EA202190016A1 - Гетеромультимеры рецепторов типа i и типа ii белков суперсемейства tgf-бета - Google Patents
Гетеромультимеры рецепторов типа i и типа ii белков суперсемейства tgf-бетаInfo
- Publication number
- EA202190016A1 EA202190016A1 EA202190016A EA202190016A EA202190016A1 EA 202190016 A1 EA202190016 A1 EA 202190016A1 EA 202190016 A EA202190016 A EA 202190016A EA 202190016 A EA202190016 A EA 202190016A EA 202190016 A1 EA202190016 A1 EA 202190016A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- type
- polypeptide complexes
- soluble
- tgf
- aspects
- Prior art date
Links
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108020003175 receptors Proteins 0.000 abstract 4
- 210000001519 tissue Anatomy 0.000 abstract 3
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 abstract 2
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 abstract 2
- 102000043168 TGF-beta family Human genes 0.000 abstract 2
- 108091085018 TGF-beta family Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- -1 ALK5 Proteins 0.000 abstract 1
- 102100034111 Activin receptor type-1 Human genes 0.000 abstract 1
- 102100034134 Activin receptor type-1B Human genes 0.000 abstract 1
- 102100034135 Activin receptor type-1C Human genes 0.000 abstract 1
- 102100025511 Anti-Muellerian hormone type-2 receptor Human genes 0.000 abstract 1
- 101710089052 Anti-Muellerian hormone type-2 receptor Proteins 0.000 abstract 1
- 102100025423 Bone morphogenetic protein receptor type-1A Human genes 0.000 abstract 1
- 102100027052 Bone morphogenetic protein receptor type-1B Human genes 0.000 abstract 1
- 101000799140 Homo sapiens Activin receptor type-1 Proteins 0.000 abstract 1
- 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 abstract 1
- 101000799193 Homo sapiens Activin receptor type-1C Proteins 0.000 abstract 1
- 101000934638 Homo sapiens Bone morphogenetic protein receptor type-1A Proteins 0.000 abstract 1
- 101000984546 Homo sapiens Bone morphogenetic protein receptor type-1B Proteins 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 abstract 1
- 210000000577 adipose tissue Anatomy 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000000750 endocrine system Anatomy 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 230000011132 hemopoiesis Effects 0.000 abstract 1
- 239000000833 heterodimer Substances 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 230000009753 muscle formation Effects 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 abstract 1
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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Abstract
В некоторых аспектах изобретение относится к растворимым гетеромерным полипептидным комплексам, содержащим внеклеточный домен серин/треонинового киназного рецептора типа I белков семейства TGF-бета и внеклеточный домен серин/треонинового киназного рецептора типа II белков семейства TGF-бета. В некоторых вариантах осуществления изобретение относится к растворимым полипептидным комплексам, содержащим внеклеточный домен рецептора типа II, выбранного из ActRIIA, ActRIIB, TGFBRII, BMPRII и MISRII. В некоторых вариантах осуществления изобретение относится к растворимым полипептидным комплексам, содержащим внеклеточный домен рецептора типа I, выбранного из ALK1, ALK2, ALK3, ALK4, ALK5, ALK6 и ALK7. Необязательно растворимый комплекс представляет собой гетеродимер. В некоторых аспектах такие растворимые полипептидные комплексы можно использовать для регуляции (стимуляции или ингибирования) роста тканей или клеток, включая, например, мышцу, кость, хрящ, жировую ткань, нервную ткань, опухоли, злокачественные клетки и/или клетки гемопоэтических ростков, включая эритроциты. В некоторых аспектах такие растворимые полипептидные комплексы можно использовать для улучшения образования мышц, образования костей, гемапоэза, метаболических параметров и для нарушений, ассоциированных с этими тканями, клеточными сетями и эндокринными системами.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143579P | 2015-04-06 | 2015-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202190016A1 true EA202190016A1 (ru) | 2021-08-31 |
Family
ID=57072866
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202190016A EA202190016A1 (ru) | 2015-04-06 | 2016-04-06 | Гетеромультимеры рецепторов типа i и типа ii белков суперсемейства tgf-бета |
| EA201792222A EA037293B1 (ru) | 2015-04-06 | 2016-04-06 | Гетеромультимеры рецепторов типа i и типа ii белков суперсемейства tgf-бета |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201792222A EA037293B1 (ru) | 2015-04-06 | 2016-04-06 | Гетеромультимеры рецепторов типа i и типа ii белков суперсемейства tgf-бета |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US10227392B2 (ru) |
| EP (4) | EP3828199A1 (ru) |
| JP (3) | JP7037363B2 (ru) |
| KR (2) | KR20180002659A (ru) |
| CN (4) | CN115073610A (ru) |
| AU (4) | AU2016246708B2 (ru) |
| BR (1) | BR112017021510A2 (ru) |
| CA (2) | CA2981737A1 (ru) |
| DK (1) | DK3280728T3 (ru) |
| EA (2) | EA202190016A1 (ru) |
| ES (1) | ES2863564T3 (ru) |
| HK (2) | HK1250373A1 (ru) |
| MA (4) | MA54328A (ru) |
| MX (1) | MX391964B (ru) |
| WO (2) | WO2016164089A2 (ru) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015027082A1 (en) | 2013-08-22 | 2015-02-26 | Acceleron Pharma, Inc. | Tgf-beta receptor type ii variants and uses thereof |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| EP3280727B1 (en) | 2015-04-06 | 2021-02-17 | Acceleron Pharma Inc. | Single-arm type i and type ii receptor fusion proteins and uses thereof |
| US10227392B2 (en) | 2015-04-06 | 2019-03-12 | Acceleron Pharma Inc. | ALK7:ActRIIB heteromultimers and uses thereof |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| JP6959487B2 (ja) | 2015-04-22 | 2021-11-02 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
| CN116327952A (zh) | 2015-08-04 | 2023-06-27 | 阿塞勒隆制药公司 | 用于治疗骨髓增生性病症的方法 |
| CN105254764A (zh) * | 2015-08-27 | 2016-01-20 | 上海康岱生物医药技术有限公司 | ACVR1-Fc融合蛋白及其制法和用途 |
| EP3439741A4 (en) * | 2016-04-06 | 2020-05-06 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
| WO2018013936A1 (en) | 2016-07-15 | 2018-01-18 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| TW201813978A (zh) | 2016-10-05 | 2018-04-16 | 美商艾瑟勒朗法瑪公司 | ＡＬＫ４：ＡｃｔＲＩＩＢ異多聚體及其用途 |
| EP3522912A4 (en) * | 2016-10-05 | 2020-10-14 | Acceleron Pharma Inc. | HETEROMULTIMERS OF TYPE I AND TYPE II RECEIVERS OF THE TGF-BETA SUPERFAMILY AND THEIR USES |
| JP2019529509A (ja) * | 2016-10-05 | 2019-10-17 | アクセレロン ファーマ インコーポレーテッド | 腎臓疾患を治療するための組成物および方法 |
| MA46471A (fr) | 2016-10-05 | 2021-05-19 | Acceleron Pharma Inc | Protéines actriib à variant et leurs utilisations |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
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2021
- 2021-01-27 AU AU2021200492A patent/AU2021200492A1/en not_active Abandoned
- 2021-04-15 JP JP2021069060A patent/JP7246618B2/ja active Active
- 2021-04-30 US US17/245,123 patent/US11827689B2/en active Active
-
2023
- 2023-08-21 US US18/236,082 patent/US20240158468A1/en active Pending
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