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EA201491982A1 - Антибактериальные хинолиновые производные - Google Patents

Антибактериальные хинолиновые производные

Info

Publication number
EA201491982A1
EA201491982A1 EA201491982A EA201491982A EA201491982A1 EA 201491982 A1 EA201491982 A1 EA 201491982A1 EA 201491982 A EA201491982 A EA 201491982A EA 201491982 A EA201491982 A EA 201491982A EA 201491982 A1 EA201491982 A1 EA 201491982A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
quinoline derivatives
pharmaceutically acceptable
composition
bacterial infection
Prior art date
Application number
EA201491982A
Other languages
English (en)
Other versions
EA035443B1 (ru
Inventor
Жером Эмиль Жорж Гийемон
Магали Мадлен Симон Мотт
Давид Франсис Ален Лансуа
Уэнди Миа Альберт Балеманс
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201491982A1 publication Critical patent/EA201491982A1/ru
Publication of EA035443B1 publication Critical patent/EA035443B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к новым замещенным хинолиновым производным согласно общей формуле (Ia) или (Ib)включая их любые стереохимически изомерные формы, их фармацевтически приемлемую соль, их N-оксидную форму или их сольват. Заявленные соединения являются применимыми для лечения бактериальной инфекции. Также заявляется композиция, включающая фармацевтически приемлемый носитель и, в качестве активного ингредиента, терапевтически эффективное количество заявленного соединения, применение заявленного соединения или композиции для производства медикамента для лечения бактериальной инфекции и способ получения заявленного соединения.
EA201491982A 2012-04-27 2013-04-26 Антибактериальные хинолиновые производные EA035443B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12165934 2012-04-27
PCT/EP2013/058703 WO2013160435A1 (en) 2012-04-27 2013-04-26 Antibacterial quinoline derivatives

Publications (2)

Publication Number Publication Date
EA201491982A1 true EA201491982A1 (ru) 2015-02-27
EA035443B1 EA035443B1 (ru) 2020-06-17

Family

ID=48227271

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491982A EA035443B1 (ru) 2012-04-27 2013-04-26 Антибактериальные хинолиновые производные

Country Status (15)

Country Link
US (1) US9133167B2 (ru)
EP (1) EP2841425B1 (ru)
JP (1) JP6153604B2 (ru)
KR (1) KR102110355B1 (ru)
CN (1) CN104254527B (ru)
AU (1) AU2013254674B2 (ru)
CA (1) CA2869718C (ru)
DK (1) DK2841425T3 (ru)
EA (1) EA035443B1 (ru)
ES (1) ES2576491T3 (ru)
HK (1) HK1205514A1 (ru)
IN (1) IN2014MN02364A (ru)
MX (1) MX355050B (ru)
PL (1) PL2841425T3 (ru)
WO (1) WO2013160435A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104254528B (zh) * 2012-04-27 2017-06-06 詹森药业有限公司 抗菌的喹啉衍生物
CN107001316A (zh) * 2014-08-06 2017-08-01 诺华股份有限公司 作为抗菌剂的喹诺酮衍生物
BR122021024097B1 (pt) * 2016-03-07 2024-04-30 The Global Alliance For Tb Drug Development, Inc Composto antibacteriano, uso do mesmo e composição farmacêutica
KR102574912B1 (ko) * 2016-08-17 2023-09-07 덕산네오룩스 주식회사 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치
WO2018048882A1 (en) 2016-09-06 2018-03-15 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
KR102695633B1 (ko) * 2021-12-17 2024-08-14 한국화학연구원 피리미딘을 포함하는 테트라하이드로이소퀴놀린 유도체 및 이의 결핵 치료제 용도
AU2023235233A1 (en) 2022-03-14 2024-09-12 Slap Pharmaceuticals Llc Multicyclic compounds

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2270123A1 (en) 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
US6103905A (en) 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
GB0118238D0 (en) * 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
ME00131B (me) 2002-07-25 2010-10-10 Janssen Pharmaceutica Nv Derivati hinolina i njihova upotreba kao mikobakterijskih inhibitora
CN1910177B (zh) * 2004-01-23 2010-05-05 詹森药业有限公司 取代的喹啉及其作为分枝杆菌抑制剂的用途
UA86952C2 (ru) 2004-01-23 2009-06-10 Янссен Фармацевтика Н.В. Производной хинолина и их применение как микобактериальных ингибиторов
WO2005075428A1 (en) 2004-01-29 2005-08-18 Janssen Pharmaceutica N.V. Quinoline derivatives for use as mycobacterial inhibitors
BRPI0510414B1 (pt) 2004-05-28 2022-04-05 Janssen Pharmaceutica N.V. Combinação e composição farmacêutica
WO2005123081A2 (en) 2004-06-22 2005-12-29 Janssen Pharmaceutica N.V. (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)-pyrrolidin-3-yl]-piperazin-1-yl}-piperidin-1-yl)-(3,5-trifluoromethyl-phenyl))-methanone for the treatment of schizophrenia
PL1797115T3 (pl) 2004-09-28 2017-12-29 Janssen Pharmaceutica N.V. Domena wiążąca bakteryjnej syntazy ATP
EE05394B1 (et) 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
CA2528849C (en) 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
JO3270B1 (ar) 2005-06-28 2018-09-16 Janssen Pharmaceutica Nv مشتقات كوينولين بصفة عوامل مضادة للبكتيريا
HUE030264T2 (en) 2005-06-28 2017-04-28 Janssen Pharmaceutica Nv Quinoline derivatives as antibacterial agents
JO2752B1 (en) 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO3077B1 (ar) 2005-07-28 2017-03-15 Janssen Pharmaceutica Nv مشتقات كوينولين مضادة للبكتيريا
JO2855B1 (en) 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2837B1 (en) 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents
JO2952B1 (en) 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2683B1 (en) 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO3271B1 (ar) 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
JO2685B1 (en) 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2725B1 (en) 2006-12-06 2013-09-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2684B1 (en) 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
CA2711912A1 (en) * 2008-01-14 2009-07-23 Jyoti Chattopadhyaya Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivates as anti-mycobacterial agents
CN104254528B (zh) * 2012-04-27 2017-06-06 詹森药业有限公司 抗菌的喹啉衍生物

Also Published As

Publication number Publication date
EA035443B1 (ru) 2020-06-17
US20150065502A1 (en) 2015-03-05
KR20150013156A (ko) 2015-02-04
DK2841425T3 (en) 2016-06-27
CA2869718A1 (en) 2013-10-31
AU2013254674A1 (en) 2014-10-16
JP2015518003A (ja) 2015-06-25
CA2869718C (en) 2021-05-11
PL2841425T3 (pl) 2016-10-31
WO2013160435A1 (en) 2013-10-31
AU2013254674B2 (en) 2017-02-02
MX2014013056A (es) 2014-12-10
CN104254527B (zh) 2017-05-31
CN104254527A (zh) 2014-12-31
JP6153604B2 (ja) 2017-06-28
ES2576491T3 (es) 2016-07-07
EP2841425A1 (en) 2015-03-04
HK1205514A1 (en) 2015-12-18
MX355050B (es) 2018-04-02
US9133167B2 (en) 2015-09-15
KR102110355B1 (ko) 2020-05-14
IN2014MN02364A (ru) 2015-08-14
EP2841425B1 (en) 2016-03-23

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TM