[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EA202192126A2 - Способы сбора культур клеток млекопитающих - Google Patents

Способы сбора культур клеток млекопитающих

Info

Publication number
EA202192126A2
EA202192126A2 EA202192126A EA202192126A EA202192126A2 EA 202192126 A2 EA202192126 A2 EA 202192126A2 EA 202192126 A EA202192126 A EA 202192126A EA 202192126 A EA202192126 A EA 202192126A EA 202192126 A2 EA202192126 A2 EA 202192126A2
Authority
EA
Eurasian Patent Office
Prior art keywords
collecting
methods
mammal cell
crops
cell crops
Prior art date
Application number
EA202192126A
Other languages
English (en)
Other versions
EA202192126A3 (ru
Inventor
Четан Гоудар
Шон Коул
Николь Сабо
Джонатан Лин
Джонатан Лалл
Тхармала Тхармалингам
Original Assignee
Эмджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53433304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA202192126(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA202192126A2 publication Critical patent/EA202192126A2/ru
Publication of EA202192126A3 publication Critical patent/EA202192126A3/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16Hollow fibers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/34Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04Filters; Permeable or porous membranes or plates, e.g. dialysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10Perfusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02Separating microorganisms from the culture medium; Concentration of biomass
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12Purification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00Cells for large scale production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00Culture process characterised by temperature

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Computer Hardware Design (AREA)
  • Water Supply & Treatment (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

В настоящем изобретении предложены способы и материалы для культивирования клеток млекопитающих и сбора рекомбинантного белка.
EA202192126A 2014-06-04 2015-06-04 Способы сбора культур клеток млекопитающих EA202192126A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462007588P 2014-06-04 2014-06-04

Publications (2)

Publication Number Publication Date
EA202192126A2 true EA202192126A2 (ru) 2021-11-30
EA202192126A3 EA202192126A3 (ru) 2022-03-31

Family

ID=53433304

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202192126A EA202192126A3 (ru) 2014-06-04 2015-06-04 Способы сбора культур клеток млекопитающих
EA201692498A EA039148B1 (ru) 2014-06-04 2015-06-04 Способ сбора рекомбинантного белка

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201692498A EA039148B1 (ru) 2014-06-04 2015-06-04 Способ сбора рекомбинантного белка

Country Status (25)

Country Link
US (3) US11384378B2 (ru)
EP (4) EP3521440B1 (ru)
JP (3) JP6695814B2 (ru)
KR (2) KR102391259B1 (ru)
CN (1) CN106687575B (ru)
AU (4) AU2015269365A1 (ru)
BR (2) BR122018011329A2 (ru)
CA (2) CA3195249A1 (ru)
CL (2) CL2016003096A1 (ru)
CY (1) CY1121217T1 (ru)
DK (2) DK3152317T3 (ru)
EA (2) EA202192126A3 (ru)
ES (3) ES2909630T3 (ru)
FI (1) FI3926051T3 (ru)
HU (2) HUE042277T2 (ru)
IL (2) IL249150B (ru)
LT (2) LT3152317T (ru)
MX (3) MX2016015944A (ru)
PL (2) PL3926051T3 (ru)
PT (2) PT3926051T (ru)
SG (2) SG11201610143VA (ru)
SI (2) SI3926051T1 (ru)
TR (1) TR201900776T4 (ru)
WO (1) WO2015188009A1 (ru)
ZA (1) ZA201608303B (ru)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10421949B2 (en) 2013-02-22 2019-09-24 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
CA2901950A1 (en) 2013-02-22 2014-08-28 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TW202246486A (zh) 2014-06-09 2022-12-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
KR20230125102A (ko) * 2014-12-22 2023-08-28 젠자임 코포레이션 포유류 세포의 배양 방법
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
US11339775B2 (en) * 2016-07-25 2022-05-24 Repligen Corporation Alternating tangential flow rapid harvesting
JP7043125B2 (ja) * 2016-10-28 2022-03-29 旭化成メディカル株式会社 連続培養における有用物質の回収方法
CN107964037A (zh) * 2017-05-16 2018-04-27 浙江海隆生物科技有限公司 基于cho细胞表达系统的重组猪瘟e2蛋白的纯化方法及应用
AU2018404665A1 (en) * 2017-08-31 2020-02-27 Massachusetts Institute Of Technology Hollow fibre membrane filtration systems and methods for manufacturing biologically-produced products
WO2019071076A1 (en) * 2017-10-06 2019-04-11 Lonza Ltd. AUTOMATED CONTROL OF CELL CULTURE BY SPECTROSCOPY RAMAN
CN111263631A (zh) 2017-10-26 2020-06-09 瑞普利金公司 微型交替切向流灌注过滤器、处理容器及其使用方法
JP7391840B2 (ja) 2017-11-20 2023-12-05 ロンザ リミテッド 乳酸塩の蓄積を予防しつつ、細胞培養物を増殖させるための方法及びシステム
EP3770266A4 (en) * 2018-03-19 2021-06-09 FUJIFILM Corporation PRODUCT MANUFACTURING PROCESS
GB201810772D0 (en) * 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
SG11202104417UA (en) * 2018-11-02 2021-05-28 Wuxi Biologics Ireland Ltd Cell culture process by intensified perfusion with continuous harvest and without cell bleeding
CA3121804A1 (en) * 2018-12-21 2020-06-25 Genentech, Inc. Methods of producing polypeptides using a cell line resistant to apoptosis
CN113226510A (zh) * 2018-12-31 2021-08-06 瑞普利金公司 用于哺乳动物细胞培养灌注和澄清的疏水中空纤维过滤器
US20210047605A1 (en) * 2019-08-13 2021-02-18 Repligen Corporation Control systems and methods for automated clarification of cell culture with high solids content
US20220389363A1 (en) * 2020-01-10 2022-12-08 Lonza Walkersville, Inc. Filter Apparatus and Method for Purifying Biological Processes and Cell Populations
KR20220129006A (ko) * 2020-01-15 2022-09-22 우시 바이올로직스 아일랜드 리미티드 배양 세포로부터 생산된 생체 물질을 연속적으로 수확하기 위한 장치 및 방법
CN111808797A (zh) * 2020-07-28 2020-10-23 湖南赛诺生物科技股份有限公司 Necrostatin-1的应用及促进新生猪胰岛细胞成熟的制剂
JP2023546736A (ja) * 2020-10-15 2023-11-07 エージーシー バイオロジクス,インコーポレーテッド 二重容器接線流濾過による連続的高細胞密度培養
US20220119759A1 (en) * 2020-10-19 2022-04-21 Emd Millipore Corporation Cascade Tangential Flow Filtration Systems for Perfusion of Cell Culture
US20220268785A1 (en) * 2021-02-19 2022-08-25 Northwestern University Facile sample preparation for quantitative single-cell proteomics
WO2022180260A1 (en) * 2021-02-25 2022-09-01 Securecell Ag Fluid sampling system for biotechnological applications, operating method and use thereof
FR3126713A1 (fr) * 2021-09-08 2023-03-10 Erypharm Procédé de production de cellules de culture à haute densité
CN114317392A (zh) * 2021-12-27 2022-04-12 无锡药明生物技术股份有限公司 优化细胞培养的方法
AU2023228549A1 (en) * 2022-03-01 2024-10-17 Biosanapharma B.V. Continuous manufacturing of a biological substance with process traceability
WO2023200918A1 (en) * 2022-04-14 2023-10-19 Terasaki Institute For Biomedical Innovation Systems and methods for recycling growth factors and other components
WO2023205075A1 (en) * 2022-04-22 2023-10-26 Coopersurgical, Inc. Methods of culturing umbilical cord mesenchymal stem cells
WO2024059235A2 (en) 2022-09-16 2024-03-21 Amgen Inc. A method for harvesting products from perfusion cultures
WO2024173685A1 (en) * 2023-02-15 2024-08-22 The Board Of Trustees Of The Leland Stanford Junior University Metabolic selection for glycogen-storing cells in vitro

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5223428A (en) 1982-12-14 1993-06-29 Baxter International Inc. Method for in vitro culture of mammalian cells
AU588819B2 (en) 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
US4968607A (en) 1987-11-25 1990-11-06 Immunex Corporation Interleukin-1 receptors
US5075222A (en) 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
JP2507552B2 (ja) * 1988-08-29 1996-06-12 株式会社ニッショー 細胞培養産生物の取出しおよび培地の交換方法
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
US4937196A (en) 1989-08-18 1990-06-26 Brunswick Corporation Membrane bioreactor system
US5395760A (en) 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
DK0417563T3 (da) 1989-09-12 2000-11-06 Hoffmann La Roche TNF-bindende proteiner
US6204363B1 (en) 1989-10-16 2001-03-20 Amgen Inc. Stem cell factor
US5272064A (en) 1989-12-19 1993-12-21 Amgen Inc. DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof
US5149792A (en) 1989-12-19 1992-09-22 Amgen Inc. Platelet-derived growth factor B chain analogs
US5378612A (en) 1990-05-11 1995-01-03 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Culture medium for production of recombinant protein
US5350683A (en) 1990-06-05 1994-09-27 Immunex Corporation DNA encoding type II interleukin-1 receptors
AU651596B2 (en) 1990-06-05 1994-07-28 Immunex Corporation Type II interleukin-1 receptors
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
EP0672141B1 (en) 1992-10-23 2003-05-14 Immunex Corporation Methods of preparing soluble, oligomeric proteins
US5554512A (en) 1993-05-24 1996-09-10 Immunex Corporation Ligands for flt3 receptors
US5981713A (en) 1994-10-13 1999-11-09 Applied Research Systems Ars Holding N.V. Antibodies to intereleukin-1 antagonists
US5721121A (en) 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
DE69635480T2 (de) 1995-06-29 2006-08-17 Immunex Corp., Thousand Oaks Apoptosis induzierendes cytokin
US6613544B1 (en) 1995-12-22 2003-09-02 Amgen Inc. Osteoprotegerin
US6096728A (en) 1996-02-09 2000-08-01 Amgen Inc. Composition and method for treating inflammatory diseases
US6271349B1 (en) 1996-12-23 2001-08-07 Immunex Corporation Receptor activator of NF-κB
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US6337072B1 (en) 1998-04-03 2002-01-08 Hyseq, Inc. Interleukin-1 receptor antagonist and recombinant production thereof
US6068775A (en) * 1998-04-13 2000-05-30 Circe Biomedical, Inc. Removal of agent from cell suspension
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
WO2001036637A1 (en) 1999-11-17 2001-05-25 Immunex Corporation Receptor activator of nf-kappa b
US6544424B1 (en) 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
AR031699A1 (es) 2000-05-26 2003-10-01 Bristol Myers Squibb Co Molecula mutante de ctla4 soluble que se enlaza a cd80 y/o cd86, molecula de acido nucleico que la codifica, vector y sistema vector que comprende a esta ultima, celula huesped que lo posee, metodo para producir una proteina mutante y dicha proteina, uso de la molecula mutante para preparar un medic
US20040185535A1 (en) 2003-03-21 2004-09-23 Giles Wilson Industrial-scale serum-free production of recombinant FVII in mammalian cells
ES2323761T3 (es) 2000-10-02 2009-07-24 Novo Nordisk Health Care Ag Metodo para la produccion de proteinas dependientes de la vitamina k.
CN1547486A (zh) * 2001-06-26 2004-11-17 抗opgl抗体
WO2004005493A1 (en) 2002-07-09 2004-01-15 Baxter International, Inc. Animal protein free media for cultivation of cells
AR041173A1 (es) * 2002-09-06 2005-05-04 Amgen Inc Aniticuerpo monoclonal anti- il- 1r1 humano terapeutico
CN101044239B (zh) * 2002-12-23 2010-12-08 布里斯托尔-迈尔斯斯奎布公司 用于蛋白质生产的哺乳动物细胞培养方法
DE10312765A1 (de) 2003-03-21 2004-09-30 Bayer Technology Services Gmbh Vorrichtung und Verfahren zur Sterilisation flüssiger Medien mittels UV-Bestrahlung und Kurzzeiterhitzung
US20050100965A1 (en) * 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
JP4655938B2 (ja) * 2004-01-21 2011-03-23 東レ株式会社 分画装置および分画方法
PT1720972E (pt) * 2004-03-05 2014-04-07 Dsm Ip Assets Bv Processo para cultura de células por perfusão contínua e fluxo alternativo tangencial
US7422875B2 (en) 2004-07-20 2008-09-09 Board Of Regents Of The University Of Nebraska Compositions and methods for increasing protein production
US8053238B2 (en) 2005-10-31 2011-11-08 Unhwa Corporation Isolated population of plant single cells and method of preparing the same
DK2634243T4 (da) * 2006-07-14 2024-09-23 Patheon Holdings I B V Forbedret fremgangsmåde til dyrkning af celler
WO2008024769A2 (en) * 2006-08-21 2008-02-28 Raven Biotechnologies, Inc. Intensified perfusion production method
CN103397065A (zh) 2006-09-13 2013-11-20 雅培制药有限公司 细胞培养改良
US20100221823A1 (en) 2007-06-11 2010-09-02 Amgen Inc. Method for culturing mammalian cells to improve recombinant protein production
EP2014760A1 (en) * 2007-06-13 2009-01-14 CMC Biopharmaceuticals A/S A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process
JP5579599B2 (ja) 2007-06-15 2014-08-27 アムジエン・インコーポレーテツド バイオリアクターにおいて使用する細胞培養培地の処理方法
EP3327132A3 (en) * 2007-08-09 2018-07-18 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
SG10201503304RA (en) 2007-12-27 2015-06-29 Baxter Int Cell culture processes
DE102008051574A1 (de) 2008-10-14 2010-04-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung von Interferon-beta und deren Varianten
JP5719301B2 (ja) 2008-11-12 2015-05-13 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated 血清不含インスリン不含で第vii因子を産生する方法
ES2583258T3 (es) 2009-07-31 2016-09-20 Baxalta GmbH Medio de cultivo celular para expresión de proteína ADAMTS
SI2493922T1 (sl) * 2009-10-26 2017-06-30 F. Hoffmann-La Roche Ag Postopek za proizvodnjo glikoziliranega imunoglobulina
EP2516623B1 (fr) 2009-12-23 2016-10-05 Sanofi Pasteur Procede de culture de cellules adherentes
EP3492574A3 (en) * 2010-08-25 2019-09-04 Refine Technology, LLC Fluid filtration systems
MX344465B (es) * 2011-02-10 2016-12-14 Crucell Holland Bv Sistema de separacion de celulas a traves de membrana por presion alternamente neumatica.
SG192905A1 (en) 2011-02-23 2013-09-30 Amgen Inc Cell culture media for uvc exposure and methods related thereto
US9133493B2 (en) 2011-04-21 2015-09-15 Amgen Inc. Method for culturing mammalian cells to improve recombinant protein production
CN103517919B (zh) 2011-05-13 2016-11-16 欧克塔医药公司 在重组fviii的生产中提高真核细胞生产率的方法
HUE033279T2 (en) 2011-07-01 2017-11-28 Amgen Inc Mammalian cell culture
CN103946366B (zh) 2011-09-16 2017-08-11 安姆根有限公司 细胞培养物的预编程非反馈控制的连续供料
KR102091294B1 (ko) 2011-10-26 2020-04-16 암젠 인크 Uv 광으로의 노출로 인한 단백질 변형 및 분해의 감소 또는 제거 방법
WO2013138159A1 (en) 2012-03-15 2013-09-19 Amgen Inc. Methods of determining exposure to uv light
US10481164B2 (en) 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
WO2014022102A1 (en) 2012-08-01 2014-02-06 Amgen Inc. Methods of using anti-apoptotic compounds to modulate one or more properties of a cell culture
TWI637057B (zh) 2012-11-09 2018-10-01 拜爾沙納有限公司 具交替生物反應器用途之不連續進料批次製程
EP2735326B1 (en) 2012-11-26 2017-03-08 Gambro Lundia AB Liver support system
EP2976418B1 (en) * 2013-03-19 2020-09-30 CMC Biologics A/S A method for producing a product (e.g. polypeptide) in a continuous cell culture fermentation process.

Also Published As

Publication number Publication date
IL249150A0 (en) 2017-01-31
IL294430A (en) 2022-09-01
SI3152317T1 (sl) 2019-03-29
JP2017519497A (ja) 2017-07-20
KR20170015464A (ko) 2017-02-08
AU2015269365A1 (en) 2016-12-15
US20220356502A1 (en) 2022-11-10
JP2022126811A (ja) 2022-08-30
WO2015188009A1 (en) 2015-12-10
HUE066803T2 (hu) 2024-09-28
JP7377316B2 (ja) 2023-11-09
ES2709994T3 (es) 2019-04-22
EP4372078A2 (en) 2024-05-22
DK3926051T3 (da) 2024-06-10
US11384378B2 (en) 2022-07-12
JP7097404B2 (ja) 2022-07-07
AU2022224699B2 (en) 2024-08-29
HUE042277T2 (hu) 2019-06-28
ZA201608303B (en) 2023-06-28
US20170114381A1 (en) 2017-04-27
AU2022224699A1 (en) 2022-09-22
EP3521440A1 (en) 2019-08-07
US11427848B2 (en) 2022-08-30
JP6695814B2 (ja) 2020-05-20
EA201692498A1 (ru) 2017-05-31
AU2020294155B2 (en) 2022-07-28
CN106687575A (zh) 2017-05-17
CN106687575B (zh) 2021-04-30
BR112016028285B1 (pt) 2023-02-23
LT3926051T (lt) 2024-06-10
TR201900776T4 (tr) 2019-02-21
SG11201610143VA (en) 2017-01-27
PL3926051T3 (pl) 2024-08-26
FI3926051T3 (fi) 2024-06-18
PL3152317T3 (pl) 2019-08-30
WO2015188009A9 (en) 2017-01-26
IL249150B (en) 2022-09-01
EP3926051A1 (en) 2021-12-22
PT3926051T (pt) 2024-06-20
CL2016003096A1 (es) 2017-11-03
MX2021008142A (es) 2021-08-11
EP4372078A3 (en) 2024-09-04
CL2019001641A1 (es) 2019-10-25
MX2021008143A (es) 2021-08-11
EP3152317B1 (en) 2019-01-02
PT3152317T (pt) 2019-04-18
LT3152317T (lt) 2019-03-12
KR102598799B1 (ko) 2023-11-07
CA3195249A1 (en) 2015-12-10
CY1121217T1 (el) 2020-05-29
EA039148B1 (ru) 2021-12-10
ES2980493T3 (es) 2024-10-01
BR122018011329A2 (pt) 2019-09-10
JP2020124207A (ja) 2020-08-20
BR112016028285A2 (pt) 2018-06-26
KR102391259B1 (ko) 2022-04-26
AU2020294155A1 (en) 2021-01-28
KR20220054903A (ko) 2022-05-03
ES2909630T3 (es) 2022-05-09
DK3152317T3 (en) 2019-04-08
EP3926051B1 (en) 2024-05-08
EP3152317A1 (en) 2017-04-12
EP3521440B1 (en) 2022-02-09
CA2951046A1 (en) 2015-12-10
CA2951046C (en) 2023-06-13
EA202192126A3 (ru) 2022-03-31
SI3926051T1 (sl) 2024-06-28
AU2019203538B2 (en) 2020-10-08
MX2016015944A (es) 2017-08-15
US20220136025A1 (en) 2022-05-05
SG10202113019XA (en) 2021-12-30
AU2019203538A1 (en) 2019-06-06

Similar Documents

Publication Publication Date Title
EA202192126A2 (ru) Способы сбора культур клеток млекопитающих
EA202090931A3 (ru) Композиции и способы перепрограммирования tcr с помощью гибридных белков
EA201692025A1 (ru) Доставка белков, осуществляемая на основе бактерий
TR201904270T4 (tr) Tanımlı koşullar altında insan pluripotent kök hücrelerinin hematoendotelyal farklılaşması için yöntemler ve materyaller.
BR112017013481A2 (pt) material permeável a gás
CY1123654T1 (el) Αποδεσμευση πρωτεϊνης me βαση βακτηρια
EA201791918A1 (ru) Модификация белков клеток-хозяев
CL2016003146A1 (es) Análisis cuantitativo de proteínas transgénicas
DK3766582T3 (da) Cellekultur
EA201691532A1 (ru) Сверхэкспрессия регуляторов пути n-гликозилирования для модуляции гликозилирования рекомбинантных белков
EA201691548A1 (ru) Экспрессирующие конструкции и способы для отбора клеток-хозяев, экспрессирующих полипептиды
DK3743266T3 (da) 3D-bioprintere med midler til cellekulturovervågning
DK3819368T3 (da) Cellekulturovervågningssystem
MX2018004005A (es) Ensayo de potencia celular.
MX2022000516A (es) Metodos relacionados con celulas pluripotentes.
EA201791233A1 (ru) Материал стволовых клеток и способ его получения
EA201992828A1 (ru) Способы культивирования клеток
WO2015117033A3 (en) Methods of increasing protein production in mammalian cells
DK3218514T3 (da) Forudsigelse af genetisk stabil rekombinant proteinproduktion i tidlig cellelinieudvikling
TH1501007595A (th) สารละลายซึ่งมีทรีฮาโลสและเดกซ์แทรนสำหรับการปลูกถ่ายเซลล์สัตว์เลี้ยงลูกด้วยนม
RU2014134753A (ru) Ген PDGF-Bopt тромбоцитарного фактора роста человека
TH1601001441A (th) ภาชนะสำหรับเลี้ยงเซลล์และภาชนะที่มีการเก็บสิ่งเลี้ยงเซลล์แล้ว
RU2013150974A (ru) Способ культивирования личинок нематод подотряда ascaridata