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EA201490578A1 - Полиморфная форма питавастатина кальция - Google Patents

Полиморфная форма питавастатина кальция

Info

Publication number
EA201490578A1
EA201490578A1 EA201490578A EA201490578A EA201490578A1 EA 201490578 A1 EA201490578 A1 EA 201490578A1 EA 201490578 A EA201490578 A EA 201490578A EA 201490578 A EA201490578 A EA 201490578A EA 201490578 A1 EA201490578 A1 EA 201490578A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polymorphic form
pitavastatina
form calcium
new polymorphic
calcium
Prior art date
Application number
EA201490578A
Other languages
English (en)
Other versions
EA024991B1 (ru
Inventor
Ален Кляйиц
Сабина Трошт
Аница Пецавар
Рок Зупет
Original Assignee
ФАРМА ДжРС, Д.О.О.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ФАРМА ДжРС, Д.О.О. filed Critical ФАРМА ДжРС, Д.О.О.
Publication of EA201490578A1 publication Critical patent/EA201490578A1/ru
Publication of EA024991B1 publication Critical patent/EA024991B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0036—Crystallisation on to a bed of product crystals; Seeding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к новой полиморфной форме питавастатина кальция, способу ее получения и фармацевтической композиции, включающей ее. Новая полиморфная форма отличается паттерном порошковой рентгеновской дифрактограммы, приведенным на фиг. 1.
EA201490578A 2011-09-12 2012-09-12 Полиморфная форма питавастатина кальция EA024991B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI201100359 2011-09-12
PCT/EP2012/067859 WO2013037838A1 (en) 2011-09-12 2012-09-12 Polymorphic form of pitavastatin calcium

Publications (2)

Publication Number Publication Date
EA201490578A1 true EA201490578A1 (ru) 2015-01-30
EA024991B1 EA024991B1 (ru) 2016-11-30

Family

ID=46829784

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490578A EA024991B1 (ru) 2011-09-12 2012-09-12 Полиморфная форма питавастатина кальция

Country Status (6)

Country Link
EP (1) EP2751081B1 (ru)
EA (1) EA024991B1 (ru)
ES (1) ES2620968T3 (ru)
PT (1) PT2751081T (ru)
SI (1) SI2751081T1 (ru)
WO (1) WO2013037838A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9630906B2 (en) 2013-03-29 2017-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Amine salts of pitavastatin and rosuvastatin
EP3058113B1 (en) 2013-10-14 2020-12-02 Orbotech Ltd. Lift printing of multi-composition material structures
EP4380323A3 (en) 2014-10-19 2024-09-25 Orbotech Ltd. Lift printing of conductive traces onto a semiconductor substrate
KR102282860B1 (ko) 2015-01-19 2021-07-28 오르보테크 엘티디. 희생 지지부를 가진 3차원 금속 구조물의 프린팅
CN108349120B (zh) 2015-11-22 2020-06-23 奥博泰克有限公司 打印的三维结构的表面性质控制
CN107115306B (zh) * 2017-04-17 2019-09-13 浙江京新药业股份有限公司 一种含匹伐他汀钙的药物组合物及其制备方法
TW201901887A (zh) 2017-05-24 2019-01-01 以色列商奧寶科技股份有限公司 於未事先圖樣化基板上電器互連電路元件

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1336714C (en) 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
JP3528186B2 (ja) 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
AU2004212160B2 (en) 2003-02-12 2009-05-14 Nissan Chemical Industries Ltd. Crystalline forms of pitavastatin calcium
TWI328006B (en) * 2003-12-26 2010-08-01 Nissan Chemical Ind Ltd Crystal form of quinoline compound and process for its production
WO2007132482A2 (en) * 2006-05-17 2007-11-22 Manne Satyanarayana Reddy Novel process for the preparation of pitavastatin and its pharmaceutically acceptable salts
CN101195603A (zh) * 2007-11-21 2008-06-11 重庆医药工业研究院有限责任公司 一种匹伐他汀钙的新晶型及其制备方法
US8487105B2 (en) 2009-01-19 2013-07-16 Msn Laboratories Limited Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof
KR20100125124A (ko) * 2009-05-20 2010-11-30 미래파인켐 주식회사 피타바스타틴 헤미칼슘염의 신규한 결정형 및 그의 제조방법
WO2011089623A2 (en) 2010-01-20 2011-07-28 Cadila Healthcare Limited Process for preparing pitavastatin and pharmaceutically acceptable salts thereof
KR101134021B1 (ko) * 2010-02-24 2012-04-05 주식회사 메디켐코리아 새로운 중간체를 이용하는 피타바스타틴 헤미칼슘의 신규한 제조방법
EP2638013A4 (en) * 2010-11-12 2014-03-26 Hetero Research Foundation NEW POLYMORPHS OF CALCIUM PIVASTATIN

Also Published As

Publication number Publication date
EP2751081B1 (en) 2017-01-04
EP2751081A1 (en) 2014-07-09
EA024991B1 (ru) 2016-11-30
PT2751081T (pt) 2017-04-04
SI2751081T1 (sl) 2017-05-31
WO2013037838A1 (en) 2013-03-21
ES2620968T3 (es) 2017-06-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title