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EA201190137A1 - Новые соли десвенлафаксина и способ их получения - Google Patents

Новые соли десвенлафаксина и способ их получения

Info

Publication number
EA201190137A1
EA201190137A1 EA201190137A EA201190137A EA201190137A1 EA 201190137 A1 EA201190137 A1 EA 201190137A1 EA 201190137 A EA201190137 A EA 201190137A EA 201190137 A EA201190137 A EA 201190137A EA 201190137 A1 EA201190137 A1 EA 201190137A1
Authority
EA
Eurasian Patent Office
Prior art keywords
salts
new
desvenafaxin
production
desvenlafaxine
Prior art date
Application number
EA201190137A
Other languages
English (en)
Other versions
EA019449B1 (ru
Inventor
Лудек Ридван
Петр Груби
Станислав Радль
Гана Брусова
Лукас Крейцик
Томас Пекарек
Наталия Цсокова
Анна Зерзанова
Original Assignee
Зентива, К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива, К.С. filed Critical Зентива, К.С.
Publication of EA201190137A1 publication Critical patent/EA201190137A1/ru
Publication of EA019449B1 publication Critical patent/EA019449B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/52—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/06—Oxalic acid
    • C07C55/07—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к новым солям десвенлафаксина в форме основания формулы (I) со щавелевой кислотой, причем новыми солями являются гидрооксалат формулы (II) с соотношением десвенлафаксин:щавелевая кислота 1:1 и гемиоксалат формулы (III) с соотношением десвенлафаксин:щавелевая кислота 2:1.
EA201190137A 2009-02-06 2010-02-03 Новые соли десвенлафаксина и способ их получения EA019449B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20090069A CZ301820B6 (cs) 2009-02-06 2009-02-06 Nové soli desvenlafaxinu a zpusob jejich prípravy
PCT/CZ2010/000010 WO2010088865A2 (en) 2009-02-06 2010-02-03 New salts of desvenlafaxine and a method of their preparation

Publications (2)

Publication Number Publication Date
EA201190137A1 true EA201190137A1 (ru) 2012-02-28
EA019449B1 EA019449B1 (ru) 2014-03-31

Family

ID=42244872

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190137A EA019449B1 (ru) 2009-02-06 2010-02-03 Новые соли десвенлафаксина и способ их получения

Country Status (6)

Country Link
US (1) US8779005B2 (ru)
EP (1) EP2393770A2 (ru)
CZ (1) CZ301820B6 (ru)
EA (1) EA019449B1 (ru)
UA (1) UA103368C2 (ru)
WO (1) WO2010088865A2 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150050337A1 (en) * 2013-08-13 2015-02-19 Generic Partners Pty. Ltd Extended Release Compositions

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
EP1153603B1 (en) * 1993-06-28 2006-10-18 Wyeth New treatments using phenethylamine derivatives
WO2000076955A1 (en) 1999-06-15 2000-12-21 American Home Products Corporation Enantiomers of o-desmethyl venlafaxine
CA2666611A1 (en) 2001-02-12 2002-08-22 Wyeth Novel succinate salt of o-desmethyl-venlafaxine
UA80543C2 (en) 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine
BR0311693A (pt) * 2002-06-10 2005-03-22 Wyeth Corp Sal de formato de o-desmetil-venlafaxina
GT200600396A (es) * 2005-09-07 2007-04-23 Dispositivos para la aplicacion de medicamentos transdermicos conteniendo o-desmetil venlafaxina (odv) o sus sales
EP1973866A1 (en) 2005-12-20 2008-10-01 Synthon B.V. Process for making desvenlafaxine
WO2007120923A1 (en) 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Substantially pure o-desmethylvenlafaxine and processes for preparing it
WO2008090465A2 (en) * 2007-01-22 2008-07-31 Medichem, S.A. Process for synthesizing desvenlafaxine free base and salts or salvates thereof
US20110046231A1 (en) * 2007-10-22 2011-02-24 Actavis Group Ptc Ehf Solid forms of (±)-o-desmethylvenlafaxine salts
EP2262758A4 (en) * 2008-03-12 2011-12-07 Reddys Lab Ltd Dr O-desmethylvenlafaxine SALTS
EP2119695A1 (en) * 2008-05-16 2009-11-18 Krka Preparation of O-desmethylvenlafaxine salts
KR20100132069A (ko) * 2008-06-16 2010-12-16 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신염의 고체 상태
WO2009155488A2 (en) * 2008-06-19 2009-12-23 Segrub, Llc Novel oxalate salt and crystal of o-desmethylvenlafaxine

Also Published As

Publication number Publication date
CZ200969A3 (cs) 2010-06-30
US8779005B2 (en) 2014-07-15
US20120041227A1 (en) 2012-02-16
UA103368C2 (ru) 2013-10-10
EP2393770A2 (en) 2011-12-14
WO2010088865A2 (en) 2010-08-12
WO2010088865A3 (en) 2010-12-02
CZ301820B6 (cs) 2010-06-30
EA019449B1 (ru) 2014-03-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU