EA201891594A1 - ANTIBODIES TO IL-17C - Google Patents
ANTIBODIES TO IL-17CInfo
- Publication number
- EA201891594A1 EA201891594A1 EA201891594A EA201891594A EA201891594A1 EA 201891594 A1 EA201891594 A1 EA 201891594A1 EA 201891594 A EA201891594 A EA 201891594A EA 201891594 A EA201891594 A EA 201891594A EA 201891594 A1 EA201891594 A1 EA 201891594A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- fragments
- psoriasis
- bind
- people
- Prior art date
Links
- 102000013691 Interleukin-17 Human genes 0.000 title abstract 2
- 108050003558 Interleukin-17 Proteins 0.000 title abstract 2
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Настоящее изобретение предусматривает антитела или фрагменты антител, которые связываются с IL-17C человека. В частности, оно относится к антителам или фрагментам антител, которые характеризуются комбинированными полезными свойствами и, таким образом, являются применимыми для лечения людей, например, с атопическим дерматитом или псориазом.The present invention provides antibodies or antibody fragments that bind to human IL-17C. In particular, it relates to antibodies or fragments of antibodies that are characterized by combined beneficial properties and, thus, are applicable to the treatment of people, for example, with atopic dermatitis or psoriasis.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16156582 | 2016-02-19 | ||
| EP16156651 | 2016-02-22 | ||
| PCT/EP2017/053592 WO2017140831A1 (en) | 2016-02-19 | 2017-02-17 | Antibodies for il-17c |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201891594A1 true EA201891594A1 (en) | 2019-01-31 |
| EA037813B1 EA037813B1 (en) | 2021-05-24 |
Family
ID=58057136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201891594A EA037813B1 (en) | 2016-02-19 | 2017-02-17 | Antibodies for il-17c |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US20190048071A1 (en) |
| EP (1) | EP3416983B1 (en) |
| JP (2) | JP6535139B2 (en) |
| KR (1) | KR102715157B1 (en) |
| CN (1) | CN108699143B (en) |
| AU (1) | AU2017219837B2 (en) |
| BR (1) | BR112018016798A2 (en) |
| CA (1) | CA3014842A1 (en) |
| CL (1) | CL2018002340A1 (en) |
| CO (1) | CO2018008724A2 (en) |
| CU (1) | CU20180087A7 (en) |
| CY (1) | CY1124296T1 (en) |
| DK (1) | DK3416983T3 (en) |
| EA (1) | EA037813B1 (en) |
| EC (1) | ECSP18070641A (en) |
| ES (1) | ES2877376T3 (en) |
| HR (1) | HRP20211059T1 (en) |
| HU (1) | HUE054755T2 (en) |
| IL (1) | IL260733B2 (en) |
| LT (1) | LT3416983T (en) |
| MA (2) | MA44227B1 (en) |
| MD (1) | MD3416983T2 (en) |
| MX (1) | MX2018009860A (en) |
| PH (1) | PH12018501739A1 (en) |
| PL (1) | PL3416983T3 (en) |
| RS (1) | RS62012B1 (en) |
| SG (1) | SG11201806161TA (en) |
| SI (1) | SI3416983T1 (en) |
| TN (1) | TN2018000289A1 (en) |
| TW (1) | TW201734041A (en) |
| WO (1) | WO2017140831A1 (en) |
| ZA (1) | ZA201806249B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3359161A1 (en) * | 2015-10-05 | 2018-08-15 | MorphoSys AG | Antagonists of il-17c for the treatment and/or prevention of atopic dermatitis |
| PL3416983T3 (en) | 2016-02-19 | 2021-10-25 | Morphosys Ag | Antibodies for il-17c |
| US20230203149A1 (en) * | 2017-09-25 | 2023-06-29 | Morphosys Ag | Treatment of atopic dermatitis |
| GB201803563D0 (en) | 2018-03-06 | 2018-04-18 | Galapagos Nv | Antibodies and pharmaceutical compositions thereof for the treatment of autoimmune skin diseases |
| TW202011995A (en) * | 2018-07-03 | 2020-04-01 | 比利時商葛萊伯格有限公司 | High concentration liquid antibody formulations |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708871A (en) | 1983-03-08 | 1987-11-24 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| CA2293632C (en) | 1997-06-12 | 2011-11-29 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
| JP3577586B2 (en) | 1998-05-15 | 2004-10-13 | ジェネンテック・インコーポレーテッド | IL-17 homologous polypeptides and their therapeutic uses |
| IL142025A0 (en) | 1999-07-20 | 2002-03-10 | Morphosys Ag | Novel methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds |
| CA2467633C (en) | 2001-12-03 | 2012-03-27 | Abgenix, Inc. | Antibody categorization based on binding characteristics |
| US20060142192A1 (en) | 2004-10-18 | 2006-06-29 | Zeren Gao | Soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners and methods of using in inflammation |
| EP1931708A1 (en) * | 2005-10-18 | 2008-06-18 | Zymogenetics, Inc. | Il-17c antagonists and methods of using the same |
| WO2008049070A2 (en) | 2006-10-18 | 2008-04-24 | Zymogenetics, Inc. | Il-17c antagonists and methods of using the same |
| WO2012061129A1 (en) * | 2010-10-25 | 2012-05-10 | Genentech, Inc | Treatment of gastrointestinal inflammation and psoriasis a |
| PL2640742T3 (en) | 2010-11-19 | 2019-01-31 | Morphosys Ag | A collection of antibody sequences its use |
| US20140234330A1 (en) | 2011-07-22 | 2014-08-21 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
| EP2768859B1 (en) * | 2011-10-19 | 2018-02-21 | MorphoSys AG | Antagonists of il17c for the treatment of inflammatory disorders |
| WO2013186236A1 (en) | 2012-06-12 | 2013-12-19 | Orega Biotech | Antagonists of il-17 isoforms and their uses |
| US20170342147A1 (en) * | 2014-12-15 | 2017-11-30 | Morphosys Ag | Antibodies for IL-17C |
| PL3416983T3 (en) | 2016-02-19 | 2021-10-25 | Morphosys Ag | Antibodies for il-17c |
-
2017
- 2017-02-17 PL PL17705873T patent/PL3416983T3/en unknown
- 2017-02-17 US US16/076,401 patent/US20190048071A1/en not_active Abandoned
- 2017-02-17 WO PCT/EP2017/053592 patent/WO2017140831A1/en active Application Filing
- 2017-02-17 MA MA44227A patent/MA44227B1/en unknown
- 2017-02-17 EP EP17705873.2A patent/EP3416983B1/en active Active
- 2017-02-17 LT LTEP17705873.2T patent/LT3416983T/en unknown
- 2017-02-17 RS RS20210775A patent/RS62012B1/en unknown
- 2017-02-17 CN CN201780011965.2A patent/CN108699143B/en active Active
- 2017-02-17 EA EA201891594A patent/EA037813B1/en unknown
- 2017-02-17 CA CA3014842A patent/CA3014842A1/en active Pending
- 2017-02-17 SI SI201730777T patent/SI3416983T1/en unknown
- 2017-02-17 MD MDE20190007T patent/MD3416983T2/en unknown
- 2017-02-17 DK DK17705873.2T patent/DK3416983T3/en active
- 2017-02-17 CU CU2018000087A patent/CU20180087A7/en unknown
- 2017-02-17 HU HUE17705873A patent/HUE054755T2/en unknown
- 2017-02-17 AU AU2017219837A patent/AU2017219837B2/en active Active
- 2017-02-17 KR KR1020187024953A patent/KR102715157B1/en not_active Application Discontinuation
- 2017-02-17 BR BR112018016798A patent/BR112018016798A2/en unknown
- 2017-02-17 IL IL260733A patent/IL260733B2/en unknown
- 2017-02-17 ES ES17705873T patent/ES2877376T3/en active Active
- 2017-02-17 MX MX2018009860A patent/MX2018009860A/en unknown
- 2017-02-17 SG SG11201806161TA patent/SG11201806161TA/en unknown
- 2017-02-17 TN TNP/2018/000289A patent/TN2018000289A1/en unknown
- 2017-02-17 JP JP2018543220A patent/JP6535139B2/en active Active
- 2017-02-17 MA MA43088A patent/MA43088B1/en unknown
- 2017-02-17 TW TW106105384A patent/TW201734041A/en unknown
-
2018
- 2018-08-08 US US16/058,143 patent/US10259869B2/en active Active
- 2018-08-16 PH PH12018501739A patent/PH12018501739A1/en unknown
- 2018-08-16 CL CL2018002340A patent/CL2018002340A1/en unknown
- 2018-08-21 CO CONC2018/0008724A patent/CO2018008724A2/en unknown
- 2018-09-17 ZA ZA2018/06249A patent/ZA201806249B/en unknown
- 2018-09-19 EC ECSENADI201870641A patent/ECSP18070641A/en unknown
-
2019
- 2019-02-26 US US16/286,231 patent/US10633439B2/en active Active
- 2019-04-26 JP JP2019086144A patent/JP6916834B2/en active Active
-
2020
- 2020-03-18 US US16/822,844 patent/US11987621B2/en active Active
-
2021
- 2021-07-02 HR HRP20211059TT patent/HRP20211059T1/en unknown
- 2021-07-06 CY CY20211100604T patent/CY1124296T1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12019502283A1 (en) | Anti-lag3 antibodies | |
| EA202091540A1 (en) | ANTIBODIES TO LILRB2 | |
| CY1123163T1 (en) | ANTIBODIES THAT BIND BETA KLOTHO REGION 2 AND METHODS OF USING THEM | |
| EA202090104A1 (en) | ANTIBODY MOLECULES TO CD73 AND WAYS OF THEIR APPLICATION | |
| EA201890453A1 (en) | ANTI-ANGPTL8 ANTIBODIES AND THEIR APPLICATION | |
| MX2022012749A (en) | Thymic stromal lymphopoietin (tslp)-binding antibodies and methods of using the antibodies. | |
| EA201792221A1 (en) | ANTIBODIES AGAINST SORTILINE AND METHODS OF THEIR APPLICATION | |
| EA201791485A1 (en) | ANTI-CD47-ANTIBODIES AND THEIR APPLICATIONS | |
| EA201890285A1 (en) | ANTIBODIES AGAINST PD-1, ACTIVATED ANTIBODIES AGAINST PD-1 AND METHODS OF THEIR APPLICATION | |
| PH12019500929A1 (en) | Anti il-33 antibodies and uses thereof | |
| MY186352A (en) | Thymic stromal lymphopoietin (tslp)-binding antibodies and methods of using the antibodies | |
| EA201790377A1 (en) | ANTIBODIES TO GLUCAGON AND THEIR APPLICATIONS | |
| JO3532B1 (en) | Anti-il-33 antibodies and uses thereof | |
| MX2018010295A (en) | Antibodies having specificity for btla and uses thereof. | |
| EA201690167A1 (en) | HUMANIZED OR CHEMICAL ANTIBODIES TO CD3 | |
| EA201791393A2 (en) | ANTIBODIES TO ErbB3 AND THEIR APPLICATION | |
| EA201891594A1 (en) | ANTIBODIES TO IL-17C | |
| EA201592203A1 (en) | METHODS OF TREATMENT OF Taupathy | |
| MX2023010076A (en) | Ilt7 binding molecules and methods of using the same. | |
| PH12021550521A1 (en) | Antibodies that potently neutralize rabies virus and other lyssaviruses and uses thereof | |
| MY197821A (en) | Anti-il-22r antibodies | |
| EA201990978A1 (en) | ANTIBODIES AGAINST PD-1 | |
| EA201790437A1 (en) | ANTIGEN-BINDING PROTEINS CONNECTING WITH CXCR3 | |
| MX2018009218A (en) | Cgrp antibodies and uses thereof. | |
| EA201891445A1 (en) | ANTIBODY MOLECULES THAT BIND WITH TNF-ALPHA |