EA201591349A1 - Способ получения вортиоксетина - Google Patents
Способ получения вортиоксетинаInfo
- Publication number
- EA201591349A1 EA201591349A1 EA201591349A EA201591349A EA201591349A1 EA 201591349 A1 EA201591349 A1 EA 201591349A1 EA 201591349 A EA201591349 A EA 201591349A EA 201591349 A EA201591349 A EA 201591349A EA 201591349 A1 EA201591349 A1 EA 201591349A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- vortioxetin
- obtaining
- dimethylthiophenolate
- dimethylthiophenol
- destruction
- Prior art date
Links
- LCUKYZMFKFXFOI-UHFFFAOYSA-N CC1=CC(=C(C=C1)S)C.CC1=CC(=C(C=C1)S)C Chemical class CC1=CC(=C(C=C1)S)C.CC1=CC(=C(C=C1)S)C LCUKYZMFKFXFOI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- YQNWZWMKLDQSAC-UHFFFAOYSA-N vortioxetine Chemical compound CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 YQNWZWMKLDQSAC-UHFFFAOYSA-N 0.000 abstract 1
- 229960002263 vortioxetine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Предлагается способ получения вортиоксетина, при котором соединение формулы Iподвергается реакции с необязательно замещенным пиперазином и 2,4-диметилтиофенолом(2,4-диметилтиофенолатом) с последующим разрушением комплекса.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767883P | 2013-02-22 | 2013-02-22 | |
| DKPA201300104 | 2013-02-22 | ||
| PCT/EP2014/053313 WO2014128207A1 (en) | 2013-02-22 | 2014-02-20 | Vortioxetine manufacturing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201591349A1 true EA201591349A1 (ru) | 2015-12-30 |
| EA027756B1 EA027756B1 (ru) | 2017-08-31 |
Family
ID=59215387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201591349A EA027756B1 (ru) | 2013-02-22 | 2014-02-20 | Способ получения вортиоксетина |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US9353073B2 (ru) |
| EP (1) | EP2958903B1 (ru) |
| JP (1) | JP6464098B2 (ru) |
| KR (1) | KR102230628B1 (ru) |
| CN (1) | CN104995181B (ru) |
| AP (1) | AP2015008640A0 (ru) |
| AU (1) | AU2014220735B2 (ru) |
| BR (1) | BR112015019268B1 (ru) |
| CA (1) | CA2901821A1 (ru) |
| CL (1) | CL2015002309A1 (ru) |
| CR (1) | CR20150423A (ru) |
| CY (1) | CY1118883T1 (ru) |
| DK (1) | DK2958903T3 (ru) |
| DO (1) | DOP2015000187A (ru) |
| EA (1) | EA027756B1 (ru) |
| ES (1) | ES2625380T3 (ru) |
| GE (1) | GEP201706749B (ru) |
| HK (1) | HK1216098A1 (ru) |
| HR (1) | HRP20170607T1 (ru) |
| IL (1) | IL240501B (ru) |
| LT (1) | LT2958903T (ru) |
| MA (1) | MA38338B1 (ru) |
| ME (1) | ME02671B (ru) |
| MX (1) | MX362355B (ru) |
| MY (1) | MY172337A (ru) |
| PE (1) | PE20151589A1 (ru) |
| PH (1) | PH12015501807A1 (ru) |
| PL (1) | PL2958903T3 (ru) |
| PT (1) | PT2958903T (ru) |
| RS (1) | RS55932B1 (ru) |
| RU (1) | RU2652265C2 (ru) |
| SG (1) | SG11201506651SA (ru) |
| SI (1) | SI2958903T1 (ru) |
| TN (1) | TN2015000335A1 (ru) |
| UA (1) | UA116236C2 (ru) |
| WO (1) | WO2014128207A1 (ru) |
| ZA (1) | ZA201506050B (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE036240T2 (hu) | 2010-08-18 | 2018-06-28 | Samumed Llc | Diketonok és hidroxiketonok mint kateninszignálút-aktivátorok |
| WO2014130869A1 (en) | 2013-02-22 | 2014-08-28 | Samumed, Llc | Gamma-diketones as wnt/beta -catenin signaling pathway activators |
| BR112017003959B1 (pt) | 2014-08-20 | 2022-08-02 | Samumed, Llc | Uso de um composto de fórmula i ou um sal dermatologicamente aceitável do mesmo |
| WO2016125191A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| EP3274330A1 (en) | 2015-03-26 | 2018-01-31 | Cipla Limited | Method for making serotonin reuptake inhibitors |
| CN106279065A (zh) * | 2015-05-12 | 2017-01-04 | 北京深蓝海生物医药科技有限公司 | 一种氢溴酸沃替西汀的精制转晶方法 |
| JO3456B1 (ar) | 2015-05-13 | 2020-07-05 | H Lundbeck As | فيروتيوكسيتين بيروجلوتامات |
| BR112017021277A2 (pt) * | 2016-02-08 | 2018-06-26 | H Lundbeck As | Síntese de 1-[2-(2,4-dimetil-fenilsulfanil)-fenil] piperazina |
| SG11201810644TA (en) | 2016-07-01 | 2018-12-28 | H Lundbeck As | Vortioxetine dosing regimes for fast onset of antidepressant effect |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| CN109912538B (zh) * | 2019-01-22 | 2021-03-12 | 安徽赛乐普制药有限公司 | 一种抗抑郁药沃替西汀的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (ru) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | производные фенилпиперазина как ингибиторы обратного захвата серотонинА |
| IL161966A0 (en) * | 2001-12-20 | 2005-11-20 | Lundbeck & Co As H | Aryloxyphenyl and arylsulfanylphenyl |
| ES2432102T3 (es) * | 2006-06-16 | 2013-11-29 | H. Lundbeck A/S | Compuestos con actividad combinada en SERT, 5-HT3 y 5-HT1A |
| TW201033181A (en) * | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
-
2014
- 2014-02-20 PT PT147055248T patent/PT2958903T/pt unknown
- 2014-02-20 PE PE2015001720A patent/PE20151589A1/es active IP Right Grant
- 2014-02-20 CA CA2901821A patent/CA2901821A1/en not_active Abandoned
- 2014-02-20 MA MA38338A patent/MA38338B1/fr unknown
- 2014-02-20 MY MYPI2015002072A patent/MY172337A/en unknown
- 2014-02-20 PL PL14705524T patent/PL2958903T3/pl unknown
- 2014-02-20 SI SI201430214T patent/SI2958903T1/sl unknown
- 2014-02-20 AU AU2014220735A patent/AU2014220735B2/en active Active
- 2014-02-20 JP JP2015558446A patent/JP6464098B2/ja active Active
- 2014-02-20 MX MX2015010656A patent/MX362355B/es active IP Right Grant
- 2014-02-20 WO PCT/EP2014/053313 patent/WO2014128207A1/en active Application Filing
- 2014-02-20 BR BR112015019268-8A patent/BR112015019268B1/pt active IP Right Grant
- 2014-02-20 KR KR1020157021985A patent/KR102230628B1/ko active IP Right Grant
- 2014-02-20 EP EP14705524.8A patent/EP2958903B1/en active Active
- 2014-02-20 RS RS20170399A patent/RS55932B1/sr unknown
- 2014-02-20 LT LTEP14705524.8T patent/LT2958903T/lt unknown
- 2014-02-20 DK DK14705524.8T patent/DK2958903T3/en active
- 2014-02-20 GE GEAP201413919A patent/GEP201706749B/en unknown
- 2014-02-20 SG SG11201506651SA patent/SG11201506651SA/en unknown
- 2014-02-20 UA UAA201509642A patent/UA116236C2/uk unknown
- 2014-02-20 ES ES14705524.8T patent/ES2625380T3/es active Active
- 2014-02-20 AP AP2015008640A patent/AP2015008640A0/xx unknown
- 2014-02-20 EA EA201591349A patent/EA027756B1/ru not_active IP Right Cessation
- 2014-02-20 RU RU2015134407A patent/RU2652265C2/ru active
- 2014-02-20 CN CN201480009227.0A patent/CN104995181B/zh active Active
- 2014-02-20 ME MEP-2017-91A patent/ME02671B/me unknown
- 2014-02-20 US US14/767,350 patent/US9353073B2/en active Active
-
2015
- 2015-08-06 TN TN2015000335A patent/TN2015000335A1/en unknown
- 2015-08-10 DO DO2015000187A patent/DOP2015000187A/es unknown
- 2015-08-11 IL IL240501A patent/IL240501B/en active IP Right Grant
- 2015-08-17 PH PH12015501807A patent/PH12015501807A1/en unknown
- 2015-08-18 CR CR20150423A patent/CR20150423A/es unknown
- 2015-08-18 CL CL2015002309A patent/CL2015002309A1/es unknown
- 2015-08-20 ZA ZA2015/06050A patent/ZA201506050B/en unknown
-
2016
- 2016-04-08 HK HK16104011.9A patent/HK1216098A1/zh unknown
-
2017
- 2017-04-18 HR HRP20170607TT patent/HRP20170607T1/hr unknown
- 2017-05-03 CY CY20171100483T patent/CY1118883T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM KG TJ TM |