EP0547178A4 - Novel cholecystokinin antagonists, their preparation and therapeutic use - Google Patents

Novel cholecystokinin antagonists, their preparation and therapeutic use

Info

Publication number: EP0547178A4
Authority: EP; European Patent Office
Prior art keywords: preparation; therapeutic use; cholecystokinin antagonists; novel; novel cholecystokinin
Prior art date: 1990-08-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19910918880

Other versions

EP0547178A1 (en

Inventor

David Christopher Horwell

Juergen Kleinschroth

David Charles Rees

Reginald Stewart Richardson

William Howard Roark

Edward Roberts

Bruce David Roth

Bharat Kalidas Trivedi

Ann Holmes

Janak Khimchand Padia

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-31

Filing date

1991-08-29

Publication date

1994-07-06

1991-08-29 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

1993-06-23 Publication of EP0547178A1 publication Critical patent/EP0547178A1/en

1994-07-06 Publication of EP0547178A4 publication Critical patent/EP0547178A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Zoology (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

EP19910918880 1990-08-31 1991-08-29 Novel cholecystokinin antagonists, their preparation and therapeutic use Withdrawn EP0547178A4 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US57662890A	1990-08-31	1990-08-31
US576628		1990-08-31
US72665591A	1991-07-12	1991-07-12
US726655		1991-07-12

Publications (2)

Publication Number	Publication Date
EP0547178A1 EP0547178A1 (en)	1993-06-23
EP0547178A4 true EP0547178A4 (en)	1994-07-06

Family

ID=27077012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19910918880 Withdrawn EP0547178A4 (en)	1990-08-31	1991-08-29	Novel cholecystokinin antagonists, their preparation and therapeutic use

Country Status (9)

Country	Link
EP (1)	EP0547178A4 (en)
JP (1)	JPH06502627A (en)
KR (1)	KR100222634B1 (en)
CA (1)	CA2088195A1 (en)
IE (1)	IE67290B1 (en)
NO (1)	NO312298B1 (en)
NZ (1)	NZ239595A (en)
PT (1)	PT98842B (en)
WO (1)	WO1992004045A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5217957A (en) *	1991-08-20	1993-06-08	Warner-Lambert Company	Cholecystokinin antagonists useful for treating depression
US5380872A (en) *	1992-07-14	1995-01-10	Glaxo Inc.	Modulators of cholecystokinin
WO1994018229A1 (en) *	1993-02-03	1994-08-18	Fisons Corporation	1,2,4-triazinone derivatives and their use in therapy
GB9304500D0 (en) *	1993-03-05	1993-04-21	Glaxo Spa	Heterocyclic compounds
NZ333038A (en)	1996-08-22	2000-10-27	Warner Lambert Co	Non-peptide bombesin receptor antagonists
US6645968B2 (en)	1999-08-03	2003-11-11	Abbott Laboratories	Potassium channel openers
US6846836B2 (en)	2003-04-18	2005-01-25	Bristol-Myers Squibb Company	N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase
EP3081214A3 (en)	2003-08-29	2016-11-16	The Brigham And Women's Hospital, Inc.	Inhibitors of cellular necrosis
CA2663254C (en)	2006-09-15	2016-04-19	Reviva Pharmaceuticals, Inc.	Synthesis, methods of using, and compositions of cycloalkylmethylamines
US20120122889A1 (en)	2008-12-23	2012-05-17	President And Fellows Of Harvard College	Small molecule inhibitors of necroptosis
GB0919194D0 (en)	2009-11-02	2009-12-16	Lytix Biopharma As	Compounds
WO2012003501A2 (en)	2010-07-02	2012-01-05	Reviva Pharmaceuticals, Inc.	Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
JP2016514693A (en)	2013-03-15	2016-05-23	プレジデントアンドフェローズオブハーバードカレッジ	Hybrid necrotosis inhibitor
US9944628B2 (en)	2014-12-11	2018-04-17	President And Fellows Of Harvard College	Inhibitors of cellular necrosis and related methods

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0224151A2 (en) *	1985-11-14	1987-06-03	Warner-Lambert Company	2-Substituted-[2-substituted-amino]-N-aralkyl-3-[indol-3-yl]propanamides
EP0230151A2 (en) *	1985-12-31	1987-07-29	Biomeasure, Inc.	Cholecystokinin antagonists
EP0336356A2 (en) *	1988-04-05	1989-10-11	Abbott Laboratories	Derivatives of tryptophan as CCK antagonists
EP0405537A1 (en) *	1989-06-29	1991-01-02	Warner-Lambert Company	N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
WO1992004322A1 (en) *	1990-08-31	1992-03-19	Warner-Lambert Company	Alpha-substituted tryptophane dipeptoid derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1291031C (en) *	1985-12-23	1991-10-22	Nikolaas C.J. De Jaeger	Method for the detection of specific binding agents and their correspondingbindable substances
FR2606963B1 (en) *	1986-11-14	1989-01-13	Cit Alcatel	SUBMARINE REPEATER BOX

1991
- 1991-08-29 EP EP19910918880 patent/EP0547178A4/en not_active Withdrawn
- 1991-08-29 NZ NZ239595A patent/NZ239595A/en unknown
- 1991-08-29 WO PCT/US1991/006180 patent/WO1992004045A1/en not_active Application Discontinuation
- 1991-08-29 KR KR1019930700601A patent/KR100222634B1/en not_active IP Right Cessation
- 1991-08-29 JP JP3517185A patent/JPH06502627A/en active Pending
- 1991-08-29 CA CA002088195A patent/CA2088195A1/en not_active Abandoned
- 1991-08-30 IE IE307791A patent/IE67290B1/en not_active IP Right Cessation
- 1991-08-30 PT PT98842A patent/PT98842B/en not_active IP Right Cessation
1993
- 1993-02-26 NO NO19930709A patent/NO312298B1/en not_active IP Right Cessation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0224151A2 (en) *	1985-11-14	1987-06-03	Warner-Lambert Company	2-Substituted-[2-substituted-amino]-N-aralkyl-3-[indol-3-yl]propanamides
EP0230151A2 (en) *	1985-12-31	1987-07-29	Biomeasure, Inc.	Cholecystokinin antagonists
EP0336356A2 (en) *	1988-04-05	1989-10-11	Abbott Laboratories	Derivatives of tryptophan as CCK antagonists
EP0405537A1 (en) *	1989-06-29	1991-01-02	Warner-Lambert Company	N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
WO1992004322A1 (en) *	1990-08-31	1992-03-19	Warner-Lambert Company	Alpha-substituted tryptophane dipeptoid derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D.C. HORWELL ET AL.: "Alpha-methyl tryptophanylphenylalanines and their arylethylamine "dipeptoid" analogues of the tetrapepetide cholecystokinin.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.CHIMICA THERAPEUTICA, vol. 25, 1990, PARIS FR, pages 53 - 60 *
D.C. HORWELL ET AL.: "Rationally designed "dipeptoid" analogues of CCK. ...", JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, no. 1, 1991, WASHINGTON US, pages 404 - 414 *
See also references of WO9204045A1 *

Also Published As

Publication number	Publication date
NO930709D0 (en)	1993-02-26
CA2088195A1 (en)	1992-03-01
AU651390B2 (en)	1994-07-21
JPH06502627A (en)	1994-03-24
PT98842A (en)	1992-08-31
IE67290B1 (en)	1996-03-20
NO930709L (en)	1993-04-15
NO312298B1 (en)	2002-04-22
NZ239595A (en)	1994-06-27
WO1992004045A1 (en)	1992-03-19
PT98842B (en)	1999-01-29
IE913077A1 (en)	1992-03-11
EP0547178A1 (en)	1993-06-23
KR100222634B1 (en)	1999-10-01
KR930703349A (en)	1993-11-29
AU8749291A (en)	1992-03-30

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Legal Events

Date	Code	Title	Description
1993-05-07	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1993-06-23	17P	Request for examination filed	Effective date: 19930220
1993-06-23	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1994-07-06	A4	Supplementary search report drawn up and despatched
1994-07-06	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1997-03-19	17Q	First examination report despatched	Effective date: 19970130
2005-11-11	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2005-12-28	18D	Application deemed to be withdrawn	Effective date: 20050625