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EA201390813A1 - Антитела и их применение - Google Patents

Антитела и их применение

Info

Publication number
EA201390813A1
EA201390813A1 EA201390813A EA201390813A EA201390813A1 EA 201390813 A1 EA201390813 A1 EA 201390813A1 EA 201390813 A EA201390813 A EA 201390813A EA 201390813 A EA201390813 A EA 201390813A EA 201390813 A1 EA201390813 A1 EA 201390813A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies
chemokine
ccr4
present
provides
Prior art date
Application number
EA201390813A
Other languages
English (en)
Inventor
Урс Беат Хагеманн
Ремко Альберт Грип
Херальд Рейерсен
Сергей Михайлович Киприянов
Original Assignee
Аффитек Рисёч Ас
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аффитек Рисёч Ас filed Critical Аффитек Рисёч Ас
Publication of EA201390813A1 publication Critical patent/EA201390813A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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Abstract

Настоящее изобретение представляет антитела, связывающиеся с эпитопом внеклеточного домена рецептора 4 СС-хемокинов (CCR4) человека и способные ингибировать связывание хемокина, продуцируемого макрофагами (MDC), и/или хемокина, регулируемого тимусом и активацией (TARC), с CCR4. Кроме того, настоящее изобретение представляет, в числе прочего, иммуноконъюгаты и композиции, включающие такие антитела, и способы использования таких антител, в частности, в областях медицины и диагностики.
EA201390813A 2010-12-07 2011-12-07 Антитела и их применение EA201390813A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42037010P 2010-12-07 2010-12-07
GB201020738A GB201020738D0 (en) 2010-12-07 2010-12-07 Antibodies
PCT/GB2011/052421 WO2012076883A1 (en) 2010-12-07 2011-12-07 Anti ccr4 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
EA201390813A1 true EA201390813A1 (ru) 2013-11-29

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Application Number Title Priority Date Filing Date
EA201390813A EA201390813A1 (ru) 2010-12-07 2011-12-07 Антитела и их применение

Country Status (17)

Country Link
US (2) US8895007B2 (ru)
EP (1) EP2649097A1 (ru)
JP (1) JP6215707B2 (ru)
KR (1) KR20130132903A (ru)
CN (1) CN103328513B (ru)
AU (1) AU2011340264B2 (ru)
BR (1) BR112013014235A2 (ru)
CA (1) CA2818313A1 (ru)
CO (1) CO6761356A2 (ru)
EA (1) EA201390813A1 (ru)
GB (1) GB201020738D0 (ru)
IL (1) IL226427A0 (ru)
MX (1) MX2013006167A (ru)
NZ (1) NZ612175A (ru)
SG (1) SG190299A1 (ru)
WO (1) WO2012076883A1 (ru)
ZA (1) ZA201304723B (ru)

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GB2512857A (en) 2013-04-09 2014-10-15 Cancer Res Technology Cancer biomarker
US20170121419A1 (en) * 2014-06-12 2017-05-04 The General Hospital Corporation Anti-human Chemokine (C-C motif) Receptor 4 Immunotoxins
CA2954934C (en) 2014-06-30 2023-09-26 Glykos Finland Oy Drug derivative and conjugates
EP3699196A1 (en) * 2014-10-06 2020-08-26 Dana Farber Cancer Institute, Inc. Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof
MX2018000959A (es) 2015-07-23 2018-06-06 Boehringer Ingelheim Int Compuesto que se dirige a il-23a y al factor de activacion de linfocitos b (baff) y usos de estos.
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