EE05000B1 - 2'-Substituted 1,1'-biphenyl-2-carboxamides, their use and pharmaceutical preparations - Google Patents

2'-Substituted 1,1'-biphenyl-2-carboxamides, their use and pharmaceutical preparations

Info

Publication number: EE05000B1
Authority: EE; Estonia
Prior art keywords: carboxamides; biphenyl; substituted; pharmaceutical preparations; preparations
Prior art date: 1999-10-02

Application number

EEP200200160A

Other languages

Estonian (et)

Inventor

Brendel Joachim

Schmidt Wolfgang

Below Peter

Original Assignee

Aventis Pharma Deutschland Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-02

Filing date

2000-09-19

Publication date

2008-04-15

2000-09-19 Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh

2003-04-15 Publication of EE200200160A publication Critical patent/EE200200160A/en

2008-04-15 Publication of EE05000B1 publication Critical patent/EE05000B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)

EEP200200160A 1999-10-02 2000-09-19 2'-Substituted 1,1'-biphenyl-2-carboxamides, their use and pharmaceutical preparations EE05000B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19947457A DE19947457A1 (en)	1999-10-02	1999-10-02	New 2'-aminomethyl-biphenyl-2-carboxamide derivatives, are potassium channel blockers especially useful for treating re-entry or supraventricular arrhythmia or atrial fibrillation or flutter
PCT/EP2000/009151 WO2001025189A1 (en)	1999-10-02	2000-09-19	2'-substituted 1,1'-biphenyl-2-carbonamides, method for the production thereof, use thereof as a medicament and pharmaceutical preparations containing said compounds

Publications (2)

Publication Number	Publication Date
EE200200160A EE200200160A (en)	2003-04-15
EE05000B1 true EE05000B1 (en)	2008-04-15

Family

ID=7924254

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200160A EE05000B1 (en)	1999-10-02	2000-09-19	2'-Substituted 1,1'-biphenyl-2-carboxamides, their use and pharmaceutical preparations

Country Status (32)

Country	Link
EP (1)	EP1222163B1 (en)
JP (1)	JP4713800B2 (en)
KR (1)	KR100722178B1 (en)
CN (1)	CN1195738C (en)
AR (1)	AR031226A1 (en)
AT (1)	ATE332890T1 (en)
AU (1)	AU766365B2 (en)
BR (1)	BR0014465B1 (en)
CA (1)	CA2385859C (en)
CY (1)	CY1106178T1 (en)
CZ (1)	CZ302591B6 (en)
DE (2)	DE19947457A1 (en)
DK (1)	DK1222163T3 (en)
EE (1)	EE05000B1 (en)
ES (1)	ES2265985T3 (en)
HK (1)	HK1048986B (en)
HR (1)	HRP20020264B1 (en)
HU (1)	HU229046B1 (en)
IL (2)	IL148870A0 (en)
ME (1)	MEP60908A (en)
MX (1)	MXPA02002691A (en)
NO (1)	NO327709B1 (en)
NZ (1)	NZ518065A (en)
PL (1)	PL204034B1 (en)
PT (1)	PT1222163E (en)
RS (1)	RS50387B (en)
RU (1)	RU2252214C2 (en)
SK (1)	SK286756B6 (en)
TR (1)	TR200200883T2 (en)
TW (1)	TWI270541B (en)
WO (1)	WO2001025189A1 (en)
ZA (1)	ZA200202521B (en)

Families Citing this family (27)

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Publication number	Priority date	Publication date	Assignee	Title
WO2002000606A1 (en)	2000-06-28	2002-01-03	Takeda Chemical Industries, Ltd.	Biphenyl compound
DE10059418A1 (en) *	2000-11-30	2002-06-20	Aventis Pharma Gmbh	Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments and pharmaceutical preparations containing them
DE10060807A1 (en) *	2000-12-07	2002-06-20	Aventis Pharma Gmbh	Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments and pharmaceutical preparations containing them
TWI311133B (en)	2001-04-20	2009-06-21	Eisai R&D Man Co Ltd	Carboxylic acid derivativeand the salt thereof
DE10121003A1 (en)	2001-04-28	2002-12-19	Aventis Pharma Gmbh	Anthranilic acid amides, processes for their preparation, their use as medicaments and pharmaceutical preparations containing them
EP1394147A4 (en) *	2001-06-04	2007-10-24	Eisai R&D Man Co Ltd	Carboxylic acid derivative and medicine comprising salt or ester of the same
DE10128331A1 (en)	2001-06-12	2002-12-19	Aventis Pharma Gmbh	New 2-(heteroarylsulfonyl-amino)-benzamide derivatives, which are potassium ion channel blocking antiarrhythmic agents, useful for e.g. treating atrial fibrillation or flutter
WO2003057671A1 (en) *	2001-12-28	2003-07-17	Takeda Chemical Industries, Ltd.	Biaryl compound and use thereof
JP4690889B2 (en)	2002-10-24	2011-06-01	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	Methylene urea derivative
DE10312061A1 (en) *	2003-03-18	2004-09-30	Aventis Pharma Deutschland Gmbh	Combination of phenylcarboxamides with blockers of the IK channel and their use for the treatment of atrial arrhythmias
GB0315950D0 (en)	2003-06-11	2003-08-13	Xention Discovery Ltd	Compounds
AU2004268621C1 (en) *	2003-08-29	2011-08-18	Exelixis, Inc.	c-Kit modulators and methods of use
DE10341233A1 (en) *	2003-09-08	2005-03-24	Aventis Pharma Deutschland Gmbh	Composition, useful to treat e.g. atrial fibrillation, atrial flutter and atrial arrhythmia, comprises at least one beta-blocker and at least one compound of a phenylcarboxylic acid amide derivative
DE102004009931A1 (en) *	2004-02-26	2005-09-15	Aventis Pharma Deutschland Gmbh	Use of specific 2-substituted benzamides for treating and preventing cardiac insufficiency, especially where caused by diastolic dysfunction, act by inhibition of the Kv1.5 potassium channel
JP2007528420A (en) *	2004-03-11	2007-10-11	グラクソ　グループ　リミテッド	Novel M3 muscarinic acetylcholine receptor antagonist
GB0412986D0 (en)	2004-06-10	2004-07-14	Xention Discovery Ltd	Compounds
US7569589B2 (en)	2004-07-29	2009-08-04	Merck & Co., Inc.	Potassium channel inhibitors
US7576212B2 (en)	2004-12-09	2009-08-18	Xention Limited	Thieno[2,3-B] pyridines as potassium channel inhibitors
GB0525164D0 (en)	2005-12-09	2006-01-18	Xention Discovery Ltd	Compounds
CN101636154B (en) *	2006-04-27	2011-12-14	塞诺菲-安万特德国有限公司	Inhibitors of the TASK-1 and TASK-3 ion channels
GB0815784D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
GB0815781D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
GB0815782D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
CN102459181B (en)	2009-06-03	2014-05-07	赛诺菲-安万特德国有限公司	Crystalline phases of 2'-{[2-(4-methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)-amide
GB201105659D0 (en)	2011-04-01	2011-05-18	Xention Ltd	Compounds
NO3175985T3 (en)	2011-07-01	2018-04-28
US20150045305A1 (en)	2012-01-27	2015-02-12	Gilead Sciences, Inc.	Combination therapies using late sodium ion channel blockers and potassium ion channel blockers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4102024A1 (en) *	1991-01-24	1992-07-30	Thomae Gmbh Dr K	BIPHENYL DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS, AND METHOD FOR THE PRODUCTION THEREOF
GB9307527D0 (en)	1993-04-13	1993-06-02	Fujisawa Pharmaceutical Co	New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same

1999
- 1999-10-02 DE DE19947457A patent/DE19947457A1/en not_active Withdrawn
2000
- 2000-01-11 TW TW2'-SUBSTIA patent/TWI270541B/zh not_active IP Right Cessation
- 2000-09-19 ES ES00967703T patent/ES2265985T3/en not_active Expired - Lifetime
- 2000-09-19 NZ NZ518065A patent/NZ518065A/en not_active IP Right Cessation
- 2000-09-19 MX MXPA02002691A patent/MXPA02002691A/en active IP Right Grant
- 2000-09-19 RS YUP-244/02A patent/RS50387B/en unknown
- 2000-09-19 PT PT00967703T patent/PT1222163E/en unknown
- 2000-09-19 WO PCT/EP2000/009151 patent/WO2001025189A1/en active IP Right Grant
- 2000-09-19 PL PL354322A patent/PL204034B1/en unknown
- 2000-09-19 DK DK00967703T patent/DK1222163T3/en active
- 2000-09-19 EP EP00967703A patent/EP1222163B1/en not_active Expired - Lifetime
- 2000-09-19 ME MEP-609/08A patent/MEP60908A/en unknown
- 2000-09-19 KR KR1020027004267A patent/KR100722178B1/en not_active IP Right Cessation
- 2000-09-19 JP JP2001528137A patent/JP4713800B2/en not_active Expired - Fee Related
- 2000-09-19 SK SK438-2002A patent/SK286756B6/en not_active IP Right Cessation
- 2000-09-19 TR TR2002/00883T patent/TR200200883T2/en unknown
- 2000-09-19 DE DE50013167T patent/DE50013167D1/en not_active Expired - Lifetime
- 2000-09-19 BR BRPI0014465-7A patent/BR0014465B1/en not_active IP Right Cessation
- 2000-09-19 AU AU77778/00A patent/AU766365B2/en not_active Ceased
- 2000-09-19 CA CA002385859A patent/CA2385859C/en not_active Expired - Fee Related
- 2000-09-19 IL IL14887000A patent/IL148870A0/en active IP Right Grant
- 2000-09-19 AT AT00967703T patent/ATE332890T1/en active
- 2000-09-19 CZ CZ20021144A patent/CZ302591B6/en not_active IP Right Cessation
- 2000-09-19 EE EEP200200160A patent/EE05000B1/en not_active IP Right Cessation
- 2000-09-19 RU RU2002111561/04A patent/RU2252214C2/en not_active IP Right Cessation
- 2000-09-19 HU HU0203505A patent/HU229046B1/en not_active IP Right Cessation
- 2000-09-19 CN CNB008127344A patent/CN1195738C/en not_active Expired - Fee Related
- 2000-09-28 AR ARP000105117A patent/AR031226A1/en active IP Right Grant
2002
- 2002-03-20 NO NO20021398A patent/NO327709B1/en not_active IP Right Cessation
- 2002-03-25 IL IL148870A patent/IL148870A/en not_active IP Right Cessation
- 2002-03-28 HR HR20020264A patent/HRP20020264B1/en not_active IP Right Cessation
- 2002-03-28 ZA ZA200202521A patent/ZA200202521B/en unknown
2003
- 2003-02-18 HK HK03101193.0A patent/HK1048986B/en not_active IP Right Cessation
2006
- 2006-09-28 CY CY20061101413T patent/CY1106178T1/en unknown

Also Published As

Publication number	Publication date
RS50387B (en)	2009-12-31
ZA200202521B (en)	2002-12-24
CZ20021144A3 (en)	2002-06-12
TWI270541B (en)	2007-01-11
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HUP0203505A3 (en)	2004-01-28
JP2003511363A (en)	2003-03-25
AU766365B2 (en)	2003-10-16
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CA2385859A1 (en)	2001-04-12
KR100722178B1 (en)	2007-05-29
BR0014465A (en)	2002-06-11
EP1222163B1 (en)	2006-07-12
DE19947457A1 (en)	2001-04-05
KR20020038791A (en)	2002-05-23
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RU2002111561A (en)	2004-01-20
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