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EA201792642A1 - Способы диагностики для т-клеточной терапии - Google Patents

Способы диагностики для т-клеточной терапии

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Publication number
EA201792642A1
EA201792642A1 EA201792642A EA201792642A EA201792642A1 EA 201792642 A1 EA201792642 A1 EA 201792642A1 EA 201792642 A EA201792642 A EA 201792642A EA 201792642 A EA201792642 A EA 201792642A EA 201792642 A1 EA201792642 A1 EA 201792642A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cell therapy
patient
diagnostic methods
physiological adaptation
introduction
Prior art date
Application number
EA201792642A
Other languages
English (en)
Inventor
Эдриан Бот
Джеффри С. Вьезорек
Уилльям Го
Раджул Джаин
Джеймс Н. Кохендерфер
Стивен А. Розенберг
Original Assignee
Кайт Фарма, Инк.
Дзе Юнайтед Стейтс Оф Эмерика, Эз Репрезентед Бай Дзе Секретэри, Дипартмент Оф Хелт Энд Хьюман Сервисиз
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57393492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201792642(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Кайт Фарма, Инк., Дзе Юнайтед Стейтс Оф Эмерика, Эз Репрезентед Бай Дзе Секретэри, Дипартмент Оф Хелт Энд Хьюман Сервисиз filed Critical Кайт Фарма, Инк.
Publication of EA201792642A1 publication Critical patent/EA201792642A1/ru

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Abstract

Изобретение предоставляет способы повышения эффективности T-клеточной терапии для нуждающегося в ней пациента. Изобретение включает в себя способы идентификации пациента, который хорошо отвечал бы на T-клеточную терапию, или физиологическую адаптацию пациента до T-клеточной терапии таким образом, чтобы пациент хорошо отвечал на T-клеточную терапию. Физиологическая адаптация включает в себя введение одного или более средств предварительной физиологической адаптации до T-клеточной терапии и идентификацию цитокинов-биомаркеров до введения T-клеточной терапии.
EA201792642A 2015-05-28 2016-05-27 Способы диагностики для т-клеточной терапии EA201792642A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562167738P 2015-05-28 2015-05-28
US201562262111P 2015-12-02 2015-12-02
PCT/US2016/034885 WO2016191755A1 (en) 2015-05-28 2016-05-27 Diagnostic methods for t cell therapy

Publications (1)

Publication Number Publication Date
EA201792642A1 true EA201792642A1 (ru) 2018-10-31

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EA201792642A EA201792642A1 (ru) 2015-05-28 2016-05-27 Способы диагностики для т-клеточной терапии

Country Status (22)

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US (2) US11779601B2 (ru)
EP (2) EP4218778A3 (ru)
JP (4) JP6917903B2 (ru)
KR (3) KR102481922B1 (ru)
CN (2) CN114452395A (ru)
AU (2) AU2016268863B2 (ru)
BR (1) BR122023022076A2 (ru)
CA (1) CA2986793A1 (ru)
CL (1) CL2017003005A1 (ru)
DO (1) DOP2017000272A (ru)
EA (1) EA201792642A1 (ru)
ES (1) ES2944962T3 (ru)
HK (2) HK1246150A1 (ru)
IL (2) IL255888B2 (ru)
MA (1) MA45281A (ru)
MX (2) MX2017015190A (ru)
PH (1) PH12017502153A1 (ru)
PL (1) PL3302507T3 (ru)
PT (1) PT3302507T (ru)
SG (2) SG10201913623PA (ru)
SI (1) SI3302507T1 (ru)
WO (1) WO2016191755A1 (ru)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9511092B2 (en) 2013-01-28 2016-12-06 St. Jude Children's Research Hospital, Inc. Chimeric receptor with NKG2D specificity for use in cell therapy against cancer and infectious disease
WO2015174928A1 (en) 2014-05-15 2015-11-19 National University Of Singapore Modified natural killer cells and uses thereof
IL255888B2 (en) 2015-05-28 2023-03-01 Kite Pharma Inc Diagnostic methods for t-cell therapy
US9855298B2 (en) 2015-05-28 2018-01-02 Kite Pharma, Inc. Methods of conditioning patients for T cell therapy
SG11201908492PA (en) 2017-03-27 2019-10-30 Nat Univ Singapore Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy
AU2018245749A1 (en) 2017-03-27 2019-10-03 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
SG10201912624VA (en) 2017-04-03 2020-02-27 Kite Pharma Inc Treatment using chimeric receptor t cells incorporating optimized polyfunctional t cells
BR112019025403A2 (pt) 2017-06-02 2020-08-18 Juno Therapeutics Inc artigos de fabricação e métodos para tratamento usando terapia celular adotiva
US12031975B2 (en) 2017-11-01 2024-07-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
WO2019207942A1 (ja) * 2018-04-27 2019-10-31 OTA Takayo 免疫チェックポイント阻害剤によるがん治療の効果を評価するためのバイオマーカー
EP4403224A3 (en) * 2018-06-01 2024-07-31 Kite Pharma, Inc. Chimeric antigen receptor t cell therapy
WO2019243888A1 (en) 2018-06-22 2019-12-26 Kite Pharma Eu B.V. Compositions and methods for making engineered t cells
CN109207430A (zh) * 2018-09-25 2019-01-15 华东师范大学 一种嵌合抗原受体nk细胞及其制备方法和应用
JP7487112B2 (ja) 2019-03-05 2024-05-20 ンカルタ・インコーポレイテッド Ｃｄ１９指向性キメラ抗原受容体および免疫療法におけるその使用
EP3958887B1 (en) * 2019-04-23 2023-11-01 Institut National de la Santé et de la Recherche Médicale (INSERM) Medical uses for inducing or restoring immune tolerance
GB201911066D0 (en) 2019-08-02 2019-09-18 Achilles Therapeutics Ltd T cell therapy
IL292665A (en) * 2019-11-06 2022-07-01 Kite Pharma Inc Chimeric t-cell antigen receptor therapy
EP4093433A1 (en) * 2020-01-24 2022-11-30 Juno Therapeutics, Inc. Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy
IL297594A (en) 2020-04-28 2022-12-01 Achilles Therapeutics Uk Ltd t cell therapy
US20240016936A1 (en) * 2020-12-04 2024-01-18 Celgene Corporation Uses of chimeric antigen receptor (car) t-cell therapies in combination with inhibitors of inflammation-related soluble factors
EP4320435A1 (en) 2021-04-09 2024-02-14 Achilles Therapeutics UK Limited Batch release assay for pharmaceutical products relating to t cell therapies
GB202109886D0 (en) 2021-07-08 2021-08-25 Achilles Therapeutics Uk Ltd Assay
WO2022241151A2 (en) * 2021-05-14 2022-11-17 Kite Pharma, Inc. Chimeric antigen receptor t cell therapy
US20240287456A1 (en) 2021-06-22 2024-08-29 Achilles Therapeutics Uk Limited A method for producing antigen-specific t cells
US20230392119A1 (en) 2022-05-27 2023-12-07 Kite Pharma, Inc. Compositions and methods for preparing engineered lymphocytes for cell therapy
WO2024092227A1 (en) 2022-10-28 2024-05-02 Kite Pharma, Inc. Factors for optimizing immunotherapy
WO2024092145A1 (en) 2022-10-28 2024-05-02 Kite Pharma, Inc. Expedited administration of engineered lymphocytes
US20240309428A1 (en) 2023-03-17 2024-09-19 Kite Pharma, Inc. Impact of tumor microenvironment on efficacy of immunotherapy

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US6406699B1 (en) 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
US20030031652A1 (en) 2001-04-16 2003-02-13 Bernhard Hering Systems and methods for inducing mixed chimerism
US7718196B2 (en) 2001-07-02 2010-05-18 The United States Of America, As Represented By The Department Of Health And Human Services Rapamycin-resistant T cells and therapeutic uses thereof
CA2497552C (en) 2002-09-06 2014-05-27 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
GB0700058D0 (en) 2007-01-03 2007-02-07 Scancell Aps Anti-tumor vaccine based on normal cells
MX362513B (es) 2010-03-23 2019-01-22 Intrexon Corp Vectores que expresan de manera condicional proteinas terapeuticas, celulas hospedadoras que comprenden vectores, y usos de los mismos.
KR20230133410A (ko) 2010-12-09 2023-09-19 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암을 치료하기 위한 키메릭 항원 수용체 변형 t 세포의 용도
SG192010A1 (en) 2011-01-18 2013-08-30 Univ Pennsylvania Compositions and methods for treating cancer
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
MX2014003176A (es) 2011-09-16 2015-08-05 Univ Pennsylvania Celulas t diseñadas mediante arn para el tratamiento de cancer.
CN104394877B (zh) 2012-05-08 2017-11-28 约翰·霍普金斯大学 用于输注短暂植入的同种异体淋巴细胞的选定群体来治疗癌症的方法和组合物
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
EP3650038A1 (en) * 2013-06-19 2020-05-13 Massachusetts Institute of Technology In vivo targeting of cells with ligand-conjugated particles
EP3065772B1 (en) * 2013-11-05 2024-07-24 Cognate Bioservices, Inc. Combinations of checkpoint inhibitors and therapeutics to treat cancer
US9855298B2 (en) 2015-05-28 2018-01-02 Kite Pharma, Inc. Methods of conditioning patients for T cell therapy
IL255888B2 (en) 2015-05-28 2023-03-01 Kite Pharma Inc Diagnostic methods for t-cell therapy
SI3436079T1 (sl) 2016-04-01 2022-01-31 Kite Pharma, Inc. Himerni antigen in T celični receptorji ter način uporabe

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