EA202092084A1 - Соединения - агонисты фактора роста и дифференцировки 15 и способы их применения - Google Patents
Соединения - агонисты фактора роста и дифференцировки 15 и способы их примененияInfo
- Publication number
- EA202092084A1 EA202092084A1 EA202092084A EA202092084A EA202092084A1 EA 202092084 A1 EA202092084 A1 EA 202092084A1 EA 202092084 A EA202092084 A EA 202092084A EA 202092084 A EA202092084 A EA 202092084A EA 202092084 A1 EA202092084 A1 EA 202092084A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- agonists
- differentiation
- growth
- methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000000556 agonist Substances 0.000 title abstract 2
- 230000004069 differentiation Effects 0.000 title 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 abstract 1
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
В данном документе предложены соединения, которые вызывают потерю массы тела и лечат диабет, дислипидемию, НАСГ и/или ожирение. Также предложены фармацевтические композиции, содержащие такие соединения, и варианты терапевтического применения таких соединений и композиций, при этом такие соединения действуют как агонисты GDF15 с продленным временем действия и другими полезными свойствами.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862653759P | 2018-04-06 | 2018-04-06 | |
| PCT/US2019/024756 WO2019195091A1 (en) | 2018-04-06 | 2019-03-29 | Growth differentiation factor 15 agonist compounds and methods of using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202092084A1 true EA202092084A1 (ru) | 2021-01-27 |
Family
ID=66630339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202092084A EA202092084A1 (ru) | 2018-04-06 | 2019-03-29 | Соединения - агонисты фактора роста и дифференцировки 15 и способы их применения |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US11104711B2 (ru) |
| EP (1) | EP3774860B1 (ru) |
| JP (1) | JP7064618B2 (ru) |
| KR (1) | KR102501922B1 (ru) |
| CN (1) | CN112004821B (ru) |
| AR (1) | AR115021A1 (ru) |
| AU (1) | AU2019248535B2 (ru) |
| BR (1) | BR112020017256A2 (ru) |
| CA (1) | CA3096375C (ru) |
| CL (1) | CL2020002564A1 (ru) |
| CO (1) | CO2020012403A2 (ru) |
| CR (1) | CR20200454A (ru) |
| DO (1) | DOP2020000157A (ru) |
| EA (1) | EA202092084A1 (ru) |
| EC (1) | ECSP20062930A (ru) |
| ES (1) | ES2937049T3 (ru) |
| IL (1) | IL276980A (ru) |
| JO (1) | JOP20200252B1 (ru) |
| MA (1) | MA52228A (ru) |
| MX (1) | MX2020010370A (ru) |
| NZ (1) | NZ767242A (ru) |
| PE (1) | PE20212133A1 (ru) |
| PH (1) | PH12020551656A1 (ru) |
| SA (1) | SA520420287B1 (ru) |
| SG (1) | SG11202009853VA (ru) |
| TW (1) | TWI724392B (ru) |
| UA (1) | UA127545C2 (ru) |
| WO (1) | WO2019195091A1 (ru) |
| ZA (1) | ZA202005385B (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103533951B (zh) | 2011-04-08 | 2017-04-19 | 安姆根有限公司 | 使用生长分化因子15(gdf‑15)治疗或改善代谢障碍的方法 |
| KR20240000642A (ko) | 2013-07-31 | 2024-01-02 | 암젠 인크 | 성장 분화 인자 15(ｇｄｆ-15) 작제물 |
| EA202092419A1 (ru) | 2018-04-09 | 2021-02-05 | Эмджен Инк. | Слитые белки ростового фактора дифференцировки 15 |
| EP4041281A1 (en) | 2019-10-04 | 2022-08-17 | Amgen Inc. | Use of gdf15 for treating cardiometabolic syndrome and other conditions |
| CA3154522A1 (en) | 2019-10-15 | 2021-04-22 | Christopher Carl Frye | Recombinantly engineered, lipase/esterase-deficient mammalian cell lines |
| US20240350588A1 (en) | 2021-08-24 | 2024-10-24 | Sunshine Lake Pharma Co., Ltd. | Gdf15 fusion proteins and use thereof |
| WO2023125881A1 (zh) | 2021-12-31 | 2023-07-06 | 广东东阳光药业有限公司 | Glp-1和gdf15的融合蛋白及其用途 |
| WO2023154953A1 (en) | 2022-02-14 | 2023-08-17 | Ngm Biopharmaceuticals, Inc. | Gdf15 polypeptides for treating and preventing autoimmune diseases |
| CN118580334A (zh) * | 2023-03-03 | 2024-09-03 | 北京志道生物科技有限公司 | 一种多肽分子 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| GB9912350D0 (en) * | 1999-05-26 | 1999-07-28 | European Molecular Biology Lab Embl | Modified cytokine |
| FI117667B (fi) * | 2001-07-05 | 2007-01-15 | Univ Zuerich | Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä |
| US20090042780A1 (en) | 2004-05-20 | 2009-02-12 | Acceleron Pharma Inc | Modified TGF-Beta Superfamily Polypeptides and Related Methods |
| WO2006031994A2 (en) | 2004-09-14 | 2006-03-23 | Xencor, Inc. | Monomeric immunoglobulin fc domains |
| BR112012029577B1 (pt) * | 2010-05-21 | 2022-04-12 | Xl-Protein Gmbh | Conjugado de fármaco compreendendo polipeptídeos helicoidais randômicos prolina/alanina biossintéticos, e composição farmacêutica ou diagnóstica |
| DK2670847T3 (en) * | 2011-02-03 | 2017-01-16 | Xoma Technology Ltd | Methods and Materials for Improving Functional Protein Expression in Bacteria |
| EP2807266B1 (en) | 2012-01-26 | 2020-01-15 | Amgen Inc. | Growth differentiation factor 15 (gdf-15) polypeptides |
| JP6254146B2 (ja) | 2012-03-27 | 2017-12-27 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 代謝障害を治療するための組成物および方法 |
| ES2791183T3 (es) * | 2012-12-21 | 2020-11-03 | Aveo Pharmaceuticals Inc | Anticuerpos anti-GDF15 |
| RU2704285C2 (ru) | 2013-01-30 | 2019-10-25 | Нгм Байофармасьютикалз, Инк. | Композиции и способы применения для лечения метаболических расстройств |
| KR20240000642A (ko) | 2013-07-31 | 2024-01-02 | 암젠 인크 | 성장 분화 인자 15(ｇｄｆ-15) 작제물 |
| KR20230141929A (ko) | 2013-07-31 | 2023-10-10 | 암젠 인크 | Ｆc-함유 폴리펩타이드의 안정화 |
| JP6675333B2 (ja) | 2014-06-23 | 2020-04-01 | ノバルティス アーゲー | 部位特異的タンパク質修飾 |
| WO2015198199A1 (en) | 2014-06-23 | 2015-12-30 | Novartis Ag | Hsa-gdf-15 fusion polypeptide and use thereof. |
| EP3160496B1 (en) | 2014-06-24 | 2021-03-03 | Novo Nordisk As | MIC-1 FUSION PROTEINS AND RELATED USES |
| AU2015296640B2 (en) | 2014-07-30 | 2020-05-21 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| AU2015339134B2 (en) | 2014-10-30 | 2021-06-17 | Acceleron Pharma Inc. | Methods and compositions using GDF15 polypeptides for increasing red blood cells |
| DK3212226T3 (da) * | 2014-10-31 | 2020-06-15 | Ngm Biopharmaceuticals Inc | Sammensætninger og anvendelsesfremgangsmåder til behandling af metaboliske lidelser |
| WO2016131893A1 (en) | 2015-02-18 | 2016-08-25 | Medimmune Limited | Incretin fusion polypeptides |
| KR20170134542A (ko) | 2015-04-02 | 2017-12-06 | 얀센 바이오테크 인코포레이티드 | 프로톡신-ii 변이체 및 사용 방법 |
| JP6946304B2 (ja) | 2015-12-22 | 2021-10-06 | ノバルティス アーゲー | 増殖分化因子１５（ｇｄｆ−１５）を使用して代謝障害を処置するまたは軽快させる方法 |
| WO2017121865A1 (en) | 2016-01-15 | 2017-07-20 | Novo Nordisk A/S | Mic-1 receptor and uses thereof |
| CN108697795A (zh) | 2016-02-29 | 2018-10-23 | 伊莱利利公司 | Gfral受体疗法 |
| EP3413620A4 (en) | 2016-02-29 | 2019-01-16 | Huawei Technologies Co., Ltd. | VIDEO OPTIMIZATION PROCEDURE, USER DEVICE UNIT AND NETWORK DEVICE UNIT |
| JP2019513224A (ja) | 2016-03-04 | 2019-05-23 | エヌジーエム バイオファーマシューティカルス，インコー | 体重を調節するための組成物及び方法 |
| US10336812B2 (en) | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
-
2019
- 2019-03-26 TW TW108110400A patent/TWI724392B/zh active
- 2019-03-27 AR ARP190100774A patent/AR115021A1/es unknown
- 2019-03-29 BR BR112020017256-1A patent/BR112020017256A2/pt unknown
- 2019-03-29 EP EP19725879.1A patent/EP3774860B1/en active Active
- 2019-03-29 UA UAA202005772A patent/UA127545C2/uk unknown
- 2019-03-29 PE PE2020001334A patent/PE20212133A1/es unknown
- 2019-03-29 US US16/369,096 patent/US11104711B2/en active Active
- 2019-03-29 ES ES19725879T patent/ES2937049T3/es active Active
- 2019-03-29 JO JOP/2020/0252A patent/JOP20200252B1/ar active
- 2019-03-29 CN CN201980024748.6A patent/CN112004821B/zh active Active
- 2019-03-29 CA CA3096375A patent/CA3096375C/en active Active
- 2019-03-29 CR CR20200454A patent/CR20200454A/es unknown
- 2019-03-29 MX MX2020010370A patent/MX2020010370A/es unknown
- 2019-03-29 KR KR1020207027912A patent/KR102501922B1/ko active IP Right Grant
- 2019-03-29 JP JP2020554477A patent/JP7064618B2/ja active Active
- 2019-03-29 NZ NZ767242A patent/NZ767242A/en unknown
- 2019-03-29 SG SG11202009853VA patent/SG11202009853VA/en unknown
- 2019-03-29 EA EA202092084A patent/EA202092084A1/ru unknown
- 2019-03-29 AU AU2019248535A patent/AU2019248535B2/en active Active
- 2019-03-29 MA MA052228A patent/MA52228A/fr unknown
- 2019-03-29 WO PCT/US2019/024756 patent/WO2019195091A1/en active Application Filing
-
2020
- 2020-08-17 DO DO2020000157A patent/DOP2020000157A/es unknown
- 2020-08-27 IL IL276980A patent/IL276980A/en unknown
- 2020-08-28 ZA ZA2020/05385A patent/ZA202005385B/en unknown
- 2020-10-01 CO CONC2020/0012403A patent/CO2020012403A2/es unknown
- 2020-10-02 CL CL2020002564A patent/CL2020002564A1/es unknown
- 2020-10-05 EC ECSENADI202062930A patent/ECSP20062930A/es unknown
- 2020-10-06 SA SA520420287A patent/SA520420287B1/ar unknown
- 2020-10-06 PH PH12020551656A patent/PH12020551656A1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA202092084A1 (ru) | Соединения - агонисты фактора роста и дифференцировки 15 и способы их применения | |
| MX2019003790A (es) | Analogos de isoxazol como agonistas de fxr y metodos de uso de los mismos. | |
| EA201992878A1 (ru) | Соединения для лечения болезни хантингтона | |
| TN2019000136A1 (en) | 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of dhodh | |
| EA201890725A1 (ru) | Агонисты фарнезоидного х-рецептора и их применение | |
| EA201891203A1 (ru) | Гетероциклические соединения в качестве иммуномодуляторов | |
| EA202090448A1 (ru) | Дигидрооксадиазиноны | |
| EA201692007A1 (ru) | Соединения изоиндолинона в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных с ними нарушений | |
| EA201692008A1 (ru) | Замещенные сконденсированные гетероциклы в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных нарушений | |
| EA201890449A1 (ru) | Фумагиллиновые гетероциклические соединения и способы их получения и применения | |
| ZA202104594B (en) | Formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4h-quinazolin-3-yl)-benzonitrile | |
| MX2021002916A (es) | Pirfenidona enriquecida con deuterio y métodos para su uso. | |
| EA202090414A1 (ru) | Соединения и их применение | |
| NZ734400A (en) | Amide compounds as 5-ht4 receptor agonists | |
| CL2018000430A1 (es) | Compuesto de hidroxitriazina y uso médico relacionado. | |
| EA201991898A1 (ru) | Двойные ингибиторы magl и faah | |
| EA201991112A1 (ru) | Композиции и способы, связанные с пиридиноилпиперидиновыми агонистами 5-ht1f | |
| ZA202005083B (en) | Solid forms of fasoracetam | |
| EA201800565A1 (ru) | Композиция для лечения заболеваний уха, содержащая (+)-азасетрон | |
| EA202190045A1 (ru) | Составы/композиции, содержащие ибрутиниб | |
| MX2020008082A (es) | Compuestos y composiciones para el tratamiento del dolor. | |
| EA201991395A1 (ru) | Новые композиции для лечения суставных нарушений | |
| EA202191294A1 (ru) | Олигосахаридные композиции и способы их применения | |
| MX2021000475A (es) | Isoxazol como agonista del receptor fxr. | |
| EA202191103A1 (ru) | Терапевтические соединения |