EE05429B1 - Karbokslhappe amiidi derivaadid, nende saamise meetod ning kasutamine - Google Patents

Karbokslhappe amiidi derivaadid, nende saamise meetod ning kasutamine

Info

Publication number: EE05429B1
Authority: EE; Estonia
Prior art keywords: sub; alkyl; sup; hydrogen; groups
Prior art date: 2001-07-24

Application number

EEP200400058A

Other languages

English (en)

Estonian (et)

Inventor

Dom βny Gy�rgy

Horv βth Csilla

βndor Farkas S

Bart βn� Szalai Gisella

Nagy J�zsef

βndor Kolok S

Kov βcsn� Boz� �va

βn Borza Istv

βn V βg� Istv

Bielik Attila

Ign βczn� Szendrei Gy�rgyi

Keseru Gy�rgy

Original Assignee

Richter Gedeon Vegy�szeti Gy βr Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-24

Filing date

2002-07-23

Publication date

2011-06-15

2001-07-24 Priority claimed from HU0103055A external-priority patent/HU226978B1/hu

2002-07-10 Priority claimed from HU0202213A external-priority patent/HU225905B1/hu

2002-07-23 Application filed by Richter Gedeon Vegy�szeti Gy βr Rt. filed Critical Richter Gedeon Vegy�szeti Gy βr Rt.

2004-04-15 Publication of EE200400058A publication Critical patent/EE200400058A/xx

2011-06-15 Publication of EE05429B1 publication Critical patent/EE05429B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A—HUMAN NECESSITIES
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Virology (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Pulmonology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Biochemistry (AREA)
AIDS & HIV (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Tropical Medicine & Parasitology (AREA)
Endocrinology (AREA)

EEP200400058A 2001-07-24 2002-07-23 Karbokslhappe amiidi derivaadid, nende saamise meetod ning kasutamine EE05429B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
HU0103055A HU226978B1 (en)	2001-07-24	2001-07-24	New carboxylic acid amide compounds, process for their preparation and pharmaceutical compositions containing them and their use
HU0202213A HU225905B1 (en)	2002-07-10	2002-07-10	Solid-supported parallel synthesis of new carboxylic acid amide derivatives
PCT/HU2002/000071 WO2003010159A1 (en)	2001-07-24	2002-07-23	Piperidine derivatives as nmda receptor antagonists

Publications (2)

Publication Number	Publication Date
EE200400058A EE200400058A (et)	2004-04-15
EE05429B1 true EE05429B1 (et)	2011-06-15

Family

ID=90001553

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200400058A EE05429B1 (et)	2001-07-24	2002-07-23	Karbokslhappe amiidi derivaadid, nende saamise meetod ning kasutamine

Country Status (32)

Country	Link
US (1)	US7435744B2 (ko)
EP (1)	EP1409477B1 (ko)
JP (1)	JP4322113B2 (ko)
KR (1)	KR100890676B1 (ko)
CN (1)	CN100413860C (ko)
AT (1)	ATE408611T1 (ko)
AU (1)	AU2002313566B2 (ko)
BG (1)	BG66441B1 (ko)
BR (1)	BR0211393A (ko)
CA (1)	CA2453383C (ko)
CO (1)	CO5560570A2 (ko)
CY (1)	CY1109401T1 (ko)
CZ (1)	CZ2004233A3 (ko)
DE (1)	DE60228969D1 (ko)
DK (1)	DK1409477T3 (ko)
EA (1)	EA010162B1 (ko)
EE (1)	EE05429B1 (ko)
ES (1)	ES2312603T3 (ko)
HR (1)	HRP20040178B1 (ko)
IL (1)	IL159393A (ko)
IS (1)	IS7066A (ko)
MX (1)	MXPA04000737A (ko)
NO (1)	NO327099B1 (ko)
NZ (1)	NZ530055A (ko)
PL (1)	PL216636B1 (ko)
PT (1)	PT1409477E (ko)
RS (1)	RS50767B (ko)
SI (1)	SI1409477T1 (ko)
SK (1)	SK287726B6 (ko)
UA (1)	UA77684C2 (ko)
WO (1)	WO2003010159A1 (ko)
ZA (1)	ZA200400417B (ko)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10210779A1 (de) *	2002-03-12	2003-10-09	Merck Patent Gmbh	Cyclische Amide
PA8575901A1 (es) *	2002-07-18	2004-07-20	Pfizer Prod Inc	Derivados de piperidina novedosos
ES2222833B1 (es) *	2003-07-30	2006-03-01	Laboratorios Del Dr. Esteve, S.A.	Compuestos piperidinicos 1,4-disustituidos, su preparacion y su uso como medicamentos.
EP1670787B1 (en)	2003-09-11	2012-05-30	iTherX Pharma, Inc.	Cytokine inhibitors
JP4737418B2 (ja) *	2003-09-25	2011-08-03	塩野義製薬株式会社	Ｎｍｄａ受容体拮抗作用を有するピペリジン誘導体
US20050182061A1 (en) *	2003-10-02	2005-08-18	Jeremy Green	Phthalimide compounds useful as protein kinase inhibitors
HUP0401522A2 (en) *	2004-07-29	2006-04-28	Richter Gedeon Vegyeszet	New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
HU227000B1 (en) *	2004-07-29	2010-04-28	Richter Gedeon Nyrt	Nmda receptor antagonist benzoyl urea derivatives, and pharmaceutical compositions containing them
WO2007099828A1 (ja) *	2006-02-23	2007-09-07	Shionogi & Co., Ltd.	環式基で置換された含窒素複素環誘導体
HUP0600809A3 (en) *	2006-10-27	2008-09-29	Richter Gedeon Nyrt	New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP0600810A3 (en) *	2006-10-27	2008-09-29	Richter Gedeon Nyrt	New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP0600808A3 (en) *	2006-10-27	2008-09-29	Richter Gedeon Nyrt	New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them
EP1918281A1 (en) *	2006-11-02	2008-05-07	Laboratorios del Dr. Esteve S.A.	Phenylamino-substituted piperidine compounds, their preparation and use as medicaments
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
ATE554085T1 (de)	2006-11-30	2012-05-15	Probiodrug Ag	Neue inhibitoren von glutaminylcyclase
WO2008104580A1 (en)	2007-03-01	2008-09-04	Probiodrug Ag	New use of glutaminyl cyclase inhibitors
EP2865670B1 (en)	2007-04-18	2017-01-11	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
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2002
- 2002-07-23 KR KR1020047001042A patent/KR100890676B1/ko not_active Expired - Fee Related
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- 2002-07-23 CN CNB028142349A patent/CN100413860C/zh not_active Expired - Lifetime
- 2002-07-23 SK SK102-2004A patent/SK287726B6/sk not_active IP Right Cessation
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- 2002-07-23 JP JP2003515518A patent/JP4322113B2/ja not_active Expired - Lifetime
- 2002-07-23 IL IL159393A patent/IL159393A/en active IP Right Grant
- 2002-07-23 RS YUP-1039/03A patent/RS50767B/sr unknown
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- 2002-07-23 CA CA2453383A patent/CA2453383C/en not_active Expired - Lifetime
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- 2002-07-23 MX MXPA04000737A patent/MXPA04000737A/es active IP Right Grant
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- 2004-01-20 UA UA2004021342A patent/UA77684C2/uk unknown
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Publication number	Publication date
RS50767B (sr)	2010-08-31
CY1109401T1 (el)	2014-07-02
WO2003010159A1 (en)	2003-02-06
CN1556805A (zh)	2004-12-22
EP1409477B1 (en)	2008-09-17
KR100890676B1 (ko)	2009-03-26
CA2453383A1 (en)	2003-02-06
ZA200400417B (en)	2005-07-27
EA010162B1 (ru)	2008-06-30
SK1022004A3 (en)	2004-07-07
AU2002313566B2 (en)	2007-05-24
RS103903A (en)	2007-02-05
HRP20040178A2 (en)	2005-04-30
PT1409477E (pt)	2008-11-20
SK287726B6 (en)	2011-07-06
IS7066A (is)	2003-12-05
EP1409477A1 (en)	2004-04-21
HRP20040178B1 (hr)	2013-05-31
AU2002313566B8 (en)	2003-02-18
PL216636B1 (pl)	2014-04-30
CA2453383C (en)	2010-04-06
NO20040307L (no)	2004-03-23
NZ530055A (en)	2005-07-29
ES2312603T3 (es)	2009-03-01
CO5560570A2 (es)	2005-09-30
WO2003010159A8 (en)	2004-02-12
BG66441B1 (bg)	2014-08-29
IL159393A (en)	2011-01-31
IL159393A0 (en)	2004-06-01
HK1063464A1 (en)	2004-12-31
EE200400058A (et)	2004-04-15
UA77684C2 (en)	2007-01-15
DK1409477T3 (da)	2008-12-08
JP4322113B2 (ja)	2009-08-26
ATE408611T1 (de)	2008-10-15
CZ2004233A3 (cs)	2004-12-15
BR0211393A (pt)	2004-08-17
US7435744B2 (en)	2008-10-14
US20040157886A1 (en)	2004-08-12
JP2005515968A (ja)	2005-06-02
CN100413860C (zh)	2008-08-27
MXPA04000737A (es)	2004-07-08
KR20040041152A (ko)	2004-05-14
BG108592A (bg)	2005-03-31
DE60228969D1 (ko)	2008-10-30
NO327099B1 (no)	2009-04-20
SI1409477T1 (sl)	2009-02-28
PL367259A1 (en)	2005-02-21
EA200400213A1 (ru)	2004-08-26

Publication	Publication Date	Title
EE05429B1 (et)	2011-06-15	Karbokslhappe amiidi derivaadid, nende saamise meetod ning kasutamine
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EE04308B1 (et)	2004-06-15	Bensimidasooli ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine
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