EP0437508A4 - Non-peptide renin inhibitors - Google Patents

Non-peptide renin inhibitors

Info

Publication number: EP0437508A4
Authority: EP; European Patent Office
Prior art keywords: renin inhibitors; peptide renin; peptide; inhibitors; renin
Prior art date: 1988-10-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP19890911665

Other versions

EP0437508A1 (en

Inventor

Anthony K. L. Fung

William R. Baker

Yoek-Lin Armiger

Saul H. Rosenberg

Biswanath De

Jacob J. Plattner

Steven A. Boyd

Dale J. Kempf

Hing Leung Sham

Hollis D. Kleinert

Robert A. Mantei

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Laboratories

Original Assignee

Abbott Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-04

Filing date

1989-10-03

Publication date

1991-11-06

1989-10-03 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

1991-07-24 Publication of EP0437508A1 publication Critical patent/EP0437508A1/en

1991-11-06 Publication of EP0437508A4 publication Critical patent/EP0437508A4/en

Status Pending legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/18—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carboxylic acids, or by sulfur or nitrogen analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EP19890911665 1988-10-04 1989-10-03 Non-peptide renin inhibitors Pending EP0437508A4 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US25328288A	1988-10-04	1988-10-04
US253282		1988-10-04
US39372189A	1989-08-14	1989-08-14
US393721		1995-02-24

Publications (2)

Publication Number	Publication Date
EP0437508A1 EP0437508A1 (en)	1991-07-24
EP0437508A4 true EP0437508A4 (en)	1991-11-06

Family

ID=26943094

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP19890911665 Pending EP0437508A4 (en)	1988-10-04	1989-10-03	Non-peptide renin inhibitors
EP89118270A Withdrawn EP0364804A1 (en)	1988-10-04	1989-10-03	Non-peptide renin inhibitors

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP89118270A Withdrawn EP0364804A1 (en)	1988-10-04	1989-10-03	Non-peptide renin inhibitors

Country Status (9)

Country	Link
EP (2)	EP0437508A4 (en)
JP (1)	JPH04505608A (en)
KR (1)	KR900701759A (en)
AU (1)	AU639212B2 (en)
CA (1)	CA1337909C (en)
DK (1)	DK59991A (en)
IL (1)	IL91780A (en)
NZ (1)	NZ230894A (en)
WO (1)	WO1990003971A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6878728B1 (en)	1999-06-11	2005-04-12	Vertex Pharmaceutical Incorporated	Inhibitors of aspartyl protease
US20040122000A1 (en)	1981-01-07	2004-06-24	Vertex Pharmaceuticals Incorporated.	Inhibitors of aspartyl protease
US5182266A (en) *	1990-01-31	1993-01-26	Abbott Laboratories	Method for treating renal disease
BR9106438A (en)	1990-05-11	1993-05-18	Pfizer	SYNERGISTIC THERAPEUTIC COMPOSITIONS AND PROCESSES
US5821232A (en) *	1990-05-11	1998-10-13	Pfizer Inc.	Synergistic therapeutic compositions and methods
EP0538366A1 (en) *	1990-07-06	1993-04-28	Smithkline Beecham Corporation	Retroviral protease inhibitors
US5244910A (en) *	1990-08-15	1993-09-14	Abbott Laboratories	Renin inhibitors
EP0543936A4 (en) *	1990-08-15	1993-06-30	Abbott Laboratories	Renin inhibitors
JPH04243835A (en) *	1990-08-29	1992-08-31	Pfizer Inc	Drug composition for therapy of disease on high intraocular tension or glaucoma and method for therapy thereof
US5442044A (en) *	1991-01-04	1995-08-15	Pfizer Inc.	Orally active renin inhibitors
US5436339A (en) *	1991-03-06	1995-07-25	Abbott Laboratories	Process for the preparation of a substituted diaminoalcohol
JPH07501556A (en) *	1992-03-25	1995-02-16	ファイザー・インコーポレーテッド	antiviral peptide
US5559256A (en) *	1992-07-20	1996-09-24	E. R. Squibb & Sons, Inc.	Aminediol protease inhibitors
DK0810209T3 (en) *	1992-08-25	2002-08-12	Monsanto Co	Alpha and beta amino acid hydroxyethylaminosulfonamides for use as inhibitors of retroviral proteases
US5783701A (en)	1992-09-08	1998-07-21	Vertex Pharmaceuticals, Incorporated	Sulfonamide inhibitors of aspartyl protease
IS2334B (en) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl protease inhibitor of a new class of sulfonamides
US5723490A (en) *	1992-09-08	1998-03-03	Vertex Pharmaceuticals Incorporated	THF-containing sulfonamide inhibitors of aspartyl protease
GB2270914A (en) *	1992-09-14	1994-03-30	Merck & Co Inc	HIV protease inhibitor compounds
EP0810208B1 (en)	1992-10-30	2002-01-02	G.D. Searle & Co.	N-substituted Hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
EP0885880A3 (en) *	1992-10-30	1999-10-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfamic acids useful as retroviral protease inhibitors
US5602119A (en) *	1993-10-29	1997-02-11	Vazquez; Michael L.	Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
MX9603909A (en) *	1994-03-07	1997-03-29	Vertex Pharma	Sulphonamide derivatives as aspartyl protease inhibitors.
US5691372A (en) *	1995-04-19	1997-11-25	Vertex Pharmaceuticals Incorporated	Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6004957A (en) *	1995-06-07	1999-12-21	Vertex Pharmaceuticals, Incorporated	Sulfonamide inhibitors of aspartyl protease
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
PT1086076E (en)	1998-06-19	2005-05-31	Vertex Pharma	SULFONAMIDE INHIBITORS OF ASPARTIL PROTEASE
US6538006B1 (en)	1998-07-08	2003-03-25	Pharmacia Corporation	Retroviral protease inhibitors
WO2003053909A1 (en) *	2001-12-21	2003-07-03	Biocon Limited	Process for preparing amino acid tert-butyl ester hydrochloric acid salts
EP1910272A4 (en) *	2005-07-22	2010-08-04	Merck Frosst Canada Ltd	Renin inhibitors
EP2619185A1 (en)	2010-09-24	2013-07-31	Ranbaxy Laboratories Limited	Matrix metalloproteinase inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0184855A2 (en) *	1984-12-14	1986-06-18	Abbott Laboratories	Resin inhibiting compounds
EP0230266A2 (en) *	1986-01-16	1987-07-29	Abbott Laboratories	Functionalized peptidyl aminodiols and -triols
EP0244083A2 (en) *	1986-04-01	1987-11-04	Kissei Pharmaceutical Co. Ltd.	Amino acid derivatives

1989
- 1989-09-26 IL IL9178089A patent/IL91780A/en not_active IP Right Cessation
- 1989-09-29 CA CA000615201A patent/CA1337909C/en not_active Expired - Fee Related
- 1989-10-03 AU AU44163/89A patent/AU639212B2/en not_active Ceased
- 1989-10-03 EP EP19890911665 patent/EP0437508A4/en active Pending
- 1989-10-03 EP EP89118270A patent/EP0364804A1/en not_active Withdrawn
- 1989-10-03 JP JP1510915A patent/JPH04505608A/en active Pending
- 1989-10-03 WO PCT/US1989/004385 patent/WO1990003971A1/en not_active Application Discontinuation
- 1989-10-03 KR KR1019900701155A patent/KR900701759A/en not_active Application Discontinuation
- 1989-10-04 NZ NZ230894A patent/NZ230894A/en unknown
1991
- 1991-04-04 DK DK059991A patent/DK59991A/en not_active Application Discontinuation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0184855A2 (en) *	1984-12-14	1986-06-18	Abbott Laboratories	Resin inhibiting compounds
EP0230266A2 (en) *	1986-01-16	1987-07-29	Abbott Laboratories	Functionalized peptidyl aminodiols and -triols
EP0244083A2 (en) *	1986-04-01	1987-11-04	Kissei Pharmaceutical Co. Ltd.	Amino acid derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NATURE vol. 299, 7 October 1982, pages 555-557, Basingstoke, GB; M. SZELKE et al.: "Potent new inhibitors of human renin" *
NATURE vol. 303, 5 May 1983, pages 81-84, Basingstoke, GB; J. BOGER et al.: "Novel renin inhibitors containing the amino acid statine" *
See also references of WO9003971A1 *

Also Published As

Publication number	Publication date
NZ230894A (en)	1991-07-26
AU4416389A (en)	1990-05-01
AU639212B2 (en)	1993-07-22
IL91780A0 (en)	1990-06-10
EP0437508A1 (en)	1991-07-24
KR900701759A (en)	1990-12-04
JPH04505608A (en)	1992-10-01
IL91780A (en)	1995-08-31
DK59991D0 (en)	1991-04-04
DK59991A (en)	1991-04-04
CA1337909C (en)	1996-01-09
EP0364804A1 (en)	1990-04-25
WO1990003971A1 (en)	1990-04-19

Publication	Publication Date	Title
IL91780A0 (en)	1990-06-10	Non-peptide renin inhibitors
IL88273A0 (en)	1989-06-30	Renin inhibitors
EP0439556A4 (en)	1991-10-30	Heterocyclic peptide renin inhibitors
PH25908A (en)	1991-12-19	Novel omicron(-glucosides inhibitors
AU1037588A (en)	1988-09-01	Renin inhibitors
HU893412D0 (en)	1991-05-28	Inhibitors of interleucin-1
EP0410260A3 (en)	1992-01-08	Peptidyl aminodiol renin inhibitors
GR871770B (en)	1988-03-17	Renin inhibitors
ZA899924B (en)	1990-09-26	Renin inhibitors
PT86374A (en)	1988-01-01	Renin inhibitors iii
IL95380A0 (en)	1991-06-30	Peptidyl difluorodiol renin inhibitors
ZA879030B (en)	1989-07-26	Renin inhibitors iii
PT86450A (en)	1988-01-01	Renin inhibitors iv
AU4717389A (en)	1990-06-28	Renin inhibitors
EP0427939A3 (en)	1991-11-06	Renin inhibitors
EP0543936A4 (en)	1993-06-30	Renin inhibitors
AU2965989A (en)	1989-08-10	Renin inhibitors
IE893158L (en)	1990-04-04	Non-peptide renin inhibitors
IE883340L (en)	1989-05-05	Renin inhibitors
IE883074L (en)	1989-04-14	Renin inhibitors
IE891826L (en)	1989-12-09	Renin inhibitors
IE894102L (en)	1990-06-27	Renin inhibitors
IE890075L (en)	1990-07-11	Renin inhibitors
ZA888239B (en)	1989-07-26	Renin inhibitors
IE873185L (en)	1988-06-15	Renin inhibitors iii

Legal Events

Date	Code	Title	Description
1991-06-07	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1991-06-07	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
1991-07-24	17P	Request for examination filed	Effective date: 19910402
1991-07-24	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE
1991-09-18	RIN1	Information on inventor provided before grant (corrected)	Inventor name: BAKER, WILLIAM, R. Inventor name: ARMIGER, YOEK-LIN Inventor name: PLATTNER, JACOB, J. Inventor name: KEMPF, DALE, J. Inventor name: ROSENBERG, SAUL, H. Inventor name: DE, BISWANATH Inventor name: BOYD, STEVEN, A. Inventor name: FUNG, ANTHONY, K., L.
1991-11-06	A4	Supplementary search report drawn up and despatched	Effective date: 19910917
1991-11-06	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE
1992-06-17	XX	Miscellaneous (additional remarks)	Free format text: VERFAHREN ABGESCHLOSSEN INFOLGE VERBINDUNG MIT 89118270.1/0364804 (EUROPAEISCHE ANMELDENUMMER/VEROEFFENTLICHUNGSNUMMER) VOM 30.04.92.