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EP0308231B1 - Appareil pour collecter des liquides - Google Patents

Appareil pour collecter des liquides Download PDF

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Publication number
EP0308231B1
EP0308231B1 EP88308558A EP88308558A EP0308231B1 EP 0308231 B1 EP0308231 B1 EP 0308231B1 EP 88308558 A EP88308558 A EP 88308558A EP 88308558 A EP88308558 A EP 88308558A EP 0308231 B1 EP0308231 B1 EP 0308231B1
Authority
EP
European Patent Office
Prior art keywords
aperture
compartment
liquid
slide valve
compartments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP88308558A
Other languages
German (de)
English (en)
Other versions
EP0308231A3 (en
EP0308231A2 (fr
Inventor
Charles Cullis Hinckley
Jr. Lewis Thomas Del Plato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eastman Kodak Co
Original Assignee
Eastman Kodak Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastman Kodak Co filed Critical Eastman Kodak Co
Priority to AT88308558T priority Critical patent/ATE78194T1/de
Publication of EP0308231A2 publication Critical patent/EP0308231A2/fr
Publication of EP0308231A3 publication Critical patent/EP0308231A3/en
Application granted granted Critical
Publication of EP0308231B1 publication Critical patent/EP0308231B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration

Definitions

  • This invention relates to a construction used to open and close vents in a liquid-collecting compartment, particularly such compartments used in assay devices.
  • vent hole is commonly provided in each of the lower compartments, to allow air to escape as liquid is entering.
  • an air lock can be created which will allow, or stop, respectively, liquid flow into the lower compartment from above. (Air cannot pass out through the filter either, once it is wetted.)
  • the stoppage of flow is appropriate to allow the liquid to incubate first at the filter, before passing down into the lower compartment, as is well-known.
  • a liquid-collecting device comprising at least one liquid-collecting compartment, means in that one compartment defining a vent aperture fluidly connecting the compartment to the atmosphere, the aperture-defining means including a portion of a wall in which the aperture is located, and closure means for shutting off the vent aperture, characterized in that a) the closure means comprise a slide valve, b) one of the slide valve and the wall portion comprises an elastomeric member, and c) there is included means for slidably mounting the slide valve and the wall portion relative to each other to move the slide valve between a first position covering the aperture and a second position which uncovers the aperture, the member being formed of an elastomer having the following properties: a durometer valve no greater than 70 Shore A, cold flow at 25°C that is between 10% and 40% lost recovery and a static coefficient of friction against polystyrene that is between 0.3 and 0.6.
  • a liquid-collecting device comprising three separate but adjacent liquid-collecting compartments, means in each of the compartments defining a vent aperture fluidly connecting each compartment to the atmospehre, the aperture-defining means including a portion of a wall in which the aperture is located, and closure means for each of the compartments for shutting off the respective aperture.
  • each of the three closure means comprises a slide valve comprising an elastomeric member and means for slidably mounting the member over the aperture to move between a first position covering the aperture and a second position in which the member uncovers the aperture, the member being formed of an elastomer having the following properties: a durometer value no greater than 70 Shore A, cold flow at 25°C that is between 10% and 40% lost recovery and a static coefficient of friction against polystyrene that is between 0.3 and 0.6.
  • a device useful in immunoassays is provided with a valve for closing the necessary vent, that is manually operable with a minimum of effort.
  • such a device is provided with a plurality of liquid-collecting compartments, each independently vented, and a slide valve that opens and closes each vent simultaneously, with a minimum of effort.
  • the invention is described herein in the context of the preferred embodiments, in which the device has three pairs of upper/lower compartments, to assay a) the patient sample, b) a positive control and c) a negative control, all more or less simultaneously.
  • aspects of the invention are useful with only a single pair of compartments, and even without the upper compartment if one simply desires control over the rate of flow into a liquid-receiving compartment.
  • the chemistries provide for an immunoassay, in which there is separately received at three filters in three compartments, a patient antigen complexed with an antigen, a positive control for the complex so formed, and a negative control for the complex so formed, respectively.
  • a device 10 constructed in accord with at least one aspect of the invention comprises, Figure 1, a frame 12 having a top surface 14, and a front edge 16. Mounted on edge 16 is a slide valve 50 in accord with the invention.
  • Top surface 14 has three wells or upper compartments 17, 18 and 19.
  • a filter 24 At the bottom of each of the compartments is a filter 24, Figures 2 and 3, of appropriate pore size and pore volume.
  • Filters 24 have an upper surface 25 and an under surface 26, Fig. 3.
  • Surface 26 is in liquid-flow contact with an absorbent material 28 that preferably occupies each of three lower compartments 30, 32 and 34, Fig. 2, paired with the upper ones.
  • liquid-flow contact means, in sufficient proximity such that a liquid meniscus emanating from surface 26 will also wet material 28 and flow into it, if no air lock exists in the lower compartment.
  • Material 28 is any bibulous material, having a sufficient pore volume to soak up about 2 cc of liquid.
  • Useful materials include cellulose acetate, cotton, and rayon.
  • Useful materials for filters 24 include polyamides, such as nylons, and for example nylon-66 microporous membranes manufactured under the tradenames BIODYNE A or ULTIPOR N-66 by Pall Corporation. Most preferably, the membranes are precoated (prior to use) with one or more water-soluble proteins, such as casein derivatives obtained from acylation, alkylation or sulfonylation of the casein.
  • the device can contain (between the filter and the absorbent material) a porous member which restricts flow back up to the filter, but allows flow from the filter to the absorbent material.
  • the filter can be treated with a water-soluble polymeric overcoat selected to provide an induction time of from about 30 to about 300 seconds of delay, for a liquid head of pressure of about 6 mm of water.
  • This treatment allows aqueous-based reagents to be coated thereafter onto the filter, and dried in less than 30 seconds, without having the reagents pass through the filter.
  • Useful examples of such polymers include polyvinyl alcohol, polyvinyl pyrrolidone, carboxymethyl cellulose, and carboxyethyl cellulose.
  • a liquid level indicator ridge 38 is provided in the wall 40 of each well, as a circular ring.
  • such an indicator can be one or two fragments of a ring vertically spaced on wall 40, or a vertical bar (not shown).
  • Vent aperture 44 is provided in each compartment 30, 32 and 34, Figures 2 and 3, to allow air passage out of the compartment as liquid flows in. Without such vents, or when the vent apertures are closed, an air lock precludes liquid from flowing through filter 24 into the lower compartments.
  • the vent apertures extend to a wall surface 46, Figure 4, each of which comprises the end face of a stud 47 extending from edge 16. Stud 47 is grooved at 48 and 49, Fig. 4, to slidably accommodate mating lips from valve 50, as will be apparent. There are three studs 47, one for each aperture, Figure 2.
  • stops 51 are pendent from frame 12, Figure 3, in a position interposed between material 28 and aperture 44.
  • valve 50 is provided to alternately open and close vent apertures 44.
  • Valve 50 comprises mounting member 52, and three valve seats 54, 56 and 58 that correspond to each of studs 47.
  • Lips 60, 62 are provided at the side edges of member 52, to ride in grooves 48 and 49, respectively, and to force studs 47 against the valve seats.
  • valve seats or the contacting wall surface 46 there is an elastomeric material, and in the other contacting member there is a relatively rigid material such as polystyrene.
  • the elastomeric member is preferably in the valve seats and is especially selected for durometer hardness, cold flow, and coefficient of friction that will ensure that, when the valve seats are to be slid to the side of studs 47, having been compressed by the studs an amount of about 0.15 mm, they can be slid with a force that is between about 0.15 newtons and 20 newtons. (Anything less than about 0.15 newtons will cause member 52 to slide uncontrollably under its own weight. A force in excess of 10, and certainly in excess of 20, newtons is too high for easy manual manipulation.). The most preferred range is 0.15 to 10 newtons.
  • the noted properties for the elastomeric material are preferably within the following ranges: Durometer (a measure of hardness) of no greater than about 70 Shore A, and most preferably from 55 to 65 Shore A.
  • Cold flow (a measure of loss of recovery after being deformed, also known as "compression set") of between about 10 and about 40% lost recovery when compressed at 25°C, and most preferably, 23% lost recovery.
  • a specific gravity of from 0.95 to 1.0 a tensile strength of from 45 Kg/cm2 to 70 Kg/cm2, ultimate elongation of from 300% to 400%, a 100% modulus value of from 20 to 25 Kg/cm2, a tear strength at 25°C of from 19 to 25 kN/m, a tension set of from 5 to 10%, flex fatigue to failure that is greater than 3.4 million, and a brittle point less than 60°C.
  • thermoplastic rubber available under the tradename Santoprene Neutral 201-55 and 201-64, from Monsanto Corp. These two rubbers have the following specific properties: Neutral 201-55 201-64 Hardness 55 Shore A 64 Shore A Spec.
  • seats 54, 56 and 58 are each chamfered at 70, Figure 5, to aid in sliding the seats onto studs 47.
  • studs 47 are optionally chamfered at 72, Figure 2, to aid in assembling slide valve 50 onto the studs during manufacturing.
  • stops 80 and 82 are preferably provided at edge 16. These stops cooperate with surfaces 84 and 86 on mounting member 52, Figure 5.
  • slide valve 50 is first kept in place with seats 54, 56 and 58 sealed over apertures 44, the position shown in Figures 1-4. This position prevents liquid from entering compartments 30, 32 and 34 because of the air lock. (Each lower compartment is fluidly isolated from the others.)
  • member 52 is slid to the left, Figures 1 and 2, to the position shown on studs 47 in phantom, Figure 5.
  • apertures 44 are uncovered simultaneously in this position, so that air can flow out. At the same time, any liquid on filter 24 flows into the lower compartment.
  • Filters 24 act as follows, in the preferred embodiment: In compartment 18, the patient sample's antigens, if any, complex with antibodies coated on wall 40 or added by the user, some of which are labeled, so that the complex is unable to pass through the filter. If no antigen is present, all the labeled antibodies pass through and are not available for detection. In compartment 19, antigen is supplied on the filter or on upper chamber wall 40 as manufactured, and when antibody is added by the filter, a complex forms as a positive control, and remains on the filter for detection.
  • Device 10 is not a large device, having a length for valve 50, Figure 2, and thus for the entire device, of no more than about 6.5 cm.
  • a length for valve 50, Figure 2 and thus for the entire device, of no more than about 6.5 cm.
  • the elastomeric member can comprise at least the surface portion 46 of stud 47, Figure 4, with the member 56 being formed of a relatively rigid material, for example, polystyrene. In that case, it is the surface portion 46 that is preferably compressed distance "d" when the slide valve is on the studs.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Claims (8)

  1. Dispositif (10) pour le recueil de liquide, comprenant au moins un compartiment (17,30 ; 18,32 ; 19,34) de recueil de liquide, des moyens (44), associés audit compartiment, délimitant une ouverture reliant fluidiquement ledit compartiment (17,30 ; 18,32 ; 19,34) à l'atmosphère, lesdits moyens (44) délimitant ladite ouverture comprenant des organes (46,47) entourant ladite ouverture (44) et des moyens de fermeture (50,52) pour obturer ladite ouverture (44) ; dispositif caractérisé en ce que :
    a) les moyens de fermeture (50,52) comprennent une valve (54 ; 56 ; 58) ;
    b) soit ladite valve (54 ; 56 ; 58) soit lesdits organes (46,47) comprennent une partie en élastomère ; et
    c) il comprend aussi un agencement (48, 49, 60, 62) pour permettre le coulissement relatif de ladite valve (54 ; 56 ; 58) par rapport auxdits organes (46, 47) de manière à déplacer ladite valve (52) entre une première position dans laquelle elle recouvre ladite ouverture (44) et une seconde position dans laquelle elle découvre ladite ouverture (44),
    ladite partie en élastomère étant formée d'un élastomère présentant les caractéristiques suivantes : une duretée Shore A inférieure à 70, un fluage à froid mesuré à 25°C compris entre 10 % et 40 % de perte de récupération et un coefficient de frottement statique avec le polystyrène compris entre 0,3 et 0,6.
  2. Dispositif selon la revendication 1, dans lequel la partie en élastomère appartient à ladite valve (54 ; 56 ; 58).
  3. Dispositif selon l'une des revendications 1 ou 2, comprenant aussi au moins un compartiment additionnel de recueil de liquide (17,30 ; 18,32 ; 19,34) des moyens (44), associé audit compartiment additionnel (17,30 ; 18,32 ; 19,34), délimitant une ouverture reliant fluidiquement ledit compartiment additionnel (17,30 ; 18,32 ; 19,34) à l'atmosphère, lesdits moyens (44) délimitant ladite ouverture comprenant des organes (46,47) entourant ladite ouverture (44) et des moyens de fermeture (50,52) pour obturer ladite ouverture, lesdits moyens de fermeture (50,52) dudit compartiment additionnel (17,30 ; 18,32 ; 19,34) comprenant une valve (54 ; 56 ; 58) pratiquement identique à ladite valve recouvrant ledit au moins un compartiment.
  4. Dispositif (10) pour le recueil de liquide, comprenant trois compartiments adjacents (17,30 ; 18,32 ; 19,34) de recueil de liquide, des moyens (44), associés à chaque compartiment, délimitant une ouverture respective reliant chaque compartiment (17,30 ; 18,32 ; 19,34) à l'atmosphère, lesdits moyens (44) délimitant une ouverture respective comprenant des organes (46,47) entourant lesdites ouvertures (44) et des moyens de fermeture (50,52) associés à chacun desdits compartiments (17,30 ; 18,32 ; 19,34) pour obturer lesdites ouvertures (44) respectives, dispositif caractérisé en ce que chacun des trois moyens de fermeture (50,52) comprend une valve (54 ; 56 ; 58) munie d'une partie en élastomère et en ce qu'il comprend un agencement (48,49,60,62) pour permettre le coulissement desdites parties en élastomère par rapport auxdites ouvertures (44) entre une première position dans laquelle elles recouvrent lesdites ouvertures et une seconde position dans laquelle elles découvrent lesdites ouvertures respectives (44), lesdites parties en élastomère étant formées d'un élastomère présentant les caractéristiques suivantes : une dureté Shore A inférieure à 70, un fluage à froid mesuré à 25°C compris entre 10 % et 40 % de perte de récupération et un coefficient de frottement statique avec le polystyrène compris entre 0,3 et 0,6.
  5. Dispositif selon la revendication 4, comprenant en plus des moyens de filtrage (24,25,26) pour chacun desdits compartiments (17,30 ; 18,32 ; 19,34) qui sont agencés pour recevoir lesdits moyens de filtrage, un pour chaque compartiment (17,30 ; 18,32 ; 19,34) respectif, un anticorps complexable avec un antigène du patient, des controles positif et négatif pour le complexe obtenu avec l'antigène d'un patient, afin de rendre le dispositif utilisable en immunotest.
  6. Dispositif selon l'une des revendications 3, 4 ou 5, dans lequel lesdites valves (54, 56, 58) comprennent un élément (52) en une seule pièce, lesdites valves (54, 56, 58) étant disposées sur ledit élément (52) pour simultanément couvrir ou découvrir lesdites ouvertures (44) lorsque ledit élément passe de la première position à la seconde position.
  7. Dispositif selon l'une quelconque des revendications précédentes, comprenant un matériau (28) absorbant l'humidité dans au moins l'un des compartiments (30 ; 32 ; 34).
  8. Dispositif selon la revendications 7, comprenant un filtre (24, 25, 26) situé en amont et "en contact" avec ledit matériau (28) absorbant l'humidité pour assurer l'écoulement dudit liquide.
EP88308558A 1987-09-18 1988-09-16 Appareil pour collecter des liquides Expired - Lifetime EP0308231B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT88308558T ATE78194T1 (de) 1987-09-18 1988-09-16 Vorrichtung zum sammeln von fluessigkeiten.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9824887A 1987-09-18 1987-09-18
US98248 1987-09-18

Publications (3)

Publication Number Publication Date
EP0308231A2 EP0308231A2 (fr) 1989-03-22
EP0308231A3 EP0308231A3 (en) 1989-07-19
EP0308231B1 true EP0308231B1 (fr) 1992-07-15

Family

ID=22268350

Family Applications (1)

Application Number Title Priority Date Filing Date
EP88308558A Expired - Lifetime EP0308231B1 (fr) 1987-09-18 1988-09-16 Appareil pour collecter des liquides

Country Status (5)

Country Link
EP (1) EP0308231B1 (fr)
JP (1) JPH021551A (fr)
AT (1) ATE78194T1 (fr)
CA (1) CA1302247C (fr)
DE (1) DE3872811T2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6439303U (fr) * 1987-08-31 1989-03-09
US5147609A (en) * 1989-05-19 1992-09-15 Pb Diagnostic Systems, Inc. Assay element
CA2041050A1 (fr) * 1990-10-29 1992-04-30 Kerinchan Babaoglu Appareil d'essai par lots contenant des rangees pour les echantillons de patients et des rangees adjacentes pour les solutions temoins negatives
DE19725894A1 (de) * 1997-06-19 1998-12-24 Biotechnolog Forschung Gmbh Differentielle Vakuumkammer
WO2015008991A1 (fr) * 2013-07-15 2015-01-22 주식회사 싸이토젠 Ensemble lame

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4246339A (en) * 1978-11-01 1981-01-20 Millipore Corporation Test device
AU2991384A (en) * 1983-06-29 1985-01-03 Precision Valve Australia Pty Limited Self sealing caps
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
DE3535292A1 (de) * 1985-10-03 1987-04-09 Bramlage Gmbh Geraet zur portionierten ausgabe koerniger medien, tabletten oder dergleichen
US4719085A (en) * 1985-12-24 1988-01-12 Eastman Kodak Company Mount for ammonia-sensitive test elements

Also Published As

Publication number Publication date
EP0308231A3 (en) 1989-07-19
CA1302247C (fr) 1992-06-02
DE3872811T2 (de) 1992-12-17
JPH021551A (ja) 1990-01-05
DE3872811D1 (de) 1992-08-20
EP0308231A2 (fr) 1989-03-22
ATE78194T1 (de) 1992-08-15

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