst Advanced Skin Res Inc MICRO-EMULSION PREPARATION CONTAINING A DIFFICULTLY ABSORBABLE SUBSTANCE
EP0710116B1 (en) * 1993-05-13 2008-09-03 Poniard Pharmaceuticals, Inc. Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
WO1995025504A1 (en) * 1994-03-18 1995-09-28 Pharmavene, Inc. Emulsified drug delivery systems
HU215966B (en) * 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Oral multiple emulsion-preconcentrate containing cyclosporin
US6187993B1 (en) 1995-02-25 2001-02-13 Imperial Cancer Research Technology Limited Transgenic animals as model of psoriasis
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US6008228A (en) * 1995-06-06 1999-12-28 Hoffman-La Roche Inc. Pharmaceutical compositions containing proteinase inhibitors
US5734770A (en) * 1995-06-29 1998-03-31 Minnesota Mining And Manufacturing Company Cleave and bevel fiber optic connector
US5660858A (en) * 1996-04-03 1997-08-26 Research Triangle Pharmaceuticals Cyclosporin emulsions
GB9613858D0 (en) * 1996-07-02 1996-09-04 Cortecs Ltd Hydrophobic preparations
WO1998022089A1 (en) * 1996-11-22 1998-05-28 Pharmacia & Upjohn Ab Pharmaceutical composition based on a lipid matrix system
EP0975340B2 (en) 1997-03-31 2009-10-28 Boston Scientific Limited Therapeutic inhibitor of vascular smooth muscle cells
DE69842121D1 (en) 1997-12-10 2011-03-17 Cyclosporine Therapeutics Ltd OMEGA-3 FATTY ACID PHARMACEUTICAL COMPOSITIONS
WO1999053941A1 (en) * 1998-04-15 1999-10-28 Shionogi & Co., Ltd. Oral preparations containing trh derivatives
DE10024451A1 (en) * 2000-05-18 2001-11-29 Asta Medica Ag Pharmaceutical dosage form for peptides, process for their preparation and use
US20020155084A1 (en) * 2000-06-02 2002-10-24 The Regents Of The University Of The Michigan Nanoemulsion formulations
CN1160122C (en) 2001-04-20 2004-08-04 清华大学 Method of preparing oil-phase oral insulin preparation
AU2002231703B2 (en) 2001-12-14 2007-03-29 Jagotec Ag Pharmaceutical formulation comprising cyclosporin and use thereof
PE20050596A1 (en) * 2003-12-19 2005-10-18 Novartis Ag MICROEMULSION INCLUDING A RENIN INHIBITOR
ATE407693T1 (en) 2004-03-22 2008-09-15 Solvay Pharm Gmbh ORAL PHARMACEUTICAL COMPOSITIONS OF PRODUCTS CONTAINING LIPASE, IN PARTICULAR PANCREATIN, WITH SURFACTANTS
US9743680B2 (en) * 2005-10-14 2017-08-29 Wild Flavors, Inc. Microemulsions for use in food and beverage products
EP1961412A1 (en) * 2006-12-27 2008-08-27 LEK Pharmaceuticals D.D. Self-microemulsifying drug delivery systems
EP2164466A1 (en) * 2007-06-01 2010-03-24 Novo Nordisk A/S Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier
KR101755434B1 (en) 2008-03-18 2017-07-10 노보 노르디스크 에이/에스 Protease stabilized, acylated insulin analogues
GB201107630D0 (en) * 2011-05-06 2011-06-22 Proxima Concepts Ltd Microemulsions
JP6199956B2 (en) 2012-04-11 2017-09-20 ノヴォ ノルディスク アー／エス Insulin preparations
PL3554534T3 (en) 2016-12-16 2021-12-13 Novo Nordisk A/S Insulin containing pharmaceutical compositions
KR101991661B1 (en) * 2017-03-02 2019-06-21 대화제약 주식회사 Stable pharmaceutical composition comprising zanamivir
WO2018159941A1 (en) * 2017-03-02 2018-09-07 대화제약 주식회사 Stable pharmaceutical composition comprising zanamivir

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146499A (en) * 1976-09-18 1979-03-27 Rosano Henri L Method for preparing microemulsions
EP0278660A1 (en) * 1987-02-03 1988-08-17 Stiefel Laboratories (Ireland) Limited Microemulsions
EP0387647A2 (en) * 1989-03-13 1990-09-19 Desitin Arzneimittel GmbH High-dispersion pharmaceutical composition
WO1991018669A1 (en) * 1990-06-08 1991-12-12 Affinity Biotech, Inc. Process for preparing microemulsion
WO1992018147A1 (en) * 1991-04-19 1992-10-29 Affinity Biotech, Inc. Convertible microemulsion formulations
WO1993002665A1 (en) * 1991-07-26 1993-02-18 Smithkline Beecham Corporation W/o microemulsions
WO1993002664A1 (en) * 1991-07-26 1993-02-18 Smithkline Beecham Corporation W/o microemulsions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110606A (en) * 1990-11-13 1992-05-05 Affinity Biotech, Inc. Non-aqueous microemulsions for drug delivery

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146499A (en) * 1976-09-18 1979-03-27 Rosano Henri L Method for preparing microemulsions
EP0278660A1 (en) * 1987-02-03 1988-08-17 Stiefel Laboratories (Ireland) Limited Microemulsions
EP0387647A2 (en) * 1989-03-13 1990-09-19 Desitin Arzneimittel GmbH High-dispersion pharmaceutical composition
WO1991018669A1 (en) * 1990-06-08 1991-12-12 Affinity Biotech, Inc. Process for preparing microemulsion
WO1992018147A1 (en) * 1991-04-19 1992-10-29 Affinity Biotech, Inc. Convertible microemulsion formulations
WO1993002665A1 (en) * 1991-07-26 1993-02-18 Smithkline Beecham Corporation W/o microemulsions
WO1993002664A1 (en) * 1991-07-26 1993-02-18 Smithkline Beecham Corporation W/o microemulsions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9408605A1 *

Also Published As

Publication number Publication date
EP0666752A1 (en) 1995-08-16
JPH08502492A (en) 1996-03-19
WO1994008605A1 (en) 1994-04-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19950510

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): BE CH DE FR GB IT LI NL

RHK1 Main classification (correction)

Ipc: A61K 38/00

RHK1 Main classification (correction)

Ipc: A61K 37/00

A4 Supplementary search report drawn up and despatched

Effective date: 19960729

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): BE CH DE FR GB IT LI NL

17Q First examination report despatched

Effective date: 19980925

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19990206