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EA201892467A1 - Олигонуклеотидные аналоги, нацеленные на lmna человека - Google Patents

Олигонуклеотидные аналоги, нацеленные на lmna человека

Info

Publication number
EA201892467A1
EA201892467A1 EA201892467A EA201892467A EA201892467A1 EA 201892467 A1 EA201892467 A1 EA 201892467A1 EA 201892467 A EA201892467 A EA 201892467A EA 201892467 A EA201892467 A EA 201892467A EA 201892467 A1 EA201892467 A1 EA 201892467A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aimed
oligonucleotide analogues
lmna
human lmna
human
Prior art date
Application number
EA201892467A
Other languages
English (en)
Inventor
Майкл Р. Эрдос
Кань Цао
Рисзард Коул
Ричард Кит Бествик
Фрэнсис С. Коллинз
Лесли Б. Гордон
Original Assignee
Сарепта Терапьютикс, Инк.
Дзе Юнайтед Стейтс Оф Эмерика, Эз Репрезентед Бай Дзе Секретэри, Депт. Оф Хелт Энд Хьюман Сервисиз
Юниверсити оф Мэриленд
Дзе Проджерия Рисерч Фаундейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сарепта Терапьютикс, Инк., Дзе Юнайтед Стейтс Оф Эмерика, Эз Репрезентед Бай Дзе Секретэри, Депт. Оф Хелт Энд Хьюман Сервисиз, Юниверсити оф Мэриленд, Дзе Проджерия Рисерч Фаундейшн filed Critical Сарепта Терапьютикс, Инк.
Publication of EA201892467A1 publication Critical patent/EA201892467A1/ru

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Abstract

Предложены LMNA-нацеленные антисмысловые олигонуклеотиды для снижения экспрессии одной или более аберрантно сплайсированных изоформ мРНК LMNA, которые кодируют прогерин.
EA201892467A 2016-04-29 2017-04-28 Олигонуклеотидные аналоги, нацеленные на lmna человека EA201892467A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662330027P 2016-04-29 2016-04-29
PCT/US2017/030174 WO2017190041A1 (en) 2016-04-29 2017-04-28 Oligonucleotide analogues targeting human lmna

Publications (1)

Publication Number Publication Date
EA201892467A1 true EA201892467A1 (ru) 2019-05-31

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EA201892467A EA201892467A1 (ru) 2016-04-29 2017-04-28 Олигонуклеотидные аналоги, нацеленные на lmna человека

Country Status (15)

Country Link
US (2) US10822608B2 (ru)
EP (1) EP3449000A1 (ru)
JP (2) JP7042255B2 (ru)
KR (1) KR102329187B1 (ru)
CN (1) CN109477109B (ru)
AU (2) AU2017258642B2 (ru)
BR (1) BR112018072279A2 (ru)
CA (1) CA3022303A1 (ru)
CO (1) CO2018012873A2 (ru)
EA (1) EA201892467A1 (ru)
MA (1) MA45616A (ru)
MX (1) MX2018013157A (ru)
NZ (1) NZ747685A (ru)
SG (1) SG11201809468XA (ru)
WO (1) WO2017190041A1 (ru)

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