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EA202090720A1 - ПРОИЗВОДНЫЕ GalNAc - Google Patents

ПРОИЗВОДНЫЕ GalNAc

Info

Publication number
EA202090720A1
EA202090720A1 EA202090720A EA202090720A EA202090720A1 EA 202090720 A1 EA202090720 A1 EA 202090720A1 EA 202090720 A EA202090720 A EA 202090720A EA 202090720 A EA202090720 A EA 202090720A EA 202090720 A1 EA202090720 A1 EA 202090720A1
Authority
EA
Eurasian Patent Office
Prior art keywords
galnac derivatives
galnac
manufacture
disclosed
methods
Prior art date
Application number
EA202090720A
Other languages
English (en)
Inventor
Сергей Грязнов
Цзинь Хун
Вивек Кумар Раджванши
Раджендра К. Пандей
Original Assignee
Янссен Байофарма, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Байофарма, Инк. filed Critical Янссен Байофарма, Инк.
Publication of EA202090720A1 publication Critical patent/EA202090720A1/ru

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
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    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
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    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Раскрыты модифицированные олигонуклеотиды, содержащие функциональную группу GalNAc настоящего изобретения, а также способы их изготовления и применения, например против ВГВ.
EA202090720A 2017-09-14 2018-09-14 ПРОИЗВОДНЫЕ GalNAc EA202090720A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762558773P 2017-09-14 2017-09-14
PCT/IB2018/057082 WO2019053661A2 (en) 2017-09-14 2018-09-14 GALNAC DERIVATIVES

Publications (1)

Publication Number Publication Date
EA202090720A1 true EA202090720A1 (ru) 2020-07-07

Family

ID=63896482

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090720A EA202090720A1 (ru) 2017-09-14 2018-09-14 ПРОИЗВОДНЫЕ GalNAc

Country Status (13)

Country Link
US (1) US20200270611A1 (ru)
EP (1) EP3682007A2 (ru)
JP (2) JP2020533009A (ru)
KR (1) KR20200100601A (ru)
CN (2) CN118345073A (ru)
AU (2) AU2018332216B2 (ru)
BR (1) BR112020004955A2 (ru)
CA (1) CA3075598A1 (ru)
EA (1) EA202090720A1 (ru)
IL (1) IL273137A (ru)
MX (1) MX2020002885A (ru)
SG (1) SG11202002149XA (ru)
WO (1) WO2019053661A2 (ru)

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JP2024523237A (ja) 2021-06-18 2024-06-28 ホンジーン バイオテック コーポレイション 官能化されたｎ－アセチルガラクトサミンヌクレオシド
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Also Published As

Publication number Publication date
CN118345073A (zh) 2024-07-16
JP2023109824A (ja) 2023-08-08
KR20200100601A (ko) 2020-08-26
BR112020004955A2 (pt) 2020-10-06
SG11202002149XA (en) 2020-04-29
IL273137A (en) 2020-04-30
US20200270611A1 (en) 2020-08-27
EP3682007A2 (en) 2020-07-22
CN111527207B (zh) 2024-04-26
WO2019053661A2 (en) 2019-03-21
MX2020002885A (es) 2020-10-01
AU2024205223A1 (en) 2024-08-15
CN111527207A (zh) 2020-08-11
AU2018332216A1 (en) 2020-03-26
JP2020533009A (ja) 2020-11-19
CA3075598A1 (en) 2019-03-21
AU2018332216B2 (en) 2024-05-02
WO2019053661A3 (en) 2019-05-02

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