EP0494819B1 - Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them - Google Patents
Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them Download PDFInfo
- Publication number
- EP0494819B1 EP0494819B1 EP92400038A EP92400038A EP0494819B1 EP 0494819 B1 EP0494819 B1 EP 0494819B1 EP 92400038 A EP92400038 A EP 92400038A EP 92400038 A EP92400038 A EP 92400038A EP 0494819 B1 EP0494819 B1 EP 0494819B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- formula
- product
- radical
- group
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims description 33
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 6
- 239000003814 drug Substances 0.000 title abstract description 7
- TVPNGVPSNXPYLT-UHFFFAOYSA-N 1-phenylimidazolidine Chemical class C1NCCN1C1=CC=CC=C1 TVPNGVPSNXPYLT-UHFFFAOYSA-N 0.000 title description 2
- 125000003118 aryl group Chemical group 0.000 claims abstract description 40
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 16
- 239000001301 oxygen Substances 0.000 claims abstract description 16
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 12
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 9
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 9
- 150000002367 halogens Chemical class 0.000 claims abstract description 8
- 125000000304 alkynyl group Chemical group 0.000 claims abstract description 7
- 239000001257 hydrogen Substances 0.000 claims abstract description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 6
- 239000005864 Sulphur Substances 0.000 claims abstract 3
- -1 - alkyl Chemical group 0.000 claims description 93
- 150000003254 radicals Chemical class 0.000 claims description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- 125000005843 halogen group Chemical group 0.000 claims description 25
- SOZGHDCEWOLLHV-UHFFFAOYSA-N 2-(trifluoromethyl)benzonitrile Chemical compound FC(F)(F)C1=CC=CC=C1C#N SOZGHDCEWOLLHV-UHFFFAOYSA-N 0.000 claims description 22
- 125000004432 carbon atom Chemical group C* 0.000 claims description 20
- 125000006239 protecting group Chemical group 0.000 claims description 19
- 238000006243 chemical reaction Methods 0.000 claims description 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
- 239000003153 chemical reaction reagent Substances 0.000 claims description 15
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 238000003379 elimination reaction Methods 0.000 claims description 12
- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical group O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 claims description 12
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 10
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 10
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 7
- 230000032050 esterification Effects 0.000 claims description 7
- 238000005886 esterification reaction Methods 0.000 claims description 7
- 125000005842 heteroatom Chemical group 0.000 claims description 7
- 238000006460 hydrolysis reaction Methods 0.000 claims description 7
- 230000008030 elimination Effects 0.000 claims description 6
- 125000000473 carbonimidoyl group Chemical group [H]\N=C(/*)* 0.000 claims description 5
- 229910052801 chlorine Inorganic materials 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims description 5
- 125000000468 ketone group Chemical group 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000005133 alkynyloxy group Chemical group 0.000 claims description 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 3
- 230000007062 hydrolysis Effects 0.000 claims description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims description 3
- 125000001174 sulfone group Chemical group 0.000 claims description 3
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 125000004423 acyloxy group Chemical group 0.000 claims description 2
- 125000003302 alkenyloxy group Chemical group 0.000 claims description 2
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical group N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 12
- 230000002280 anti-androgenic effect Effects 0.000 abstract description 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract description 3
- 239000000051 antiandrogen Substances 0.000 abstract description 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 194
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 52
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 39
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 39
- 238000002329 infrared spectrum Methods 0.000 description 35
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 30
- 238000004458 analytical method Methods 0.000 description 30
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 28
- 239000000377 silicon dioxide Substances 0.000 description 26
- 239000003480 eluent Substances 0.000 description 25
- 239000000203 mixture Substances 0.000 description 24
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 21
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 20
- 239000000243 solution Substances 0.000 description 19
- 238000004587 chromatography analysis Methods 0.000 description 17
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
- 235000011167 hydrochloric acid Nutrition 0.000 description 15
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 14
- 229910000104 sodium hydride Inorganic materials 0.000 description 14
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 13
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 13
- FDSGHYHRLSWSLQ-UHFFFAOYSA-N dichloromethane;propan-2-one Chemical compound ClCCl.CC(C)=O FDSGHYHRLSWSLQ-UHFFFAOYSA-N 0.000 description 13
- 239000012312 sodium hydride Substances 0.000 description 13
- 238000010992 reflux Methods 0.000 description 12
- 239000003921 oil Substances 0.000 description 11
- 235000019198 oils Nutrition 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 11
- 239000002904 solvent Substances 0.000 description 11
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 10
- 239000003054 catalyst Substances 0.000 description 10
- 229910052717 sulfur Inorganic materials 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 229940088597 hormone Drugs 0.000 description 9
- 239000005556 hormone Substances 0.000 description 9
- NOTFZGFABLVTIG-UHFFFAOYSA-N Cyclohexylethyl acetate Chemical compound CC(=O)OCCC1CCCCC1 NOTFZGFABLVTIG-UHFFFAOYSA-N 0.000 description 8
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- WBKFWQBXFREOFH-UHFFFAOYSA-N dichloromethane;ethyl acetate Chemical compound ClCCl.CCOC(C)=O WBKFWQBXFREOFH-UHFFFAOYSA-N 0.000 description 8
- XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 description 8
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 description 8
- 125000004434 sulfur atom Chemical group 0.000 description 8
- 239000000725 suspension Substances 0.000 description 8
- 125000004429 atom Chemical group 0.000 description 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 7
- 239000000460 chlorine Substances 0.000 description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 7
- HLBUAKQNKJTEIU-UHFFFAOYSA-N 2-(trifluoromethyl)-4-(3,4,4-trimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl)benzonitrile Chemical compound O=C1C(C)(C)N(C)C(=S)N1C1=CC=C(C#N)C(C(F)(F)F)=C1 HLBUAKQNKJTEIU-UHFFFAOYSA-N 0.000 description 6
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 6
- WACQKHWOTAEEFS-UHFFFAOYSA-N cyclohexane;ethyl acetate Chemical compound CCOC(C)=O.C1CCCCC1 WACQKHWOTAEEFS-UHFFFAOYSA-N 0.000 description 6
- CFHGBZLNZZVTAY-UHFFFAOYSA-N lawesson's reagent Chemical compound C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 6
- 239000012074 organic phase Substances 0.000 description 6
- YITSWKVUAMHMIV-UHFFFAOYSA-N 3-(3,4-dichlorophenyl)-1,5,5-trimethyl-2-sulfanylideneimidazolidin-4-one Chemical compound O=C1C(C)(C)N(C)C(=S)N1C1=CC=C(Cl)C(Cl)=C1 YITSWKVUAMHMIV-UHFFFAOYSA-N 0.000 description 5
- FUHSAPKUKZPRCD-UHFFFAOYSA-N 4-(4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile Chemical compound O=C1C(C)(C)NC(=S)N1C1=CC=C(C#N)C(C(F)(F)F)=C1 FUHSAPKUKZPRCD-UHFFFAOYSA-N 0.000 description 5
- HNTMVNIRYPJDDJ-UHFFFAOYSA-N 4-[3-(2-hydroxyethyl)-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile Chemical compound O=C1C(C)(C)N(CCO)C(=S)N1C1=CC=C(C#N)C(C(F)(F)F)=C1 HNTMVNIRYPJDDJ-UHFFFAOYSA-N 0.000 description 5
- 0 CC(B*1)(C)CN1c1ccc(*)c(*)c1 Chemical compound CC(B*1)(C)CN1c1ccc(*)c(*)c1 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 150000008064 anhydrides Chemical class 0.000 description 5
- 239000012043 crude product Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 4
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 4
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 4
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 4
- 239000005700 Putrescine Substances 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 239000000538 analytical sample Substances 0.000 description 4
- 230000008485 antagonism Effects 0.000 description 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 4
- 229960003104 ornithine Drugs 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 4
- 235000020004 porter Nutrition 0.000 description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- 239000012429 reaction media Substances 0.000 description 4
- 238000001953 recrystallisation Methods 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 229960003604 testosterone Drugs 0.000 description 4
- 230000009466 transformation Effects 0.000 description 4
- YFNKIDBQEZZDLK-UHFFFAOYSA-N triglyme Chemical compound COCCOCCOCCOC YFNKIDBQEZZDLK-UHFFFAOYSA-N 0.000 description 4
- RDRDMDCAEHPIRR-UHFFFAOYSA-N 1,5,5-trimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione Chemical compound O=C1C(C)(C)N(C)C(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 RDRDMDCAEHPIRR-UHFFFAOYSA-N 0.000 description 3
- JQULXIOYDDCNGR-UHFFFAOYSA-N 2-amino-2-methylpropanenitrile Chemical compound CC(C)(N)C#N JQULXIOYDDCNGR-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
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- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
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- PDMMFKSKQVNJMI-BLQWBTBKSA-N Testosterone propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 PDMMFKSKQVNJMI-BLQWBTBKSA-N 0.000 description 3
- 230000009435 amidation Effects 0.000 description 3
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- 239000010949 copper Substances 0.000 description 3
- BERDEBHAJNAUOM-UHFFFAOYSA-N copper(I) oxide Inorganic materials [Cu]O[Cu] BERDEBHAJNAUOM-UHFFFAOYSA-N 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- KRFJLUBVMFXRPN-UHFFFAOYSA-N cuprous oxide Chemical compound [O-2].[Cu+].[Cu+] KRFJLUBVMFXRPN-UHFFFAOYSA-N 0.000 description 3
- 229940112669 cuprous oxide Drugs 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 150000003457 sulfones Chemical class 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- 229960001712 testosterone propionate Drugs 0.000 description 3
- 230000001131 transforming effect Effects 0.000 description 3
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 2
- VSHIRTNKIXRXMI-UHFFFAOYSA-N 2,2-dimethyl-1,3-oxazolidine Chemical compound CC1(C)NCCO1 VSHIRTNKIXRXMI-UHFFFAOYSA-N 0.000 description 2
- YCADCBJTVOGBQO-UHFFFAOYSA-N 2-(2-hydroxyethylamino)-2-methylpropanenitrile Chemical compound N#CC(C)(C)NCCO YCADCBJTVOGBQO-UHFFFAOYSA-N 0.000 description 2
- KDOLCNOULYMUKY-UHFFFAOYSA-N 2-(trifluoromethyl)-4-[3,4,4-trimethyl-2,5-bis(sulfanylidene)imidazolidin-1-yl]benzonitrile Chemical compound S=C1C(C)(C)N(C)C(=S)N1C1=CC=C(C#N)C(C(F)(F)F)=C1 KDOLCNOULYMUKY-UHFFFAOYSA-N 0.000 description 2
- NKQVYJRZBVRXRU-UHFFFAOYSA-N 2-methyl-2-(methylamino)propanenitrile Chemical compound CNC(C)(C)C#N NKQVYJRZBVRXRU-UHFFFAOYSA-N 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
Definitions
- the present invention relates to new phenylimidazolidines, their preparation process, their application as medicaments and the pharmaceutical compositions containing them.
- alkyl having at most 12 carbon atoms is meant for example the values methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, sec-pentyl, tert-pentyl, neo-pentyl , hexyl, isohexyl, isohexyl, tert-hexyl, heptyl, octyl, decyl, undecyl, dodecyl, linear or branched.
- alkyl radicals having at most 4 carbon atoms and in particular methyl, ethyl, propyl, isopropyl radicals.
- Alkenyl values having at most 4 carbon atoms are preferred, and in particular vinyl or allyl values.
- Alkynyl values having at most 4 carbon atoms are preferred, and in particular ethynyl and propargyl values.
- aryl is meant carbocyclic aryl radicals such as phenyl or naphthyl or 5 or 6-membered heterocyclic aryls comprising one or more heteroatoms preferably chosen from oxygen, sulfur and nitrogen.
- heterocyclic 5-membered aryls mention may be made of the furyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, thiadiazolyl, pyrazolyl, isoxazolyl radicals.
- 6-membered heterocyclic aryls mention may be made of the pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl radicals.
- the phenyl radical is preferred.
- arylalkyl is meant the radicals resulting from the combination of the alkyl radicals mentioned above and the aryl radicals also mentioned above.
- halogen is understood, of course, the atoms of fluorine, chlorine, bromine or iodine.
- Fluorine, chlorine or bromine atoms are preferred.
- substituted alkyl radicals by one or more halogens mention may be made of monofluoro, chloro, bromo or iodomethyl, difluoro, dichloro or dibromomethyl, trifluoromethyl.
- aryl or substituted aralkyl radicals mention may be made of those in which the phenyl radical is substituted in the para position, by a fluorine atom or by a methoxy or trifluoromethyl radical.
- acyl radical preferably means a radical having at most 7 carbon atoms such as the acetyl, propionyl, butyryl or benzoyl radical, but may also represent a valeryl, hexanoyl, acryloyl, crotonoyl or carbamoyl radical: mention may also be made of formyl radical.
- acyloxy radical is meant the radicals in which the acyl radicals have the meaning indicated above and for example the acetoxy or propionyloxy radicals.
- esterified carboxy is meant, for example, radicals such as alkyloxycarbonyl radicals, for example methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, butyl or tert-butyloxycarbonyl.
- radicals formed with easily cleavable ester residues such as the methoxymethyl and ethoxymethyl radicals; acyloxyalkyl radicals such as pivaloyloxymethyl, pivaloyloxyethyl, acetoxymethyl or acetoxyethyl; alkylalkylcarbonyloxyalkyl radicals such as methoxycarbonyloxy methyl or ethyl radicals, isopropyloxycarbonyloxy methyl or ethyl radicals.
- ester radicals can be found, for example, in European patent EP 0 034 536.
- Amidified carboxy means radicals of the type in which the identical or different radicals R 4 and R 5 represent a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms such as the methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl radicals or tert-butyl.
- radicals amino mono or dimethylamino radicals are preferred.
- the radical may also represent a heterocycle which may or may not have an additional heteroatom. Mention may be made of the pyrrolyl, imidazolyl, pyridyl, pyrazinyl, pyrimidyl, indolyl, piperidino, morpholino, piperazinyl radicals. The piperidino or morpholino radicals are preferred.
- salified carboxy is meant the salts formed for example with an equivalent of sodium, potassium, lithium, calcium, magnesium or ammonium. Mention may also be made of the salts formed with organic bases such as methylamine, propylamine, trimethylamine, diethylamine, triethylamine.
- the sodium salt is preferred.
- alkylamino radical is meant methylamino, ethylamino, propylamino or butyl, linear or branched, amino.
- alkyl radicals having at most 4 carbon atoms are preferred, the alkyl radicals can be chosen from the alkyl radicals mentioned above.
- dialkylamino radical is meant, for example, the dimethylamino, diethylamino, methylethylamino radicals.
- alkyl radicals having at most 4 carbon atoms chosen from the list indicated above are preferred.
- heterocyclic radical containing one or more heteroatoms is understood to mean, for example, saturated monocyclic, heterocyclic radicals such as the oxirannyl, oxolannyl, dioxolannyl, imidazolidinyl, pyrazolidinyl, piperidyl, piperazinyl or morpholinyl radicals.
- alkyl alkenyl or alkynyl radicals optionally interrupted by a heteroatom chosen from sulfur, oxygen or nitrogen atoms, is meant radicals comprising one or more of these atoms, which are identical or different in their structure. These heteroatoms obviously cannot not be located at the end of the radical. Mention may be made, for example, of alkoxyalkyl radicals such as methoxymethyl or methoxyethyl or alternatively alkoxyalkyl radicals such as methoxyethoxymethyl.
- a particular subject of the invention is the products of formula (I) as defined above in which Y represents an oxygen atom with the exception of the products in which: the group -AB- represents the radical: wherein X represents an oxygen atom and R 3 represents a hydrogen atom and R 2 represents a halogen atom or a trifluoromethyl radical and R 1 represents a nitro radical or a halogen atom.
- the invention particularly relates to those in which the group -AB- represents the radical: in which X represents a sulfur atom and R 3 has the meaning indicated above.
- the invention particularly relates to those in which R represents a hydrogen atom or an alkyl radical having at most 4 carbon atoms optionally substituted by a hydroxy radical.
- the invention particularly relates to those in which R 1 represents a cyano radical or a halogen atom and in particular a chlorine atom.
- Another subject of the invention is also the products of formula (I) as defined above in which the group -AB- represents a group: or a group: in which R 3 represents an alkyl or alkenyl radical having at most 4 carbon atoms or an optionally substituted aralkyl radical.
- Another subject of the present invention is the products of formula (I) as defined above and corresponding to formula (I '): in which R 1 , R 2 and R 3 have the meaning indicated above with the exception of the products in which R 1 represents a nitro radical, R 2 represents a trifluoromethyl radical and R 3 represents a hydrogen atom.
- the present invention also relates to the products of formula (I) as defined above in which R 1 represents a nitro radical and R 3 represents an alkyl or alkenyl radical having at most 4 carbon atoms optionally substituted by an esterified or salified free carboxy radical.
- the action of the products of formula (II) with the products of formula (III) is preferably carried out in an organic solvent such as tetrahydrofuran or dichloroethane but it is also possible to use ethyl ether or isopropyl ether.
- the operation is carried out in the presence of a tertiary base such as triethylamine or else pyridine or methylethylpyridine.
- a tertiary base such as triethylamine or else pyridine or methylethylpyridine.
- R 3 may contain and which are optionally protected in the product of formula (III) or (IV ⁇ ) are the hydroxy or amino functions.
- Usual protective groups are used to protect these functions. Mention may be made, for example, of the following protective groups of the amino radical: tert-butyl, tert-amyl, trichloroacetyl, chloroacetyl, benzhydryl, trityl, formyl, benzyloxycarbonyl.
- radicals such as formyl, chloroacetyl, tetrahydropyrannyl, trimethylsilyl, tert-butyl dimethylsilyl.
- the possible reactions for removing protective groups are carried out as indicated in said patent BF 2,499,995.
- the preferred mode of elimination is acid hydrolysis using the acids chosen from hydrochloric, benzene sulfonic or para-toluene sulfonic, formic or trifluoroacetic acids. Hydrochloric acid is preferred.
- the present invention also relates to a process for preparing the products of formula (I ⁇ ): in which R ⁇ 1 , R ⁇ 2 , -A ⁇ -B ⁇ - have the meanings indicated above for R 1 , R 2 and -AB- it being understood that when -A ⁇ -B ⁇ - represents a group -CO -N (R ⁇ ′ 3 ) - in which R ⁇ ′ 3 represents a hydrogen atom or a linear or branched alkyl radical having at most 7 carbon atoms and Y represents an oxygen atom, R ⁇ 1 represents a radical cyano, this process being characterized in that a product of formula (V) is reacted: in which R ⁇ 1 and R ⁇ 2 have the above meanings and Hal represents a halogen atom with a product of formula (VI): in which -A ⁇ -B ⁇ - and Y have the meaning indicated above, the reaction taking place in the presence of a catalyst and optionally a solvent.
- Hal preferably designates the chlorine atom, but can also represent a bromine or iodine atom.
- the role of the catalyst is probably to trap the hydrogen halide which is released and thus to facilitate the condensation reaction of the product of formula (V) with the product of formula (VI) to give the desired product.
- a more specific subject of the invention is a process as defined above in which the catalyst is a metal in native or oxidized form or a base.
- the catalyst used can be a metal in native form, in the form of metal oxide or also in the form of metal salts.
- the catalyst can also be a base.
- this metal can be copper or nickel.
- the metal salts can be a chloride or an acetate.
- this base can for example be sodium hydroxide or potassium hydroxide and it is possible, if desired, to add dimethyl sulfoxide to the reaction medium.
- the invention more specifically relates to a process as defined above in which the catalyst is chosen from cuprous oxide, cupric oxide, copper in native form and a base such as sodium hydroxide or potassium hydroxide.
- the copper in native form used as catalyst is preferably in the form of powder.
- the invention particularly relates to a process as defined above in which the catalyst is cuprous oxide.
- the solvent used is preferably chosen from high boiling point ethers such as, for example, phenyl oxide, diglyme, triglyme and dimethyl sulfoxide but can also be, for example, a high point oil. boiling such as paraffin or petroleum jelly.
- the invention more particularly relates to a process as defined above characterized in that one operates in the presence of an ether type solvent such as oxide phenyl, diglyme, triglyme or dimethylsulfoxide.
- an ether type solvent such as oxide phenyl, diglyme, triglyme or dimethylsulfoxide.
- the invention particularly relates to a process as defined above in which the solvent used is phenyl oxide or triglyme.
- the process for the preparation of the desired product defined above can be carried out under pressure or at atmospheric pressure, at a preferably high temperature.
- the subject of the invention is therefore a process as defined above, characterized in that the reaction is carried out at a temperature above 100 ° C and preferably above 150 ° C.
- the invention more specifically relates to a process as defined above, characterized in that the reaction is carried out for more than 2 hours.
- a very specific subject of the invention is a process as defined above, characterized in that the reaction is carried out in the presence of cuprous oxide, in the triglyme, at a temperature greater than or equal to 200 ° C. and for more than 3 hours.
- the products which are the subject of the present invention are endowed with interesting pharmacological properties; in particular, they have been found to inhibit the effects of androgens on peripheral receptors.
- the products of the invention can be used in therapy in adults without having to fear certain effects of chemical castration.
- the products of general formula (I) of the invention also find their use in the treatment of hirsutism, acne, seborrhea, androgenic alopecia, hyperpilosity.
- a subject of the invention is therefore the application, as medicaments, of products of general formula (I) which are pharmaceutically acceptable.
- the products can be administered parenterally, buccally, perlingually, rectally or topically.
- a subject of the invention is also pharmaceutical compositions, characterized in that they contain, as active principle, at least one of the drugs of general formula (I).
- compositions can be presented in the form of solutions or injectable suspensions, tablets, coated tablets, capsules, syrups, suppositories, creams, ointments and lotions.
- These pharmaceutical forms are prepared according to the usual methods.
- the active ingredient can usually be incorporated into excipients used in these compositions, such as aqueous vehicles or not, talc, gum arabic, lactose, starch, magnesium stearate, cocoa butter, fatty substances of animal or vegetable origin, paraffinic derivatives , glycols, various wetting agents, dispersants or emulsifiers, preservatives.
- the usual dose which varies depending on the subject treated and the condition in question, can be, for example, from 10 mg to 500 mg per day in humans, orally.
- the subject of the invention is also, as new industrial products and in particular as new industrial products which can be used as intermediates for the preparation of the products of general formula (I).
- R 1 , R 2 and Y have the meanings indicated above and the grouping: is chosen from the radicals: in which X represents an oxygen or sulfur atom and R 3i is chosen from the values of R 3 comprising a protected reactive function, with the exception of products in which the group -A i B i - represents the radical: in which X represents an oxygen atom and R 3i represents a hydrogen atom and Y represents an oxygen atom or an NH radical and R 2 represents a halogen atom or a trifluoromethyl radical and R 1 represents a nitro radical or a halogen atom.
- Example 1 1- (4-nitro-3- (trifluoromethyl) phenyl) -3,4,4-trimethyl-2,5-imidazolidinedione.
- Example 3 5,5-Dimethyl-3- (4-nitro-3- (trifluoromethyl) phenyl ) -1-propyl-2,4-imidazolidine-dione.
- Example 5 5,5-Dimethyl-3- (4-nitro-3-trifluoromethyl) phenyl) -1- (2-propenyl) -2,4-imidazolidinedione.
- Example 7 4- (4,4-dimethyl-5-imino-2-oxo-1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile.
- Example 8 4- (4,4-dimethyl-2,5-dioxo-1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile.
- Example 10 3- (4-cyano-3- (trifluoromethyl) phenyl) -5,5-dimethyl-2,4-dioxo-1-imidazolidine ethyl acetate.
- Example 11 4- (5-imino-2-thioxo-3,4,4-trimethyl-1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile.
- Example 12 4- (5-oxo-2-thioxo-3,4,4-trimethyl-1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile.
- Example 13 4- (2,5-dithioxo-3,4,4-trimethyl-1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile.
- Example 14 4- (4,4-dimethyl-5-imino-2-thioxo-1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile.
- the expected product insoluble, precipitates.
- the desired product is thus obtained with a yield of 60%.
- Example 15 4- (4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile.
- Example 16 5,5-Dimethyl-3- (4-nitro-3- (trifluoromethyl) phenyl) -1-pentyl-2,4-imidazolidinedione.
- Example 17 5,5-Dimethyl-3- (4-nitro-3- (trifluoromethyl) phenyl) -1-nonyl-2,4-imidazolidinedione.
- Example 18 4- (3,4,4-trimethyl-2,5-dioxo 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile.
- Example 19 4- (5-thioxo-2-oxo-3,4,4-trimethyl-1-imidazolidinyl) 2- (trifluoromethyl) -benzonitrile
- product A 4- (5-oxo-2-thioxo-3, 4,4-trimethyl 1-imidazolidinyl) 2- (trifluoromethyl) -benzonitrile
- product B 4- (2,5-dithioxo-3,4,4-trimethyl-1-imidazolidinyl) 2- (trifluoromethyl) -benzonitrile (product VS).
- Example 20 4- (4,5-dihydro 4,4-dimethyl 2- (methylthio) 5-oxo 1H-imidazol-1-yl) 2- (trifluoromethyl) -benzonitrile.
- a solution of 626 mg of product of Example 15 in 6 cm 3 of dimethylformamide is added to a suspension consisting of 108 mg of 50% sodium hydride in oil and 1.8 cm 3 of dimethylformamide. Rinsed with 0.3 cm 3 of dimethylformamide and stirred for 10 minutes after cessation of the evolution of hydrogen. 0.19 cm 3 is then added dropwise methyl iodide in 1 cm 3 of dimethylformamide.
- Example 21 4- [4,5-dihydro 4,4-dimethyl 5-oxo 2 - [(phenylmethyl) thio] 1H-imidazol-1-yl] 2- (trifluoromethyl) benzonitrile.
- Example 22 4- [4,4-dimethyl 3- (2-hydroxyethyl) 5-imino 2-thioxo 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 23 4- [4,4-dimethyl 3- (2-hydroxyethyl) 5-oxo 2-thioxo 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile (Product A) and 4- [4,4-dimethyl 2,5-dioxo 3- (2-mercaptoethyl) 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile (Product B).
- Example 24 4- (4,4-dimethyl 2,5-dioxo 3-ethyl 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile.
- Example 25 4- (4,4-dimethyl 2,5-dioxo 3- (2-propenyl) 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile.
- Example 26 4- (4,4-dimethyl 2,5-dioxo 3- (phenylmethyl) 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile.
- Example 27 4- [4,4-dimethyl 2,5-dioxo 3 - [(4-fluorophenyl) methyl] 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 28 4- [4,4-dimethyl 2,5-dioxo 3 - [(4-methoxyphenyl) methyl] 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 29 4- [4,4-dimethyl 2,5-dioxo 3 - [[4- [trifluoromethyl) phenyl] methyl] 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 30 4- [4,4-dimethyl 2,5-dioxo 3- (2-epoxymethyl) 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 31 4- (4,4-dimethyl 2,5-dioxo 3-propyl-1H-imidazolidinyl) 2- (trifluoromethyl) benzonitrile.
- Example 32 4- (4,4-dimethyl 2,5-dioxo 3- (1-methylethyl) 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 33 4- [4,5-dihydro 4,4-dimethyl 2- (nonylthio) 5-oxo 1H-imidazol-1-yl] 2- (trifluoromethyl) benzonitrile.
- Example 34 4- [4,5-dihydro 4,4-dimethyl 2 - [(3-hydroxypropyl) thio] 5-oxo 1H-imidazol-1-yl] 2- (trifluoromethyl) benzonitrile.
- Example 35 [[1- [4-cyano 3- (trifluoromethyl) phenyl] 4,5-dihydro 4,4-dimethyl 5-oxo 1H-imidazol-2-yl] thio] ethyl acetate.
- Example 36 4- (4,4-dimethyl 3-ethyl 5-imino 2-thioxo 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile.
- Example 37 4- (4,4-dimethyl 5-imino 3-pentyl 2-thioxo 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile.
- Example 38 4- (4,4-dimethyl 3-ethyl 5-oxo 2-thioxo 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile.
- Example 39 4- (4,4-dimethyl 5-oxo 3-pentyl 2-thioxo 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile.
- Example 40 4- [4,5-dihydro 4,4-dimethyl 2- (methylthio) 5-thioxo 1H-imidazol-1-yl] 2- (trifluoromethyl) benzonitrile.
- Example 41 4- [4,5-dihydro 4,4-dimethyl 2 - [(phenylmethyl) thio] 5-thioxo 1H-imidazol-1-yl] 2- (trifluoromethyl) benzonitrile.
- Example 42 3- [4-cyano 3- (trifluoromethyl) phenyl] 5,5-dimethyl 2,4-dioxo N-methyl N- (1-methylethyl) 1-imidazolidine acetamide.
- Example 43 4, - [4,4-dimethyl 2,5-dioxo 3- (2-hydroxyethyl) 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 9 The procedure is as in Example 9 from 900 mg of product obtained in Example 8 and 1.91 g of 2-bromoethanolterbutyl-dimethylsilylether. 1 g of the silyloxy ether derivative is obtained. Mp 86-87 ° C after chromatography on silica (eluent: cyclohexane-ethyl acetate 7-3).
- Example 44 4- [4,4-dimethyl 2,5-dioxo 3- (3-hydroxypropyl) 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 45 4- [3- [2- (acetyloxy) ethyl] 4,4-dimethyl 2,5-dioxo 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 46 4- [4,4-dimethyl 2,5-dioxo 3- (5-hydroxypentyl) 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 47 4- [4,4-dimethyl 2,5-dioxo 3- (2-methoxyethyl) 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 48 4- [4,4-dimethyl 2,5-dioxo 3- (cyanomethyl) 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 49 4- [4,4-dimethyl 2,5-dioxo 3 - [(1,3-dioxalan-2-yl) methyl] 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 50 4- [4,4-dimethyl 2,5-dioxo 3- (2-chloroethyl) 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile.
- Example 51 1- (3,4-dichlorophenyl) 5-imino 3,4,4-trimethyl 2-imidazolidine thione.
- Example 52 3- (3,4-dichlorophenyl) 2-thioxo 1,5,5-trimethyl 4-imidazolidinone.
- Example 53 3- (3,4-dichlorophenyl) 3,5-dihydro 5,5-dimethyl, 2- (methylthio) 4H-imidazol-4-one.
- Example 54 1- (3,4-dichlorophenyl) 3,4,4-trimethyl 2,5-imidazolidine dithione.
- Example 55 1- [4-chloro 3- (trifluoromethyl) phenyl] 4,4-dimethyl 2-thioxo 5-imidazolidinone.
- Example 56 1- [4-chloro 3- (trifluoromethyl) phenyl] 4,4-dimethyl 5-imino 2-imidazolidine thione.
- Example 57 3- (3,4-dichlorophenyl) 3,5-dihydro 5,5-dimethyl 2 - [(phenylmethyl) thio] 4H-imidazol-4-one.
- the following products constitute products which can be obtained in the context of the present invention, namely the products of formula: in which Y A represents an oxygen or sulfur atom and R 3A has the following values: . - (CH 2 ) n Cl . - (CH 2 ) n -OH . (CH 2 ) n -COO-alk . - (CH 2 ) n -CO-alk . - (CH 2 ) n -C ⁇ N alk, alk 1 and alk 2 representing an alkyl radical containing up to 4 carbon atoms and n represents an integer between 1 and 4.
- the intersections of the straight line I 50 and the curves make it possible to evaluate the concentrations of the cold reference hormone (CH) and of the cold product tested (CX) which inhibit by 50% the binding of the tritiated hormone to the receptor .
- Agonist activity is determined in the absence of testosterone propionate.
- test products and testosterone propionate are administered in a volume of 10 ml / kg.
- the animals 16 hours after the treatments, the animals are sacrificed, the kidneys removed, then homogenized at 0 ° C., using a teflon-glass grinder in 10 volumes of 50 mM Tris-HCl buffer (pH 7.4) containing 250 ⁇ M pyridoxal phosphate, 0.1 mM EDTA, and 5 mM dithiothreitol. The homogenate is then centrifuged at 105,000 g for 45 min.
- renal ornithine decarboxylase transforms an isotopic mixture of cold ornithine and tritiated ornithine into cold putrescine and tritiated putrescine.
- the putrescine is then collected on selective papers, ion exchangers. After drying, the excess of unprocessed tritiated and cold ornithine is eliminated by 3 washes of 0.1 M ammonia. The papers are dried, then the radioactivity is counted after addition of Aqualite scintillant.
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Abstract
Description
La présente invention concerne de nouvelles phénylimidazolidines, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.The present invention relates to new phenylimidazolidines, their preparation process, their application as medicaments and the pharmaceutical compositions containing them.
Dans la demande japonaise J 48087030 sont décrites des 3-phényl 2-thiohydantoïnes qui sont présentées comme inhibant la germination de certaines plantes.In Japanese application J 48087030, 3-phenyl 2-thiohydantoins are described which are presented as inhibiting the germination of certain plants.
Dans le brevet français 2.329.276 ainsi que dans EP-A-0 01 813 sont décrites des imidazolidines qui sont présentées comme possédant une activité antiandrogène. Les produits de ce brevet sont cependant différents des produits de la présente demande de brevet.In French patent 2,329,276 as well as in EP-A-0 01 813 are described imidazolidines which are presented as having an antiandrogenic activity. The products of this patent are however different from the products of the present patent application.
La présente invention a donc pour objet les produits de formule générale (I) :
- R 1 représente un radical cyano ou nitro ou un atome d'halogène,
- R 2 représente un radical trifluorométhyle ou un atome d'halogène,
- le groupement -A-B- est choisi parmi les radicaux
- R 3 est choisi parmi les radicaux suivants :
- un atome d'hydrogène,
- les radicaux alkyle, alkényle, alkynyle, aryle ou arylalkyle ayant au plus 12 atomes de carbone, ces radicaux étant éventuellement substitués par un ou plusieurs substituants choisis parmi les radicaux hydroxy, halogène, mercapto, cyano, acyle ou acyloxy ayant au plus 7 atomes de carbone, S-aryle éventuellement substitué, dans lequel l'atome de soufre est éventuellement oxydé sous forme de sulfoxyde ou de sulfone, carboxy libre, estérifié, amidifié ou salifié, amino, mono ou dialkylamino ou un radical hétérocyclique comprenant 3 à 6 chaînons et renfermant un ou plusieurs hétéroatomes choisis parmi les atomes de soufre, d'oxygène ou d'azote,
les radicaux alkyle, alkényle ou alkynyle étant de plus éventuellement interrompus par un ou plusieurs atomes d'oxygène, d'azote ou de soufre éventuellement oxydé sous forme de sulfoxyde ou de sulfone,
les radicaux aryle et aralkyle étant de plus éventuellement substitués par un radical alkyle, alkényle ou alkynyle, alkoxy, alkényloxy, alkynyloxy ou trifluorométhyle,
Y représente un atome d'oxygène ou de soufre ou un radical =NH,
à l'exception des produits dans lesquels le groupement A-B représente le radical :
- R 1 represents a cyano or nitro radical or a halogen atom,
- R 2 represents a trifluoromethyl radical or a halogen atom,
- the group -AB- is chosen from radicals
- R 3 is chosen from the following radicals:
- a hydrogen atom,
- the alkyl, alkenyl, alkynyl, aryl or arylalkyl radicals having at most 12 carbon atoms, these radicals being optionally substituted by one or more substituents chosen from hydroxy, halogen, mercapto, cyano, acyl or acyloxy radicals having at most 7 atoms of carbon, optionally substituted S-aryl, in which the sulfur atom is optionally oxidized in the form of sulphoxide or sulphone, free carboxy, esterified, amidified or salified, amino, mono or dialkylamino or a heterocyclic radical comprising 3 to 6 members and containing one or more heteroatoms chosen from sulfur, oxygen or nitrogen atoms,
the alkyl, alkenyl or alkynyl radicals being additionally optionally interrupted by one or more oxygen, nitrogen or sulfur atoms optionally oxidized in the form of sulfoxide or sulfone,
the aryl and aralkyl radicals being additionally optionally substituted by an alkyl, alkenyl or alkynyl, alkoxy, alkenyloxy, alkynyloxy or trifluoromethyl radical,
Y represents an oxygen or sulfur atom or a radical = NH,
with the exception of products in which the group AB represents the radical:
Pour la définition de R 3 et dans ce qui suit, les définitions utilisées peuvent avoir les valeurs suivantes.For the definition of R 3 and in what follows, the definitions used can have the following values.
Par alkyle ayant au plus 12 atomes de carbone on entend par exemple les valeurs méthyle, éthyle, propyle, isopropyle, butyle, isobutyle, sec-butyle, tert-butyle, pentyle, isopentyle, sec-pentyle, tert-pentyle, néo-pentyle, hexyle, isohexyle, isohexyle,tert-hexyle, heptyle, octyle, décyle, undécyle, dodécyle, linéaires ou ramifiés.By alkyl having at most 12 carbon atoms is meant for example the values methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, sec-pentyl, tert-pentyl, neo-pentyl , hexyl, isohexyl, isohexyl, tert-hexyl, heptyl, octyl, decyl, undecyl, dodecyl, linear or branched.
On préfère les radicaux alkyle ayant au plus 4 atomes de carbone et notamment les radicaux méthyle, éthyle, propyle, isopropyle.Preferred are alkyl radicals having at most 4 carbon atoms and in particular methyl, ethyl, propyl, isopropyl radicals.
Par alkényle ayant au plus 12 atomes de carbone on entend par exemple les valeurs suivantes :
- vinyle, allyle, 1-propényle, butényle, pentényle, hexenyle.
- vinyl, allyl, 1-propenyl, butenyl, pentenyl, hexenyl.
On préfère les valeurs alkényle ayant au plus 4 atomes de carbone et notamment les valeurs vinyle ou allyle.Alkenyl values having at most 4 carbon atoms are preferred, and in particular vinyl or allyl values.
Par alkynyle ayant au plus 12 atomes de carbone on entend par exemple les valeurs suivantes :
- éthynyle, propargyle, butynyle, pentynyle ou hexynyle.
- ethynyl, propargyl, butynyl, pentynyl or hexynyl.
On préfère les valeurs alkynyle ayant au plus 4 atomes de carbone et notamment les valeurs éthynyle et propargyle.Alkynyl values having at most 4 carbon atoms are preferred, and in particular ethynyl and propargyl values.
Par aryle on entend les radicaux aryles carbocyclique tels que le phényle ou le naphtyle ou les aryles hétérocycliques à 5 ou 6 chaînons comportant un ou plusieurs hétéroatomes choisis de préférence parmi l'oxygène, le soufre et l'azote. Parmi les aryles hétérocycliques à 5 chaînons on peut citer les radicaux furyle, thiényle, pyrrolyle, thiazolyle, oxazolyle, imidazolyle, thiadiazolyle, pyrazolyle, isoxazolyle.By aryl is meant carbocyclic aryl radicals such as phenyl or naphthyl or 5 or 6-membered heterocyclic aryls comprising one or more heteroatoms preferably chosen from oxygen, sulfur and nitrogen. Among the heterocyclic 5-membered aryls, mention may be made of the furyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, thiadiazolyl, pyrazolyl, isoxazolyl radicals.
Parmi les aryles hétérocycliques à 6 chaînons on peut citer les radicaux pyridyle, pyrimidinyle, pyridazinyle, pyrazinyle.Among the 6-membered heterocyclic aryls, mention may be made of the pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl radicals.
Parmi les radicaux aryles condensés on peut citer les radicaux indolyle, benzofurannyle, benzothiényle, quinoléïnyle.Among the condensed aryl radicals, mention may be made of the indolyl, benzofurannyl, benzothienyl and quinolinyl radicals.
On préfère le radical phényle.The phenyl radical is preferred.
Par arylalkyle on entend les radicaux résultant de la combinaison des radicaux alkyle cités précédemment et les radicaux aryle également cités ci-dessus.By arylalkyl is meant the radicals resulting from the combination of the alkyl radicals mentioned above and the aryl radicals also mentioned above.
On préfère les radicaux benzyle ou phényléthyle.Benzyl or phenylethyl radicals are preferred.
Par halogène, on entend bien entendu, les atomes de fluor, de chlore, de brome ou d'iode.By halogen is understood, of course, the atoms of fluorine, chlorine, bromine or iodine.
On préfère les atomes de fluor, de chlore ou de brome.Fluorine, chlorine or bromine atoms are preferred.
Comme exemples particuliers de radicaux alkyle substitués par un ou plusieurs halogènes, on peut citer les monofluoro, chloro, bromo ou iodométhyle, les difluoro, dichloro ou dibromométhyle, le trifluorométhyle.As particular examples of substituted alkyl radicals by one or more halogens, mention may be made of monofluoro, chloro, bromo or iodomethyl, difluoro, dichloro or dibromomethyl, trifluoromethyl.
Comme exemples particuliers de radicaux aryles ou aralkyles substitués, on peut citer ceux dans lesquels le radical phényle est substitué en position para, par un atome de fluor ou par un radical méthoxy ou trifluorométhyle.As particular examples of aryl or substituted aralkyl radicals, mention may be made of those in which the phenyl radical is substituted in the para position, by a fluorine atom or by a methoxy or trifluoromethyl radical.
Par radical acyle, on entend de préférence un radical ayant au plus 7 atomes de carbone tel que le radical acétyle, propionyle, butyryle ou benzoyle, mais peut également représenter un radical valéryle, hexanoyle, acryloyle, crotonoyle ou carbamoyle : on peut également citer le radical formyle.The term “acyl radical” preferably means a radical having at most 7 carbon atoms such as the acetyl, propionyl, butyryl or benzoyl radical, but may also represent a valeryl, hexanoyl, acryloyl, crotonoyl or carbamoyl radical: mention may also be made of formyl radical.
Par radical acyloxy, on entend les radicaux dans lesquels les radicaux acyle ont la signification indiquée ci-dessus et par exemple les radicaux acétoxy ou propionyloxy.By acyloxy radical is meant the radicals in which the acyl radicals have the meaning indicated above and for example the acetoxy or propionyloxy radicals.
Par carboxy estérifié on entend par exemple les radicaux tels que les radicaux alkyloxycarbonyle par exemple méthoxycarbonyle, éthoxycarbonyle, propoxycarbonyle, butyl ou tert-butyloxycarbonyle.By esterified carboxy is meant, for example, radicals such as alkyloxycarbonyl radicals, for example methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, butyl or tert-butyloxycarbonyl.
On peut également citer des radicaux formés avec les restes esters facilement clivables tels que les radicaux méthoxyméthyle, éthoxyméthyle ; les radicaux acyloxyalkyle tels que pivaloyloxyméthyle, pivaloyloxyéthyle, acétoxyméthyle ou acétoxyéthyle ; les radicaux alkyloxycarbonyloxy alkyle tels que les radicaux méthoxycarbonyloxy méthyle ou éthyle, les radicaux isopropyloxycarbonyloxy méthyle ou éthyle.Mention may also be made of radicals formed with easily cleavable ester residues such as the methoxymethyl and ethoxymethyl radicals; acyloxyalkyl radicals such as pivaloyloxymethyl, pivaloyloxyethyl, acetoxymethyl or acetoxyethyl; alkylalkylcarbonyloxyalkyl radicals such as methoxycarbonyloxy methyl or ethyl radicals, isopropyloxycarbonyloxy methyl or ethyl radicals.
Une liste de tels radicaux esters peut-être trouvée par exemple dans le brevet européen EP 0 034 536.A list of such ester radicals can be found, for example, in European patent EP 0 034 536.
Par carboxy amidifié on entend les radicaux du type
Parmi les radicaux
Le radical
Par carboxy salifié on entend les sels formés par exemple avec un équivalent de sodium, de potassium, de lithium, de calcium, de magnésium ou d'ammonium. On peut également citer les sels formés avec les bases organiques telles que la méthylamine, la propylamine, la triméthylamine, la diéthylamine, la triéthylamine.By salified carboxy is meant the salts formed for example with an equivalent of sodium, potassium, lithium, calcium, magnesium or ammonium. Mention may also be made of the salts formed with organic bases such as methylamine, propylamine, trimethylamine, diethylamine, triethylamine.
On préfère le sel de sodium.The sodium salt is preferred.
Par radical alkylamino on entend les radicaux méthylamino, éthylamino, propylamino ou butyl, linéaire ou ramifié, amino. On préfère les radicaux alkyle ayant au plus 4 atomes de carbone, les radicaux alkyle peuvent être choisis parmi les radicaux alkyle cités ci-dessus.By alkylamino radical is meant methylamino, ethylamino, propylamino or butyl, linear or branched, amino. The alkyl radicals having at most 4 carbon atoms are preferred, the alkyl radicals can be chosen from the alkyl radicals mentioned above.
Par radical dialkylamino on entend par exemple les radicaux diméthylamino, diéthylamino, méthyléthylamino. Comme précédemment on préfère les radicaux alkyle ayant au plus 4 atomes de carbone choisis dans la liste indiquée ci-dessus.By dialkylamino radical is meant, for example, the dimethylamino, diethylamino, methylethylamino radicals. As before, the alkyl radicals having at most 4 carbon atoms chosen from the list indicated above are preferred.
Par radical hétérocyclique renfermant un ou plusieurs hétéroatomes, on entend par exemple les radicaux monocycliques, hétérocycliques saturés tels que les radicaux oxirannyle, oxolannyle, dioxolannyle, imidazolidinyle, pyrazolidinyle, pipéridyle, pipérazinyle ou morpholinyle.The term heterocyclic radical containing one or more heteroatoms is understood to mean, for example, saturated monocyclic, heterocyclic radicals such as the oxirannyl, oxolannyl, dioxolannyl, imidazolidinyl, pyrazolidinyl, piperidyl, piperazinyl or morpholinyl radicals.
Par radicaux alkyle, alkényle, ou alkynyle éventuellement interrompus par un hétéroatome choisis parmi les atomes de soufre, d'oxygène ou d'azote, on entend les radicaux comprenant un ou plusieurs de ces atomes, identiques ou différents dans leur structure. Ces hétéroatomes ne pouvant évidemment pas être situés à l'extrémité du radical. On peut citer par exemple les radicaux alkoxyalkyle tels que méthoxyméthyle ou méthoxyéthyle ou encore les radicaux alkoxy alkoxyalkyle tels que méthoxyéthoxyméthyle.By alkyl, alkenyl or alkynyl radicals optionally interrupted by a heteroatom chosen from sulfur, oxygen or nitrogen atoms, is meant radicals comprising one or more of these atoms, which are identical or different in their structure. These heteroatoms obviously cannot not be located at the end of the radical. Mention may be made, for example, of alkoxyalkyl radicals such as methoxymethyl or methoxyethyl or alternatively alkoxyalkyl radicals such as methoxyethoxymethyl.
Lorsque les produits de formule (I) comportent un radical amino salifiable par un acide il est bien entendu que ces sels d'acides font également partie de l'invention. On peut citer les sels fournis avec les acides chlorhydrique en méthanesulfonique par exemple.When the products of formula (I) comprise an amino radical salifiable by an acid, it is understood that these acid salts are also part of the invention. Mention may be made of the salts supplied with hydrochloric acids in methanesulfonic acid for example.
L'invention a notamment pour objet les produits de formule (I) telle que définie ci-dessus dans laquelle Y représente un atome d'oxygène à l'exception des produits dans lesquels :
le groupement -A-B- représente le radical :
the group -AB- represents the radical:
Parmi ces produits, l'invention a particulièrement pour objet ceux dans lequel le groupement -A-B- représente le radical :
Parmi ces produits, l'invention a particulièrement pour objet ceux dans lesquels R représente un atome d'hydrogène ou un radical alkyle ayant au plus 4 atomes de carbone éventuellement substitué par un radical hydroxy.Among these products, the invention particularly relates to those in which R represents a hydrogen atom or an alkyl radical having at most 4 carbon atoms optionally substituted by a hydroxy radical.
Parmi ces produits, l'invention a tout particulièrement pour objet ceux dans lesquels R 1 représente un radical cyano ou un atome d'halogène et notamment un atome de chlore.Among these products, the invention particularly relates to those in which R 1 represents a cyano radical or a halogen atom and in particular a chlorine atom.
L'invention a aussi particulièrement pour objet les produits de formule (I) telle que définie ci-dessus dans laquelle le groupement -A-B- représente un groupement :
La présente invention a encore pour objet les produits de formule (I) telle que définie ci-dessus et répondant à la formule (I') :
Parmi ces produits, la présente invention a aussi pour objet les produits de formule (I) telle que définie ci-dessus dans laquelle R 1 représente un radical nitro et R 3 représente un radical alkyle ou alkényle ayant au plus 4 atomes de carbone éventuellement substitué par un radical carboxy libre estérifié ou salifié.Among these products, the present invention also relates to the products of formula (I) as defined above in which R 1 represents a nitro radical and R 3 represents an alkyl or alkenyl radical having at most 4 carbon atoms optionally substituted by an esterified or salified free carboxy radical.
Parmi les produits préférés de l'invention, on peut citer plus précisément les produits de formule (I) telle que définie ci-dessus dont les noms suivent :
- le 4-(5-oxo-2-thioxo-3,4,4-triméthyl-1-imidazolidinyl)-2-(trifluorométhyl)-benzonitrile,
- le 4-(4,4-diméthyl-5-oxo-2-thioxo 1-imidazolidinyl)-2-(trifluorométhyl)-benzonitrile,
- le 4-[4,4-diméthyl 3-(2-hydroxyéthyl) 5-oxo 2-thioxo 1-imidazolidinyl] 2-(trifluorométhyl) benzonitrile,
- le 3-(3,4-dichlorophényl) 2-thioxo 1,5,5-triméthyl 4-imidazolidinone,
- le 1-(4-nitro-3-(trifluorométhyl) phényl)-3,4,4-triméthyl-2,5-imidazolidinedione,
- le 4-[[4,5-dihydro 4,4-diméthyl 5-oxo 2-(phénylméthyl) thio] 1H-imidazol-1-yl] 2-(trifluorométhyl) benzonitrile.
- 4- (5-oxo-2-thioxo-3,4,4-trimethyl-1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile,
- 4- (4,4-dimethyl-5-oxo-2-thioxo 1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile,
- 4- [4,4-dimethyl 3- (2-hydroxyethyl) 5-oxo 2-thioxo 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile,
- 3- (3,4-dichlorophenyl) 2-thioxo 1,5,5-trimethyl 4-imidazolidinone,
- 1- (4-nitro-3- (trifluoromethyl) phenyl) -3,4,4-trimethyl-2,5-imidazolidinedione,
- 4 - [[4,5-dihydro 4,4-dimethyl 5-oxo 2- (phenylmethyl) thio] 1H-imidazol-1-yl] 2- (trifluoromethyl) benzonitrile.
L'invention a aussi pour objet un procédé de préparation des produits de formule générale (I) telle que définie ci-dessus caractérisé en ce que :
soit l'on fait agir en présence d'une base tertiaire un produit de formule (II) :
- a) réaction d'élimination des éventuels groupements protecteurs que peut porter R′ 3 ;
- b) réaction d'hydrolyse du groupement >C=NH en fonction cétone et le cas échéant transformation du groupement >C=S en groupement >C=O ;
- c) réaction de transformation du ou des groupements >C=O en groupement >C=S ;
- d) action sur les produits de formule (IV) dans laquelle R′ 3 représente un atome d'hydrogène, et après hydrolyse au groupement >C=NH en fonction cétone d'un réactif de formule Hal-R˝ 3 dans laquelle R˝ 3 a les valeurs de R′ 3 à l'exception de la valeur hydrogène et Hal représente un atome d'halogène pour obtenir des produits de formule (I) dans laquelle le groupement -A-B- représente le groupement
- a) réaction d'élimination des éventuels groupements protecteurs que peut porter R˝ 3 puis le cas échéant action d'un agent d'estérification, d'amidification ou de salification ;
- b) réaction de transformation du ou des groupements >C=O en groupements >C=S.
either act in the presence of a tertiary base a product of formula (II):
- a) reaction for eliminating any protective groups which R ′ 3 can carry;
- b) hydrolysis reaction of the group> C = NH as a ketone function and, where appropriate, transformation of the group> C = S into a group> C = O;
- c) reaction for transforming the group (s)> C = O into a group> C = S;
- d) action on the products of formula (IV) in which R ′ 3 represents a hydrogen atom, and after hydrolysis to the group> C = NH as a ketone function of a reagent of formula Hal-R˝ 3 in which R˝ 3 has the values of R ′ 3 with the exception of the hydrogen value and Hal represents a halogen atom to obtain products of formula (I) in which the group -AB- represents the group
- a) reaction for the elimination of any protective groups which R˝ 3 can carry, then, if necessary, the action of an esterification, amidation or salification agent;
- b) reaction for transforming the group (s)> C = O into groups> C = S.
L'action des produits de formule (II) avec les produits de formule (III) est effectuée de préférence dans un solvant organique tel que le tétrahydrofuranne ou le dichloroéthane mais on peut également utiliser l'éther éthylique ou l'éther isopropylique.The action of the products of formula (II) with the products of formula (III) is preferably carried out in an organic solvent such as tetrahydrofuran or dichloroethane but it is also possible to use ethyl ether or isopropyl ether.
On opère en présence d'une base tertiaire telle que la triéthylamine ou encore la pyridine ou la méthyléthylpyridine.The operation is carried out in the presence of a tertiary base such as triethylamine or else pyridine or methylethylpyridine.
Les éventuelles fonctions réactives que peut comporter R 3 et qui sont éventuellement protégées dans le produit de formule (III) ou (IV˝) sont les fonctions hydroxy ou amino. On utilise pour protéger ces fonctions des groupements protecteurs usuels. On peut citer par exemples les groupements protecteurs suivants du radical amino : tert-butyle, tert-amyle, trichloroacétyle, chloroacétyle, benzhydryle, trityle, formyle, benzyloxycarbonyle.The possible reactive functions which R 3 may contain and which are optionally protected in the product of formula (III) or (IV˝) are the hydroxy or amino functions. Usual protective groups are used to protect these functions. Mention may be made, for example, of the following protective groups of the amino radical: tert-butyl, tert-amyl, trichloroacetyl, chloroacetyl, benzhydryl, trityl, formyl, benzyloxycarbonyl.
Comme groupement protecteur du radical hydroxy on peut citer les radicaux tels que formyle, chloroacétyle, tétrahydropyrannyle, triméthylsilyle, tert-butyl diméthylsilyle.As protecting group for the hydroxy radical, mention may be made of radicals such as formyl, chloroacetyl, tetrahydropyrannyl, trimethylsilyl, tert-butyl dimethylsilyl.
Il est bien entendu que la liste ci-dessus n'est pas limitative et que d'autres groupements protecteurs, par exemple connus dans la chimie des peptides peuvent être utilisés. Une liste de tels groupements protecteurs se trouve par exemple dans le brevet français BF 2.499.995 dont le contenu est incorporé ici par référence.It is understood that the above list is not exhaustive and that other protective groups, for example known in peptide chemistry can be used. A list of such protective groups can be found, for example, in French patent BF 2,499,995, the content of which is incorporated here by reference.
Les réactions éventuelles d'élimination des groupements protecteurs sont effectuées comme indiqué dans ledit brevet BF 2.499.995. Le mode préféré d'élimination est l'hydrolyse acide à l'aide des acides choisis parmi les acides chlorhydrique, benzène sulfonique ou para toluène sulfonique, formique ou trifluoroacétique. On préfère l'acide chlorhydrique.The possible reactions for removing protective groups are carried out as indicated in said patent BF 2,499,995. The preferred mode of elimination is acid hydrolysis using the acids chosen from hydrochloric, benzene sulfonic or para-toluene sulfonic, formic or trifluoroacetic acids. Hydrochloric acid is preferred.
La réaction éventuelle d'hydrolyse du groupement >C=NH en groupement cétone est également effectuée de préférence à l'aide d'un acide tel que l'acide chlorhydrique aqueux par exemple au reflux.The optional hydrolysis reaction of the> C = NH group into a ketone group is also preferably carried out using an acid such as aqueous hydrochloric acid, for example at reflux.
Lorsque l'hydrolyse du groupement >C=NH en groupement cétone est effectuée sur une molécule comportant également un groupement >C=S, celui-ci peut être transformé en groupement >C=O. Le radical OH libre que peut comporter éventuellement R 3 peut être alors transformé en radical SH.When the hydrolysis of the> C = NH group into a ketone group is carried out on a molecule also comprising a> C = S group, the latter can be transformed into a> C = O group. The free OH radical which may optionally comprise R 3 can then be transformed into an SH radical.
La réaction de transformation du ou des groupements >C=O en groupement >C=S est effectuée à l'aide du réactif dit de Lawesson de formule :
Lorsque l'on veut transformer deux fonctions >C=O en deux fonctions >C=S on opère en présence d'un excès de réactif de Lawesson. Il en est de même lorsque l'on part d'une molécule comportant une fonction >C=S et une fonction >C=O et que l'on veut transformer ladite fonction >C=O en fonction >C=S.When we want to transform two functions> C = O into two functions> C = S we operate in the presence of an excess of Lawesson's reagent. It is the same when we start from a molecule comprising a function> C = S and a function> C = O and we want to transform said function> C = O into function> C = S.
Par contre lorsque l'on part d'une molécule comportant deux fonctions >C=O et que l'on veut obtenir un produit ne comportant qu'une seule fonction >C=S. On opère en présence d'un déficit de réactif de Lawesson. On obtient alors en général un mélange de trois produits : chacun des deux produits comportant une fonction >C=O et une fonction >C=S et le produit comportant deux fonctions >C=S. Ces produits peuvent être ensuite séparés par les méthodes usuelles telles que la chromatographie.On the other hand, when we start from a molecule comprising two functions> C = O and we want to obtain a product comprising only one function> C = S. We operate in the presence of a Lawesson reagent deficit. We then generally obtain a mixture of three products: each of the two products comprising a function> C = O and a function> C = S and the product comprising two functions> C = S. These products can then be separated by the usual methods such as chromatography.
L'action sur les produits de formules (IV) ou (IV′) du réactif de formule Hal-R˝ 3 est effectuée en présence d'une base forte telle que l'hydrure de sodium ou de potassium. On peut opérer par réaction de transfert de phase en présence de sels d'ammonium quaternaires tels que le tert-butyl ammonium.
- Les groupements protecteurs que peut porter le substituant R˝ 3 pouvant être par exemple un de ceux précédemment cités pour R 3 . Les réactions d'élimination des groupements protecteurs s'effectuent dans les conditions indiquées ci-dessus.
- The protective groups which the substituent R˝ 3 can carry can, for example, be one of those previously mentioned for R 3 . Protective group elimination reactions are carried out under the conditions indicated above.
Un exemple d'élimination du groupement terbutyldiméthylsilyle au moyen de l'acide chlorhydrique est donné ci-après dans les exemples.
- L'estérification éventuelle des produits de formule (I) dans laquelle R˝ 3 comporte un radical OH libre est effectuée dans des conditions classiques. On peut utiliser par exemple un acide ou un dérivé fonctionnel, par exemple un anhydride tel que l'anhydride acétique en présence d'une base telle que la pyridine.
- The optional esterification of the products of formula (I) in which R˝ 3 comprises a free OH radical is carried out under conventional conditions. One can use for example an acid or a functional derivative, for example an anhydride such as acetic anhydride in the presence of a base such as pyridine.
L'estérification ou la salification éventuelle des produits de formule (I) dans laquelle R˝ 3 représente un groupement COOH est effectuée dans les conditions classiques connues de l'homme du métier.
- L'amidification éventuelle des produits de formule (I) dans laquelle R˝ 3 comporte un radical COOH est effectuée dans des conditions classiques. On peut utiliser une amine primaire ou secondaire sur un dérivé fonctionnel de l'acide par exemple un anhydride symétrique ou mixte.
- The optional amidation of the products of formula (I) in which R˝ 3 comprises a COOH radical is carried out in classic conditions. A primary or secondary amine can be used on a functional derivative of the acid, for example a symmetrical or mixed anhydride.
La présente invention a également pour objet un procédé de préparation des produits de formule (I˝) :
En ce qui concerne les produits de formule (V), le terme Hal désigne de préférence l'atome de chlore, mais peut aussi représenter un atome de brome ou d'iode.As regards the products of formula (V), the term Hal preferably designates the chlorine atom, but can also represent a bromine or iodine atom.
Le rôle du catalyseur est vraisemblablement de piéger l'halogénure d'hydrogène qui se dégage et ainsi de faciliter la réaction de condensation du produit de formule (V) avec le produit de formule (VI) pour donner le produit recherché.The role of the catalyst is probably to trap the hydrogen halide which is released and thus to facilitate the condensation reaction of the product of formula (V) with the product of formula (VI) to give the desired product.
L'invention a plus précisément pour objet un procédé tel que défini ci-dessus dans lequel le catalyseur est un métal sous forme native ou oxydée ou une base.A more specific subject of the invention is a process as defined above in which the catalyst is a metal in native or oxidized form or a base.
Le catalyseur utilisé peut être un métal sous forme native, sous forme d'oxyde métallique ou encore sous forme de sels métalliques. Le catalyseur peut également être une base. Quand le catalyseur utilisé est un métal, ce métal peut être du cuivre ou du nickel.The catalyst used can be a metal in native form, in the form of metal oxide or also in the form of metal salts. The catalyst can also be a base. When the catalyst used is a metal, this metal can be copper or nickel.
Les sels métalliques peuvent être un chlorure ou un acétate.The metal salts can be a chloride or an acetate.
Quand le catalyseur est une base, cette base peut être par exemple la soude ou la potasse et on peut, si désiré, ajouter au milieu réactionnel du diméthylsulfoxyde.When the catalyst is a base, this base can for example be sodium hydroxide or potassium hydroxide and it is possible, if desired, to add dimethyl sulfoxide to the reaction medium.
L'invention a plus précisément pour objet un procédé tel que défini ci-dessus dans lequel le catalyseur est choisi parmi l'oxyde cuivreux, l'oxyde cuivrique, le cuivre sous forme native et une base telle que la soude ou la potasse.The invention more specifically relates to a process as defined above in which the catalyst is chosen from cuprous oxide, cupric oxide, copper in native form and a base such as sodium hydroxide or potassium hydroxide.
Le cuivre sous forme native utilisé comme catalyseur est préférentiellement sous forme de poudre.The copper in native form used as catalyst is preferably in the form of powder.
L'invention a particulièrement pour objet un procédé tel que défini ci-dessus dans lequel le catalyseur est l'oxyde cuivreux.The invention particularly relates to a process as defined above in which the catalyst is cuprous oxide.
Le solvant utilisé est préférentiellement choisi parmi des éthers à haut point d'ébullition tels que, par exemple, l'oxyde de phényle, le diglyme, le triglyme et le diméthylsulfoxyde mais peut être également, par exemple, une huile à haut point d'ébullition telle que la paraffine ou la vaseline.The solvent used is preferably chosen from high boiling point ethers such as, for example, phenyl oxide, diglyme, triglyme and dimethyl sulfoxide but can also be, for example, a high point oil. boiling such as paraffin or petroleum jelly.
L'invention a plus particulièrement pour objet un procédé tel que défini ci-dessus caractérisé en ce que l'on opère en présence d'un solvant de type éther tel que l'oxyde de phényle, le diglyme, le triglyme ou le diméthylsulfoxyde.The invention more particularly relates to a process as defined above characterized in that one operates in the presence of an ether type solvent such as oxide phenyl, diglyme, triglyme or dimethylsulfoxide.
L'invention a tout particulièrement pour objet un procédé tel que défini ci-dessus dans lequel le solvant utilisé est l'oxyde de phényle ou le triglyme.The invention particularly relates to a process as defined above in which the solvent used is phenyl oxide or triglyme.
Le procédé de préparation du produit recherché défini ci-dessus peut être réalisé sous pression ou à la pression atmosphérique, à une température préférentiellement élevée.The process for the preparation of the desired product defined above can be carried out under pressure or at atmospheric pressure, at a preferably high temperature.
L'invention a ainsi pour objet un procédé tel que défini ci-dessus caractérisé en ce que la réaction est réalisée à une température supérieure à 100°C et de préférence supérieure à 150°C.The subject of the invention is therefore a process as defined above, characterized in that the reaction is carried out at a temperature above 100 ° C and preferably above 150 ° C.
L'invention a plus précisément pour objet un procédé tel que défini ci-dessus caractérisé en ce que la réaction est réalisée pendant plus de 2 heures.The invention more specifically relates to a process as defined above, characterized in that the reaction is carried out for more than 2 hours.
L'invention a très précisément pour objet un procédé tel que défini ci-dessus caractérisé en ce que la réaction est réalisée en présence d'oxyde cuivreux, dans le triglyme, à une température supérieure ou égale à 200°C et pendant plus de 3 heures.A very specific subject of the invention is a process as defined above, characterized in that the reaction is carried out in the presence of cuprous oxide, in the triglyme, at a temperature greater than or equal to 200 ° C. and for more than 3 hours.
Les produits objets de la présente invention sont doués de propriétés pharmacologiques intéressantes ; on a constaté notamment qu'ils inhibaient les effets des androgènes sur les récepteurs périphériques.The products which are the subject of the present invention are endowed with interesting pharmacological properties; in particular, they have been found to inhibit the effects of androgens on peripheral receptors.
Des tests donnés dans la partie expérimentale illustrent cette activité anti-androgène.Tests given in the experimental part illustrate this anti-androgenic activity.
Du fait de cette activité anti-androgène, les produits de l'invention peuvent être utilisés en thérapeutique chez les adultes sans avoir à redouter certains effets d'une castration chimique.Due to this anti-androgenic activity, the products of the invention can be used in therapy in adults without having to fear certain effects of chemical castration.
Ces propriétés rendent les produits de formule générale (I) de la présente invention utilisables comme médicaments pour le traitement des adénomes et des néoplasies de la prostate ainsi que pour lutter contre l'hypertrophie bénigne de la prostate.These properties make the products of general formula (I) of the present invention usable as medicaments for the treatment of adenomas and neoplasias of the prostate as well as for combating benign prostatic hyperplasia.
Ces propriétés rendent les produits de formule générale (I) également utilisables dans le traitement des tumeurs bénignes ou malignes dont les cellules contiennent notamment des récepteurs androgènes. On peut en particulier citer principalement les cancers du sein, du cerveau, de la peau et des ovaires mais également les cancers de la vessie, du système lymphatique, du rein, du foie.These properties make the products of general formula (I) also usable in the treatment of benign or malignant tumors whose cells contain in particular androgen receptors. We can in particular quote mainly breast, brain, skin and ovarian cancers, but also bladder, lymphatic system, kidney and liver cancers.
Les produits de formule générale (I) de l'invention trouvent également leur utilisation dans le traitement de l'hirsutisme, de l'acné, de la seborrhée, de l'alopécie androgénique, de l'hyperpilosité.The products of general formula (I) of the invention also find their use in the treatment of hirsutism, acne, seborrhea, androgenic alopecia, hyperpilosity.
Ils peuvent également être utilisés dans le domaine vétérinaire.They can also be used in the veterinary field.
L'invention a donc pour objet l'application, à titre de médicaments, des produits de formule générale (I) pharmaceutiquement acceptables.A subject of the invention is therefore the application, as medicaments, of products of general formula (I) which are pharmaceutically acceptable.
L'invention a particulièrement pour objet l'application à titre de médicaments, des produits dont les noms suivent :
- le 4-(5-oxo-2-thioxo-3,4,4-triméthyl-1-imidazolidinyl)-2-(trifluorométhyl)-benzonitrile,
- le 4-(4,4-diméthyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluorométhyl)-benzonitrile,
- le 4-[4,4-diméthyl 3-(2-hydroxyéthyl) 5-oxo 2-thioxo 1-imidazolidinyl] 2-(trifluorométhyl) benzonitrile,
- le 3-(3,4-dichlorophényl) 2-thioxo 1,5,5-triméthyl 4-imidazolidinone,
- le 1-(4-nitro-3-(trifluorométhyl) phényl)-3,4,4-triméthyl-2,5-imidazolidinedione,
- le 4-[[4,5-dihydro 4,4-diméthyl 5-oxo 2-(phénylméthyl) thio] 1H-imidazol-A-yl] 2-(trifluorométhyl) benzonitrile.
- 4- (5-oxo-2-thioxo-3,4,4-trimethyl-1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile,
- 4- (4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl) -2- (trifluoromethyl) -benzonitrile,
- 4- [4,4-dimethyl 3- (2-hydroxyethyl) 5-oxo 2-thioxo 1-imidazolidinyl] 2- (trifluoromethyl) benzonitrile,
- 3- (3,4-dichlorophenyl) 2-thioxo 1,5,5-trimethyl 4-imidazolidinone,
- 1- (4-nitro-3- (trifluoromethyl) phenyl) -3,4,4-trimethyl-2,5-imidazolidinedione,
- 4 - [[4,5-dihydro 4,4-dimethyl 5-oxo 2- (phenylmethyl) thio] 1H-imidazol-A-yl] 2- (trifluoromethyl) benzonitrile.
Les produits peuvent être administrés par voie parentérale, buccale, perlinguale, rectale ou topique.The products can be administered parenterally, buccally, perlingually, rectally or topically.
L'invention a aussi pour objet les compositions pharmaceutiques, caractérisées en ce qu'elles renferment, à titre de principe actif, un au moins des médicaments de formule générale (I).A subject of the invention is also pharmaceutical compositions, characterized in that they contain, as active principle, at least one of the drugs of general formula (I).
Ces compositions peuvent être présentées sous forme de solutions ou de suspensions injectables, de comprimés, de comprimés enrobés, de capsules, de sirops, de suppositoires, de crèmes, de pommades et de lotions. Ces formes pharmaceutiques sont préparées selon les méthodes usuelles. Le principe actif peut être incorporé à des excipients habituellement employés dans ces compositions, tels que les véhicules aqueux ou non, le talc, la gomme arabique, le lactose, l'amidon, le stéarate de magnésium, le beurre de cacao, les corps gras d'origine animale ou végétale, les dérivés paraffiniques, les glycols, les divers agents mouillants, dispersants ou émulsifiants, les conservateurs.These compositions can be presented in the form of solutions or injectable suspensions, tablets, coated tablets, capsules, syrups, suppositories, creams, ointments and lotions. These pharmaceutical forms are prepared according to the usual methods. The active ingredient can usually be incorporated into excipients used in these compositions, such as aqueous vehicles or not, talc, gum arabic, lactose, starch, magnesium stearate, cocoa butter, fatty substances of animal or vegetable origin, paraffinic derivatives , glycols, various wetting agents, dispersants or emulsifiers, preservatives.
La dose usuelle, variable selon le sujet traité et l'affection en cause, peut être, par exemple, de 10 mg à 500 mg par jour chez l'homme, par voie orale.The usual dose, which varies depending on the subject treated and the condition in question, can be, for example, from 10 mg to 500 mg per day in humans, orally.
Les produits de formule (II) utilisés au départ de l'invention peuvent être obtenus par action du phosgène lorsque X représente un atome d'oxygène ou du thiophosgène lorsque X représente un atome de soufre sur l'amine correspondante de formule (A) :
Un exemple d'une telle préparation est donné ci-après dans la partie expérimentale. Un produit de ce type est décrit également dans le brevet français BF 2.329.276.An example of such a preparation is given below in the experimental part. A product of this type is also described in French patent BF 2,329,276.
Les amines de formule (A) sont décrites dans le brevet européen EP 0.002.892 ou le brevet français BF 2.142.804.The amines of formula (A) are described in European patent EP 0.002,892 or French patent BF 2,142,804.
Les produits de formule (III) sont connus ou peuvent être préparés à partir de la cyanhydrine correspondante selon le procédé décrit dans la publication : J. Am. Chem. Soc. (1953), 75, 4841.The products of formula (III) are known or can be prepared from the corresponding cyanohydrin according to the method described in the publication: J. Am. Chem. Soc. (1953), 75 , 4841.
Les produits de formule (III) dans lesquels R′ 3 est différent d'un atome d'hydrogène peuvent être obtenus par action d'un produit de formule R˝ 3 Hal sur le 2-cyano 2-amino propane dans les conditions énoncées ci-dessus pour l'action de R˝ 3 Hal sur les produits de formule (IV). Un exemple de préparation de ce type est décrit dans la référence :
- Jilek et Coll. Collect. Cyech. Chem. Comm. 54(8) 2248 (1989).
- Jilek et al. Collect. Cyech. Chem. Comm. 54 (8) 2248 (1989).
Les produits de formule (IV′) sont décrits dans le brevet français BF 2.329.276.The products of formula (IV ′) are described in French patent BF 2,329,276.
Les produits de départ de formules (V) et (VI), sur lesquels s'exerce un procédé, objet de l'invention, pour l'obtention des produits de formule (I), sont connus et disponibles dans le commerce ou peuvent être préparés selon des méthodes connues de l'homme de métier.The starting materials of formulas (V) and (VI), on which a process, object of the invention is carried out, for obtaining the products of formula (I), are known and available commercially or can be prepared according to methods known to those skilled in the art.
La préparation de produits de formule (VI) est décrite notamment dans les publications suivantes :
- Zhur. Préklad. Khim. 28, 969-75 (1955) (CA 50, 4881a, 1956)
- Tétrahédron 43, 1753 (1987)
- J. Org. 52, 2407 (1987)
- Zh. Org. Khim. 21, 2006 (1985)
- J. Fluor. Chem. 17, 345 (1981) ou dans les brevets :
- allemand DRP 637.318 (1935)
- européen EP 0.130.875
- japonais JP 81.121.524.
- Zhur. Preklad. Khim. 28, 969-75 (1955) (CA 50 , 4881a, 1956)
- Tetrahedron 43 , 1753 (1987)
- J. Org. 52 , 2407 (1987)
- Zh. Org. Khim. 21 , 2006 (1985)
- J. Fluor. Chem. 17 , 345 (1981) or in patents:
- German DRP 637.318 (1935)
- European EP 0.130.875
- Japanese JP 81,121,524.
Les produits de formule (VI) qui sont des dérivés de l'hydantoïne sont largement utilisés et cités dans la littérature comme par exemple dans les articles suivants :
- J. Pharm. Pharmacol., 67, Vol. 19(4), p. 209-16 (1967)
- J. Chem. Soc., 74, (2), p. 219-21 (1972)
- Khim. Farm. Zh., 67, Vol. 1 (5) p. 51-2
- Brevet allemand 2.217.914
- Brevet européen 0.091.596
- J. Chem. Soc. Perkin. Trans. 1, 74 (2) p. 48, p. 219-21.
- J. Pharm. Pharmacol., 67, Vol. 19 (4), p. 209-16 (1967)
- J. Chem. Soc., 74, (2), p. 219-21 (1972)
- Khim. Farm. Zh., 67, Vol. 1 (5) p. 51-2
- German patent 2,217,914
- European patent 0.091.596
- J. Chem. Soc. Perkin. Trans. 1.74 (2) p. 48, p. 219-21.
L'invention a également pour objet, à titre de produits industriels nouveaux et notamment à titre de produits industriels nouveaux utilisables comme intermédiaires pour la préparation des produits de formule générale (I).The subject of the invention is also, as new industrial products and in particular as new industrial products which can be used as intermediates for the preparation of the products of general formula (I).
Les produits de formule (IVi) :
à l'exception des produits dans lesquels le groupement -A i B i - représente le radical :
with the exception of products in which the group -A i B i - represents the radical:
Parmi les fonctions réactives protégées on peut citer les fonctions hydroxyle et amino. Ces fonctions peuvent être protégées comme indiqué ci-dessus pour le substituant R 3 .Among the protected reactive functions, mention may be made of the hydroxyl and amino functions. These functions can be protected as indicated above for the substituent R 3 .
Les exemples suivants illustrent l'invention sans toutefois la limiter.The following examples illustrate the invention without, however, limiting it.
A une suspension de 492 mg d'hydrure de sodium à 50 % dans l'huile et 3 cm 3 de diméthyl formamide, on ajoute, à une température comprise entre 23 et 26°C, une solution de 3,17 g de 1-(3'-trifluorométhyl 4-nitrophényl) 4,4-diméthyl imidazoline 2,5-dione (obtenu selon BF 2.329.276) et 32 cm 3 de diméthyl formamide, on agite 15 minutes et ajoute une solution de 0,7 cm 3 d'iodure de méthyle dans 2 cm 3 de diméthyl formamide. On agite 25 minutes entre 24 et 28°C puis verse sur 200 g d'un mélange 1-1 d'eau et de glace. On extrait avec de l'éther, lave à l'eau saturée de chlorure de sodium, sèche, filtre et évapore à sec sous pression réduite, on obtient 3,6 g du produit recherché F=116°C.To a suspension of 492 mg of sodium hydride at 50% in oil and 3 cm 3 of dimethyl formamide, a solution of 3.17 g of 1-7 is added at a temperature between 23 and 26 ° C. (3'-trifluoromethyl 4-nitrophenyl) 4,4-dimethyl imidazoline 2,5-dione (obtained according to BF 2,329,276) and 32 cm 3 of dimethyl formamide, the mixture is stirred for 15 minutes and a solution of 0.7 cm 3 of methyl iodide in 2 cm 3 of dimethyl formamide is added. The mixture is stirred for 25 minutes at 24 to 28 ° C and then poured into 200 g of a 1-1 mixture of water and ice. Extracted with ether, washed with water saturated with sodium chloride, dried, filtered and evaporated to dryness under reduced pressure, 3.6 g of the desired product are obtained, M = 116 ° C.
Un échantillon analytique a été obtenu par recristallisation dans l'alcool isopropylique on recueille ainsi 2,73 g du produit attendu F = 116°C.
C=O (1780, 1727 cm -1 )
aromatiques (1615, 1596, 1497 cm -1 )
NO 2 (1545, 1357 cm -1 )An analytical sample was obtained by recrystallization from isopropyl alcohol, thus 2.73 g of the expected product are collected, F = 116 ° C.
C = O (1780, 1727 cm -1 )
aromatic (1615, 1596, 1497 cm -1 )
NO 2 (1545, 1357 cm -1 )
On opère comme à l'exemple 1 à partir de 1 g de 1-(3'-trifluorométhyl 4'-nitrophényl) 4,4-diméthyl imidazoline-2,5-dione obtenu selon BF 2.329.276 en utilisant 0,33 cm 3 d'iodure d'éthyle et 166 mg d'hydrure de sodium à 50 % dans l'huile. On obtient 1,19 g du produit recherché F = 110-111°C. Le produit ci-dessus est recristallisé dans l'isopropanol. On obtient 934 mg du produit attendu F = 110-111°C.
C=O (1777 cm -1 , 1724 (F))
NO 2 (1545, 1356 cm -1 )
aromatique (1614, 1596, 1497 cm -1 )The procedure is as in Example 1, starting with 1 g of 1- (3'-trifluoromethyl 4'-nitrophenyl) 4,4-dimethyl imidazoline-2,5-dione obtained according to BF 2,329,276 using 0.33 cm 3 ethyl iodide and 166 mg of 50% sodium hydride in oil. 1.19 g of the desired product are obtained, F = 110-111 ° C. The above product is recrystallized from isopropanol. 934 mg of the expected product is obtained, F = 110-111 ° C.
C = O (1777 cm -1 , 1724 (F))
NO 2 (1545, 1356 cm -1 )
aromatic (1614, 1596, 1497 cm -1 )
On opère comme à l'exemple 1 à partir de 1 g de 1-(3'-trifluorométhyl 4-nitrophényl) 4,4-diméthyl imidazoline 2,5-dione (obtenu selon BF 2.329.276) en utilisant 155 mg d'hydrure de sodium à 50 % dans l'huile et 0,35 cm 3 de 1-iodo propane. Après chromatographie sur silice éluant acétone-chlorure de méthylène 1-99 on obtient 1,087 g de produit brut (F=102°C). Après recristallisation dans l'isopropanol, on recueille 945 mg de produit recherché (F = 102°C).
C=O (1778, 1724 cm -1 )
NO 2 (1544, 1358 cm -1 )
aromatique (1615, 1596, 1497 cm -1 )The procedure is as in Example 1, starting with 1 g of 1- (3'-trifluoromethyl 4-nitrophenyl) 4,4-dimethyl imidazoline 2,5-dione (obtained according to BF 2,329,276) using 155 mg of 50% sodium hydride in oil and 0.35 cm 3 of 1-iodo propane. After chromatography on silica eluting acetone-methylene chloride 1-99, 1.087 g of crude product is obtained (mp = 102 ° C.). After recrystallization from isopropanol, 945 mg of sought product is collected (mp = 102 ° C.).
C = O (1778, 1724 cm -1 )
NO 2 (1544, 1358 cm -1 )
aromatic (1615, 1596, 1497 cm -1 )
On opère comme à l'exemple 1 à partir de 1 g de 1-(3′-trifluorométhyl 4-nitrophényl) 4,4-diméthyl imidazoline 2,5-dione (obtenu selon BF 2.329.276) en utilisant 166 mg d'hydrure de sodium à 50 % dans l'huile et 0,4 cm 3 de 2-iodo propane pendant 18 heures à 50°C. Après chromatographie sur silice (éluant chlorure de méthylène-acétone 99-1) on obtient 685 mg du produit attendu F = 130°C. On recristallise le produit obtenu ci-dessus dans l'isopropanol et on recueille 661 mg de produit recherché F = 130°C.
C=O (1779, 1771, 1723 cm -1 )
NO 2 (1544, 1361 cm -1 )
aromatiques (1615, 1596, 1497 cm -1 )The procedure is as in Example 1, starting from 1 g of 1- (3′-trifluoromethyl 4-nitrophenyl) 4,4-dimethyl imidazoline 2,5-dione (obtained according to BF 2,329,276) using 166 mg of 50% sodium hydride in oil and 0.4 cm 3 of 2-iodo propane for 18 hours at 50 ° C. After chromatography on silica (eluent methylene chloride-acetone 99-1), 685 mg of the expected product are obtained M = 130 ° C. The product obtained above is recrystallized from isopropanol and 661 mg of sought product is collected, F = 130 ° C.
C = O (1779, 1771, 1723 cm -1 )
NO 2 (1544, 1361 cm -1 )
aromatic (1615, 1596, 1497 cm -1 )
On opère comme à l'exemple 1 à partir de 1 g de 1-(3′-trifluorométhyl 4-nitrophényl) 4,4-diméthyl imidazoline 2,5-dione (obtenu selon BF 2.329.276) en utilisant 166 mg d'hydrure de sodium à 50 % dans l'huile et 0,35 cm 3 de bromure d'allyle. Après chromatographie sur silice, éluant chlorure de méthylène-acétone 99-1, on obtient 1,19 g de produit que l'on recristallise dans l'isopropanol, on recueille 1,01 g de produit recherché F = 105°C.
C=O (1779, 1724 cm -1 )
NO 2 (1545, 1358 cm -1 )
aromatique (1615, 1596, 1497 cm -1 )
CH=CH 2 (1643, 930 cm -1 )The procedure is as in Example 1, starting from 1 g of 1- (3′-trifluoromethyl 4-nitrophenyl) 4,4-dimethyl imidazoline 2,5-dione (obtained according to BF 2,329,276) using 166 mg of 50% sodium hydride in oil and 0.35 cm 3 of allyl bromide. After chromatography on silica, eluting with methylene chloride-acetone 99-1, 1.19 g of product is obtained which is recrystallized from isopropanol, 1.01 g of sought product is collected, F = 105 ° C.
C = O (1779, 1724 cm -1 )
NO 2 (1545, 1358 cm -1 )
aromatic (1615, 1596, 1497 cm -1 )
CH = CH 2 (1643, 930 cm -1 )
On opère comme à l'exemple 1 à partir de 2 g de 1-(3′-trifluorométhyl 4-nitrophényl) 4,4-diméthyl imidazoline 2,5-dione (obtenu selon BF 2.329.276) en utilisant 332 mg d'hydrure de sodium à 50 % dans l'huile et 0,71 cm 3 de bromure de benzyle. Après chromatographie sur silice, éluant chlorure de méthylène-acétone 99-1 on obtient 2,375 g de produit que l'on recristallise dans l'isopropanol, on recueille 2,165 g du produit recherché F = 99°C.
C=O (1799 cm -1 (m), 1723 cm -1 (F))
- aromatique + NO2
- (1608 cm -1 )
(1594 cm -1 (m))
(1545 cm -1 (F))
(1497 cm -1 )
C = O (1799 cm -1 (m), 1723 cm -1 (F))
- aromatic + NO 2
- (1608 cm -1 )
(1594 cm -1 (m))
(1545 cm -1 (F))
(1497 cm -1 )
A une solution de 2,63 g de 2-amino-2-cyano propane et 36 cm 3 de 1,2-dichloroéthane avec 0,9 cm 3 de triéthylamine, on ajoute à 5°C, une solution de 6,6 g de 4-isocyanate de 2-(trifluorométhyl) benzonitrile préparé comme indiqué dans la préparation ci-après dans 10 cm 3 de dichloréthane. On agite 16 heures à température ambiante. On évapore à secet chromatographie le résidu (7,7 g) sur silice, éluant chlorure de méthylène-acétone 85-15, on obtient 3,54 g du produit attendu F = 228°C.To a solution of 2.63 g of 2-amino-2-cyano propane and 36 cm 3 of 1,2-dichloroethane with 0.9 cm 3 of triethylamine, a solution of 6.6 g is added at 5 ° C. 2- (trifluoromethyl) benzonitrile 4-isocyanate prepared as indicated in the preparation below in 10 cm 3 of dichloroethane. The mixture is stirred for 16 hours at room temperature. The residue (7.7 g) is evaporated to dryness and chromatography on silica, eluting with methylene chloride-acetone 85-15, 3.54 g of the expected product are obtained F = 228 ° C.
Un échantillon analytique a été préparé par recristallisation de 300 mg du produit ci-dessus dans l'isopropanol, on recueille 267 mg de produit recherché F = 228°C.
NH/OH (3340, 3290 cm -1 )
C≡N 2240 cm -1
C=O 1760 cm -1
C=N 1655 cm -1
aromatiques (1606, 1570, 1502 cm -1 )An analytical sample was prepared by recrystallization of 300 mg of the above product from isopropanol, 267 mg of sought product is collected, mp = 228 ° C.
NH / OH (3340, 3290 cm -1 )
C≡N 2240 cm -1
C = O 1760 cm -1
C = N 1655 cm -1
aromatic (1606, 1570, 1502 cm -1 )
A 33,6 cm 3 d'une solution toluénique de phosgène à 1,93 M/l portée à 0-5°C on ajoute en 20 minutes 10 g de 4-cyano 3-(trifluorométhyl) aniline (décrite dans le brevet européen EP 0.002.892) en solution dans 30 cm 3 d'acétate d'éthyle. On agite 30 minutes à une température comprise entre 0 et 5°C puis laisse remonter à 25°C. On chauffe jusqu'à distillation en compensant le volume distillé par du toluène jusqu'à ce que la température de distillation atteigne 110°C. On met alors le réfrigérant en position reflux jusqu'à cessation du dégagement d'acide chlorhydrique (soit 4 heures 30). On ramène à température ambiante essore le léger insoluble blanc sous azote sur sulfate de sodium puis rince par trois fois 10 cm 3 de toluène et évapore à sec sous pression réduite. On termine par un chauffage à 60°C pendant 1 heure puis revient sous atmosphère d'argon et obtient 11,6 g de produit attendu utilisé tel quel dans le stade suivant :
Infra-rouge
-N=C=O 2268 cm -1
-CN 2233 cm -1 At 33.6 cm 3 of a toluene phosgene solution at 1.93 M / l brought to 0-5 ° C., 10 g of 4-cyano 3- (trifluoromethyl) aniline (described in European patent) are added in 20 minutes EP 0.002.892) dissolved in 30 cm 3 of ethyl acetate. Stirred 30 minutes at a temperature between 0 and 5 ° C and then allowed to rise to 25 ° C. The mixture is heated to distillation, compensating for the volume distilled with toluene until the distillation temperature reaches 110 ° C. The refrigerant is then put in the reflux position until the release of hydrochloric acid (4 hours 30 minutes). The light white insoluble material is brought back to ambient temperature under nitrogen over sodium sulfate and then rinsed with three times 10 cm 3 of toluene and evaporated to dryness under reduced pressure. It is terminated by heating at 60 ° C. for 1 hour then returns under an argon atmosphere and obtains 11.6 g of the expected product used as it is in the following stage:
Infrared
-N = C = O 2268 cm -1
-CN 2233 cm -1
On chauffe 35 minutes au reflux une suspension de 2,76 g du produit obtenu à l'exemple 7 et 60 cm 3 d'acide chlorhydrique au demi. On verse sur 100 g d'eau et glace et extrait avec de l'acétate d'éthyle. On lave à l'eau, sèche et évapore à sec. On obtient 2,70 g du produit recherché F = 210°C.A suspension of 2.76 g of the product obtained in Example 7 and 60 cm 3 of half hydrochloric acid is heated at reflux for half an hour. Poured onto 100 g of water and ice and extracted with ethyl acetate. Wash with water, dry and evaporate to dryness. 2.70 g of the desired product are obtained, F = 210 ° C.
Un échantillon analytique a été obtenu par recristallisation de 440 mg du produit ci-dessus, dans l'isopropanol on recueille 383 mg de produit attendu F = 210-211°C.
C≡N 2245 cm -1
C=O (1788, 1722 cm -1 )
aromatique (1610, 1572, 1502 cm -1 )
NH (max) 3340 cm -1 An analytical sample was obtained by recrystallization from 440 mg of the above product, from isopropanol 383 mg of expected product is collected, mp 210-211 ° C.
C≡N 2245 cm -1
C = O (1788, 1722 cm -1 )
aromatic (1610, 1572, 1502 cm -1 )
NH (max) 3340 cm -1
A une suspension de 210 mg d'hydrure de sodium (à 50 % dans l'huile) et 3 cm 3 de diméthyl formamide on ajoute une solution de 600 mg du produit obtenu à l'exemple 8 dans 6 cm 3 de diméthyl formamide on agite 15 minutes puis ajoute 290 mg d'acide bromoacétique et agite 16 heures à température ambiante. On ajoute à nouveau 105 mg d'hydrure de sodium puis 15 minutes après 145 mg d'acide bromoacétique. On agite 30 minutes puis verse dans une solution composée de 50 cm 3 d'eau et 5 cm 3 d'acide chlorhydrique 2N. On extrait à l'éther, lave avec une solution saturée de chlorure de sodium, sèche, filtre et évapore à sec ; on obtient 1,22 g de produit brut que l'on chromatographie sur silice éluant chlorure de méthylèneméthanol-acide acétique (90-10-0,5). On obtient 367 mg du produit recherché.
Spectre IR : C≡N 2238 cm -1
C=O hydantoïne et acide (1784, 1725, 1710 cm -1 )
aromatique (1616, 1580, 1508 cm -1 )
Ultra-violet
- EtOH Hcl 0,1 N
- max 258 nm Epsilon = 13300
infl 277 nm Epsilon = 5000
infl 285 nm Epsilon = 2600 - EtOH NaOH 0,1 N
- max 287 nm Epsilon = 19100
max 342 nm Epsilon = 1900
IR spectrum: C≡N 2238 cm -1
C = O hydantoin and acid (1784, 1725, 1710 cm -1 )
aromatic (1616, 1580, 1508 cm -1 )
Ultraviolet
- EtOH Hcl 0.1 N
- max 258 nm Epsilon = 13300
infl 277 nm Epsilon = 5000
infl 285 nm Epsilon = 2600 - EtOH NaOH 0.1 N
- max 287 nm Epsilon = 19100
max 342 nm Epsilon = 1900
A une suspension de 100 mg d'hydrure de sodium à 50 % dans l'huile et 3 cm 3 de diméthylformamide, on ajoute 600 mg du produit obtenu à l'exemple 8 en solution dans 6 cm 3 de diméthyl formamide. On agite 15 minutes puis ajoute lentement sans dépasser 30°C 0,25 cm 3 de bromoacétate d'éthyle. On agite 30 minutes, verse sur 50 g d'un mélange eau + glace (1-1), ajoute 0,5 g de phosphate monopotassique et extrait à l'éther. On lave la phase organique à l'eau, sèche et évapore à sec on recueille 1,1 g de produit brut que l'on chromatographie sur silice (éluant chlorure de méthylène-acétone (97-3)). On obtient 709 mg du produit attendu F = 152°C.To a suspension of 100 mg of sodium hydride at 50% in oil and 3 cm 3 of dimethylformamide, 600 mg of the product obtained in Example 8 is added in solution in 6 cm 3 of dimethyl formamide. The mixture is stirred for 15 minutes then slowly added without exceeding 30 ° C 0.25 cm 3 of ethyl bromoacetate. The mixture is stirred for 30 minutes, poured onto 50 g of a water + ice mixture (1-1), added 0.5 g of monopotassium phosphate and extracted with ether. The organic phase is washed with water, dried and evaporated to dryness collects 1.1 g of crude product which is chromatographed on silica (eluent methylene chloride-acetone (97-3)). 709 mg of the expected product are obtained, F = 152 ° C.
On a obtenu un échantillon analytique en recristallisant dans l'isopropanol le produit ci-dessus et recueilli ainsi 667 mg du produit recherché F = 152°C.
C≡N 2225 cm -1
imidazolidine (1786, 1729 cm -1 )
CO 2 Et 1751 cm -1
aromatiques (1616, 1572, 1505 cm -1 )An analytical sample was obtained by recrystallizing the above product from isopropanol and thus collecting 667 mg of the desired product M = 152 ° C.
C≡N 2225 cm -1
imidazolidine (1786, 1729 cm -1 )
CO 2 And 1751 cm -1
aromatic (1616, 1572, 1505 cm -1 )
A une solution de 22 cm 3 d'eau distillée et 1 cm 3 de thiophosgène on ajoute lentement 2,23 g de 1-trifluorométhyl-4-amino benzonitrile (préparé selon EP 0002892) on agite pendant 1 heure, extrait avec du chloroforme, lave à l'eau salée, sèche et évapore à sec sous pression réduite on obtient 3 g de produit utilisé tel quel pour l'obtention de l'imine.2.23 g of 1-trifluoromethyl-4-amino benzonitrile (prepared according to EP 0002892) is slowly added to a solution of 22 cm 3 of distilled water and 1 cm 3 of thiophosgene, stirred for 1 hour, extracted with chloroform, washed with salt water, dried and evaporated to dryness under reduced pressure, 3 g of product used as is for obtaining the imine are obtained.
On agite pendant 40 minutes au reflux 3 g du produit obtenu ci-dessus avec 1,33 cm 3 de 2-méthylamino 2-cyanopropane, 23 cm 3 de tétrahydrofuranne et 0,23 cm 3 de triéthylamine. On évapore à sec et chromatographie le résidu (3,07 g) sur silice (éluant : cyclohexane-acétate d'éthyle (1-1) puis chlorure de méthylène-acétone (95-5)), on obtient 2,83 g de produit attendu que l'on recristallise dans l'isopropanol pour obtenir 2,63 g de produit recherché F = 173-174°C.
C=NH (3308, 1679 cm -1 )
C=S + aromatiques (1608, 1575, 1505, 1488 cm -1 )
C≡N 2230 cm -1
CF 3 = 1185 cm -1 Stirred for 40 minutes at reflux 3 g of the product obtained above with 1.33 cm 3 of 2-methylamino 2-cyanopropane, 23 cm 3 of tetrahydrofuran and 0.23 cm 3 of triethylamine. The residue is evaporated to dryness and the residue (3.07 g) is chromatographed on silica (eluent: cyclohexane-ethyl acetate (1-1) then methylene chloride-acetone (95-5)), 2.83 g of expected product which is recrystallized from isopropanol to obtain 2.63 g of desired product, mp = 173-174 ° C.
C = NH (3308, 1679 cm -1 )
C = S + aromatic (1608, 1575, 1505, 1488 cm -1 )
C≡N 2230 cm -1
CF 3 = 1185 cm -1
On agite 1 heure au reflux 2,21 g du produit obtenu à l'exemple 11 et 44 cm 3 d'acide chlorhydrique au demi. On verse le milieu réactionnel sur un mélange eau + glace (1-1) 200 g, extrait avec du chlorure de méthylène, lave avec de l'eau saturée de chlorure de sodium, sèche et évapore à sec, on chromatographie le résidu sur silice, éluant cyclohexaneacétate d'éthyle 1-1 on obtient 2,1 g de produit (F=171°C) que l'on recristallise dans l'isopropanol pour obtenir 1,99 g de produit recherché F = 171°C.
C=O (1761, 1756 cm -1 )
aromatiques (1610, 1578, 1505 cm -1 )
C≡N 2230 cm -1
CF 3 1178 cm -1 2.21 g of the product obtained in Example 11 and 44 cm 3 of half hydrochloric acid are stirred for 1 hour at reflux. The reaction medium is poured onto a water + ice (1-1) 200 g mixture, extracted with methylene chloride, washed with water saturated with sodium chloride, dried and evaporated to dryness, the residue is chromatographed on silica , eluting with ethyl cyclohexaneacetate 1-1, 2.1 g of product are obtained (M = 171 ° C.) which is recrystallized from isopropanol to obtain 1.99 g of sought product M = 171 ° C.
C = O (1761, 1756 cm -1 )
aromatic (1610, 1578, 1505 cm -1 )
C≡N 2230 cm -1
CF 3 1178 cm -1
On agite 24 heures au reflux 839 mg de produit obtenu à l'exemple 12 avec 518 mg de réactif de Lawesson et 4,7 cm 3 de toluène. On évapore à sec sous pression réduite on recueille 1,36 g de produit que l'on chromatographie sur silice éluant chlorure de méthylène-acétate d'éthyle (99-1) puis cyclohexane-acétate d'éthyle (85-15). On obtient 783 mg de produit que l'on recristallise dans l'isopropanol on recueille 690 mg de produit recherché F = 211-212°C.
C≡N 2230 cm -1
aromatique + syst. conjugué (1612, 1582, 1508 cm -1 )
CF 3 1178 cm -1 839 mg of product obtained in Example 12 are stirred at reflux for 24 hours with 518 mg of Lawesson reagent and 4.7 cm 3 of toluene. Evaporated to dryness under reduced pressure, 1.36 g of product are collected which is chromatographed on silica eluting with methylene chloride-ethyl acetate (99-1) then cyclohexane-ethyl acetate (85-15). 783 mg of product are obtained, which product is recrystallized from isopropanol, 690 mg of sought product is collected, mp = 211-212 ° C.
C≡N 2230 cm -1
aromatic + syst. conjugate (1612, 1582, 1508 cm -1 )
CF 3 1178 cm -1
A un mélange de 2,54 g de produit obtenu comme en a) de l'exemple 11 avec 20 cm 3 de tétrahydrofuranne et 0,2 cm 3 de triéthylamine on ajoute 1 g de 2-amino-2-cyano propane et 1 cm 3 de tétrahydrofuranne on agite à température ambiante. On évapore à sec et chromatographie le résidu (3,5 g) sur silice éluant acétate d'éthyle-cyclohexane (7-3) puis cyclohexaneacétate d'éthyle (1-1) et obtient 940 mg de produit recherché dont on recristallise 300 mg dans l'isopropanol pour recueillir 263 mg de produit F = 296°C.
OH/NH 3260 cm -1
C≡N 2230 cm -1
C=S 1764 cm -1
aromatique + C=C (1612, 1575, 1530, 1501 cm -1 )To a mixture of 2.54 g of product obtained as in a) of Example 11 with 20 cm 3 of tetrahydrofuran and 0.2 cm 3 of triethylamine is added 1 g of 2-amino-2-cyano propane and 1 cm 3 of tetrahydrofuran is stirred at room temperature. The residue is evaporated to dryness and the residue (3.5 g) is chromatographed on silica eluting with ethyl acetate-cyclohexane (7-3) then ethyl cyclohexaneacetate (1-1) and 940 mg of sought product is obtained, from which 300 mg is recrystallized. in isopropanol to collect 263 mg of product F = 296 ° C.
OH / NH 3260 cm -1
C≡N 2230 cm -1
C = S 1764 cm -1
aromatic + C = C (1612, 1575, 1530, 1501 cm -1 )
Une nouvelle préparation du produit a été effectuée en remplaçant le tétrahydrofuranne par le 1,2-dichloroéthane.A new preparation of the product was carried out by replacing tetrahydrofuran with 1,2-dichloroethane.
Le produit attendu, insoluble, précipite. On obtient ainsi le produit recherché avec un rendement de 60 %.The expected product, insoluble, precipitates. The desired product is thus obtained with a yield of 60%.
On agite pendant 1 heure au reflux 635 mg du produit obtenu à l'exemple 14 et 14 cm 3 d'acide chlorhydrique dilué au demi. On refroidit, ajoute 100 cm 3 d'eau et extrait avec de l'acétate d'éthyle, lave à l'eau salée, sèche et évapore à sec on obtient 600 mg de produit que l'on chromatographie sur silice éluant chlorure de méthylène-acétone (95-5) on obtient 590 mg du produit attendu (F = 190-191°C) que l'on recristallise dans l'isopropanol pour obtenir 490 mg du produit recherché F = 190-191°C.
=C-NH 3430 cm -1
C≡N 2230 cm -1
C=O 1766 cm -1
Syst. conjugué + aromatiques (1612, 1578, 1505 cm -1 )Stirred for 1 hour at reflux 635 mg of the product obtained in Example 14 and 14 cm 3 of hydrochloric acid diluted to half. Cool, add 100 cm 3 of water and extract with ethyl acetate, wash with salt water, dry and evaporate to dryness 600 mg of product is obtained which is chromatographed on silica eluting with methylene chloride -acetone (95-5), 590 mg of the expected product is obtained (F = 190-191 ° C) which is recrystallized from isopropanol to obtain 490 mg of the desired product F = 190-191 ° C.
= C-NH 3430 cm -1
C≡N 2230 cm -1
C = O 1766 cm -1
Syst. conjugate + aromatic (1612, 1578, 1505 cm -1 )
On opère comme à l'exemple 1 à partir de 1 g de 1-(3′-trifluorométhyl 4-nitrophényl) 4,4-diméthyl imidazoline-2,5-dione (obtenu selon BF 2.329.276) en utilisant 170 mg d'hydrure de sodium et 0,47 cm 3 de 1-bromopentane, après chromatographie sur silice, éluant chlorure de méthylène-cyclohexane (8-2) on obtient 1,23 g de produit recherché que l'on cristallise dans l'isopropanol pour recueillir 995 mg de produit F = 84°C.
C=O (1778, 1723 cm -1 )
NO 2 (1544, 1360 cm -1 )The procedure is as in Example 1, starting from 1 g of 1- (3′-trifluoromethyl 4-nitrophenyl) 4,4-dimethyl imidazoline-2,5-dione (obtained according to BF 2,329,276) using 170 mg d sodium hydride and 0.47 cm 3 of 1-bromopentane, after chromatography on silica, eluting with methylene chloride-cyclohexane (8-2), 1.23 g of sought product is obtained which is crystallized from isopropanol to collect 995 mg of product F = 84 ° C.
C = O (1778, 1723 cm -1 )
NO 2 (1544, 1360 cm -1 )
On opère comme à l'exemple 1 à partir de 1 g de 1-(3′-trifluorométhyl 4-nitrophényl) 4,4-diméthyl imidazoline 2,5-dione (obtenu selon BF 2.329.276) en utilisant 170 mg d'hydrure de sodium à 50 % dans l'huile et 0,7 cm 3 de 1-bromononane. Après chromatographie sur silice on obtient 1,08 g du produit recherché F = 63°C.
C=O (1788, 1723 cm -1 )
NO 2 (1544, 1359 cm -1 )The procedure is as in Example 1, starting from 1 g of 1- (3′-trifluoromethyl 4-nitrophenyl) 4,4-dimethyl imidazoline 2,5-dione (obtained according to BF 2,329,276) using 170 mg of 50% sodium hydride in oil and 0.7 cm 3 of 1-bromononane. After chromatography on silica, 1.08 g of the desired product is obtained, F = 63 ° C.
C = O (1788, 1723 cm -1 )
NO 2 (1544, 1359 cm -1 )
En opérant comme à l'exemple 1 au départ de 300 mg de produit décrit à l'exemple 8 on obtient 275 mg de produit attendu (F=158°C).
Spectre IR (CHCl 3 ) : C=O (1780, 1727 cm -1 )
aromatiques : (1615, 1574, 1505 cm -1 )
C≡N : 2238 cm -1 By operating as in Example 1 starting from 300 mg of product described in Example 8, 275 mg of product are obtained. expected (M = 158 ° C).
IR spectrum (CHCl 3 ): C = O (1780, 1727 cm -1 )
aromatic: (1615, 1574, 1505 cm -1 )
C≡N: 2238 cm -1
On porte au reflux pendant 9 heures une suspension de 230 mg de produit obtenu à l'exemple 18 dans 1,4 cm 3 de toluène et 78 mg de réactif de Lawesson, ramène à température ambiante puis évapore à sec. On purifie les 330 mg de produit obtenus par chromatographie sur silice (éluant chlorure de méthylène-acétone 99:1).A suspension of 230 mg of product obtained in Example 18 in 1.4 cm 3 of toluene and 78 mg of Lawesson reagent is brought to reflux for 9 hours, brought to room temperature and then evaporated to dryness. The 330 mg of product obtained is purified by chromatography on silica (eluent methylene chloride-acetone 99: 1).
On obtient par ordre d'élution :
- 46 mg de produit C (Rf=0,63 F=210-211°C) identique au produit décrit à l'exemple 13 ;
- 26 mg de produit B (Rf=0,49 F=170-171°C) identique au produit décrit à l'exemple 12 ;
- 42 mg de produit A (Rf=0,34 F=194°C).
- 46 mg of product C (Rf = 0.63 F = 210-211 ° C) identical to the product described in Example 13;
- 26 mg of product B (Rf = 0.49 F = 170-171 ° C) identical to the product described in Example 12;
- 42 mg of product A (Rf = 0.34 F = 194 ° C).
Analyse physique du produit A.
- Spectre IR (CHCl 3 ) :
- C=O :1760 cm -1
-C≡N : 2235 cm -1 - aromatiques :
- (1615, 1580, 1508 cm -1 )
max 228 nm epsilon = 19400
256 nm epsilon = 12100
298 nm epsilon = 8600
390 nm epsilon = 70Physical analysis of product A.
- IR spectrum (CHCl 3 ):
- C = O: 1760 cm -1
-C≡N: 2235 cm -1 - aromatic:
- (1615, 1580, 1508 cm -1 )
max 228 nm epsilon = 19400
256 nm epsilon = 12100
298 nm epsilon = 8600
390 nm epsilon = 70
On ajoute une solution de 626 mg de produit de l'exemple 15 dans 6 cm 3 de diméthylformamide à une suspension constituée de 108 mg d'hydrure de sodium à 50 % dans l'huile et 1,8 cm 3 de diméthylformamide. On rince avec 0,3 cm 3 de diméthylformamide et agite pendant 10 minutes après cessation du dégagement d'hydrogène. On ajoute alors, goutte à goutte, 0,19 cm 3 d'iodure de méthyle dans 1 cm 3 de diméthylformamide.A solution of 626 mg of product of Example 15 in 6 cm 3 of dimethylformamide is added to a suspension consisting of 108 mg of 50% sodium hydride in oil and 1.8 cm 3 of dimethylformamide. Rinsed with 0.3 cm 3 of dimethylformamide and stirred for 10 minutes after cessation of the evolution of hydrogen. 0.19 cm 3 is then added dropwise methyl iodide in 1 cm 3 of dimethylformamide.
Après 45 minutes de réaction on verse sur 50 g d'un mélange glace-eau contenant 0,5 g de phosphate monopotassique et extrait 4 fois à l'éther. On lave la phase organique à l'eau salée, sèche sur sulfate de magnésium et évapore à sec. On purifie les 668 mg de produit obtenu par chromatographie sur silice (éluant CH 2 Cl 2 -AcOEt 95:5).After 45 minutes of reaction, pour onto 50 g of an ice-water mixture containing 0.5 g of monopotassium phosphate and extracted 4 times with ether. The organic phase is washed with salt water, dried over magnesium sulfate and evaporated to dryness. The 668 mg of product obtained is purified by chromatography on silica (eluent CH 2 Cl 2 -AcOEt 95: 5).
On obtient 640 mg de produit que l'on chromatographie à nouveau sur silice (éluant cyclohexane-AcOEt 7:3) et obtient après reprise à l'éther 507 mg de produit recherché F = 62°C.
Spectre Infra-Rouge
C=O : 1747 cm -1
C=N et aromatique (1614, 1581, 1569, 1503 cm -1 )
Spectre Ultra-Violet (EtOH)
max 209 nm Epsilon = 26000
infl 236 nm Epsilon = 11500
infl 264 nm Epsilon = 8700640 mg of product is obtained which is again chromatographed on silica (eluent cyclohexane-AcOEt 7: 3) and after 50% of sought product is obtained after recovery with ether. F = 62 ° C.
Infra-red spectrum
C = O: 1747 cm -1
C = N and aromatic (1614, 1581, 1569, 1503 cm -1 )
Ultra-violet spectrum (EtOH)
max 209 nm Epsilon = 26000
infl 236 nm Epsilon = 11500
infl 264 nm Epsilon = 8700
A 53 mg d'hydrure de sodium en suspension dans 0,5 cm 3 de diméthylformamide, on ajoute en 5 minutes 313 mg de 4-(4,4-diméthyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluorométhyl)-benzonitrile préparé comme à l'exemple 15 en solution dans 3 cm 3 de diméthylformamide. On agite 10 minutes, ajoute 0,1 cm 3 de bromure de benzyle et maintient 30 minutes sous agitation. On verse le milieu réactionnel dans l'eau glacée additionnée de 500 mg de phosphate de potassium, extrait à l'éther, lave la phase organique à l'eau salée, sèche et évapore le solvant. On obtient 450 mg de produit brut que l'on chromatographie sur silice (éluant : chlorure de méthylèneacétate d'éthyle 97,5-2,5). On recueille 316 mg de produit attendu. Rf = 0,38.
- C=O :
- 1746 cm -1
- C≡N :
- 2236 cm -1
- Système conjugué + aromatiques :
- 1614, 1580, 1570, 1503, 1499 cm -1
- C = O:
- 1746 cm -1
- C≡N:
- 2236 cm -1
- Conjugated system + aromatics:
- 1614, 1580, 1570, 1503, 1499 cm -1
On porte 30 minutes au reflux une solution comprenant 2,11 g de l'isothiocyanate préparé au stade a) de l'exemple 11 avec 1,18 g de mélange de 2-[(2-hydroxyéthyl) amino] 2-méthylpropane nitrile et de 2,2-diméthyloxazolidine (8-2) dans 20 cm 3 de tétrahydrofuranne en présence de 0,5 cm 3 de triéthylamine. On évapore le solvant, chromatographie le résidu sur silice (éluant : chlorure de méthylène-acétone 95-5) et obtient 1,26 g de produit attendu brut et 686 mg de N-[4-cyano 2-(trifluorométhyl) phényl] 2,2-diméthyl 3-oxazolidinecarbothioamide. On dissout les 686 mg de ce produit dans 10 cm 3 d'acétate d'éthyle, ajoute 30 cm 3 de cyclohexane, concentre à 4 cm 3 , essore et sèche pour obtenir 518 mg de produit attendu supplémentaire. On dissout le produit brut dans 20 cm 3 d'isopropanol, concentre à 5 cm 3 essore et sèche. On obtient 1,04 g de produit attendu. F = 181°C.
- OH
- : 3630 cm -1
- >=NH
- : 3314, 1677 cm -1
- C≡N
- : 2230 cm -1
- aromatiques
- : 1611, 1576, 1504 cm -1
- OH
- : 3630 cm -1
- > = NH
- : 3314, 1677 cm -1
- C≡N
- : 2230 cm -1
- aromatic
- : 1611, 1576, 1504 cm -1
On ajoute goutte à goutte à une température comprise entre 20°C et 30°C, 8 cm 3 d'éthanoline à 12,3 cm 3 de cyanhydrine de l'acétone. On agite pendant 18 heures, distille sous pression réduite et recueille 2,3 g de mélange comprenant le produit attendu et du 2,2-diméthyloxazolidine, utilisé tel quel pour le stade suivant.8 cm 3 of ethanoline to 12.3 cm 3 of acetone cyanohydrin are added dropwise at a temperature between 20 ° C and 30 ° C. Stirred for 18 hours, distilled under reduced pressure and collected 2.3 g of mixture comprising the expected product and 2,2-dimethyloxazolidine, used as it is for the following stage.
On chauffe pendant 10 minutes au reflux 680 mg de produit obtenu à l'exemple 22 dans 7 cm 3 d'eau en présence de 7 cm 3 d'acide chlorhydrique, refroidit à température ambiante, extrait à l'acétate d'éthyle, lave la phase organique à l'eau salée, sèche et évapore le solvant. Après chromatographie du résidu sur silice (éluant : cyclohexane-acétate d'éthyle 1-1), on obtient 119 mg de produit B soit le dérivé 2,5-dioxo 3-(2-mercaptoéthyl) rf = 0,35 et 569 mg de produit A soit le dérivé 5-oxo 2-thioxo 3-(2-hydroxyéthyl) rf = 0,14; F ≈ 130°C.
Produit A:
- OH
- : 3626 cm -1
- C≡N
- : 2236 cm -1
- C=O
- : 1763 cm -1
- aromatiques
- : 1615, 1578, 1504 cm -1
Absence d'OH
- C≡N
- : 2228 cm -1
- C=O
- : 1780, 1726 cm -1
- aromatiques
- : 1615, 1578, 1505 cm -1
Product A:
- OH
- : 3626 cm -1
- C≡N
- : 2236 cm -1
- C = O
- : 1763 cm -1
- aromatic
- : 1615, 1578, 1504 cm -1
Absence of OH
- C≡N
- : 2228 cm -1
- C = O
- : 1780, 1726 cm -1
- aromatic
- : 1615, 1578, 1505 cm -1
En opérant comme indiqué dans les exemples 1 à 23 :
A) en utilisant le 4-(4,4-diméthyl 2,5-dioxo 1-imidazolidinyl) 2-(trifluorométhyl) benzonitrile préparé comme à l'exemple 8 et les réactifs appropriés, on a obtenu les composés des exemples suivants :By operating as indicated in examples 1 to 23:
A) using 4- (4,4-dimethyl 2,5-dioxo 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile prepared as in Example 8 and the appropriate reagents, the compounds of the following examples were obtained:
F= 100-101°C.
- C≡N
- : 2238 cm -1
- C=O
- : 1777, 1724 cm -1
- aromatiques
- : 1617, 1575, 1505 cm -1
- C≡N
- : 2238 cm -1
- C = O
- : 1777, 1724 cm -1
- aromatic
- : 1617, 1575, 1505 cm -1
F = 109-110°C.
- C≡N
- : 2238 cm -1
- C=O
- : 1728, 1725 cm -1
- HC=CH 2
- : 1645 cm -1
- aromatiques
- : 1616, 1575, 1505 cm -1
- C≡N
- : 2238 cm -1
- C = O
- : 1728, 1725 cm -1
- HC = CH 2
- : 1645 cm -1
- aromatic
- : 1616, 1575, 1505 cm -1
F = 98-99°C.
- =C-NH
- : 3430 cm -1
- C≡N
- : 2238 cm -1
- C=O
- : 1779, 1724 cm -1
- aromatiques
- : 1615, 1605, 1575, 1504, 1497 cm -1
- = C-NH
- : 3430 cm -1
- C≡N
- : 2238 cm -1
- C = O
- : 1779, 1724 cm -1
- aromatic
- : 1615, 1605, 1575, 1504, 1497 cm -1
F = 101-102°C.
- C≡N
- : 2238 cm -1
- C=O
- : 1780, 1724 cm -1
- aromatiques
- : 1615, 1612, 1505 cm -1
- C≡N
- : 2238 cm -1
- C = O
- : 1780, 1724 cm -1
- aromatic
- : 1615, 1612, 1505 cm -1
F = 95-96°C.
- C≡N
- : 2238 cm -1
- C=O
- : 1778, 1723 cm -1
- aromatiques
- : 1615, 1584, 1514, 1505 cm -1
- C≡N
- : 2238 cm -1
- C = O
- : 1778, 1723 cm -1
- aromatic
- : 1615, 1584, 1514, 1505 cm -1
F ≈ 89-90°C.
- C≡N
- : 2238 cm -1
- C=O
- : 1615, 1505 cm -1
- aromatiques
- : 1615, 1505 cm -1
- C≡N
- : 2238 cm -1
- C = O
- : 1615, 1505 cm -1
- aromatic
- : 1615, 1505 cm -1
F =112-113°C.
- C≡N
- : 2235 cm -1
- C=O
- : 1781, 1725 cm -1
- aromatiques
- : 1615, 1576,1505 cm -1
- C≡N
- : 2235 cm -1
- C = O
- : 1781, 1725 cm -1
- aromatic
- : 1615, 1576,1505 cm -1
F = 113-114°C.
- C≡N
- :2236 cm -1
- C=O
- : 1778, 1725 cm -1
- aromatiques
- : 1616, 1505 cm -1
- C≡N
- : 2236 cm -1
- C = O
- : 1778, 1725 cm -1
- aromatic
- : 1616, 1505 cm -1
F = 138-139°C.
- C≡N
- : 2236 cm -1
- C=O
- : 1778, 1724 cm -1
- aromatiques
- : 1616, 1575, 1505 cm -1
- C≡N
- : 2236 cm -1
- C = O
- : 1778, 1724 cm -1
- aromatic
- : 1616, 1575, 1505 cm -1
rf = 0,35 (éluant : chlorure de méthylène-acétate d'éthyle 97,5-2,5).rf = 0.35 (eluent: methylene chloride-ethyl acetate 97.5-2.5).
rf = 0,17 (éluant : chlorure de méthylène-acétate d'éthyle 8-2).rf = 0.17 (eluent: methylene chloride-ethyl acetate 8-2).
rf = 0,20 (éluant : cyclohexane-acétate d'éthyle 65-35).
C) En utilisant le thiocyanate préparé à l'exemple 11 et les réactifs appropriés, on a obtenu les composés suivants :rf = 0.20 (eluent: cyclohexane-ethyl acetate 65-35).
C) Using the thiocyanate prepared in Example 11 and the appropriate reagents, the following compounds were obtained:
rf = 0,16 (éluant : chlorure de méthylène-acétone 95-5).rf = 0.16 (eluent: methylene chloride-acetone 95-5).
rf = 0,35 (éluant : acétate d'éthyle-cyclohexane 8-2).
D) En utilisant respectivement le 4-(4,4-diméthyl 3-éthyl 5-imino 2-thioxo 1-imidazolidinyl) 2-(trifluorométhyl) benzonitrile préparé comme à l'exemple 36 et le 4-(4,4-diméthyl 5-imino 3-pentyl 2-thioxo 1-imidazolidinyl) 2-(trifluorométhyl) benzonitrile préparé comme à l'exemple 37 et l'acide chlorhydrique au demi, on a obtenu les composés suivants :rf = 0.35 (eluent: ethyl acetate-cyclohexane 8-2).
D) Using 4- (4,4-dimethyl 3-ethyl 5-imino, respectively) 2-thioxo 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile prepared as in Example 36 and 4- (4,4-dimethyl 5-imino 3-pentyl 2-thioxo 1-imidazolidinyl) 2- (trifluoromethyl) benzonitrile prepared as in Example 37 and half hydrochloric acid, the following compounds were obtained:
rf = 0,38 (éluant : acétate d'éthyle-cyclohexane 1-1).rf = 0.38 (eluent: ethyl acetate-cyclohexane 1-1).
F = 78°C. rf = 0,66 (éluant : acétate d'éthyle-cyclohexane 8-2).
E) En utilisant le 4-(4,5-dihydro 4,4-diméthyl 2-(méthylthio) 5-oxo 1H-imidazol-1-yl) 2-(trifluorométhyl)-benzonitrile préparé comme à l'exemple 20 et le 4-[4,5-dihydro 4,4-diméthyl 5-oxo 2-[(phénylméthyl) thio] 1H-imidazol-1-yl] 2-(trifluorométhyl) benzonitrile préparé comme à l'exemple 21 et le réactif de Lawesson, on a obtenu les composés suivants :Mp 78 ° C. rf = 0.66 (eluent: ethyl acetate-cyclohexane 8-2).
E) Using 4- (4,5-dihydro 4,4-dimethyl 2- (methylthio) 5-oxo 1H-imidazol-1-yl) 2- (trifluoromethyl) -benzonitrile prepared as in Example 20 and the 4- [4,5-dihydro 4,4-dimethyl 5-oxo 2 - [(phenylmethyl) thio] 1H-imidazol-1-yl] 2- (trifluoromethyl) benzonitrile prepared as in Example 21 and the Lawesson reagent , the following compounds were obtained:
rf = 0,36 (éluant : chlorure de méthylène-acétate d'éthyle 97,5-2,5).rf = 0.36 (eluent: methylene chloride-ethyl acetate 97.5-2.5).
rf = 0,62 (éluant : chlorure de méthylène-acétate d'éthyle 98-2).rf = 0.62 (eluent: methylene chloride-ethyl acetate 98-2).
On ajoute 0,1 cm 3 de N-méthylmorpholine à 235 mg d'acide 3-[4-cyano 3-(trifluorométhyl) phényl] 5,5-diméthyl 2,4-dioxo 1-imidazolidine acétique préparé comme à l'exemple 9, en suspension dans 4 cm 3 de chlorure de méthylène. On refroidit la solution obtenue à -10°C, ajoute goutte à goutte 0,1 cm 3 de chloroformiate d'isobutyle et agite 25 minutes à -10°C. On ajoute 0,15 cm 3 de N-méthyl N-isopropylamine, laisse revenir à température ambiante en 40 minutes environ, ajoute 5 cm 3 d'une solution aqueuse saturée en bicarbonate de sodium, agite 30 minutes, extrait au chlorure de méthylène, lave la phase organique à l'eau, sèche et évapore le solvant sous pression réduite. Après chromatographie sur silice (éluant : chlorure de méthylène-acétone 96-4), on obtient 147 mg de produit attendu.
Spectre IR (CHCl 3 )
- C≡N
- : 2236 cm -1
- C=O hydantoïne
- : 1783, 1728 cm -1
- C=O amide
- : 1661 cm -1
- aromatiques
- : 1615, 1575, 1505 cm -1
IR spectrum (CHCl 3 )
- C≡N
- : 2236 cm -1
- C = O hydantoin
- : 1783, 1728 cm -1
- C = O amide
- : 1661 cm -1
- aromatic
- : 1615, 1575, 1505 cm -1
On opère comme à l'exemple 9 à partir de 900 mg de produit obtenu à l'exemple 8 et 1,91 g de 2-bromoéthanolterbutyl-diméthylsilyléther. On obtient 1 g de l'éther silyloxy dérivé. F = 86-87°C après chromatographie sur silice (éluant : cyclohexane-acétate d'éthyle 7-3).The procedure is as in Example 9 from 900 mg of product obtained in Example 8 and 1.91 g of 2-bromoethanolterbutyl-dimethylsilylether. 1 g of the silyloxy ether derivative is obtained. Mp 86-87 ° C after chromatography on silica (eluent: cyclohexane-ethyl acetate 7-3).
On ajoute 1 cm 3 d'acide chlorhydrique 2N à 380 mg de produit obtenu ci-dessus en solution dans 4 cm 3 de méthanol et 1 cm 3 de chlorure de méthylène. On agite 40 minutes à température ambiante, verse sur 15 cm 3 d'eau, extrait au chlorure de méthylène, lave à l'eau, sèche et évapore le solvant. On purifie le résidu par chromatographie sur silice (éluant : chlorure de méthylène-acétate d'éthyle 7-3), rf = 0,9, cristallise dans l'éther et recueille 270 mg de produit attendu. F = 109-110°C après cristallisation dans l'isopropanol.
En opérant de manière identique, en utilisant au départ le 2-bromopropanoltertubyldiméthylsilyléther, on a préparé le produit suivant :By operating in an identical manner, initially using 2-bromopropanoltertubyldimethylsilylether, the following product was prepared:
F = 131-132°C. Rf = 0,13 (éluant : CH 2 Cl 2 -AcOEt 75-25).Mp 131-132 ° C. Rf = 0.13 (eluent: CH 2 Cl 2 -AcOEt 75-25).
On agite 30 minutes à température ambiante, 215 mg de produit obtenu à l'exemple 43, 15 mg de 4-diméthylaminopyridine, 1 cm 3 de pyridine et 0,5 cm 3 d'anhydride acétique. On verse le milieu réactionnel dans 20 cm 3 d'une solution aqueuse saturée en bicarbonate de sodium, agite 20 minutes, extrait à l'acétate d'éthyle, lave à l'eau, évapore à sec. On élimine la pyridine et l'acide acétique résiduel par distillation, purifie le résidu par chromatographie sur silice (éluant : chlorure de méthylène-acétate d'éthyle 65-35), reprend le résidu (rf = 0,35) à l'isopropanol, concentre partiellement, glace, essore et obtient après séchage, 210 mg de produit attendu. F = 99-100°C.
En opérant comme dans les exemples précédents, on a préparé les exemples des produits suivants :By operating as in the previous examples, the examples of the following products were prepared:
F = 101-102°C.Mp 101-102 ° C.
F = 68-69°C.Mp 68-69 ° C.
F = 186-187°C.Mp 186-187 ° C.
F = 135-136°C.Mp 135-136 ° C.
F = 120-121°C.M = 120-121 ° C.
On chauffe 16 heures au reflux 2,4 g d'isocyanate de 3,4-dichlorophényle et 1,3 cm 3 de 2-méthylamino 2-cyanopropane dans 23 cm 3 de tétrahydrofuranne en présence de 0,23 cm 3 de triéthylamine. On élimine le solvant sous pression réduite et purifie le résidu par chromatographie sur silice (éluant : chlorure de méthylène-acétone 96-4 puis acétate d'éthylecyclohexane 1-1). Après cristallisation dans l'éther, on obtient 2,54 g de produit attendu. F = 133°C.2.4 g of 3,4-dichlorophenyl isocyanate and 1.3 cm 3 of 2-methylamino 2-cyanopropane are heated at reflux for 16 hours. in 23 cm 3 of tetrahydrofuran in the presence of 0.23 cm 3 of triethylamine. The solvent is removed under reduced pressure and the residue is purified by chromatography on silica (eluent: methylene chloride-acetone 96-4 then ethylecyclohexane acetate 1-1). After crystallization from ether, 2.54 g of expected product is obtained. Mp 133 ° C.
On chauffe au reflux 45 minutes 1,88 g de produit obtenu à l'exemple 51 en suspension dans 14 cm 3 d'acide chlorhydrique 6N puis ajoute de nouveau 14 cm 3 d'acide chlorhydrique 6N et poursuit le chauffage pendant 2 heures. Après une nouvelle addition de 4 cm 3 d'acide chlorhydrique 6N et chauffage au reflux pendant 1 heure et demie, on laisse revenir à température ambiante, ajoute 100 g de glace et extrait à l'acétate d'éthyle. On lave la phase organique à l'eau, sèche et évapore le solvant. Après chromatographie sur silice (éluant : cyclohexane-acétate d'éthyle 1-1), on obtient 1,84 g de produit attendu. F = 129°C après cristallisation dans l'isopropanol.
- C=O
- : 1753 cm -1
- C=S et aromatiques
- : 1595, 1570, 1496 cm -1
- C = O
- : 1753 cm -1
- C = S and aromatic
- : 1595, 1570, 1496 cm -1
En opérant comme dans les exemples précédents en utilisant les produits et réactifs appropriés, on a préparé les composés suivants :By operating as in the previous examples using the appropriate products and reagents, the following compounds were prepared:
F = 110°C.Mp 110 ° C.
F ≈ 146°C.F ≈ 146 ° C.
F = 176°C.Mp 176 ° C.
F = 173-174°C.Mp 173-174 ° C.
Spectre IR (CHCl 3 )
- C=O
- : 1736 cm -1
- C=N et aromatiques
- : 1578, 1496 cm -1
- C = O
- : 1736 cm -1
- C = N and aromatics
- : 1578, 1496 cm -1
En plus des produits décrits ci-dessus, les produits suivants constituent des produits pouvant être obtenus dans le cadre de la présente invention, à savoir les produits de formule :
. -(CH 2 ) n Cl
. -(CH 2 ) n -OH
. (CH 2 ) n -COO-alk
. -(CH 2 ) n -CO-alk
. -(CH 2 ) n -C≡N
alk, alk 1 et alk 2 représentant un radical alkyle renfermant jusqu'à 4 atomes de carbone et n représente un nombre entier compris entre 1 et 4.In addition to the products described above, the following products constitute products which can be obtained in the context of the present invention, namely the products of formula:
. - (CH 2 ) n Cl
. - (CH 2 ) n -OH
. (CH 2 ) n -COO-alk
. - (CH 2 ) n -CO-alk
. - (CH 2 ) n -C ≡ N
alk, alk 1 and alk 2 representing an alkyl radical containing up to 4 carbon atoms and n represents an integer between 1 and 4.
On a préparé un comprimé ayant la composition suivante :
- 4-(5-oxo-2-thioxo-3,4,4-triméthyl 1-imidazolinyl)-2-(trifluorométhyl) benzonitrile 100 mg
- Excipient q.s. pour un comprimé terminé à 300 mg
- 4- (5-oxo-2-thioxo-3,4,4-trimethyl 1-imidazolinyl) -2- (trifluoromethyl) benzonitrile 100 mg
- Excipient qs for a tablet finished at 300 mg
Des rats mâles Sprague Dawley EOPS de 180-200 g, castrés de 24 heures, sont sacrifiés, les prostates prélevées, pesées et homogénéisées à 0°C à l'aide d'un potter verre-verre, dans une solution tamponnée (Tris 10mM, saccharose 0,25M, PMSF (phénylméthanesulfonylfluoride) 0,1mM, Molybdate de sodium 20mM, HCl pH 7,4 ; auxquels on ajoute extemporanément 2mM de DTT (DL dithiothreitol), à raison de 1 g de tissu pour 8 ml de tampon.Male rats Sprague Dawley EOPS of 180-200 g, castrated for 24 hours, are sacrificed, the prostates removed, weighed and homogenized at 0 ° C using a glass-glass potter, in a buffered solution (Tris 10mM , 0.25M sucrose, PMSF (phenylmethanesulfonylfluoride) 0.1mM, 20mM sodium molybdate, HCl pH 7.4; to which 2mM DTT (DL dithiothreitol) is added immediately, at the rate of 1 g of tissue per 8 ml of buffer.
L'homogénat est ensuite ultracentrifugé à 0°C, 45 minutes à 105 000 g. Des aliquotes du surnageant obtenu (=cytosol), sont incubées 30 minutes et 24 heures à 0°C, avec une concentration constante (T) de Testostérone tritiée et en présence de concentrations croissantes (0 à 2500.10 -9 M), soit de testostérone froide, soit des produits à tester. La concentration de Testostérone tritiée liée (B) est ensuite mesurée dans chaque incubat par la méthode d'adsorption au charbon-dextran.The homogenate is then ultracentrifuged at 0 ° C, 45 minutes at 105,000 g. Aliquots of the supernatant obtained (= cytosol) are incubated for 30 minutes and 24 hours at 0 ° C, with a constant concentration (T) of tritiated Testosterone and in the presence of increasing concentrations (0 to 2500.10 -9 M), ie testosterone cold, or products to be tested. The concentration of bound tritiated testosterone (B) is then measured in each incubate by the carbon-dextran adsorption method.
On trace les 2 courbes suivantes : le pourcentage de l'hormone tritiée liée B/T en fonction du logarithme de la concentration de l'hormone de référence froide et B/T en fonction du logarithme de la concentration du produit froid testé. On détermine la droite d'équation I 50 =(B/Tmax + B/Tmin)/2.
B/T max= % de l'hormone tritiée liée pour une incubation de cette hormone tritiée à la concentration (T).
B/T min= % de l'hormone tritiée liée pour une incubation de cette hormone tritiée à la concentration (T) en présence d'un grand excès d'hormone froide (2500.10 -9 M).We draw the following 2 curves: the percentage of the bound tritiated hormone B / T as a function of the logarithm of the concentration of the cold reference hormone and B / T as a function of the logarithm of the concentration of the cold product tested. We determine the line of equation I 50 = (B / Tmax + B / Tmin) / 2.
B / T max =% of the tritiated hormone bound for an incubation of this tritiated hormone at the concentration (T).
B / T min =% of the tritiated hormone bound for an incubation of this tritiated hormone at the concentration (T) in the presence of a large excess of cold hormone (2500.10 -9 M).
Les intersections de la droite I 50 et des courbes, permettent d'évaluer les concentrations de l'hormone de référence froide (CH) et du produit froid testé (CX) qui inhibent de 50 % la liaison de l'hormone tritiée sur le récepteur. L'affinité relative de liaison (ARL) du produit testé est déterminé par l'équation ARL=100 (CH)/(CX).The intersections of the straight line I 50 and the curves make it possible to evaluate the concentrations of the cold reference hormone (CH) and of the cold product tested (CX) which inhibit by 50% the binding of the tritiated hormone to the receptor . The relative binding affinity (ARL) of the test product is determined by the equation ARL = 100 (CH) / (CX).
On obtient les résultats suivants exprimés en ARL.The following results are obtained, expressed in ARL.
Produit de référence (Testostérone) : 100
Des souris mâles SWISS âgées de 6 semaines, et castrées de 24 heures, reçoivent par voie orale les produits à étudier (suspension en méthyl cellulose à 0,5 %), simultanément avec une injection sous-cutanée de Propionate de testostérone 3 mg/kg (solution en huile de sésame, contenant 5 % d'alcool benzylique) pour déterminer l'activité anti-androgène. L'activité agoniste est déterminèe en l'absence de propionate de testostérone.SWISS male mice aged 6 weeks, and castrated for 24 hours, receive the oral products to be studied (methyl cellulose suspension at 0.5%), simultaneously with a subcutaneous injection of testosterone propionate 3 mg / kg (sesame oil solution, containing 5% benzyl alcohol) to determine the anti-androgen activity. Agonist activity is determined in the absence of testosterone propionate.
Les produits à étudier ainsi que le Propionate de testostérone sont administrés sous un volume de 10 ml/kg.The test products and testosterone propionate are administered in a volume of 10 ml / kg.
16 heures après les traitements, les animaux sont sacrifiés, les reins prélevés, puis homogénéisés à 0°C , à l'aide d'un broyeur téflon-verre dans 10 volumes de tampon Tris-HCl 50 mM (pH 7,4) contenant 250 uM de phosphate de pyridoxal, 0,1 mM EDTA, et 5 mM de dithiothreitol. L'homogenat est ensuite centrifugé à 105000 g pendant 45 mn.16 hours after the treatments, the animals are sacrificed, the kidneys removed, then homogenized at 0 ° C., using a teflon-glass grinder in 10 volumes of 50 mM Tris-HCl buffer (pH 7.4) containing 250 µM pyridoxal phosphate, 0.1 mM EDTA, and 5 mM dithiothreitol. The homogenate is then centrifuged at 105,000 g for 45 min.
A 37°C, l'ornithine décarboxylase rénale transforme un mélange isotopique d'ornithine froide et d'ornithine tritiée en putrescine froide et putrescine tritiée.At 37 ° C, renal ornithine decarboxylase transforms an isotopic mixture of cold ornithine and tritiated ornithine into cold putrescine and tritiated putrescine.
La putrescine est ensuite recueillie sur des papiers sélectifs, échangeurs d'ions. Après séchage, l'excès d'ornithine tritiée et froide non transformée est éliminé, par 3 lavages d'ammoniaque 0,1 M. Les papiers sont séchés, puis la radioactivité est comptée après addition de scintillant Aqualite.The putrescine is then collected on selective papers, ion exchangers. After drying, the excess of unprocessed tritiated and cold ornithine is eliminated by 3 washes of 0.1 M ammonia. The papers are dried, then the radioactivity is counted after addition of Aqualite scintillant.
Les résultats sont exprimés en fmoles (10 -15 M) de putrescine tritiée formée/heure/mg de protéines.The results are expressed in fmoles (10 -15 M) of tritiated putrescine formed / hour / mg of proteins.
On obtient les résultats suivants :
Les tests indiqués ci-dessus montrent que les produits de l'invention testés possèdent une forte activité anti-androgène et sont dénués d'activité agoniste.The tests indicated above show that the products of the invention tested have a strong anti-androgenic activity and are devoid of agonist activity.
Claims (14)
- Process for preparing the products of general formula (I):R1 represents a cyano or nitro radical or a halogen atom,R2 represents a trifluoromethyl radical or a halogen atom, the group -A-B- is chosen from the radicals:- a hydrogen atom,- alkyl, alkenyl, alkynyl, aryl or arylalkyl radicals having at most 12 carbon atoms, these radicals being optionally substituted by one or more substituents chosen from the following radicals: hydroxy, halogen, mercapto, cyano, acyl or acyloxy having at most 7 carbon atoms, optionally substituted S-aryl, in which the sulphur atom is optionally oxidized in the form of the sulphoxide or sulphone, free, esterified, amidified or salified carboxy, amino, mono- or dialkylamino or a heterocyclic radical having 3 to 6 links and containing one or more heteroatoms chosen from sulphur, oxygen or nitrogen atoms,the alkyl, alkenyl or alkynyl radicals being moreover optionally interrupted by one or more oxygen, nitrogen or sulphur atoms optionally oxidized in the form of the sulphoxide or sulphone,
the aryl and aralkyl radicals moreover being optionally substituted by one of the following radicals: alkyl, alkenyl or alkynyl, alkoxy, alkenyloxy, alkynyloxy or trifluoromethyl,
Y represents an oxygen or sulphur atom or an =NH radical, with the exception of the products in which the group -A-B- represents the radical:
either a product of formula (II):a) elimination reaction of the optional protective groups which can be carried by R'3;b) hydrolysis reaction of the >C=NH group into a ketone function and if appropriate conversion of the >C=S group into the >C=O group;c) conversion reaction of the >C=O group or groups into the >C=S group;d) the action on the products of formula (IV) in which R'3 represents a hydrogen atom, and after hydrolysis of the >C=NH group into a ketone function, of a reagent of formula Hal-R"3 in which R"3 has the values of R'3 with the exception of the hydrogen value and Hal represents a halogen atom in order to obtain products of formula (I) in which the group -A-B- represents the groupamidification or salification agent,
or a reagent of formula Hal-R"3 in which Hal and R"3 have the values indicated previously is reacted on a product of formula (IV'):
a) elimination reaction of the optional protective groups which can be carried by R"3 then if appropriate the action of an esterification, amidification or salification agent;b) conversion reaction of the >C=O group or groups into >C=S groups. - Process according to claim 1 for preparing a product of formula (I) as defined in claim 1, in which Y represents an oxygen atom, with the exception of the products in which the group -A-B- represents the radical:
either a compound of formula (IV) as defined in claim 1 with the exception of the products in which X represents an oxygen atom, R'3 represents a hydrogen atom, R2 represents a halogen atom or a trifluoromethyl radical and R1 represents a nitro radical or a halogen atom, is subjected to any one or more of the following reactions, in any order:a) elimination reaction of the optional protective groups which can be carried by R'3;b) hydrolysis reaction of the >C=NH group into the ketone function then if desired the action of a reagent of formula Hal-R"3 in which R"3 has the values of R'3 with the exception of the hydrogen value and Hal represents a halogen atom, in order to obtain products of formula (I) in which the group -A-B- represents the groupamidification or salification agent,
or a reagent of formula Hal-R"3 in which Hal and R"3 have the values indicated previously is reacted on a product of formula (IV') as defined in claim 1 in order to obtain a product of formula (IV") which, if necessary or if desired, is subjected to an elimination reaction of the optional protective groups which can be carried by R"3 and if appropriate to the action of an esterification, amidification or salification agent. - Process according to claim 1 or 2 for preparing a product of formula (I) as defined in claim 1 in which the group -A-B- represents the group- elimination reaction of the optional protective groups which can be carried by R'3 or R"3;- conversion reaction of the >C=O group or groups into the >C=S group.
- Process according to claim 3 for preparing a product of formula (I) as defined in claim 3 in which R3 represents a hydrogen atom or an alkyl radical having at most 4 carbon atoms optionally substituted by a hydroxy radical,
characterized in that either a product of formula (III) is used at the start in which R'3 has the optionally protected values of R3 indicated above, or the product of formula (IV') is treated with a reagent of formula Hal-R"3 in which R"3 has the optionally protected values of R3 indicated above with the exception of the hydrogen value then if appropriate the product obtained is subjected to the action of an elimination agent of the protective groups. - Process according to any one of claims 1 to 4, characterized in that a product of formula (IT) is used at the start in which R1 represents a cyano radical or a halogen atom.
- Process according to claim 5, characterized in that a product of formula (II) is used at the start in which R1 represents a chlorine atom.
- Process according to claim 1 or 2 for preparing a product of formula (I) as defined in claim 1 in which the group -A-B- represents a group
- Process according to any one of claims 1 to 5, characterized in that the starting products and reagents are chosen in such a way that any one of the products of which the names follow is prepared:- 4-(5-oxo-2-thioxo-3,4,4-trimethyl-1-imidazolidinyl)-2(trifluoromethyl)-benzonitrile,- 4-(4,4-dimethyl-5-oxo-2-thioxo 1-imidazolidinyl)-2(trifluoromethyl)-benzonitrile,- 4-[4,4-dimethyl 3-(2-hydroxyethyl) 5-oxo 2-thioxo 1imidazolidinyl] 2-(trifluoromethyl) benzonitrile,- 3-(3,4-dichlorophenyl) 2-thioxo 1,5,5-trimethyl 4-imidazolidinone.
- Process according to claim 1, 2 or 7, characterized in that the starting products and reagents are chosen in such a way that any one of the products of which the names follow is prepared:- 1-(4-nitro-3-(trifluoromethyl) phenyl)-3,4,4-trimethyl-2,5-imidazolidinedione,- 4-[[4,5-dihydro 4,4-dimethyl 5-oxo 2-(phenylmethyl) thio] 1H-imidazol-1-yl] 2-(trifluoromethyl) benzonitrile.
- Process for preparing pharmaceutical compositions, characterized in that at least one of the compounds of formula (I) as defined in claim 1 is put as active ingredient in a form intended for this use.
- Process for preparing pharmaceutical compositions, characterized in that at least one of the compounds of formula (I) as defined in any one of claims 2 to 7 is put as active ingredient in a form intended for this use.
- Process for preparing pharmaceutical compositions, characterized in that at least one of the compounds of formula (I) as defined in claim 8 or 9 is put as active ingredient in a form intended for this use.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9100185 | 1991-01-09 | ||
FR9100185A FR2671348B1 (en) | 1991-01-09 | 1991-01-09 | NOVEL PHENYLIMIDAZOLIDINES, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
Publications (2)
Publication Number | Publication Date |
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EP0494819A1 EP0494819A1 (en) | 1992-07-15 |
EP0494819B1 true EP0494819B1 (en) | 1996-07-10 |
Family
ID=9408539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EP92400038A Expired - Lifetime EP0494819B1 (en) | 1991-01-09 | 1992-01-08 | Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0494819B1 (en) |
JP (1) | JP3383320B2 (en) |
KR (1) | KR100238385B1 (en) |
CN (1) | CN1049214C (en) |
AT (1) | ATE140218T1 (en) |
AU (1) | AU648376B2 (en) |
CA (1) | CA2059052C (en) |
DE (1) | DE69212007T2 (en) |
DK (1) | DK0494819T3 (en) |
ES (1) | ES2089425T3 (en) |
FR (1) | FR2671348B1 (en) |
GR (1) | GR3020510T3 (en) |
HU (1) | HU223310B1 (en) |
IE (1) | IE76143B1 (en) |
RU (1) | RU2076101C1 (en) |
UA (1) | UA45299C2 (en) |
ZA (1) | ZA9290B (en) |
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US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
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US8110594B2 (en) | 2006-03-29 | 2012-02-07 | The Regents Of The University Of California | Diarylthiohydantoin compounds |
US8445507B2 (en) | 2006-03-27 | 2013-05-21 | The Regents Of The University Of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
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FR2693461B1 (en) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | New substituted phenylimidazolidines, process for their preparation, their use as medicaments and the pharmaceutical compositions containing them. |
FR2685328B1 (en) * | 1991-12-20 | 1995-12-01 | Rhone Poulenc Agrochimie | DERIVATIVES OF 2-IMIDAZOLINE-5-ONES AND 2-IMIDAZOLINE-5-THIONES FUNGICIDES. |
FR2706456B1 (en) * | 1993-06-18 | 1996-06-28 | Rhone Poulenc Agrochimie | Optically active derivatives of 2-imidazoline-5-ones and 2-imidazoline-5-thiones fungicides. |
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FR2715402B1 (en) * | 1994-01-05 | 1996-10-04 | Roussel Uclaf | New phenylimidazolines optionally substituted, their process and preparation intermediates, their use as medicaments and the pharmaceutical compositions containing them. |
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FR2716110B1 (en) * | 1994-02-16 | 1996-04-05 | Roussel Uclaf | Cosmetic or pharmaceutical compositions comprising liposomes. |
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FR2619381B1 (en) * | 1987-08-13 | 1989-12-08 | Roussel Uclaf | NOVEL IMIDAZOLIDINES SUBSTITUTED BY A RADICAL HYDROXYMETHYL AND A RADICAL PHENYL SUBSTITUTED, THEIR PREPARATION METHOD, THEIR APPLICATION AS MEDICAMENTS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND AN INTERMEDIATE FOR THEIR PREPARATION |
-
1991
- 1991-01-09 FR FR9100185A patent/FR2671348B1/en not_active Expired - Fee Related
-
1992
- 1992-01-07 ZA ZA9290A patent/ZA9290B/en unknown
- 1992-01-08 RU SU925010932A patent/RU2076101C1/en not_active IP Right Cessation
- 1992-01-08 HU HU9200065A patent/HU223310B1/en not_active IP Right Cessation
- 1992-01-08 DK DK92400038.3T patent/DK0494819T3/en active
- 1992-01-08 AU AU10106/92A patent/AU648376B2/en not_active Ceased
- 1992-01-08 CA CA002059052A patent/CA2059052C/en not_active Expired - Fee Related
- 1992-01-08 EP EP92400038A patent/EP0494819B1/en not_active Expired - Lifetime
- 1992-01-08 KR KR1019920000124A patent/KR100238385B1/en not_active IP Right Cessation
- 1992-01-08 IE IE920059A patent/IE76143B1/en not_active IP Right Cessation
- 1992-01-08 DE DE69212007T patent/DE69212007T2/en not_active Expired - Fee Related
- 1992-01-08 ES ES92400038T patent/ES2089425T3/en not_active Expired - Lifetime
- 1992-01-08 AT AT92400038T patent/ATE140218T1/en not_active IP Right Cessation
- 1992-01-09 CN CN92100140A patent/CN1049214C/en not_active Expired - Fee Related
- 1992-01-09 JP JP01935392A patent/JP3383320B2/en not_active Expired - Fee Related
-
1993
- 1993-06-18 UA UA93003049A patent/UA45299C2/en unknown
-
1996
- 1996-07-11 GR GR960400495T patent/GR3020510T3/en unknown
Cited By (11)
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US7655689B2 (en) | 2000-06-28 | 2010-02-02 | Bristol-Myers Squibb Company | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
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US8445507B2 (en) | 2006-03-27 | 2013-05-21 | The Regents Of The University Of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
US8802689B2 (en) | 2006-03-27 | 2014-08-12 | The Regents Of The University Of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
US9388159B2 (en) | 2006-03-27 | 2016-07-12 | The Regents Of The University Of California | Substituted diazaspiroalkanes as androgen receptor modulators |
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Also Published As
Publication number | Publication date |
---|---|
IE920059A1 (en) | 1992-07-15 |
FR2671348A1 (en) | 1992-07-10 |
CA2059052C (en) | 2004-11-23 |
AU1010692A (en) | 1992-07-16 |
HUT60250A (en) | 1992-08-28 |
CN1049214C (en) | 2000-02-09 |
HU9200065D0 (en) | 1992-03-30 |
KR920014786A (en) | 1992-08-25 |
HU223310B1 (en) | 2004-05-28 |
ES2089425T3 (en) | 1996-10-01 |
CN1063102A (en) | 1992-07-29 |
EP0494819A1 (en) | 1992-07-15 |
IE76143B1 (en) | 1997-10-08 |
RU2076101C1 (en) | 1997-03-27 |
UA45299C2 (en) | 2002-04-15 |
JPH04308579A (en) | 1992-10-30 |
CA2059052A1 (en) | 1992-07-10 |
DK0494819T3 (en) | 1996-08-12 |
GR3020510T3 (en) | 1996-10-31 |
FR2671348B1 (en) | 1993-03-26 |
ZA9290B (en) | 1993-03-31 |
DE69212007T2 (en) | 1997-01-09 |
DE69212007D1 (en) | 1996-08-14 |
JP3383320B2 (en) | 2003-03-04 |
AU648376B2 (en) | 1994-04-21 |
ATE140218T1 (en) | 1996-07-15 |
KR100238385B1 (en) | 2000-03-02 |
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