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ECSP099821A - METABOLITES OF THE JANUS QUINASA INHIBITOR (R) -3- (4- (7H-PIRROLO [2,3-d] PIRIMIDIN-4-IL) -1H-PIRAZOL-1-IL) -3-CYCLOPENTILPROPANONITRILE - Google Patents

METABOLITES OF THE JANUS QUINASA INHIBITOR (R) -3- (4- (7H-PIRROLO [2,3-d] PIRIMIDIN-4-IL) -1H-PIRAZOL-1-IL) -3-CYCLOPENTILPROPANONITRILE

Info

Publication number
ECSP099821A
ECSP099821A EC2009009821A ECSP099821A ECSP099821A EC SP099821 A ECSP099821 A EC SP099821A EC 2009009821 A EC2009009821 A EC 2009009821A EC SP099821 A ECSP099821 A EC SP099821A EC SP099821 A ECSP099821 A EC SP099821A
Authority
EC
Ecuador
Prior art keywords
janus
metabolites
cyclopentilpropanonitrile
quinasa
pirimidin
Prior art date
Application number
EC2009009821A
Other languages
Spanish (es)
Inventor
James D Rodgers
Argyrios G Arvanitis
Jack Guoen Shi
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ECSP099821A publication Critical patent/ECSP099821A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

La presente invención provee metabolitos activos de 3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo que modulan la actividad de Janus quinasas y son útiles para el tratamiento de enfermedades relacionadas con la actividad de Janus quinasas que incluyen, por ejemplo, enfermedades relacionadas con el sistema inmune, trastornos cutáneos, trastornos proliferativos mieloides, cáncer y otras enfermedades.The present invention provides active metabolites of 3- (4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanonitrile that modulate the activity of Janus kinases and they are useful for the treatment of diseases related to the activity of Janus kinases that include, for example, diseases related to the immune system, skin disorders, myeloid proliferative disorders, cancer and other diseases.

EC2009009821A 2007-06-13 2009-12-21 METABOLITES OF THE JANUS QUINASA INHIBITOR (R) -3- (4- (7H-PIRROLO [2,3-d] PIRIMIDIN-4-IL) -1H-PIRAZOL-1-IL) -3-CYCLOPENTILPROPANONITRILE ECSP099821A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94369507P 2007-06-13 2007-06-13
PCT/US2008/066658 WO2008157207A2 (en) 2007-06-13 2008-06-12 Metabolites of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-lh-pyrazol-l-yl)-3- cyclopentylpropanenitrile

Publications (1)

Publication Number Publication Date
ECSP099821A true ECSP099821A (en) 2010-01-29

Family

ID=40029276

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009821A ECSP099821A (en) 2007-06-13 2009-12-21 METABOLITES OF THE JANUS QUINASA INHIBITOR (R) -3- (4- (7H-PIRROLO [2,3-d] PIRIMIDIN-4-IL) -1H-PIRAZOL-1-IL) -3-CYCLOPENTILPROPANONITRILE

Country Status (26)

Country Link
US (5) US7834022B2 (en)
EP (1) EP2173751B1 (en)
JP (1) JP5479331B2 (en)
KR (1) KR20100049008A (en)
CN (1) CN101815717B (en)
AR (1) AR067024A1 (en)
AU (1) AU2008266182B8 (en)
BR (1) BRPI0812563A2 (en)
CA (1) CA2689158C (en)
CL (1) CL2008001709A1 (en)
CO (1) CO6251255A2 (en)
CR (1) CR11149A (en)
EA (1) EA017790B1 (en)
EC (1) ECSP099821A (en)
ES (1) ES2448868T3 (en)
GE (1) GEP20125534B (en)
HK (1) HK1141020A1 (en)
IL (1) IL202429A0 (en)
MX (2) MX2009013403A (en)
NZ (1) NZ581801A (en)
PL (1) PL2173751T3 (en)
PT (1) PT2173751E (en)
TW (1) TWI426911B (en)
UA (1) UA99465C2 (en)
WO (1) WO2008157207A2 (en)
ZA (1) ZA200908820B (en)

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