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EG18188A - Process for preparation anti-arhythmia agents - Google Patents

Process for preparation anti-arhythmia agents

Info

Publication number
EG18188A
EG18188A EG230/87A EG23087A EG18188A EG 18188 A EG18188 A EG 18188A EG 230/87 A EG230/87 A EG 230/87A EG 23087 A EG23087 A EG 23087A EG 18188 A EG18188 A EG 18188A
Authority
EG
Egypt
Prior art keywords
alkyl
group
formula
compounds
agents
Prior art date
Application number
EG230/87A
Other languages
English (en)
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26290703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG18188(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB868610668A external-priority patent/GB8610668D0/en
Priority claimed from GB868630059A external-priority patent/GB8630059D0/en
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Application granted granted Critical
Publication of EG18188A publication Critical patent/EG18188A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
  • Polyamides (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Lubricants (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
EG230/87A 1986-05-01 1987-04-19 Process for preparation anti-arhythmia agents EG18188A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868610668A GB8610668D0 (en) 1986-05-01 1986-05-01 Anti-arrhythmia agents
GB868630059A GB8630059D0 (en) 1986-12-17 1986-12-17 Antiarrhythmic agents

Publications (1)

Publication Number Publication Date
EG18188A true EG18188A (en) 1992-09-30

Family

ID=26290703

Family Applications (1)

Application Number Title Priority Date Filing Date
EG230/87A EG18188A (en) 1986-05-01 1987-04-19 Process for preparation anti-arhythmia agents

Country Status (27)

Country Link
US (2) US4959366A (xx)
EP (1) EP0245997B1 (xx)
KR (2) KR870011084A (xx)
CN (1) CN1019801B (xx)
AT (1) ATE74906T1 (xx)
AU (1) AU578557B2 (xx)
BA (2) BA98301A (xx)
CA (1) CA1289140C (xx)
DE (2) DE3778201D1 (xx)
DK (1) DK175096B1 (xx)
EG (1) EG18188A (xx)
ES (1) ES2033840T3 (xx)
FI (1) FI88291C (xx)
GR (1) GR3004457T3 (xx)
HU (1) HU196743B (xx)
IE (1) IE59366B1 (xx)
IL (1) IL82373A (xx)
LU (1) LU90519I2 (xx)
LV (1) LV5715B4 (xx)
MY (1) MY111142A (xx)
NL (1) NL300002I2 (xx)
NO (2) NO168527C (xx)
NZ (1) NZ220151A (xx)
PH (1) PH23425A (xx)
PL (1) PL149924B1 (xx)
PT (1) PT84782B (xx)
YU (2) YU46195B (xx)

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US5602174A (en) * 1986-02-15 1997-02-11 Beecham Wuefling Gmbh & Co. Treatment
NL8700842A (xx) * 1987-04-10 1988-11-01 Duphar Int Res
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
GB8809314D0 (en) * 1988-04-20 1988-05-25 Wellcome Found Anti-hypertensive sulfonanilides
GB8819307D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Antiarrhythmic agents
US5086073A (en) * 1989-06-02 1992-02-04 John Wyeth & Brother Limited Composition for treating depression with aralkyl amines
US5166209A (en) * 1989-04-21 1992-11-24 Burroughs Wellcome Co. Pharmacologically active compounds
US5084463A (en) * 1989-12-11 1992-01-28 American Home Products Corporation N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity
AU4787593A (en) * 1992-07-31 1994-03-03 Syntex (U.S.A.) Inc. Heterocyclic derivatives useful in the treatment of cardiovascular diseases
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
DE4422517A1 (de) * 1994-06-28 1996-01-04 Dresden Arzneimittel Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ES2206508T3 (es) * 1994-08-04 2004-05-16 C & C RESEARCH LABS. Nuevo derivado aminado, procedimiento de obtencion de este derivado y su utilizacion como antiarritmico.
DE69500377T2 (de) 1994-08-19 1997-10-09 Mitsui Toatsu Chemicals Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
FR2726267B1 (fr) * 1994-10-26 1998-01-02 Smithkline Beecham Lab Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer
CN1055679C (zh) * 1995-12-06 2000-08-23 中国药科大学 具有心血管活性的苯乙胺衍生物
CN1055682C (zh) * 1995-12-06 2000-08-23 中国药科大学 甲磺酰胺基苯乙胺衍生物的新制备方法
GB9722662D0 (en) * 1997-10-27 1997-12-24 Pfizer Ltd Polymorphs
HUP9702411A2 (hu) * 1997-12-11 2000-03-28 Gyógyszerkutató Intézet Kft. Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények
CA2440284A1 (en) * 2001-03-08 2002-09-19 Emory University Ph-dependent nmda receptor antagonists
CN100358865C (zh) * 2001-07-30 2008-01-02 中国科学院上海药物研究所 一类磺酰胺苯烷胺类化合物及其制备方法和用途
DE10201550A1 (de) * 2002-01-17 2003-07-31 Merck Patent Gmbh Phenoxy-Piperidine
WO2003091205A1 (fr) * 2002-04-26 2003-11-06 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Sulfamidophenylalkylamines, production et utilisation de ces dernieres
EA016558B1 (ru) * 2003-06-17 2012-05-30 Арена Фармасьютикалз, Инк. Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
AU2004267016B2 (en) * 2003-06-17 2011-11-24 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
DE102004025726B4 (de) * 2004-05-26 2006-07-06 Roder, Hanno, Dr. Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit
AU2007334381B2 (en) * 2006-12-14 2014-02-13 Tautatis, Inc. Compositions and methods for the treatment of cancer
KR20100045983A (ko) 2007-06-29 2010-05-04 에모리 유니버시티 신경보호를 위한 ｎｍｄａ 수용체 길항물질
CN101372467B (zh) * 2007-08-23 2011-09-14 明德国际仓储贸易(上海)有限公司 具有n,n-二烷氨基的桥基化合物及所应用的染料化合物
WO2009111004A1 (en) 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
KR20140091458A (ko) 2010-09-01 2014-07-21 아레나 파마슈티칼스, 인크. 신장 손상을 갖는 개체에 대한 로카세린의 투여
WO2012030957A2 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
WO2012030938A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
CN102531946A (zh) * 2012-01-05 2012-07-04 山东大学 3-甲氧基苯甲酰胺衍生物及其制备方法与应用
CA2886875A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management
FR3029113A1 (fr) 2014-12-02 2016-06-03 Univ Paris-Sud Composes pour le traitement des maladies mitochondriales
CZ307826B6 (cs) * 2017-12-01 2019-05-29 Farmak, A.S. Způsob přípravy N-[4-(2-{[2-(4-methansulfonamidofenoxy)ethyl](methyl)amino}ethyl)fenyl]methansulfonamidu (Dofetilidu)
US10888524B2 (en) 2018-02-05 2021-01-12 Enaltec Pharma Research Pvt. Ltd. Immediate release tablet of dofetilide

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR977261A (fr) * 1948-11-04 1951-03-29 équilibrage des masses dans les moteurs à combustion interne
GB993584A (xx) * 1962-01-24
US3478149A (en) * 1962-01-24 1969-11-11 Mead Johnson & Co Therapeutic compositions and methods employing sulfonamidophenethanolamines
US3852468A (en) * 1967-02-27 1974-12-03 Ici Ltd Alkanolamine derivatives as {62 -adrenergic blocking agents
US3574741A (en) * 1969-04-14 1971-04-13 Mead Johnson & Co Sulfonamidophenalkylamines
US3758692A (en) * 1969-04-14 1973-09-11 Mead Johnson & Co Ylamines sympathomimetic process and compositions employing sulfonamidophenalk
GB1263987A (en) * 1969-05-30 1972-02-16 Allen & Hanburys Ltd Phenethylamine derivatives
BE757005A (fr) * 1969-10-02 1971-04-02 Bristol Myers Co Phenethanolamines substituees et procede pour leur preparation
GB1301134A (en) * 1970-07-18 1972-12-29 Pfizer Ltd SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES
EP0006735B1 (en) * 1978-06-28 1983-06-15 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
CA1120058A (en) * 1978-07-03 1982-03-16 Jack Mills Phenethanolamines, formulations and potentiation of oncolytic drugs
DE3061205D1 (en) * 1979-06-16 1983-01-05 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
DD202692A5 (de) * 1979-12-04 1983-09-28 Ciba Geigy Verfahren zur herstellung neuer derivate des 2-amino-aethanols
FR2541999B1 (fr) * 1983-03-04 1986-09-19 Bristol Myers Co Phenethanolamines et leurs utilisations
DE3566886D1 (en) * 1984-05-04 1989-01-26 Upjohn Co N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use
US4569801A (en) * 1984-10-15 1986-02-11 Eli Lilly And Company Alkylsulfonamidophenylalkylamines

Also Published As

Publication number Publication date
CA1289140C (en) 1991-09-17
NO871820L (no) 1987-11-02
NL300002I1 (nl) 2000-04-03
IE59366B1 (en) 1994-02-09
YU46195B (sh) 1993-05-28
CN87103300A (zh) 1987-11-11
NO871820D0 (no) 1987-04-30
LV5715A4 (lv) 1995-10-20
PL265418A1 (en) 1988-07-21
PL149924B1 (en) 1990-04-30
DK220287D0 (da) 1987-04-30
YU73588A (en) 1990-04-30
DE10075004I1 (de) 2000-04-13
EP0245997A3 (en) 1989-12-20
GR3004457T3 (xx) 1993-03-31
KR870011084A (ko) 1987-12-19
DE10075004I2 (de) 2006-02-02
NO168527B (no) 1991-11-25
BA98211B1 (bs) 1999-08-02
PT84782B (pt) 1989-12-29
US5079248A (en) 1992-01-07
DK220287A (da) 1987-11-02
HUT43558A (en) 1987-11-30
HU196743B (en) 1989-01-30
FI871898A0 (fi) 1987-04-29
DK175096B1 (da) 2004-06-01
FI871898A (fi) 1987-11-02
ES2033840T3 (es) 1993-04-01
LV5715B4 (lv) 1996-02-20
AU7226087A (en) 1987-11-19
FI88291B (fi) 1993-01-15
KR930001339B1 (ko) 1993-02-26
AU578557B2 (en) 1988-10-27
NO168527C (no) 1992-03-04
YU78387A (en) 1988-08-31
US4959366A (en) 1990-09-25
NO2001011I1 (no) 2001-07-16
ATE74906T1 (de) 1992-05-15
LU90519I2 (fr) 2000-04-10
YU46541B (sh) 1993-11-16
EP0245997B1 (en) 1992-04-15
BA98301A (bs) 2001-09-14
FI88291C (fi) 1993-04-26
IL82373A0 (en) 1987-10-30
IE871165L (en) 1987-11-01
DE3778201D1 (de) 1992-05-21
CN1019801B (zh) 1992-12-30
IL82373A (en) 1992-01-15
PH23425A (en) 1989-08-07
KR920014397A (ko) 1992-07-30
EP0245997A2 (en) 1987-11-19
NZ220151A (en) 1989-02-24
MY111142A (en) 1999-09-30
PT84782A (en) 1987-05-01
NL300002I2 (nl) 2000-05-01

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