EP0420620A2 - Pressure regulator for implantable pump - Google Patents
Pressure regulator for implantable pump Download PDFInfo
- Publication number
- EP0420620A2 EP0420620A2 EP90310550A EP90310550A EP0420620A2 EP 0420620 A2 EP0420620 A2 EP 0420620A2 EP 90310550 A EP90310550 A EP 90310550A EP 90310550 A EP90310550 A EP 90310550A EP 0420620 A2 EP0420620 A2 EP 0420620A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- drug
- chamber
- pressure
- outlet
- regulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims abstract description 37
- 229940079593 drug Drugs 0.000 claims abstract description 37
- 239000003380 propellant Substances 0.000 claims abstract description 21
- 230000008878 coupling Effects 0.000 claims abstract description 3
- 238000010168 coupling process Methods 0.000 claims abstract description 3
- 238000005859 coupling reaction Methods 0.000 claims abstract description 3
- 239000012530 fluid Substances 0.000 claims description 22
- 230000001105 regulatory effect Effects 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 10
- 238000012377 drug delivery Methods 0.000 claims description 8
- 238000004891 communication Methods 0.000 claims description 4
- 238000002955 isolation Methods 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 210000004907 gland Anatomy 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16877—Adjusting flow; Devices for setting a flow rate
- A61M5/16881—Regulating valves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/12—Pressure infusion
Definitions
- This invention is directed to a system for accurately controlling a flow rate of a drug from an implantable drug delivery device and maintaining in-vivo a higher degree of safety.
- Devices of this type have reached the point of commercial utilization as typified by the Infusaid models 100 and 400 devices available from Infusaid Inc., Norwood, Massachusetts USA. Such devices are implantable to deliver a drug at a very slow flow rate over a long period of time. They are refilled subcutaneously.
- An implantable infusion pump of the prior art utilizes the vapor pressure of a two stage gas to provide a constant pressure for a drug flowing through a capillary tube in order to maintain a constant flow rate.
- This technique of flow control while simple and reliable, is sensitive to outside variables such as changes in temperature and atmospheric pressure. For example, if the patient has a fever, or works in a cold environment, the temperature of the implanted gland can change several degrees. The internal pressure change is about 0.5 psi per degree F. A 25 percent increase in pressure and drug flow rate can result from a fever of 102.5°F. This change is more than can be tolerated when a critical drug is being administered.
- Another implantable pump of the prior art uses a flow regulator to compensate for variations in temperature and pressure.
- This regulating device comprises a pair of chambers separated by a flexible diaphragm.
- the first chamber is in fluid contact with the reservoir of the pump and has an outlet allowing the reservoir fluid to flow into a restrictor.
- This restrictor flows into the other chamber and communicates with the pump outlet via a centrally located regulating seal.
- the relationship of the regulator seal to the flexible diaphragm permits the regulator to maintain a constant pressure drop across the restrictor despite reservoir or outlet pressure variations.
- the flow regulator comprises a body made up of mating top member and bottom member.
- the top portion of the bottom body member has a deep recess into which the bottom portion of top body member is received in mating relation.
- a resilient gasket is seated in the cavity bottom.
- a resilient diaphragm composed of flexible but impervious material (such as 0.003 inch titanium metal, for example) is disposed in the cavity resting on the resilient gasket.
- a resilient O-ring is disposed in the cavity on top of the diaphragm so as to engage the bottom chamfered edge of the top member so as to seal the unit when the top and bottom members are assembled and fastened together, as by means of a plurality of screws.
- the upper and lower body members and diaphragm may be welded together into an integral unit.
- there are opposing forces on the diaphragm which balance out and the diaphragm is stationary. If the forces are unbalanced, for example, by a decrease in flow that reduces the pressure difference across the capillary, the diaphragm will deflect. The diaphragm position determines the resistance to flow of the control valve.
- the control valve seal presses against the low pressure side of the diaphragm and, therefore, will open the valve when the pressure drop across the capillary is low and close the valve when the pressure drop is high.
- This negative feedback controls the flow to maintain it constant at a value determined by the balance of pressure on the diaphragm. Flow rates as small as 1 ml/day may be controlled to within ⁇ 5 percent. This flow rate is so low that even small leakage paths through the valve would exceed the control range.
- the polished surface of the diaphragm forces an elastomer O-ring to conform to its surface profile to reduce the leakage path to zero when fully seated.
- the present invention provides an improved pressurized flow regulator for use in an implantable drug system.
- an implantable drug delivery system comprising a pressure actuated drug dispensing device having a sealed housing, a flexible drug reservoir containing a fluid therein, an outlet from said drug reservoir and a propellant chamber to urge said fluid from said reservoir into said outlet, and characterized by a flow regulating device having a regulator chamber and a sensing chamber separated and maintained in isolation from each other by a flexible diaphragm, said outlet supplying said fluid into said regulator chamber, an outlet catheter coupling said regulator chamber to a drug delivery site and means to establish a reference pressure in said sensing chamber that is substantially equal to the pressure in said propellant chamber.
- a drug delivery device comprises an implantable infusion pump 10 having a housing 12 divided into a drug reservoir chamber 14 and a propellant chamber 16 by a bellows diaphragm 18.
- a septum is formed of a penetrable resilient stopper material and provides a fluid communication to allow for subcutaneous refilling of the drug reservoir 14.
- the propellant chamber 16 contains a liquid such as "Freon" having a vapor pressure which, under condition of normal body pressure exerts a pressure on the bellows to force a drug contained in the drug reservoir 14 through outlet conduit 22.
- a bacteria filter 24 can be placed in-line between the drug reservoir 14 and the outlet conduit 22.
- a flow restrictor 28 is placed on the outlet conduit 22 to provide a suitable pressure drop.
- a flow regulating device 30 comprises a regulator chamber 32 and a sensing chamber 34 divided by a thin flexible diaphragm 36.
- a regulator seal 38 is employed to define a stop for the flexible diaphragm 36.
- the regulator seal 38 and the flexible diaphragm 36 are worked in the manner described earlier herein with reference to US Patent 4 299 220.
- a drug at the delivered pressure is then input into flow regulating device 30.
- a regulator was in fluid contact with the implantable infusion pump drug reservoir and maintained a constant flow rate by compensating for changes in the pump reservoir or outlet pressures.
- the prior art uses a diaphragm-to-seal technology which has the sensing chamber in fluid contact with the reservoir.
- the sensing chamber 34 is sealed from the fluid flow path. It is filled with the same 2-phase fluid as in the pump propellant chamber 16.
- the sensing chamber 34 contains the same vapor pressure as the pump propellant chamber 16. It thus parallels pressure fluctuations experienced by the propellant chamber 16.
- the regulator contains an independent pressure source allows the sensing chamber 34 to operate without commnunicating with the drug reservoir 14. This eliminates the possibility of drug solution bypassing the regulator due to a diaphragm hermeticity failure.
- the regulator of Figure 1 can be an independent component added to the outlet 22 of the pump system, as shown, or alternatively can be contained within the housing for the implantable pump component within the container 12.
- a second embodiment of this invention which incorporates a second restrictor 40 to establish a pressure drop across the regulator 30.
- the first restrictor 26 establishes a pressure drop between the pump 10 and the regulator 30 while the downstream second restrictor 40 establishes a pressure drop between an outlet catheter 42 and the flow regulating device 30.
- the restrictor 26 has a low restrictive value, and is used to establish the pressure drop across the regulating chambers 32 and 34.
- the majority of the pump's flow restriction is established by the second restrictor 40 located downstream of the regulator seal. With the majority of the restriction located downstream, a failure in the regulator seal 38 will not result in excessive pump flow rates.
- FIG. 3 a third embodiment of this invention is illustrated in which the propellant chamber 16 is physically coupled to the sensing chamber 34 in the regulating device 30 via a line 44.
- the embodiment of Figure 3 departs from that of Figure 1 in that, instead of having the sensing chamber 34 provided with an independent source of 2-phase propellant fluid, the same fluid is used in common in chamber 16 and chamber 34.
- Figure 4 represents a fourth embodiment that is a combination of Figures 2 and 3.
- the combination of upstream restrictor 26 and downstream second restrictor 40 is used to provide two differential pressure drops respectively between the pump 10 and the regulator 30 and the outlet catheter 42. Additionally, the common interconnection of the propellant chamber 16 and the sensing chamber 34 utilizing the line 44 is accomplished so that those two chambers are in direct fluid communication with each other.
- regulator sensing is not dependent on the flow of drug from the outlet 22. Rather, in each embodiment the sensing chamber in the regulator is established with either an independent source of propellant to establish a base line regulating pressure or, is coupled in direct fluid communication with the propellant chamber in the drug dispensing device. In addition, by the use of a downstream restrictor, a failure in the regulator seal will not cause a catastrophic failure since the restrictor will still establish the necessary pressure drop.
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
- Jet Pumps And Other Pumps (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Reciprocating Pumps (AREA)
Abstract
Description
- This invention is directed to a system for accurately controlling a flow rate of a drug from an implantable drug delivery device and maintaining in-vivo a higher degree of safety. Devices of this type have reached the point of commercial utilization as typified by the Infusaid models 100 and 400 devices available from Infusaid Inc., Norwood, Massachusetts USA. Such devices are implantable to deliver a drug at a very slow flow rate over a long period of time. They are refilled subcutaneously.
- An implantable infusion pump of the prior art (U.S. 3,731,681) utilizes the vapor pressure of a two stage gas to provide a constant pressure for a drug flowing through a capillary tube in order to maintain a constant flow rate. This technique of flow control, while simple and reliable, is sensitive to outside variables such as changes in temperature and atmospheric pressure. For example, if the patient has a fever, or works in a cold environment, the temperature of the implanted gland can change several degrees. The internal pressure change is about 0.5 psi per degree F. A 25 percent increase in pressure and drug flow rate can result from a fever of 102.5°F. This change is more than can be tolerated when a critical drug is being administered. A more serious situation results from the reduced air pressure in airplane cabins when the patient is traveling. The standard airplane pressure is maintained at a level corresponding to an altitude of about 5,000 feet above sea level. With a gland using an 8.2 psi internal pressure, this would increase the differential pressure by 26 percent over the sea level setting. Although the drug dosage can be adjusted by changing the concentration of drug in the gland, this is a serious inconvenience and hardship for patients who must travel by air frequently.
- To compensate for variations in temperature and pressure, another implantable pump of the prior art (U.S. 4,299,220) uses a flow regulator to compensate for variations in temperature and pressure. This regulating device comprises a pair of chambers separated by a flexible diaphragm. The first chamber is in fluid contact with the reservoir of the pump and has an outlet allowing the reservoir fluid to flow into a restrictor. This restrictor flows into the other chamber and communicates with the pump outlet via a centrally located regulating seal. The relationship of the regulator seal to the flexible diaphragm permits the regulator to maintain a constant pressure drop across the restrictor despite reservoir or outlet pressure variations.
- In more detail, the flow regulator comprises a body made up of mating top member and bottom member. The top portion of the bottom body member has a deep recess into which the bottom portion of top body member is received in mating relation. A resilient gasket is seated in the cavity bottom. A resilient diaphragm composed of flexible but impervious material (such as 0.003 inch titanium metal, for example) is disposed in the cavity resting on the resilient gasket. A resilient O-ring is disposed in the cavity on top of the diaphragm so as to engage the bottom chamfered edge of the top member so as to seal the unit when the top and bottom members are assembled and fastened together, as by means of a plurality of screws. Alternatively, the upper and lower body members and diaphragm may be welded together into an integral unit. A shallow recess in the bottom surface of the top member along with the remaining space in the bottom body portion after assembly of the body, forms a shallow internal cavity which is divided by the diaphragm into a first or upper chamber and a second or lower chamber. Ordinarily there are opposing forces on the diaphragm which balance out and the diaphragm is stationary. If the forces are unbalanced, for example, by a decrease in flow that reduces the pressure difference across the capillary, the diaphragm will deflect. The diaphragm position determines the resistance to flow of the control valve. The control valve seal presses against the low pressure side of the diaphragm and, therefore, will open the valve when the pressure drop across the capillary is low and close the valve when the pressure drop is high. This negative feedback controls the flow to maintain it constant at a value determined by the balance of pressure on the diaphragm. Flow rates as small as 1 ml/day may be controlled to within ± 5 percent. This flow rate is so low that even small leakage paths through the valve would exceed the control range. The polished surface of the diaphragm forces an elastomer O-ring to conform to its surface profile to reduce the leakage path to zero when fully seated.
- While this configuration provides pressure regulation, the flow paths have potentially undesirable failure modes. For example, since the regulator depends on the drug fluid to supply the regulator sensing pressure, a diaphragm failure, such as a hole in the membrane, would allow the drug to bypass the regulator's restrictor resulting in an undesirable increase in flow rate. Another potential problem is a failure of the regulator seal, that is, a seal leak or physical dislocation of the seal relative to the seat. This would result in a flow rate increase due to the lack of seal restriction.
- The present invention provides an improved pressurized flow regulator for use in an implantable drug system.
- According to the present invention, there is provided an implantable drug delivery system comprising a pressure actuated drug dispensing device having a sealed housing, a flexible drug reservoir containing a fluid therein, an outlet from said drug reservoir and a propellant chamber to urge said fluid from said reservoir into said outlet, and characterized by a flow regulating device having a regulator chamber and a sensing chamber separated and maintained in isolation from each other by a flexible diaphragm, said outlet supplying said fluid into said regulator chamber, an outlet catheter coupling said regulator chamber to a drug delivery site and means to establish a reference pressure in said sensing chamber that is substantially equal to the pressure in said propellant chamber.
- The invention will now be described by way of example only, reference being made to the accompanying drawings in which:-
- Figure 1 is a first embodiment of an implantable drug system in accordance with this invention;
- Figure 2 is a second embodiment of this invention utilizing a downstream restrictor element in accordance with this invention;
- Figure 3 is a third embodiment of this invention which couples the propellant and sensing chambers together in accordance with this invention; and
- Figure 4 is a fourth embodiment of this invention utilizing the combination of a downstream restrictor and the propellant and sensing chambers coupled together.
- Referring now to Figure 1, a first preferred embodiment of this invention is illustrated in which a drug delivery device comprises an
implantable infusion pump 10 having ahousing 12 divided into adrug reservoir chamber 14 and apropellant chamber 16 by abellows diaphragm 18. A septum is formed of a penetrable resilient stopper material and provides a fluid communication to allow for subcutaneous refilling of thedrug reservoir 14. Thepropellant chamber 16 contains a liquid such as "Freon" having a vapor pressure which, under condition of normal body pressure exerts a pressure on the bellows to force a drug contained in thedrug reservoir 14 throughoutlet conduit 22. Abacteria filter 24 can be placed in-line between thedrug reservoir 14 and theoutlet conduit 22. A flow restrictor 28 is placed on theoutlet conduit 22 to provide a suitable pressure drop. - In accordance with this invention a
flow regulating device 30 comprises aregulator chamber 32 and asensing chamber 34 divided by a thinflexible diaphragm 36. Aregulator seal 38 is employed to define a stop for theflexible diaphragm 36. Theregulator seal 38 and theflexible diaphragm 36 are worked in the manner described earlier herein with reference to US Patent 4 299 220. A drug at the delivered pressure is then input intoflow regulating device 30. - In the prior art device, a regulator was in fluid contact with the implantable infusion pump drug reservoir and maintained a constant flow rate by compensating for changes in the pump reservoir or outlet pressures. Thus, the prior art uses a diaphragm-to-seal technology which has the sensing chamber in fluid contact with the reservoir. However, in accordance with this invention, as illustrated in Figure 1, the
sensing chamber 34 is sealed from the fluid flow path. It is filled with the same 2-phase fluid as in thepump propellant chamber 16. Thus, thesensing chamber 34 contains the same vapor pressure as thepump propellant chamber 16. It thus parallels pressure fluctuations experienced by thepropellant chamber 16. Thus, the fact that the regulator contains an independent pressure source allows thesensing chamber 34 to operate without commnunicating with thedrug reservoir 14. This eliminates the possibility of drug solution bypassing the regulator due to a diaphragm hermeticity failure. - The regulator of Figure 1 can be an independent component added to the
outlet 22 of the pump system, as shown, or alternatively can be contained within the housing for the implantable pump component within thecontainer 12. - Referring now to Figure 2, a second embodiment of this invention is illustrated which incorporates a
second restrictor 40 to establish a pressure drop across theregulator 30. Thus, thefirst restrictor 26 establishes a pressure drop between thepump 10 and theregulator 30 while the downstreamsecond restrictor 40 establishes a pressure drop between anoutlet catheter 42 and theflow regulating device 30. Therestrictor 26 has a low restrictive value, and is used to establish the pressure drop across theregulating chambers second restrictor 40 located downstream of the regulator seal. With the majority of the restriction located downstream, a failure in theregulator seal 38 will not result in excessive pump flow rates. - Referring now to Figure 3, a third embodiment of this invention is illustrated in which the
propellant chamber 16 is physically coupled to thesensing chamber 34 in the regulatingdevice 30 via aline 44. The embodiment of Figure 3 departs from that of Figure 1 in that, instead of having thesensing chamber 34 provided with an independent source of 2-phase propellant fluid, the same fluid is used in common inchamber 16 andchamber 34. - Figure 4 represents a fourth embodiment that is a combination of Figures 2 and 3. In Figure 4 the combination of
upstream restrictor 26 and downstreamsecond restrictor 40 is used to provide two differential pressure drops respectively between thepump 10 and theregulator 30 and theoutlet catheter 42. Additionally, the common interconnection of thepropellant chamber 16 and thesensing chamber 34 utilizing theline 44 is accomplished so that those two chambers are in direct fluid communication with each other. - As is apparent, in each of these embodiments regulator sensing is not dependent on the flow of drug from the
outlet 22. Rather, in each embodiment the sensing chamber in the regulator is established with either an independent source of propellant to establish a base line regulating pressure or, is coupled in direct fluid communication with the propellant chamber in the drug dispensing device. In addition, by the use of a downstream restrictor, a failure in the regulator seal will not cause a catastrophic failure since the restrictor will still establish the necessary pressure drop.
Claims (10)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/412,376 US5067943A (en) | 1989-09-26 | 1989-09-26 | Pressure regulator for implantable pump |
US412376 | 1989-09-26 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0420620A2 true EP0420620A2 (en) | 1991-04-03 |
EP0420620A3 EP0420620A3 (en) | 1991-11-27 |
EP0420620B1 EP0420620B1 (en) | 1995-06-28 |
Family
ID=23632742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP90310550A Expired - Lifetime EP0420620B1 (en) | 1989-09-26 | 1990-09-26 | Pressure regulator for implantable pump |
Country Status (8)
Country | Link |
---|---|
US (2) | US5067943A (en) |
EP (1) | EP0420620B1 (en) |
JP (1) | JPH0822313B2 (en) |
AT (1) | ATE124274T1 (en) |
AU (1) | AU625000B2 (en) |
CA (1) | CA2026077C (en) |
DE (1) | DE69020474T2 (en) |
ES (1) | ES2073536T3 (en) |
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995004571A1 (en) * | 1993-08-11 | 1995-02-16 | Thomas John Berrigan | Implantable drug delivery means |
EP0761256A2 (en) * | 1995-09-01 | 1997-03-12 | Strato/Infusaid Inc. | Power supply for implantable device |
AU684811B2 (en) * | 1993-08-11 | 1998-01-08 | Thomas John Berrigan | Drug delivery means |
EP0860173A2 (en) * | 1997-02-25 | 1998-08-26 | Minimed Inc. | Flow rate controller for a medication infusion pump |
US6319245B1 (en) | 1996-10-09 | 2001-11-20 | Thomas John Berrigan | Drug delivery means |
WO2002036184A1 (en) | 2000-11-03 | 2002-05-10 | Endoart Sa | Implantable medical device for delivering a liquid |
WO2002070047A1 (en) * | 2001-03-01 | 2002-09-12 | Advanced Neuromodulation Systems, Inc. | Non-constant pressure infusion pump |
WO2005120606A1 (en) * | 2004-06-07 | 2005-12-22 | Medtronic, Inc. | Drug delivery system |
US6979315B2 (en) | 1999-04-30 | 2005-12-27 | Medtronic, Inc. | Passive flow control devices for implantable pumps |
FR2905429A1 (en) * | 2006-09-04 | 2008-03-07 | Debiotech Sa | DEVICE FOR DELIVERING A LIQUID COMPRISING A PUMP AND A VALVE |
EP2338547A3 (en) * | 2006-02-09 | 2011-12-07 | DEKA Products Limited Partnership | Fluid delivery systems |
US8251981B2 (en) | 2004-06-07 | 2012-08-28 | Medtronic, Inc. | Regulator |
US8414563B2 (en) | 2007-12-31 | 2013-04-09 | Deka Products Limited Partnership | Pump assembly with switch |
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Also Published As
Publication number | Publication date |
---|---|
ES2073536T3 (en) | 1995-08-16 |
CA2026077C (en) | 1997-11-25 |
AU625000B2 (en) | 1992-06-25 |
EP0420620A3 (en) | 1991-11-27 |
CA2026077A1 (en) | 1991-03-27 |
AU6320790A (en) | 1991-04-11 |
JPH0822313B2 (en) | 1996-03-06 |
EP0420620B1 (en) | 1995-06-28 |
US5067943A (en) | 1991-11-26 |
DE69020474T2 (en) | 1995-11-09 |
DE69020474D1 (en) | 1995-08-03 |
ATE124274T1 (en) | 1995-07-15 |
JPH03121076A (en) | 1991-05-23 |
US5088983A (en) | 1992-02-18 |
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