ECSP22016209A - Síntesis de un inhibidor de calicreína plasmática a escala de proceso - Google Patents
Síntesis de un inhibidor de calicreína plasmática a escala de procesoInfo
- Publication number
- ECSP22016209A ECSP22016209A ECSENADI202216209A ECDI202216209A ECSP22016209A EC SP22016209 A ECSP22016209 A EC SP22016209A EC SENADI202216209 A ECSENADI202216209 A EC SENADI202216209A EC DI202216209 A ECDI202216209 A EC DI202216209A EC SP22016209 A ECSP22016209 A EC SP22016209A
- Authority
- EC
- Ecuador
- Prior art keywords
- kallicerein
- inhibitor
- synthesis
- scale plasma
- plasma
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE ADJUNTA RESUMEN
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962883396P | 2019-08-06 | 2019-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP22016209A true ECSP22016209A (es) | 2022-06-30 |
Family
ID=74504082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202216209A ECSP22016209A (es) | 2019-08-06 | 2022-03-03 | Síntesis de un inhibidor de calicreína plasmática a escala de proceso |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20220289683A1 (es) |
| EP (1) | EP4010320A4 (es) |
| JP (1) | JP7626751B2 (es) |
| KR (1) | KR20220044276A (es) |
| CN (1) | CN114206839A (es) |
| AR (1) | AR119617A1 (es) |
| AU (1) | AU2020324422A1 (es) |
| BR (1) | BR112022002060A2 (es) |
| CA (1) | CA3149176A1 (es) |
| CL (2) | CL2022000264A1 (es) |
| CO (1) | CO2022002392A2 (es) |
| CR (1) | CR20220092A (es) |
| EC (1) | ECSP22016209A (es) |
| IL (1) | IL290113A (es) |
| JO (1) | JOP20220021A1 (es) |
| MX (1) | MX2022001608A (es) |
| PE (1) | PE20221009A1 (es) |
| PH (1) | PH12022550221A1 (es) |
| TN (1) | TN2022000028A1 (es) |
| TW (1) | TW202120481A (es) |
| UY (1) | UY38826A (es) |
| WO (1) | WO2021026182A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA53399B1 (fr) | 2014-03-07 | 2022-10-31 | Biocryst Pharm Inc | Pyrazoles substitués en tant qu`inhibiteurs de la kallicréine plasmatique humaine |
| CN116375648A (zh) * | 2023-03-22 | 2023-07-04 | 苏州农平科技发展有限公司 | 贝罗司他中间体的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| LU86084A1 (fr) | 1985-09-20 | 1987-04-02 | Faco Sa | Apparei de massage electrique |
| US5102417A (en) | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
| US4800882A (en) | 1987-03-13 | 1989-01-31 | Cook Incorporated | Endovascular stent and delivery system |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4886062A (en) | 1987-10-19 | 1989-12-12 | Medtronic, Inc. | Intravascular radially expandable stent and method of implant |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| WO1990013332A1 (en) | 1989-05-11 | 1990-11-15 | Cedars-Sinai Medical Center | Stent with sustained drug delivery |
| CA2049973C (en) | 1990-02-28 | 2002-12-24 | Rodney G. Wolff | Intralumenal drug eluting prosthesis |
| US5429634A (en) | 1993-09-09 | 1995-07-04 | Pdt Systems | Biogenic implant for drug delivery and method |
| US5419760A (en) | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
| US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| CA2454298A1 (en) * | 2001-08-13 | 2003-02-27 | Gary David Annis | Substituted 1h-dihydropyrazoles, their preparation and use |
| US6770729B2 (en) | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
| BRPI0922996B1 (pt) * | 2008-12-18 | 2018-08-28 | Bayer Cropscience Ag | amidas de ácido antranílico substituídas por tetrazol, seu uso, processo para combater parasitas animais, composição agroquímica e seu processo de preparação |
| MA53399B1 (fr) * | 2014-03-07 | 2022-10-31 | Biocryst Pharm Inc | Pyrazoles substitués en tant qu`inhibiteurs de la kallicréine plasmatique humaine |
-
2020
- 2020-08-05 MX MX2022001608A patent/MX2022001608A/es unknown
- 2020-08-05 TN TNP/2022/000028A patent/TN2022000028A1/en unknown
- 2020-08-05 KR KR1020227003932A patent/KR20220044276A/ko active Search and Examination
- 2020-08-05 CR CR20220092A patent/CR20220092A/es unknown
- 2020-08-05 WO PCT/US2020/044921 patent/WO2021026182A1/en active Application Filing
- 2020-08-05 JP JP2022506947A patent/JP7626751B2/ja active Active
- 2020-08-05 PE PE2022000188A patent/PE20221009A1/es unknown
- 2020-08-05 US US17/632,585 patent/US20220289683A1/en active Pending
- 2020-08-05 EP EP20850499.3A patent/EP4010320A4/en active Pending
- 2020-08-05 PH PH1/2022/550221A patent/PH12022550221A1/en unknown
- 2020-08-05 JO JOP/2022/0021A patent/JOP20220021A1/ar unknown
- 2020-08-05 AU AU2020324422A patent/AU2020324422A1/en active Pending
- 2020-08-05 CN CN202080055475.4A patent/CN114206839A/zh active Pending
- 2020-08-05 CA CA3149176A patent/CA3149176A1/en active Pending
- 2020-08-05 BR BR112022002060A patent/BR112022002060A2/pt unknown
- 2020-08-05 TW TW109126552A patent/TW202120481A/zh unknown
- 2020-08-06 UY UY0001038826A patent/UY38826A/es unknown
- 2020-08-06 AR ARP200102248A patent/AR119617A1/es unknown
-
2022
- 2022-01-25 IL IL290113A patent/IL290113A/en unknown
- 2022-02-01 CL CL2022000264A patent/CL2022000264A1/es unknown
- 2022-02-28 CO CONC2022/0002392A patent/CO2022002392A2/es unknown
- 2022-03-03 EC ECSENADI202216209A patent/ECSP22016209A/es unknown
-
2023
- 2023-03-30 CL CL2023000942A patent/CL2023000942A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4010320A4 (en) | 2023-08-16 |
| TN2022000028A1 (en) | 2023-10-09 |
| IL290113A (en) | 2022-03-01 |
| CL2023000942A1 (es) | 2023-11-24 |
| CL2022000264A1 (es) | 2022-10-21 |
| CO2022002392A2 (es) | 2022-04-08 |
| AR119617A1 (es) | 2021-12-29 |
| CA3149176A1 (en) | 2021-02-11 |
| JOP20220021A1 (ar) | 2023-01-30 |
| CR20220092A (es) | 2022-06-03 |
| US20220289683A1 (en) | 2022-09-15 |
| JP7626751B2 (ja) | 2025-02-04 |
| MX2022001608A (es) | 2022-03-11 |
| EP4010320A1 (en) | 2022-06-15 |
| WO2021026182A1 (en) | 2021-02-11 |
| PE20221009A1 (es) | 2022-06-15 |
| JP2022543419A (ja) | 2022-10-12 |
| UY38826A (es) | 2021-02-26 |
| PH12022550221A1 (en) | 2022-12-19 |
| KR20220044276A (ko) | 2022-04-07 |
| BR112022002060A2 (pt) | 2022-06-07 |
| TW202120481A (zh) | 2021-06-01 |
| CN114206839A (zh) | 2022-03-18 |
| AU2020324422A1 (en) | 2022-03-17 |
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