EA201600323A1 - Производные пиперазина и их применение в качестве лекарственного средства - Google Patents
Производные пиперазина и их применение в качестве лекарственного средстваInfo
- Publication number
- EA201600323A1 EA201600323A1 EA201600323A EA201600323A EA201600323A1 EA 201600323 A1 EA201600323 A1 EA 201600323A1 EA 201600323 A EA201600323 A EA 201600323A EA 201600323 A EA201600323 A EA 201600323A EA 201600323 A1 EA201600323 A1 EA 201600323A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- piperazine
- medicine
- application
- compounds
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102100023145 Sodium- and chloride-dependent glycine transporter 1 Human genes 0.000 abstract 1
- 101710083171 Sodium- and chloride-dependent glycine transporter 1 Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к замещенным производным пиперазина общей формулы (I)и к получению указанных соединений, фармацевтических композиций, содержащих соединение в соответствии с общей формулой (I), и к применению указанных соединений для лечения различных терапевтических состояний, связанных с переносчиком глицина-1 (GlyT1).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13188904 | 2013-10-16 | ||
| PCT/EP2014/072085 WO2015055698A1 (en) | 2013-10-16 | 2014-10-15 | Piperazine derivatives and the use thereof as medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201600323A1 true EA201600323A1 (ru) | 2016-10-31 |
| EA029313B1 EA029313B1 (ru) | 2018-03-30 |
Family
ID=49354583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201600323A EA029313B1 (ru) | 2013-10-16 | 2014-10-15 | Производные пиперазина и их применение в качестве лекарственного средства |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9233953B2 (ru) |
| EP (1) | EP3057963B1 (ru) |
| JP (1) | JP6483105B2 (ru) |
| KR (1) | KR102281284B1 (ru) |
| CN (1) | CN105636961B (ru) |
| AR (1) | AR098037A1 (ru) |
| AU (1) | AU2014336258B2 (ru) |
| BR (1) | BR112016008062B1 (ru) |
| CA (1) | CA2926754C (ru) |
| CL (1) | CL2016000884A1 (ru) |
| DK (1) | DK3057963T3 (ru) |
| EA (1) | EA029313B1 (ru) |
| ES (1) | ES2745555T3 (ru) |
| HU (1) | HUE047044T2 (ru) |
| IL (1) | IL244693B (ru) |
| MX (1) | MX370006B (ru) |
| PH (1) | PH12016500577B1 (ru) |
| PL (1) | PL3057963T3 (ru) |
| TW (1) | TW201609716A (ru) |
| UY (1) | UY35785A (ru) |
| WO (1) | WO2015055698A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106854189A (zh) * | 2015-12-08 | 2017-06-16 | 湖南华腾制药有限公司 | 一种哌嗪化合物的合成方法 |
| CN107778257A (zh) * | 2016-08-29 | 2018-03-09 | 湖南华腾制药有限公司 | 一种哌嗪衍生物的合成方法 |
| CN106977463A (zh) * | 2017-05-31 | 2017-07-25 | 湖南华腾制药有限公司 | 一种联苯取代哌嗪衍生物的合成方法 |
| CN107417679A (zh) * | 2017-08-04 | 2017-12-01 | 河南农业大学 | 1,3‑唑类取代吡嗪类化合物的制备方法 |
| CN116212025A (zh) | 2020-01-09 | 2023-06-06 | 迪斯克医药公司 | 治疗红细胞生成性原卟啉病、x连锁原卟啉病或先天性红细胞生成性卟啉病的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0224084D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| GB0505085D0 (en) | 2005-03-11 | 2005-04-20 | Glaxo Group Ltd | Compounds |
| EP1871762A2 (en) * | 2005-04-18 | 2008-01-02 | Neurogen Corporation | Subtituted heteroaryl cb1 antagonists |
| AR077465A1 (es) | 2009-07-08 | 2011-08-31 | Leo Pharma As | Derivados de pirrolopirimidina como inhibidores de receptores jak y protein tirosin quinasas y uso farmaceutico de los mismos |
-
2014
- 2014-10-14 US US14/513,918 patent/US9233953B2/en active Active
- 2014-10-15 CN CN201480056368.8A patent/CN105636961B/zh active Active
- 2014-10-15 AR ARP140103834A patent/AR098037A1/es unknown
- 2014-10-15 AU AU2014336258A patent/AU2014336258B2/en active Active
- 2014-10-15 ES ES14784235T patent/ES2745555T3/es active Active
- 2014-10-15 CA CA2926754A patent/CA2926754C/en active Active
- 2014-10-15 EA EA201600323A patent/EA029313B1/ru not_active IP Right Cessation
- 2014-10-15 MX MX2016004847A patent/MX370006B/es active IP Right Grant
- 2014-10-15 HU HUE14784235A patent/HUE047044T2/hu unknown
- 2014-10-15 BR BR112016008062-9A patent/BR112016008062B1/pt active IP Right Grant
- 2014-10-15 WO PCT/EP2014/072085 patent/WO2015055698A1/en active Application Filing
- 2014-10-15 EP EP14784235.5A patent/EP3057963B1/en active Active
- 2014-10-15 PL PL14784235T patent/PL3057963T3/pl unknown
- 2014-10-15 JP JP2016523968A patent/JP6483105B2/ja active Active
- 2014-10-15 TW TW103135739A patent/TW201609716A/zh unknown
- 2014-10-15 KR KR1020167012860A patent/KR102281284B1/ko active IP Right Grant
- 2014-10-15 DK DK14784235.5T patent/DK3057963T3/da active
- 2014-10-16 UY UY0001035785A patent/UY35785A/es unknown
-
2016
- 2016-03-21 IL IL244693A patent/IL244693B/en active IP Right Grant
- 2016-03-30 PH PH12016500577A patent/PH12016500577B1/en unknown
- 2016-04-14 CL CL2016000884A patent/CL2016000884A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016008062B1 (pt) | 2022-11-16 |
| TW201609716A (zh) | 2016-03-16 |
| PH12016500577A1 (en) | 2016-06-20 |
| AU2014336258B2 (en) | 2018-07-12 |
| EP3057963A1 (en) | 2016-08-24 |
| UY35785A (es) | 2015-04-30 |
| MX370006B (es) | 2019-11-28 |
| CA2926754C (en) | 2021-09-14 |
| AR098037A1 (es) | 2016-04-27 |
| WO2015055698A1 (en) | 2015-04-23 |
| PL3057963T3 (pl) | 2019-12-31 |
| HUE047044T2 (hu) | 2020-04-28 |
| EA029313B1 (ru) | 2018-03-30 |
| CN105636961A (zh) | 2016-06-01 |
| BR112016008062A2 (ru) | 2017-08-01 |
| CA2926754A1 (en) | 2015-04-23 |
| CL2016000884A1 (es) | 2016-12-30 |
| JP6483105B2 (ja) | 2019-03-13 |
| IL244693B (en) | 2019-08-29 |
| KR20160062187A (ko) | 2016-06-01 |
| IL244693A0 (en) | 2016-04-21 |
| JP2016533368A (ja) | 2016-10-27 |
| KR102281284B1 (ko) | 2021-07-23 |
| PH12016500577B1 (en) | 2016-06-20 |
| DK3057963T3 (da) | 2019-09-16 |
| US20150105397A1 (en) | 2015-04-16 |
| AU2014336258A1 (en) | 2016-04-14 |
| EP3057963B1 (en) | 2019-06-19 |
| NZ718251A (en) | 2021-02-26 |
| ES2745555T3 (es) | 2020-03-02 |
| MX2016004847A (es) | 2016-07-19 |
| US9233953B2 (en) | 2016-01-12 |
| CN105636961B (zh) | 2019-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1120635T1 (el) | Βενζαμιδια αμινοετεροαρυλιου ως αναστολεις κινασης | |
| CY1120703T1 (el) | Ετεροκυκλικες ενωσεις και χρησεις αυτων | |
| EA201200176A1 (ru) | Производные оксазина и их применение для лечения неврологических нарушений | |
| EA201491362A1 (ru) | Анестезирующие соединения и способы их применения | |
| EA201690247A1 (ru) | Аминометилбиарильные производные-ингибиторы фактора d комплемента и их применения | |
| EA201401292A2 (ru) | Новые тиенопиримидиновые производные, способ их получения и фармацевтические композиции, содержащие их | |
| EA201591727A1 (ru) | Соединения биариламида в качестве ингибиторов киназы | |
| TR201904340T4 (tr) | Yeni bileşikler. | |
| EA201591003A1 (ru) | Производные бороновой кислоты и их терапевтическое применение | |
| EA201591195A1 (ru) | Новые хинолоновые производные | |
| GEP201706671B (en) | Heterocyclyl compounds as mek inhibitors | |
| EA201490888A1 (ru) | Новые производные пурина и их применение для лечения заболевания | |
| EA201790599A1 (ru) | Соединения и композиции в качестве ингибиторов киназ | |
| EA201591301A1 (ru) | Новые пиримидиновые и пиридиновые соединения и их применение | |
| EA201492023A1 (ru) | Регуляторы пути комплемента и их применение | |
| EA201492287A1 (ru) | Дейтерированные производные руксолитиниба | |
| EA201890331A1 (ru) | Пиридинондикарбоксамиды для применения в качестве ингибиторов бромодомена | |
| EA201690888A1 (ru) | Новые гетероциклические соединения | |
| EA201600434A1 (ru) | Применение производных бензимидазолпролина | |
| CY1122077T1 (el) | Νεα δακτυλιωμενα φαινοξυακεταμιδια | |
| EA201790496A1 (ru) | Соединения 1-алкил-6-оксо-1,6-дигидропиридин-3-ила и применение в качестве модуляторов sgrm | |
| EA201590364A1 (ru) | Применение орвепитанта, его солей и кристаллических форм и композиций, его содержащих, для лечения зуда | |
| EA201690972A1 (ru) | Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов | |
| TR201902057T4 (tr) | Tetrasiklin bileşikleri. | |
| EA201792425A1 (ru) | Трициклические соединения и их применение в качестве ингибиторов фосфодиэстераз |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |