[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EA201891878A1 - Очистка белков - Google Patents

Очистка белков

Info

Publication number
EA201891878A1
EA201891878A1 EA201891878A EA201891878A EA201891878A1 EA 201891878 A1 EA201891878 A1 EA 201891878A1 EA 201891878 A EA201891878 A EA 201891878A EA 201891878 A EA201891878 A EA 201891878A EA 201891878 A1 EA201891878 A1 EA 201891878A1
Authority
EA
Eurasian Patent Office
Prior art keywords
proteins
cleaning
cleaning proteins
eluate
semi
Prior art date
Application number
EA201891878A
Other languages
English (en)
Other versions
EA038538B1 (ru
Inventor
Майкл Гарри Роуз
Original Assignee
Юсб Биофарма Спрл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55752913&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201891878(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Юсб Биофарма Спрл filed Critical Юсб Биофарма Спрл
Publication of EA201891878A1 publication Critical patent/EA201891878A1/ru
Publication of EA038538B1 publication Critical patent/EA038538B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к способу очистки белка, содержащему стадию полунепрерывной хроматографии, посредством которой элюат собирают и повторно загружают на хроматографическую матрицу.
EA201891878A 2016-02-19 2017-02-17 Очистка белков EA038538B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1602938.1A GB201602938D0 (en) 2016-02-19 2016-02-19 Protein purification
PCT/EP2017/053677 WO2017140881A1 (en) 2016-02-19 2017-02-17 Protein purification

Publications (2)

Publication Number Publication Date
EA201891878A1 true EA201891878A1 (ru) 2019-01-31
EA038538B1 EA038538B1 (ru) 2021-09-13

Family

ID=55752913

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891878A EA038538B1 (ru) 2016-02-19 2017-02-17 Очистка белков

Country Status (26)

Country Link
US (2) US20190202859A1 (ru)
EP (2) EP3416974B1 (ru)
JP (1) JP6911040B2 (ru)
CN (1) CN108779143B (ru)
AU (1) AU2017220675B2 (ru)
CA (1) CA3014488A1 (ru)
CL (1) CL2018002373A1 (ru)
CO (1) CO2018009057A2 (ru)
CY (1) CY1123802T1 (ru)
DK (2) DK3730511T3 (ru)
EA (1) EA038538B1 (ru)
ES (2) ES2960723T3 (ru)
FI (1) FI3730511T3 (ru)
GB (1) GB201602938D0 (ru)
HR (2) HRP20231432T1 (ru)
HU (2) HUE050774T2 (ru)
IL (1) IL261040B (ru)
LT (2) LT3730511T (ru)
MX (1) MX2018009829A (ru)
MY (1) MY186560A (ru)
PL (2) PL3730511T3 (ru)
PT (2) PT3416974T (ru)
RU (1) RU2018133009A (ru)
SG (1) SG11201806852PA (ru)
SI (2) SI3730511T1 (ru)
WO (1) WO2017140881A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201628649A (zh) 2014-10-09 2016-08-16 再生元醫藥公司 減少醫藥調配物中微可見顆粒之方法
AU2017312785B2 (en) 2016-08-16 2024-10-10 Regeneron Pharmaceuticals, Inc. Methods for quantitating individual antibodies from a mixture
EP4071469A3 (en) 2016-10-25 2022-12-14 Regeneron Pharmaceuticals, Inc. Methods and systems for chromatography data analysis
GB201711481D0 (en) 2017-07-17 2017-08-30 Ucb Biopharma Sprl Protein purification
SG11202001564QA (en) 2017-09-19 2020-04-29 Regeneron Pharma Methods of reducing particle formation and compositions formed thereby
GB201805142D0 (en) * 2018-03-29 2018-05-16 Ge Healthcare Bioprocess R&D Ab Separation method
US11884698B2 (en) * 2018-07-02 2024-01-30 Regeneron Pharmaceuticals, Inc. Systems and methods for preparing a polypeptide from a mixture
JP7063759B2 (ja) * 2018-07-25 2022-05-09 株式会社日立プラントサービス 精製装置
CN110348089B (zh) * 2019-06-28 2021-05-04 浙江大学 基于层析模型实现多柱连续流层析设计及分析的方法
WO2024056626A1 (en) * 2022-09-13 2024-03-21 Sanofi Aventis Deutschland Gmbh Continuous gradient elution chromatographic fractionation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6055162B2 (ja) * 1977-05-26 1985-12-04 参松工業株式会社 カラムクロマト分離法
US9433922B2 (en) * 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
US20090149638A1 (en) * 2007-10-03 2009-06-11 Ley Arthur C Systems and methods for purifying proteins
CN101318991A (zh) 2008-07-04 2008-12-10 陈志南 一种采用复合层析介质纯化Fc融合蛋白的方法
GB201012603D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
EP2633306B1 (en) * 2010-10-27 2016-03-23 GE Healthcare Bio-Sciences AB Chromatography system with guard columns
DK2776466T3 (da) 2011-11-11 2017-11-20 Ucb Biopharma Sprl Albuminbindende antistoffer og bindingsfragmenter deraf
EP2836515A1 (en) * 2013-03-14 2015-02-18 AbbVie Inc. Low acidic species compositions and methods for producing and using the same

Also Published As

Publication number Publication date
PT3416974T (pt) 2020-08-11
AU2017220675B2 (en) 2023-11-16
ES2960723T3 (es) 2024-03-06
EP3416974A1 (en) 2018-12-26
US20210323999A1 (en) 2021-10-21
JP6911040B2 (ja) 2021-07-28
LT3416974T (lt) 2020-12-10
MX2018009829A (es) 2018-09-11
IL261040B (en) 2021-07-29
DK3730511T3 (da) 2023-10-30
CN108779143B (zh) 2022-08-12
MY186560A (en) 2021-07-27
JP2019509998A (ja) 2019-04-11
SI3730511T1 (sl) 2023-12-29
SG11201806852PA (en) 2018-09-27
PT3730511T (pt) 2023-10-23
US20190202859A1 (en) 2019-07-04
BR112018016742A2 (pt) 2018-12-26
HRP20201415T1 (hr) 2020-11-27
EA038538B1 (ru) 2021-09-13
CO2018009057A2 (es) 2018-11-13
US11905310B2 (en) 2024-02-20
CY1123802T1 (el) 2022-03-24
KR20180128910A (ko) 2018-12-04
CN108779143A (zh) 2018-11-09
IL261040A (en) 2018-10-31
FI3730511T3 (fi) 2023-10-31
EP3730511B1 (en) 2023-09-20
WO2017140881A1 (en) 2017-08-24
CL2018002373A1 (es) 2018-12-07
PL3416974T3 (pl) 2020-12-14
DK3416974T3 (da) 2020-09-07
HUE064240T2 (hu) 2024-02-28
GB201602938D0 (en) 2016-04-06
LT3730511T (lt) 2023-10-25
AU2017220675A1 (en) 2018-08-23
SI3416974T1 (sl) 2020-11-30
HRP20231432T1 (hr) 2024-03-01
HUE050774T2 (hu) 2021-01-28
PL3730511T3 (pl) 2024-03-11
ES2822918T3 (es) 2021-05-05
RU2018133009A (ru) 2020-03-19
EP3416974B1 (en) 2020-07-29
EP3730511A1 (en) 2020-10-28
CA3014488A1 (en) 2017-08-24

Similar Documents

Publication Publication Date Title
EA201891878A1 (ru) Очистка белков
CO2020000090A2 (es) Cromatografia
EA201790247A1 (ru) Платформа для очистки биспецифичных антител
EA201890039A1 (ru) Антитела, специфичные к гиперфосфорилированному тау-белку, и способы их применения
EA201792573A1 (ru) Триспецифические связанные белки и способы их применения
EA201890790A1 (ru) Связывающие pd-1 белки и способы их применения
CO2018007203A2 (es) Focalización de péptidos para dirigir virus adenoasociados (aavs)
EA201791773A1 (ru) Цистеиновая протеаза
EP3442988A4 (en) METHOD FOR IMPROVING THE PERFORMANCE OF CHROMATOGRAPHY PROCESSES FOR THE PURIFICATION OF PROTEINS
EA201890572A1 (ru) Биофармацевтические композиции
EA201892624A1 (ru) Растения, дающие бессемянные плоды
DK3728288T3 (da) Fremgangsmåder til forbedret fjernelse af urenheder under protein a-kromatografi
ECSP17080733A (es) Anticuerpos dirigidos a la proteína morfogenética ósea 9 (bmp9) y métodos a partir de estos
EA202090084A1 (ru) Новый терапевтический ферментный слитый белок и его применение
EA202091239A1 (ru) Слитый белок на основе терапевтического фермента, имеющий новую структуру, и его применение
EA201890340A1 (ru) Моноклональное антитело-ингибитор фактора xiia
EA201491564A1 (ru) Осаждение фракции i-iv-1 иммуноглобулинов из плазмы
EA201990593A1 (ru) Непрерывный способ для снижения гетерогенности терапевтического белка
EA201691834A1 (ru) Новый способ очистки гонадотропина
EA201990052A1 (ru) ПОЛУЧЕНИЕ ПРОИЗВОДНЫХ ФАКТОРА Ха
EA202091259A1 (ru) Способ получения опикапона и его интермедиатов
EA201890171A1 (ru) Слитые белки btla агонисты и их применение
EA201890177A1 (ru) Мультиспецифические связывающие белки
CL2019003167A1 (es) Proteínas de unión al antígeno anti-jagged1.
BR112016024586A8 (pt) método de preparação de clara de ovo para o processamento cromatográfico em massa, método de isolamento de uma proteína recombinante da clara de ovo e método de filtração de clara de ovo acidificada