[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EP0410974A4 - Nonionic x-ray contrast agents, compositions and methods - Google Patents

Nonionic x-ray contrast agents, compositions and methods

Info

Publication number
EP0410974A4
EP0410974A4 EP19890903414 EP89903414A EP0410974A4 EP 0410974 A4 EP0410974 A4 EP 0410974A4 EP 19890903414 EP19890903414 EP 19890903414 EP 89903414 A EP89903414 A EP 89903414A EP 0410974 A4 EP0410974 A4 EP 0410974A4
Authority
EP
European Patent Office
Prior art keywords
nonionic
compositions
methods
contrast agents
ray contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890903414
Other versions
EP0410974A1 (en
Inventor
David H. White
Youlin Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of EP0410974A1 publication Critical patent/EP0410974A1/en
Publication of EP0410974A4 publication Critical patent/EP0410974A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP19890903414 1988-03-01 1989-02-09 Nonionic x-ray contrast agents, compositions and methods Withdrawn EP0410974A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16263288A 1988-03-01 1988-03-01
US162632 1988-03-01

Publications (2)

Publication Number Publication Date
EP0410974A1 EP0410974A1 (en) 1991-02-06
EP0410974A4 true EP0410974A4 (en) 1991-09-11

Family

ID=22586472

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890903414 Withdrawn EP0410974A4 (en) 1988-03-01 1989-02-09 Nonionic x-ray contrast agents, compositions and methods

Country Status (4)

Country Link
EP (1) EP0410974A4 (en)
JP (1) JPH0625094B2 (en)
AU (1) AU612510B2 (en)
WO (1) WO1989008101A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013865A (en) * 1988-04-06 1991-05-07 Mallinckrodt, Inc. Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds
US5869024A (en) * 1989-11-29 1999-02-09 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US4997983A (en) * 1990-01-31 1991-03-05 Mallinckrodt, Inc. Process for production of ioversol
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
US5019371A (en) * 1990-11-21 1991-05-28 Mallinckrodt Medical, Inc. Novel x-ray contrast agents, compositions and methods
DE4109169A1 (en) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz WATER-SOLUBLE NON-IONIC X-RAY CONTRASTING AGENTS AND AGENTS AND METHOD FOR THE PRODUCTION THEREOF
CA2068089C (en) * 1991-05-31 2003-09-16 Ramachandran S. Ranganathan Method and compositions for using non-ionic contrast agents to reduce the risk of clot formulation in diagnostic procedures
GB9710726D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Compound
KR101833334B1 (en) * 2016-04-29 2018-02-28 (주)유케이케미팜 Novel intermediate compound and preparation process of iomeprol using thereof
CN115160174A (en) * 2022-07-09 2022-10-11 浙江海洲制药有限公司 Synthesis method of ioversol

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364921A (en) * 1979-03-08 1982-12-21 Schering, Aktiengesellschaft Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast media
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US4474747A (en) * 1981-08-28 1984-10-02 Guerbet S.A. Process for increasing the tolerance of X-ray contrast media, and contrast media obtained thereby
DE3429949A1 (en) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Novel non-ionic 2,4,6-triiodoisophthalic acid bisamides, process for the preparation thereof and the use thereof as X-ray contrast media

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1327600C (en) * 1987-05-22 1994-03-08 Ernest Felder Process for the preparation of 5-acylamino-2,4,6- triiodo-or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process
DE3731542A1 (en) * 1987-09-17 1989-03-30 Schering Ag NEW DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIIOD-ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THESE CONTAINING X-RAY AGENTS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364921A (en) * 1979-03-08 1982-12-21 Schering, Aktiengesellschaft Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast media
US4474747A (en) * 1981-08-28 1984-10-02 Guerbet S.A. Process for increasing the tolerance of X-ray contrast media, and contrast media obtained thereby
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
DE3429949A1 (en) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Novel non-ionic 2,4,6-triiodoisophthalic acid bisamides, process for the preparation thereof and the use thereof as X-ray contrast media

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8908101A1 *

Also Published As

Publication number Publication date
EP0410974A1 (en) 1991-02-06
JPH03504124A (en) 1991-09-12
AU612510B2 (en) 1991-07-11
AU4072789A (en) 1989-09-22
WO1989008101A1 (en) 1989-09-08
JPH0625094B2 (en) 1994-04-06

Similar Documents

Publication Publication Date Title
ZA902231B (en) Composition and use
GB8917470D0 (en) Composition and method
EP0411512A3 (en) Dental composition
EP0410974A4 (en) Nonionic x-ray contrast agents, compositions and methods
GB8923820D0 (en) Compound,composition,process and use
GB9021911D0 (en) Compositions and methods for weight reduction
EP0420097A3 (en) Coreactable powdered compositions
PH27336A (en) Antipasmodic agent
GB8908361D0 (en) Composition
EP0386359A3 (en) Konjak-containing composition
GB9006671D0 (en) Diagnostic method and compositions
EP0619744A4 (en) Nonionic x-ray contrast agents, compositions and methods.
GB2231575B (en) Command-curable composition
GB9016171D0 (en) Fungicidal compositions and method
GB8916151D0 (en) Composition
EP0139922A3 (en) Heat-sensitizing agents, their preparation and use
AU5093993A (en) Nonionic X-ray contrast agents compositions and methods
EP0431844A3 (en) Sterilizing compositions and their use
GB2238721B (en) Sterilizing compositions and their use
NZ232981A (en) 5-heterocyclic substituted-1,3,4-oxa-, and thia-diazoles and pesticidal compositions
GB9026896D0 (en) Method and composition
GB9004943D0 (en) Dental compositions,procedure and method
GB8905212D0 (en) Dental compositions,procedure and method
EP0434164A3 (en) Frying-fat composition
GB9008583D0 (en) Compound,composition and use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19900831

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19910722

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19930511

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19930922