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EA201600242A1 - PHARMACEUTICAL COMPOSITION IN THE FORM OF A TABLET AND METHOD FOR ITS PREPARATION - Google Patents

PHARMACEUTICAL COMPOSITION IN THE FORM OF A TABLET AND METHOD FOR ITS PREPARATION

Info

Publication number
EA201600242A1
EA201600242A1 EA201600242A EA201600242A EA201600242A1 EA 201600242 A1 EA201600242 A1 EA 201600242A1 EA 201600242 A EA201600242 A EA 201600242A EA 201600242 A EA201600242 A EA 201600242A EA 201600242 A1 EA201600242 A1 EA 201600242A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tablet
pharmaceutical composition
preparation
nootropic
relates
Prior art date
Application number
EA201600242A
Other languages
Russian (ru)
Other versions
EA029369B1 (en
Inventor
Николай Витальевич ПЕТРОВ
Ирина Александровна ШИЛОВА
Маргарита Эдуардовна БРЫЛЁВА
Алексей Алексеевич САМСОНОВ
Original Assignee
Общество с ограниченной ответственностью "ВАЛЕНТА ИНТЕЛЛЕКТ"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общество с ограниченной ответственностью "ВАЛЕНТА ИНТЕЛЛЕКТ" filed Critical Общество с ограниченной ответственностью "ВАЛЕНТА ИНТЕЛЛЕКТ"
Publication of EA201600242A1 publication Critical patent/EA201600242A1/en
Publication of EA029369B1 publication Critical patent/EA029369B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к области медицины, химико-фармацевтической промышленности и касается средств, обладающих ноотропной и нейромодуляторной активностью. Фармацевтическая композиция в форме таблетки, обладающая ноотропной и нейромодуляторной активностью, характеризующаяся тем, что она включает в качестве активного начала N-карбамоилметил-4-фенил-2-пирролидон, в качестве вспомогательных веществ - лактозу моногидрат, целлюлозу микрокристаллическую, кроскармеллозу натрия, кремния диоксид коллоидный (аэросил) и кальция стеарат. Таблетки композиции получают методом прямого прессования. Полученный препарат имеет более низкую вариабельность фармакологического действия.The invention relates to the field of medicine, pharmaceutical industry and relates to agents with nootropic and neuromodulatory activity. Pharmaceutical composition in the form of a tablet, possessing nootropic and neuromodulatory activity, characterized in that it includes N-carbamoylmethyl-4-phenyl-2-pyrrolidone as an active principle, lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide as excipients colloid (aerosil) and calcium stearate. Tablets composition obtained by direct compression. The resulting preparation has a lower variability of pharmacological action.

EA201600242A 2013-11-07 2014-03-13 Pharmaceutical composition in tablet form and method for the production thereof EA029369B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2013149439/15A RU2539375C1 (en) 2013-11-07 2013-11-07 Tabletted pharmaceutical composition and method for producing it
PCT/RU2014/000161 WO2015069140A1 (en) 2013-11-07 2014-03-13 Pharmaceutical composition in tablet form and method for the production thereof

Publications (2)

Publication Number Publication Date
EA201600242A1 true EA201600242A1 (en) 2016-07-29
EA029369B1 EA029369B1 (en) 2018-03-30

Family

ID=53041799

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201600242A EA029369B1 (en) 2013-11-07 2014-03-13 Pharmaceutical composition in tablet form and method for the production thereof

Country Status (4)

Country Link
CN (1) CN106061472A (en)
EA (1) EA029369B1 (en)
RU (1) RU2539375C1 (en)
WO (1) WO2015069140A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2699669C1 (en) * 2018-07-04 2019-09-09 Общество С Ограниченной Ответственностью "Валента - Интеллект" Novel compositions of n-carbamoylmethyl-4-phenyl-2-pyrrolidone
CN110075079A (en) * 2019-06-05 2019-08-02 深圳立健药业有限公司 A kind of appropriate logical sequence pivoxil plain piece of spore, the appropriate logical sequence pivoxil piece of spore and preparation method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8576201A1 (en) * 2002-07-10 2004-05-26 Pfizer Prod Inc PHARMACEUTICAL COMPOSITION THAT HAS A DISTRIBUTION AND UNIFORM POWER OF FARMACO
RU2240783C1 (en) * 2003-07-17 2004-11-27 Открытое акционерное общество "Щелковский витаминный завод" Pharmaceutical composition eliciting nootropic activity and method for its preparing
RU2480214C1 (en) * 2011-09-22 2013-04-27 Валентина Ивановна Ахапкина Formulation possessing modulatory activity with adequate effect, pharmaceutical substance (versions), use of pharmaceutical substance, pharmaceutical and parapharmaceutical composition (versions), method for preparing pharmaceutical formulations

Also Published As

Publication number Publication date
RU2539375C1 (en) 2015-01-20
EA029369B1 (en) 2018-03-30
CN106061472A (en) 2016-10-26
WO2015069140A1 (en) 2015-05-14

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