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EA202190094A1 - Антитела против cd40 для применения в лечении аутоиммунного заболевания - Google Patents

Антитела против cd40 для применения в лечении аутоиммунного заболевания

Info

Publication number
EA202190094A1
EA202190094A1 EA202190094A EA202190094A EA202190094A1 EA 202190094 A1 EA202190094 A1 EA 202190094A1 EA 202190094 A EA202190094 A EA 202190094A EA 202190094 A EA202190094 A EA 202190094A EA 202190094 A1 EA202190094 A1 EA 202190094A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies against
treatment
autoimmune disease
therapeutic
compositions
Prior art date
Application number
EA202190094A
Other languages
English (en)
Inventor
Йюрген Теодор Штеффген
Дэвид П. Джозеф
Джеймс Майкл Хилберт
Патанджали Равва
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA202190094A1 publication Critical patent/EA202190094A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к новым антагонистическим гуманизированным антителам против CD40, к терапевтическим и диагностическим способам, а также к композициям для их применения.
EA202190094A 2018-06-29 2019-06-28 Антитела против cd40 для применения в лечении аутоиммунного заболевания EA202190094A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862691766P 2018-06-29 2018-06-29
PCT/US2019/039715 WO2020006347A1 (en) 2018-06-29 2019-06-28 Anti-cd40 antibodies for use in treating autoimmune disease

Publications (1)

Publication Number Publication Date
EA202190094A1 true EA202190094A1 (ru) 2021-04-21

Family

ID=67297421

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190094A EA202190094A1 (ru) 2018-06-29 2019-06-28 Антитела против cd40 для применения в лечении аутоиммунного заболевания

Country Status (13)

Country Link
US (2) US20210261678A1 (ru)
EP (1) EP3813950A1 (ru)
JP (1) JP7504808B2 (ru)
KR (1) KR20210027436A (ru)
CN (1) CN112334195A (ru)
AU (1) AU2019291890A1 (ru)
BR (1) BR112020024078A2 (ru)
CA (1) CA3101469A1 (ru)
CL (1) CL2020003348A1 (ru)
EA (1) EA202190094A1 (ru)
MX (1) MX2020013885A (ru)
PH (1) PH12020552235A1 (ru)
WO (1) WO2020006347A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202229344A (zh) * 2020-09-21 2022-08-01 德商百靈佳殷格翰國際股份有限公司 抗-cd40抗體用於治療發炎病況之用途
AU2022214319A1 (en) 2021-01-28 2023-08-03 Regeneron Pharmaceuticals, Inc. Compositions and methods for treating cytokine release syndrome
TW202309095A (zh) * 2021-06-28 2023-03-01 大陸商江蘇恆瑞醫藥股份有限公司 抗cd40抗體、其抗原結合片段及醫藥用途
WO2023198194A1 (en) * 2022-04-15 2023-10-19 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Anti-cd40 antibodies and uses thereof
WO2024140917A1 (zh) * 2022-12-28 2024-07-04 上海盛迪医药有限公司 抗cd40抗体药物偶联物、其制备方法及其医药用途

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Also Published As

Publication number Publication date
MX2020013885A (es) 2021-03-09
JP2021529754A (ja) 2021-11-04
KR20210027436A (ko) 2021-03-10
AU2019291890A1 (en) 2020-12-17
US20240309105A1 (en) 2024-09-19
JP7504808B2 (ja) 2024-06-24
CN112334195A (zh) 2021-02-05
WO2020006347A1 (en) 2020-01-02
CL2020003348A1 (es) 2021-07-19
EP3813950A1 (en) 2021-05-05
BR112020024078A2 (pt) 2021-02-17
CA3101469A1 (en) 2020-01-02
PH12020552235A1 (en) 2021-06-28
US20210261678A1 (en) 2021-08-26

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