EA202192170A1 - ТИЕНО[3,2-b]ПИРИДИН-7-АМИНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ СЕМЕЙНОЙ ВЕГЕТО-СОСУДИСТОЙ ДИСТОНИИ - Google Patents
ТИЕНО[3,2-b]ПИРИДИН-7-АМИНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ СЕМЕЙНОЙ ВЕГЕТО-СОСУДИСТОЙ ДИСТОНИИInfo
- Publication number
- EA202192170A1 EA202192170A1 EA202192170A EA202192170A EA202192170A1 EA 202192170 A1 EA202192170 A1 EA 202192170A1 EA 202192170 A EA202192170 A EA 202192170A EA 202192170 A EA202192170 A EA 202192170A EA 202192170 A1 EA202192170 A1 EA 202192170A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- pyridine
- thieno
- family
- amine compounds
- Prior art date
Links
- 208000014094 Dystonic disease Diseases 0.000 title abstract 2
- 208000010118 dystonia Diseases 0.000 title abstract 2
- CWXZEXZFHGYYCD-UHFFFAOYSA-N thieno[3,2-b]pyridin-7-amine Chemical class NC1=CC=NC2=C1SC=C2 CWXZEXZFHGYYCD-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical class C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к соединениям формулы (I), применимым для улучшения сплайсинга пре-мРНК в клетке. В частности, другой аспект изобретения относится к замещенным тиено[3,2-b]пиридиновым соединениям, их формам и фармацевтическим композициям, а также к способам применения для лечения или облегчения семейной вегето-сосудистой дистонии.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962805283P | 2019-02-13 | 2019-02-13 | |
PCT/US2020/017430 WO2020167628A1 (en) | 2019-02-13 | 2020-02-10 | Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202192170A1 true EA202192170A1 (ru) | 2021-11-15 |
Family
ID=69960696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202192170A EA202192170A1 (ru) | 2019-02-13 | 2020-02-10 | ТИЕНО[3,2-b]ПИРИДИН-7-АМИНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ СЕМЕЙНОЙ ВЕГЕТО-СОСУДИСТОЙ ДИСТОНИИ |
Country Status (16)
Country | Link |
---|---|
US (1) | US20220135586A1 (ru) |
EP (1) | EP3924049A1 (ru) |
JP (1) | JP7587511B2 (ru) |
KR (1) | KR20210137040A (ru) |
CN (1) | CN113795304A (ru) |
AU (1) | AU2020222881A1 (ru) |
BR (1) | BR112021015853A2 (ru) |
CA (1) | CA3129067A1 (ru) |
CL (1) | CL2021002137A1 (ru) |
CO (1) | CO2021010598A2 (ru) |
EA (1) | EA202192170A1 (ru) |
IL (1) | IL285399A (ru) |
MX (1) | MX2021009667A (ru) |
PE (1) | PE20220139A1 (ru) |
SG (1) | SG11202108519TA (ru) |
WO (1) | WO2020167628A1 (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL298109A (en) | 2020-05-13 | 2023-01-01 | Chdi Foundation Inc | Htt modulators for treating huntington's disease |
CA3204868A1 (en) * | 2021-01-14 | 2022-07-21 | Charbel MOUSSA | Usp13 inhibitors and methods of use thereof |
CN112920053B (zh) * | 2021-02-01 | 2022-07-01 | 暨明医药科技(苏州)有限公司 | 一种手性α-甲基芳乙胺的制备方法 |
EP4288059A4 (en) * | 2021-02-05 | 2025-01-08 | Ptc Therapeutics Inc | COMPOUNDS FOR THE TREATMENT OF SPINOCEREBELLAR ATAXIA TYPE 3 |
US20240051968A1 (en) * | 2021-02-05 | 2024-02-15 | Ptc Therapeutics, Inc. | Methods for treating spinocerebellar ataxia type 3 |
TW202313623A (zh) | 2021-06-03 | 2023-04-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 具有整合酶抑制活性的吡啶酮化合物及其藥用用途 |
EP4398987A1 (en) * | 2021-09-07 | 2024-07-17 | PTC Therapeutics, Inc. | Methods for treating neurogenerative diseases |
EP4426704A1 (en) * | 2021-11-04 | 2024-09-11 | Skyhawk Therapeutics, Inc. | Condensed pyridazine amine derivatives treating sca3 |
WO2023212231A1 (en) | 2022-04-27 | 2023-11-02 | Skyhawk Therapeutics, Inc. | Compositions useful for modulating splicing |
WO2023220433A1 (en) * | 2022-05-12 | 2023-11-16 | Skyhawk Therapeutics, Inc. | Compositions useful for modulating splicing |
AU2023289366A1 (en) * | 2022-06-22 | 2025-01-23 | Ptc Therapeutics, Inc. | Compounds for treating spinocerebellar ataxia type 3 |
WO2024036143A2 (en) * | 2022-08-09 | 2024-02-15 | Ptc Therapeutics, Inc. | Methods for modulating rna splicing |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9879014B2 (en) * | 2013-07-12 | 2018-01-30 | Kyoto University | Method for screening substance capable of inhibiting abnormal splicing causative of onset or progress of disease |
CA2973949C (en) | 2015-01-16 | 2023-07-11 | The General Hospital Corporation | Compounds for improving mrna splicing |
CN109819066A (zh) | 2019-01-31 | 2019-05-28 | 平安科技(深圳)有限公司 | 一种基于地理位置的智能解析域名方法及装置 |
-
2020
- 2020-02-10 CN CN202080028449.2A patent/CN113795304A/zh active Pending
- 2020-02-10 EA EA202192170A patent/EA202192170A1/ru unknown
- 2020-02-10 US US17/430,511 patent/US20220135586A1/en active Pending
- 2020-02-10 CA CA3129067A patent/CA3129067A1/en active Pending
- 2020-02-10 BR BR112021015853-7A patent/BR112021015853A2/pt unknown
- 2020-02-10 JP JP2021547446A patent/JP7587511B2/ja active Active
- 2020-02-10 KR KR1020217028864A patent/KR20210137040A/ko not_active Application Discontinuation
- 2020-02-10 EP EP20714017.9A patent/EP3924049A1/en active Pending
- 2020-02-10 WO PCT/US2020/017430 patent/WO2020167628A1/en active Application Filing
- 2020-02-10 SG SG11202108519TA patent/SG11202108519TA/en unknown
- 2020-02-10 PE PE2021001329A patent/PE20220139A1/es unknown
- 2020-02-10 AU AU2020222881A patent/AU2020222881A1/en active Pending
- 2020-02-10 MX MX2021009667A patent/MX2021009667A/es unknown
-
2021
- 2021-08-05 IL IL285399A patent/IL285399A/en unknown
- 2021-08-12 CO CONC2021/0010598A patent/CO2021010598A2/es unknown
- 2021-08-12 CL CL2021002137A patent/CL2021002137A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CL2021002137A1 (es) | 2022-02-25 |
KR20210137040A (ko) | 2021-11-17 |
CA3129067A1 (en) | 2020-08-20 |
CN113795304A (zh) | 2021-12-14 |
EP3924049A1 (en) | 2021-12-22 |
JP7587511B2 (ja) | 2024-11-20 |
JP2022520822A (ja) | 2022-04-01 |
CO2021010598A2 (es) | 2021-08-30 |
AU2020222881A1 (en) | 2021-09-09 |
BR112021015853A2 (pt) | 2021-10-05 |
MX2021009667A (es) | 2021-12-10 |
WO2020167628A1 (en) | 2020-08-20 |
IL285399A (en) | 2021-09-30 |
SG11202108519TA (en) | 2021-09-29 |
US20220135586A1 (en) | 2022-05-05 |
PE20220139A1 (es) | 2022-01-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA202192170A1 (ru) | ТИЕНО[3,2-b]ПИРИДИН-7-АМИНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ СЕМЕЙНОЙ ВЕГЕТО-СОСУДИСТОЙ ДИСТОНИИ | |
EA202092896A1 (ru) | Гетероциклические и гетероарильные соединения для лечения болезни гентингтона | |
EA202092899A1 (ru) | Гетероарильные соединения для лечения болезни гентингтона | |
EA201591965A1 (ru) | Производные бензимидазола в качестве ингибиторов бромодомена | |
EA201100604A1 (ru) | Соединения пиридиловых ингибиторов передачи сигналов белком hedgehog, способ их получения, композиция и способы лечения рака и ингибирований ангиогенеза и сигнального пути hedgehog в клетках на их основе | |
BR112012017269A2 (pt) | compostos heterocíclicos tricíclicos, composições e métodos de uso dos mesmos | |
AU2016361478A8 (en) | Bivalent bromodomain inhibitors and uses thereof | |
EA202092490A1 (ru) | Модуляторы метилмодифицирующих ферментов, композиции и их применения | |
EA201390877A1 (ru) | Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение | |
CY1123689T1 (el) | Κρυσταλλικη μορφη ελευθερης βασης λορλατινιβης | |
EA201792214A1 (ru) | Соединения замещенного хиназолина | |
MD3442972T2 (ro) | Inhibitori ai bromodomeniului | |
EA201200669A1 (ru) | ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα | |
EA202092086A1 (ru) | Ингибиторы аргиназы | |
EA202091708A1 (ru) | Ингибиторы днк-пк | |
EA200800760A1 (ru) | ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα | |
MX2021008533A (es) | Inhibidores de la pcsk9 y metodos de uso de los mismos. | |
EA202091530A1 (ru) | Диазаиндольные соединения | |
EA200870127A1 (ru) | Полициклические производные аминокислот и способы их применения | |
EA201291073A1 (ru) | Производные транилципромина в качестве ингибиторов гистон деметилаз lsd1 и/или lsd2 | |
EA201000642A1 (ru) | 2'-фтор-2'-дезокситетрагидроуридины в качестве ингибиторов цитидиндеаминазы | |
EA200501676A1 (ru) | Фосфонатсодержащие ингибиторы киназы (варианты), способ их получения, фармацевтическая композиция, лекарственная форма на их основе и способ ингибирования киназы у млекопитающего (варианты) | |
EA201270339A1 (ru) | Замещенные производные ксантина | |
EA200800374A1 (ru) | 1,4-дигидропиридин-конденсированные гетероциклы, способы их получения, применение и содержащие их композиции | |
EA201290980A1 (ru) | Производные 1-амино-2-циклопропилэтилбороновой кислоты |