EP0568902A2 - Micropump avoiding microcavitation - Google Patents
Micropump avoiding microcavitation Download PDFInfo
- Publication number
- EP0568902A2 EP0568902A2 EP93106828A EP93106828A EP0568902A2 EP 0568902 A2 EP0568902 A2 EP 0568902A2 EP 93106828 A EP93106828 A EP 93106828A EP 93106828 A EP93106828 A EP 93106828A EP 0568902 A2 EP0568902 A2 EP 0568902A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- pump
- membrane
- micropump
- pump chamber
- descending
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012528 membrane Substances 0.000 claims abstract description 31
- 230000001174 ascending effect Effects 0.000 claims abstract description 24
- 230000005284 excitation Effects 0.000 claims abstract description 19
- 230000007423 decrease Effects 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims description 5
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 239000011521 glass Substances 0.000 description 15
- 239000007788 liquid Substances 0.000 description 10
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 8
- 229910052710 silicon Inorganic materials 0.000 description 8
- 239000010703 silicon Substances 0.000 description 8
- 238000005452 bending Methods 0.000 description 5
- 230000008602 contraction Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005459 micromachining Methods 0.000 description 2
- 230000004913 activation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000001259 photo etching Methods 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
- F04B43/046—Micropumps with piezoelectric drive
Definitions
- the descending ramp has a linear shape starting from the end of the holding phase during which the voltage is kept at maximum level, until the beginning of the next following ascending ramp.
- the descending ramp is linear and shorter than the time period between the end of the holding phase and the beginning of the next following ascending ramp.
- the descending ramp follows an exponential or otherwise non-linearly decaying curve.
- the present invention relates to a method of operating a micropump having a pump chamber which is closed by a pump membrane, which membrane is driven by a piezoelectric microactuator, whereby this method is characterized by the following steps:
- reference number 1 designates a micropump comprising a glass support body 4, a glass membrane 2 and sandwiched therebetween a silicon wafer 3, which has been machined by any appropriate technique such as photo lithography and etching in order to obtain a structure such as indicated in Fig. 1 in very simplified fashion.
- micropump of Fig. 1 The structure of the micropump of Fig. 1 is of course only an example, it being understood that the activation mode for a micropump according to the present invention is applicable to any other specifically structured micropump.
- micropump 1 comprises an inlet 6 and an outlet 5 for a liquid to be transported by the operation of the micropump, inlet 6 being provided with an inlet valve 7 and outlet 5 being provided with an outlet valve 8.
- Inlet and outlet valves 7 and 8 comprise membranes 11 and 12, which carry on their lower surface ring-shaped projections 13, 14 and 15, 16, which are located such as to surround the opening holes of inlet and outlet 6, 5 at the interface level between glass plate 4 and silicon wafer 3.
- a pump chamber 10 is provided whereas the thickness of land 17 of the silicon wafer determines the volume of pump chamber 10.
- Glass membrane 2 comprises a central portion 18 which carries a piezoelectric microactuator 9, which may be excited by an appropriate electric wave form in order to produce a periodically alternating contraction and expansion movement in a direction parallel to the plane of the membrane.
- the microactuator Since the microactuator is intimately attached to the membrane, the two elements together execute a bending movement according to the principle of a bimetallic strip, whereby the bending direction depends on the polarity of the applied voltage.
- microactuator 9 executes a contraction movement and, together with glass plate 2, bends in a direction such as to assume an upwards directed concave shape, and due to the maintenance of the side portions of glass plate 2 on the silicon wafer, membrane 18 of the glass plate bulges downwards such as to decrease the volume of the pump chamber 10.
- membrane 12 of outlet valve 8 bulges upwards in response to the pressure build-up within pump chamber 10 and annular projections 15, 16 are lifted from their seat on the upper surface of glass plate 4 in order to permit escape of the liquid contained within pump chamber 10 through outlet 5.
- microactuator 9 not only executes a bending movement but also a downwards movement due to the downwards bulging of center portion 18 of the glass membrane 2, whereas the degree of this downwards movement of microactuator 9 is a measure for the decrease of the volume within pump chamber 10.
- Fig. 3 illustrates an operation phase of micropump 1 corresponding to the end of a suction stroke whereby microactuator 9 has been excited previously in order to assume, together with the glass plate 2, a configuration in which both elements together form an upwards convex shape such that center portion 18 bulges upwards, due to the fact that glass membrane 2 is withheld at the side edges on silicon wafer 3.
- Pressure in chamber 21 which is located between the membrane of outlet valve 8 and glass membrane 2 is maintained at a level between minimum and maximum pressure of the liquid within pump chamber 10, in order to secure that outlet valve will securely open if pressure in pump chamber 10 essentially exceeds the pressure in chamber 21, and that the outlet valve is closed when the pressure in pump chamber 10 is essentially inferior to the pressure in chamber 21. Since a certain amount of pressure difference is required in order to overcome the pretension of the valve, this pressure difference has to be taken into account when regulating the pressure in chamber 21.
- the pressure in chamber 21 may be atmospheric pressure for applications where the liquid which enters into the micropump is maintained under atmospheric pressure and where, accordingly, the suction pressure of the micropump is slightly below and the thrust pressure of the micropump is slightly above atmospheric pressure, however, the pressure in chamber 21 can be adapted to any desired value corresponding to the needs and the application of the micropump.
- Fig. 4a illustrates a typical wave form for the excitation voltage of a prior art piezoelectric actuator for a micropump, whereby an ascending ramp 19 lasts approximately 1 ms, which is followed by a holding phase 22 at the end 24 of which begins the descending ramp 20 which lasts also approximately 1 ms. For the rest of the duration of a pump cycle which lasts between 100 and 1000 ms typically, the excitation voltage is kept at the lower level.
- the descending ramp according to Fig. 4b may last 10 to 100 ms depending on the entire duration of a pump cycle and on the duration of the holding phase 22.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Reciprocating Pumps (AREA)
Abstract
A micropump (1) which is reciprocatingly driven by a membrane (18) into subsequent outwards and inwards bulging movements, in response to the application of an excitation voltage to a piezoelectric microactuator 9. The application of the excitation voltage follows a wave form which includes rapidly ascending ramps which produce rapid decrease of the volume of the pump chamber, and slowly descending ramps which produce sufficiently moderate rates of increase of the volume of the pump chamber in order to avoid microcavitation.
Description
- The present invention relates to a micropump comprising a structural intermediate member, which is at least partially sandwiched between an upper plate and a lower support plate, at least one of said upper plate and structural member forming a membrane, which structural member defines at least one valve element and a pump chamber, said membrane closing said pump chamber and carring a microactuator susceptible of causing said membrane to carry out a reciprocating outwards and inwards bulging in response to an excitation voltage applied to said microactuator from a control unit for said actuator, wherein the outwards and inwards bulging movements of said membrane increase and decrease respectively the volume of said pump chamber and are controlled by the variation of said excitation voltage which comprises an ascending ramp for one of the thrust phase or the suction phase of the micropump and a descending ramp for the other one of said two phases.
- In an article published in "Sensors and Actuators, 15 (1988) 153-167" the article entitled "A piezoelectric micropump based on micromachining of silicon" of H.T.G. van Lintel, F.C.M. van de Pol and S. Bouwstra describes a micropump which is produced by micromachining of silicon and which comprises an inlet valve, an outlet valve, and a pump chamber which is closed by a glass membrane which carries a piezoelectric disc. This piezoelectric disc is capable of bending the membrane upwards and downwards in response to an applied excitation voltage, and creates thus a pumping effect within the pump chamber.
- The electrical control of a piezoelectric actuator of micropumps is traditionally carried out in a way such as illustrated in Fig. 2 of
British patent application 1 344 754, which describes a reciprocating pump. According to Fig. 2 of this British patent application, the ascending and the descending ramps of the pump control current are symmetric and this type of pump control has hitherto been used also for micropumps. - According to the specific geometrical configuration of a micropump as well as to material parameters, it has been advantageous to apply an ascending ramp of considerable steepness, in order to rapidly open the outlet valve during the decrease of the volume of the pump chamber in response to the application of an ascending voltage to the piezoelectric microactuator.
- After a predetermined holding time, the excitation voltage has been reduced at the same rate as it had been increased during the ascending ramp, and it has been found by the inventor of the present application that problems have occured during the operation of a micropump using descending ramps for the excitation voltages which have essentially the same steepness as the ascending ramps, which problems are believed to be due to the occurrance of microcavitation following rapid expansion of the volume of the pump chamber at the beginning of the suction phase.
- It is the object of the present invention to provide a micropump which avoids the above problem of microcavitation during the increase of the volume of the pump chamber, and this object is met according to the present invention by a micropump such as described hereabove which is further characterized in that the voltage variation of the descending ramp is selected such as to produce an outwards bulging of the membrane for the starting of the suction phase which is sufficiently moderate in order to avoid microcavitation.
- According to an embodiment of the present invention the pump frequency is between approximately 1 and 10 Hz, the ascending ramp of the excitation voltage may last about one ms and the descending ramp may last at least 10 ms.
- According to a particular embodiment of the present invention the descending ramp has a linear shape starting from the end of the holding phase during which the voltage is kept at maximum level, until the beginning of the next following ascending ramp.
- In another embodiment of the present invention the descending ramp is linear and shorter than the time period between the end of the holding phase and the beginning of the next following ascending ramp.
- In an alternative embodiment of the present invention the descending ramp follows an exponential or otherwise non-linearly decaying curve.
- The maximum excitation voltage which is maintained during the holding phase is typically between 100 V and 150 V.
- Further the present invention relates to a method of operating a micropump having a pump chamber which is closed by a pump membrane, which membrane is driven by a piezoelectric microactuator, whereby this method is characterized by the following steps:
- providing a micropump and a controllable voltage source;
- applying voltage from said voltage source to said piezoelectric microactuator whereby said applied voltage comprises alternating rapidly ascending ramps and slower descending ramps such as to;
- rapidly decrease the volume of said pump chamber in response to said rapidly ascending ramps; and
- sufficiently slowly increase the volume of said pump chamber in response to said slowly decreasing ramps in order to avoid microcavitation.
- Typically in a micropump according to the present invention ascending ramps last about 1 ms and descending ramps last about 10 to 100 ms.
- The present invention will now be described in more detail with reference to the drawings, whereby
- Fig. 1 illustrates schematically a micropump in a non-operating condition,
- Fig. 2 illustrates the same micropump in a condition corresponding to a point of time just after the beginning of a thrust phase,
- Fig. 3 illustrates the same micropump at a condition approximately at the end of a suction phase,
- Fig. 4a illustrates a wave form for the excitation voltage of the piezoelectric microactuator according to the prior art, and
- Fig. 4b illustrates a wave form for the excitation voltage of a piezoelectric microactuator of a micropump according to the present invention.
- With reference to Fig. 1,
reference number 1 designates a micropump comprising aglass support body 4, aglass membrane 2 and sandwiched therebetween asilicon wafer 3, which has been machined by any appropriate technique such as photo lithography and etching in order to obtain a structure such as indicated in Fig. 1 in very simplified fashion. - The structure of the micropump of Fig. 1 is of course only an example, it being understood that the activation mode for a micropump according to the present invention is applicable to any other specifically structured micropump.
- Details of the exact configuration or surface treatment of portions of the silicon wafer are not subject of the present invention and are therefore not referred to nor represented.
- Further,
micropump 1 comprises aninlet 6 and anoutlet 5 for a liquid to be transported by the operation of the micropump,inlet 6 being provided with aninlet valve 7 andoutlet 5 being provided with anoutlet valve 8. - Inlet and
outlet valves membranes shaped projections outlet glass plate 4 andsilicon wafer 3. - Between
inlet valve 7 andoutlet valve 8, apump chamber 10 is provided whereas the thickness ofland 17 of the silicon wafer determines the volume ofpump chamber 10. -
Glass membrane 2 comprises acentral portion 18 which carries apiezoelectric microactuator 9, which may be excited by an appropriate electric wave form in order to produce a periodically alternating contraction and expansion movement in a direction parallel to the plane of the membrane. - Since the microactuator is intimately attached to the membrane, the two elements together execute a bending movement according to the principle of a bimetallic strip, whereby the bending direction depends on the polarity of the applied voltage.
- Figs. 2 and 3 illustrate the operation of the micropump according to Fig. 1, and like elements of the micropump according to Figs. 2 and 3 are therefore designated with the same reference numbers as in Fig. 1.
- Upon application of the appropriate voltage,
microactuator 9 executes a contraction movement and, together withglass plate 2, bends in a direction such as to assume an upwards directed concave shape, and due to the maintenance of the side portions ofglass plate 2 on the silicon wafer,membrane 18 of the glass plate bulges downwards such as to decrease the volume of thepump chamber 10. In a first phase of this downwards movement ofcenter portion 18 of theglass plate 2,membrane 12 ofoutlet valve 8 bulges upwards in response to the pressure build-up withinpump chamber 10 andannular projections glass plate 4 in order to permit escape of the liquid contained withinpump chamber 10 throughoutlet 5. - At the same time, the pressure in
pump chamber 10 causesinlet valve 7 to remain closed such as to avoid any escape of liquid frompump chamber 10 throughinlet 6. - As will be seen from Fig. 2,
microactuator 9 not only executes a bending movement but also a downwards movement due to the downwards bulging ofcenter portion 18 of theglass membrane 2, whereas the degree of this downwards movement ofmicroactuator 9 is a measure for the decrease of the volume withinpump chamber 10. - Fig. 3 illustrates an operation phase of
micropump 1 corresponding to the end of a suction stroke wherebymicroactuator 9 has been excited previously in order to assume, together with theglass plate 2, a configuration in which both elements together form an upwards convex shape such thatcenter portion 18 bulges upwards, due to the fact thatglass membrane 2 is withheld at the side edges onsilicon wafer 3. - This upwards bulging of
center portion 18 increases the volume ofpump chamber 10 whereas pressure withinpump chamber 10 is reduced such as to openinlet valve 7, wherebymembrane 11 is slightly bent upwards under the pressure of liquid entering throughinlet 6, whereasannular projections glass plate 4 in order to permit liquid entering throughinlet 6 to flow intopump chamber 10. - Simultaneously,
outlet valve 8 is maintained in its closed position. - Pressure in
chamber 21 which is located between the membrane ofoutlet valve 8 andglass membrane 2 is maintained at a level between minimum and maximum pressure of the liquid withinpump chamber 10, in order to secure that outlet valve will securely open if pressure inpump chamber 10 essentially exceeds the pressure inchamber 21, and that the outlet valve is closed when the pressure inpump chamber 10 is essentially inferior to the pressure inchamber 21. Since a certain amount of pressure difference is required in order to overcome the pretension of the valve, this pressure difference has to be taken into account when regulating the pressure inchamber 21. - The pressure in
chamber 21 may be atmospheric pressure for applications where the liquid which enters into the micropump is maintained under atmospheric pressure and where, accordingly, the suction pressure of the micropump is slightly below and the thrust pressure of the micropump is slightly above atmospheric pressure, however, the pressure inchamber 21 can be adapted to any desired value corresponding to the needs and the application of the micropump. -
Microactuator 9 andmembrane 18 together in Fig. 3 do not only perform a bending movement in the indicated sense, but also an upwards movement in response to the upwards bulging of said two elements, and the degree of this upwards movement is an indication of the increase of the volume ofpump chamber 10. - During the upwards bulging of the
microactuator 9 and themembrane 18, the volume of the pump chamber is increased and the pressure therein decreases accordingly in abrupt fashion if the excitation of the piezoelectric actuator is changed abruptly. Such rapid change of the pressure accompagnied by an increase of the volume results in a "boiling effect" of the liquid which is referred to as microcavitation. Gases which are dissolved in the liquid are suddenly set free in the form of microbubbles and hinder proper transportation of the liquid through the micropump. - Eventually, such microbubbles may form a large bubble through coalescence, which large bubble could bring the pump operation to a complete stop.
- Fig. 4a illustrates a typical wave form for the excitation voltage of a prior art piezoelectric actuator for a micropump, whereby an
ascending ramp 19 lasts approximately 1 ms, which is followed by aholding phase 22 at theend 24 of which begins the descendingramp 20 which lasts also approximately 1 ms. For the rest of the duration of a pump cycle which lasts between 100 and 1000 ms typically, the excitation voltage is kept at the lower level. - Fig. 4b shows the wave form of the excitation voltage according to the present invention, whereby the
ascending ramp 19 is followed by holdingphase 22 in conventional manner, however the descendingramp 25 follows a slowly and linearly descending line from theend 24 of theholding phase 22 until thestarting point 23 of the next ascending phase. - The descending ramp according to Fig. 4b may last 10 to 100 ms depending on the entire duration of a pump cycle and on the duration of the
holding phase 22. - It is understood of course, that the descending
ramp 25 need not be linear, but could also follow an exponential or other shape such as indicated by dashedline 25' or according to a sinus function such as indicated byreference number 25''. - Also, the duration of the descending phase need not be as long as the difference between the
end point 24 ofholding phase 22 and thestarting point 23 for the net ascending ramp, but could be shorter. However it must be sufficiently long in order to produce a moderately fast expansion of the volume of the pump chamber such as to reliably avoid the formation of microcavitation.
Claims (9)
- A micropump comprising a structural intermediate member (3) which is at least partially sandwiched between an upper plate (2), and a lower support plate (4), at least one of said upper plate (2) and said structural member (3) forming a membrane (18), which structural member defines at least one valve element (7, 8) and a pump chamber (10), said membrane (18) closing said pump chamber and carrying a microactuator (9) susceptible of causing said membrane to carry out a reciprocating outwards and inwards bulging in response of an excitation voltage applied to said microactuator from a control unit for said actuator and wherein the outwards and inwards bulging movements of said membrane increase and decrease respectively the volume of said pump chamber 10 and are controlled by the variation of said excitation voltage which comprises an ascending ramp for one of the thrust phase or the suction phase of the micropump and a descending ramp for the other one of said two phases, characterized in that the voltage variation of the descending ramp is selected such as to produce an outwards bulging of the membrane for the starting of the suction phase which is sufficiently moderated in order to avoid microcavitation.
- The pump of claim 1, wherein the ascending ramp of the excitation voltage lasts about 1 ms.
- The pump of any one of claims 1 or 2, wherein the descending ramps last at least 10 ms.
- The pump of any one of claims 1-3, wherein the descending ramp has a linear shape starting from the end of a holding phase 22 during which the voltage is kept at a maximum level, until the beginning of the next following ascending ramp 19.
- The pump of any one of claims 1-3, wherein the descending ramp is linear and shorter than the time period between the end 24 of the holding phase 22 and the beginning 23 of the next following ascending ramp.
- The pump of any one of claims 1-3, wherein the descending ramp 25' follows an exponential curve.
- The pump of any one of claims 1-6, wherein the maximum excitation voltage is between 100 V and 150 V.
- A method of operating a micropump having a pump chamber which is closed by a pump membrane, which membrane is driven by a piezoelectric microactuator, comprising the following steps:- providing a micropump and a controllable voltage source;- applying voltage from said voltage source to said piezoelectric microactuator, whereby said applied voltage comprises alternating rapidly ascending ramps and slower descending ramps, such as to;- rapidly decreasing the volume of said pump chamber in response to said rapidly ascending ramps; and- sufficiently slowly increasing the volume of said pump chamber in response to said slowly descending ramps in order to avoid microcavitation.
- The method of claim 8 wherein the ascending ramps last about 1 ms and the descending ramps last about 10 to 100 ms.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9209593 | 1992-05-02 | ||
GB9209593A GB2266751A (en) | 1992-05-02 | 1992-05-02 | Piezoelectric micropump excitation voltage control. |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0568902A2 true EP0568902A2 (en) | 1993-11-10 |
EP0568902A3 EP0568902A3 (en) | 1994-03-02 |
Family
ID=10714963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93106828A Withdrawn EP0568902A2 (en) | 1992-05-02 | 1993-04-27 | Micropump avoiding microcavitation |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0568902A2 (en) |
GB (1) | GB2266751A (en) |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4405026A1 (en) * | 1994-02-17 | 1995-08-24 | Rossendorf Forschzent | Micro fluid manipulator |
DE19534378C1 (en) * | 1995-09-15 | 1997-01-02 | Inst Mikro Und Informationstec | Fluid pump for liquids and gases |
EP0789146A1 (en) * | 1995-07-27 | 1997-08-13 | Seiko Epson Corporation | Microvalve and method of manufacturing the same, micropump using the microvalve and method of manufacturing the same, and apparatus using the micropump |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US6074725A (en) * | 1997-12-10 | 2000-06-13 | Caliper Technologies Corp. | Fabrication of microfluidic circuits by printing techniques |
US6132685A (en) * | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US6267858B1 (en) | 1996-06-28 | 2001-07-31 | Caliper Technologies Corp. | High throughput screening assay systems in microscale fluidic devices |
WO2001090577A1 (en) * | 2000-05-25 | 2001-11-29 | Westonbridge International Limited | Micromachined fluidic device and method for making same |
US6382254B1 (en) | 2000-12-12 | 2002-05-07 | Eastman Kodak Company | Microfluidic valve and method for controlling the flow of a liquid |
EP1313949A1 (en) * | 2000-08-31 | 2003-05-28 | Advanced Sensor Technologies, Inc. | Micro-fluidic pump |
US6622746B2 (en) | 2001-12-12 | 2003-09-23 | Eastman Kodak Company | Microfluidic system for controlled fluid mixing and delivery |
DE10238564A1 (en) * | 2002-08-22 | 2004-03-11 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Pipetting device and method for operating a pipetting device |
EP1403518A2 (en) * | 2002-09-19 | 2004-03-31 | The Foundation for the Promotion of Industrial Science | Microfluidic device made at least partially of an elastic material |
EP1489306A2 (en) * | 2003-06-17 | 2004-12-22 | Seiko Epson Corporation | Pump |
EP1959255A2 (en) | 1997-04-04 | 2008-08-20 | Caliper Life Sciences, Inc. | Closed-loop biochemical analyzers |
US7749444B2 (en) | 2004-05-13 | 2010-07-06 | Konica Minolta Sensing, Inc. | Microfluidic device, method for testing reagent and system for testing reagent |
WO2011058140A3 (en) * | 2009-11-13 | 2011-12-01 | Commissariat à l'énergie atomique et aux énergies alternatives | Method for producing at least one deformable membrane micropump and deformable membrane micropump |
JP2017196614A (en) * | 2010-05-21 | 2017-11-02 | ヒューレット−パッカード デベロップメント カンパニー エル.ピー.Hewlett‐Packard Development Company, L.P. | Generating fluid flow in fluidic network |
US10272691B2 (en) | 2010-05-21 | 2019-04-30 | Hewlett-Packard Development Company, L.P. | Microfluidic systems and networks |
CN109882380A (en) * | 2019-03-01 | 2019-06-14 | 浙江师范大学 | A kind of double oscillator self-excitation pumps |
US10415086B2 (en) | 2010-05-21 | 2019-09-17 | Hewlett-Packard Development Company, L.P. | Polymerase chain reaction systems |
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EP0393602A2 (en) * | 1989-04-17 | 1990-10-24 | Seiko Epson Corporation | Ink-jet printer driver |
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GB2248891A (en) * | 1990-10-18 | 1992-04-22 | Westonbridge Int Ltd | Membrane micropump |
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US4449893A (en) * | 1982-05-04 | 1984-05-22 | The Abet Group | Apparatus and method for piezoelectric pumping |
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1992
- 1992-05-02 GB GB9209593A patent/GB2266751A/en not_active Withdrawn
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- 1993-04-27 EP EP93106828A patent/EP0568902A2/en not_active Withdrawn
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US4344743A (en) * | 1979-12-04 | 1982-08-17 | Bessman Samuel P | Piezoelectric driven diaphragm micro-pump |
US4519751A (en) * | 1982-12-16 | 1985-05-28 | The Abet Group | Piezoelectric pump with internal load sensor |
EP0393602A2 (en) * | 1989-04-17 | 1990-10-24 | Seiko Epson Corporation | Ink-jet printer driver |
EP0467656A2 (en) * | 1990-07-16 | 1992-01-22 | Tektronix, Inc. | Method of operating an on-demand ink jet print head |
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Cited By (45)
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DE4405026A1 (en) * | 1994-02-17 | 1995-08-24 | Rossendorf Forschzent | Micro fluid manipulator |
EP0789146A1 (en) * | 1995-07-27 | 1997-08-13 | Seiko Epson Corporation | Microvalve and method of manufacturing the same, micropump using the microvalve and method of manufacturing the same, and apparatus using the micropump |
EP0789146A4 (en) * | 1995-07-27 | 1998-10-28 | Seiko Epson Corp | Microvalve and method of manufacturing the same, micropump using the microvalve and method of manufacturing the same, and apparatus using the micropump |
DE19534378C1 (en) * | 1995-09-15 | 1997-01-02 | Inst Mikro Und Informationstec | Fluid pump for liquids and gases |
US7091048B2 (en) | 1996-06-28 | 2006-08-15 | Parce J Wallace | High throughput screening assay systems in microscale fluidic devices |
US6306659B1 (en) | 1996-06-28 | 2001-10-23 | Caliper Technologies Corp. | High throughput screening assay systems in microscale fluidic devices |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US6630353B1 (en) | 1996-06-28 | 2003-10-07 | Caliper Technologies Corp. | High throughput screening assay systems in microscale fluidic devices |
US6150180A (en) * | 1996-06-28 | 2000-11-21 | Caliper Technologies Corp. | High throughput screening assay systems in microscale fluidic devices |
US6267858B1 (en) | 1996-06-28 | 2001-07-31 | Caliper Technologies Corp. | High throughput screening assay systems in microscale fluidic devices |
US6274337B1 (en) | 1996-06-28 | 2001-08-14 | Caliper Technologies Corp. | High throughput screening assay systems in microscale fluidic devices |
US6046056A (en) * | 1996-06-28 | 2000-04-04 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
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Also Published As
Publication number | Publication date |
---|---|
GB2266751A (en) | 1993-11-10 |
GB9209593D0 (en) | 1992-06-17 |
EP0568902A3 (en) | 1994-03-02 |
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