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EA201891336A1 - Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj - Google Patents

Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj

Info

Publication number
EA201891336A1
EA201891336A1 EA201891336A EA201891336A EA201891336A1 EA 201891336 A1 EA201891336 A1 EA 201891336A1 EA 201891336 A EA201891336 A EA 201891336A EA 201891336 A EA201891336 A EA 201891336A EA 201891336 A1 EA201891336 A1 EA 201891336A1
Authority
EA
Eurasian Patent Office
Prior art keywords
agonists
heteroarylhydroxypyrimidinones
apj receptor
compounds
apj
Prior art date
Application number
EA201891336A
Other languages
English (en)
Other versions
EA036736B1 (ru
Inventor
Майкл С. Майерс
Р. Майкл Лоренс
Донна М. Байлдер
Вей Менг
Зулан Пай
Роберт Пол Бриганс
Хизер Финлэй
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201891336A1 publication Critical patent/EA201891336A1/ru
Publication of EA036736B1 publication Critical patent/EA036736B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

Настоящее изобретение относится к соединениям с формулой (I)где все переменные являются такими, как определено в описании, и к композициям, содержащим любое из таких новых соединений. Данные соединения являются агонистами APJ, которые можно применять в качестве лекарственных препаратов.
EA201891336A 2015-12-16 2016-12-15 Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj EA036736B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562267997P 2015-12-16 2015-12-16
PCT/US2016/066750 WO2017106396A1 (en) 2015-12-16 2016-12-15 Heteroarylhydroxypyrimidinones as agonists of the apj receptor

Publications (2)

Publication Number Publication Date
EA201891336A1 true EA201891336A1 (ru) 2019-01-31
EA036736B1 EA036736B1 (ru) 2020-12-14

Family

ID=57708840

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891336A EA036736B1 (ru) 2015-12-16 2016-12-15 Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj

Country Status (21)

Country Link
US (1) US10669261B2 (ru)
EP (1) EP3390400B1 (ru)
JP (1) JP6948322B2 (ru)
KR (1) KR20180095577A (ru)
CN (1) CN108602813B (ru)
AR (1) AR107061A1 (ru)
AU (1) AU2016372048B2 (ru)
BR (1) BR112018012112A2 (ru)
CA (1) CA3008630A1 (ru)
CL (1) CL2018001621A1 (ru)
CO (1) CO2018007221A2 (ru)
EA (1) EA036736B1 (ru)
ES (1) ES2854733T3 (ru)
HK (1) HK1255163A1 (ru)
IL (1) IL259947B (ru)
MX (1) MX2018007155A (ru)
PE (1) PE20181487A1 (ru)
SG (1) SG11201804674UA (ru)
TW (1) TW201725203A (ru)
UY (1) UY37026A (ru)
WO (1) WO2017106396A1 (ru)

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BR112018010720A8 (pt) 2015-12-04 2019-02-26 Bristol Myers Squibb Co agonistas do receptor de apelina e métodos de uso
US10695323B2 (en) 2015-12-16 2020-06-30 Loxo Oncology, Inc. Compounds useful as kinase inhibitors
MA43761A (fr) 2016-03-24 2021-05-05 Bristol Myers Squibb Co 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides comme inhibiteurs de la apj
EP3452466B1 (en) 2016-05-03 2020-08-12 Amgen Inc. Heterocyclic triazole compounds as agonists of the apj receptor
WO2017218633A1 (en) 2016-06-14 2017-12-21 Bristol-Myers Squibb Company 6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1h)-one as apj agonists
EP3468952B1 (en) 2016-06-14 2020-11-25 Bristol-Myers Squibb Company 4-hydroxy-3-sulfonylpyridin-2(1h)-ones as apj receptor agonists
US10669258B2 (en) 2016-10-14 2020-06-02 Bristol-Myers Squibb Company 3-sulfonyl-5-aminopyridine-2,4-diol APJ agonists
EP3541805B1 (en) 2016-11-16 2020-10-14 Amgen Inc. Heteroaryl-substituted triazoles as apj receptor agonists
EP3541803B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
US10736883B2 (en) 2016-11-16 2020-08-11 Amgen Inc. Triazole furan compounds as agonists of the APJ receptor
US11020395B2 (en) 2016-11-16 2021-06-01 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
MA46824A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
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WO2019213006A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the apj receptor

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Also Published As

Publication number Publication date
CA3008630A1 (en) 2017-06-22
IL259947A (en) 2018-07-31
PE20181487A1 (es) 2018-09-18
IL259947B (en) 2020-10-29
JP2018538304A (ja) 2018-12-27
TW201725203A (zh) 2017-07-16
EP3390400A1 (en) 2018-10-24
EP3390400B1 (en) 2021-01-20
MX2018007155A (es) 2018-08-15
BR112018012112A2 (pt) 2018-12-04
AU2016372048B2 (en) 2021-02-04
SG11201804674UA (en) 2018-06-28
AR107061A1 (es) 2018-03-14
EA036736B1 (ru) 2020-12-14
CN108602813B (zh) 2021-10-29
WO2017106396A1 (en) 2017-06-22
US20180362508A1 (en) 2018-12-20
CN108602813A (zh) 2018-09-28
JP6948322B2 (ja) 2021-10-13
CL2018001621A1 (es) 2018-08-03
ES2854733T3 (es) 2021-09-22
CO2018007221A2 (es) 2018-07-19
US10669261B2 (en) 2020-06-02
KR20180095577A (ko) 2018-08-27
UY37026A (es) 2017-06-30
HK1255163A1 (zh) 2019-08-09
AU2016372048A1 (en) 2018-08-02

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM