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EA201592144A1 - Производное фенола, способ его получения и его применение в медицине - Google Patents

Производное фенола, способ его получения и его применение в медицине

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Publication number
EA201592144A1
EA201592144A1 EA201592144A EA201592144A EA201592144A1 EA 201592144 A1 EA201592144 A1 EA 201592144A1 EA 201592144 A EA201592144 A EA 201592144A EA 201592144 A EA201592144 A EA 201592144A EA 201592144 A1 EA201592144 A1 EA 201592144A1
Authority
EA
Eurasian Patent Office
Prior art keywords
medicine
preparation
application
phenol derivative
derivative
Prior art date
Application number
EA201592144A
Other languages
English (en)
Other versions
EA029073B1 (ru
Inventor
Линьлинь Цинь
Фанцюн Ли
Шисюй И
Хуадун Ло
Синьфын Ло
Сунлинь Вань
Лэй Жэнь
Голян Лю
Юнган Вэй
Цзяньюй Лю
Пэн Чо Тан
Original Assignee
Сычуань Хайско Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сычуань Хайско Фармасьютикал Ко., Лтд. filed Critical Сычуань Хайско Фармасьютикал Ко., Лтд.
Publication of EA201592144A1 publication Critical patent/EA201592144A1/ru
Publication of EA029073B1 publication Critical patent/EA029073B1/ru

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    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • A—HUMAN NECESSITIES
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Abstract

Настоящее изобретение относится к производному фенола и к способу его получения и применения в медицине, и в частности, к производному фенола, представленному общей формулой (А), или его стереоизомеру, сольвату, метаболиту, пролекарству, фармацевтически приемлемой соли или сокристаллу, к способу его получения, к включающей его фармацевтической композиции и к применению соединения или композиции согласно настоящему изобретению в области центральной нервной системы; причем определения заместителей в общей формуле (А) являются такими, как приведены в описании.
EA201592144A 2013-05-09 2014-05-06 Производное фенола и способ его получения и его применение в медицине EA029073B1 (ru)

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CN105384619B (zh) * 2014-08-22 2020-05-29 四川海思科制药有限公司 一种异丙基苯酚衍生物及其制备方法
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CN106187702A (zh) * 2015-05-28 2016-12-07 四川海思科制药有限公司 一种2‑[1‑环烷基乙烯基]苯酚的制备方法及其中间体
CN107108416B (zh) * 2015-05-28 2019-12-20 四川海思科制药有限公司 一种1,2-二环丙基乙基苯酚及其光学异构体的制备方法
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CN109071392B (zh) * 2016-06-08 2020-10-02 四川海思科制药有限公司 苯环衍生物及其制备方法和在医药上的应用
CN108017559B (zh) * 2016-11-04 2020-08-04 四川海思科制药有限公司 苯环衍生物及其在医药上的应用
CN108069833B (zh) * 2016-11-15 2020-11-06 四川海思科制药有限公司 苯并四环衍生物及其制备方法和在医药上的应用
CN108164419B (zh) * 2017-12-25 2021-03-16 武汉大学 单分散聚乙二醇单甲醚修饰的丙泊酚前药的制备与应用
CN110063947A (zh) * 2018-01-24 2019-07-30 四川海思科制药有限公司 苯酚衍生物用于制备麻醉药物中的用途
US20210253513A1 (en) * 2018-06-15 2021-08-19 Pharmathen S.A. A novel process for the preparation of tapentadol
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CN113105313A (zh) * 2020-01-11 2021-07-13 四川海思科制药有限公司 苯酚衍生物及其医药用途
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CN113912592B (zh) * 2021-11-03 2023-03-10 西北农林科技大学 一种和厚朴酚并二氢呋喃酯类衍生物、制备方法及其应用

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