EA201100142A1 - Циклические сулфоны, замещенные аминобензилом, применимые в качестве ингибиторов васе - Google Patents
Циклические сулфоны, замещенные аминобензилом, применимые в качестве ингибиторов васеInfo
- Publication number
- EA201100142A1 EA201100142A1 EA201100142A EA201100142A EA201100142A1 EA 201100142 A1 EA201100142 A1 EA 201100142A1 EA 201100142 A EA201100142 A EA 201100142A EA 201100142 A EA201100142 A EA 201100142A EA 201100142 A1 EA201100142 A1 EA 201100142A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- sulfons
- wse
- aminobenzyl
- inhibitors
- cyclic
- Prior art date
Links
- -1 AMINOBENZYL Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
В заявке описаны новые гетероциклические соединения формулы (I)в которой все переменные являются такими, как определено в описании, в свободной форме или в форме соли, их получение, их применение в качестве лекарственных средств и содержащие их лекарственные средства.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08160123 | 2008-07-10 | ||
| US15457309P | 2009-02-23 | 2009-02-23 | |
| PCT/EP2009/058661 WO2010003976A1 (en) | 2008-07-10 | 2009-07-08 | Cyclic sulfones with aminobenzyl substitution useful as bace inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201100142A1 true EA201100142A1 (ru) | 2011-10-31 |
Family
ID=39737611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201100142A EA201100142A1 (ru) | 2008-07-10 | 2009-07-08 | Циклические сулфоны, замещенные аминобензилом, применимые в качестве ингибиторов васе |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8093406B2 (ru) |
| EP (1) | EP2303857A1 (ru) |
| JP (1) | JP2011527311A (ru) |
| KR (1) | KR20110050616A (ru) |
| CN (1) | CN102076678A (ru) |
| AR (1) | AR073455A1 (ru) |
| AU (1) | AU2009268024A1 (ru) |
| BR (1) | BRPI0915541A2 (ru) |
| CA (1) | CA2730003A1 (ru) |
| EA (1) | EA201100142A1 (ru) |
| MX (1) | MX2011000390A (ru) |
| TW (1) | TW201006810A (ru) |
| WO (1) | WO2010003976A1 (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014127042A1 (en) | 2013-02-12 | 2014-08-21 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT75074B (en) * | 1981-06-27 | 1986-02-26 | Smith Kline French Lab | Process for preparing certain pyrimidone derivatives and compositions containing them |
| BR0010099A (pt) * | 1999-04-28 | 2002-06-04 | Univ Kingston | Métodos para modular a agregação de amilóides em um indivìduo, para o tratamento de um estado doentio associado com amiloidose, composição para modular amiloidose, e, métodos para inibir os depósitos de amilóide associados com iapp em um indivìduo, para inibir fibrilogenese iapp em um indivìduo, para reduzir os agregados de amilóides associados com iapp em um indivìduo, para modular dano associado com amilóides em células, e para modular amiloidose in vivo ou ex vivo |
| GB0602951D0 (en) * | 2006-02-14 | 2006-03-29 | Novartis Ag | Organic Compounds |
| WO2009024615A1 (en) * | 2007-08-23 | 2009-02-26 | Novartis Ag | Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors |
-
2009
- 2009-07-08 EP EP09780309A patent/EP2303857A1/en not_active Withdrawn
- 2009-07-08 AU AU2009268024A patent/AU2009268024A1/en not_active Abandoned
- 2009-07-08 CA CA2730003A patent/CA2730003A1/en not_active Abandoned
- 2009-07-08 KR KR1020117000414A patent/KR20110050616A/ko not_active Application Discontinuation
- 2009-07-08 WO PCT/EP2009/058661 patent/WO2010003976A1/en active Application Filing
- 2009-07-08 CN CN2009801248410A patent/CN102076678A/zh active Pending
- 2009-07-08 BR BRPI0915541A patent/BRPI0915541A2/pt not_active Application Discontinuation
- 2009-07-08 AR ARP090102594A patent/AR073455A1/es unknown
- 2009-07-08 JP JP2011517152A patent/JP2011527311A/ja active Pending
- 2009-07-08 MX MX2011000390A patent/MX2011000390A/es not_active Application Discontinuation
- 2009-07-08 EA EA201100142A patent/EA201100142A1/ru unknown
- 2009-07-09 US US12/500,093 patent/US8093406B2/en not_active Expired - Fee Related
- 2009-07-09 TW TW098123259A patent/TW201006810A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010003976A1 (en) | 2010-01-14 |
| AU2009268024A1 (en) | 2010-01-14 |
| TW201006810A (en) | 2010-02-16 |
| US8093406B2 (en) | 2012-01-10 |
| US20100056490A1 (en) | 2010-03-04 |
| KR20110050616A (ko) | 2011-05-16 |
| EP2303857A1 (en) | 2011-04-06 |
| AR073455A1 (es) | 2010-11-10 |
| JP2011527311A (ja) | 2011-10-27 |
| CA2730003A1 (en) | 2010-01-14 |
| BRPI0915541A2 (pt) | 2016-01-26 |
| CN102076678A (zh) | 2011-05-25 |
| MX2011000390A (es) | 2011-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201170772A1 (ru) | Органические соединения | |
| EA201100037A1 (ru) | Органические соединения | |
| EA201001205A1 (ru) | Соединения, содержащие циклобутоксигруппу | |
| EA201201677A1 (ru) | Производные гетероарилимидазолона в качестве ингибиторов jak | |
| MA32508B1 (fr) | Composes organiques | |
| EA201591455A1 (ru) | Производные бензимидазолона в качестве ингибиторов бромодомена | |
| EA201591965A1 (ru) | Производные бензимидазола в качестве ингибиторов бромодомена | |
| EA201190235A1 (ru) | Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750 | |
| EA201200176A1 (ru) | Производные оксазина и их применение для лечения неврологических нарушений | |
| EA201001683A1 (ru) | Производные фенил- или пиридинилзамещенных индазолов | |
| EA201400412A1 (ru) | ЗАМЕЩЕННЫЕ БЕНЗИЛИНДАЗОЛЫ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Bub1 КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ | |
| EA201200952A1 (ru) | Производные пиразина и их применение для лечения неврологических нарушений | |
| EA201690598A1 (ru) | Аминогетероарил бензамиды в качестве ингибиторов киназы | |
| EA201400753A1 (ru) | Новые пиррольные соединения, способ их получения и фармацевтические композиции, содержащие их | |
| EA200970156A1 (ru) | Пиридизиноновые производные | |
| EA201071339A1 (ru) | Фосфорсодержащие производные в качестве ингибиторов киназы | |
| EA201300200A1 (ru) | N-((6-аминопиридин-3-ил)метил)гетероарилкарбоксамиды в качестве ингибиторов калликреина в плазме | |
| EA200700168A1 (ru) | Производные замещенной циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназы | |
| UA107951C2 (xx) | Похідні імідазопіридину як інгібітори jak | |
| EA201201143A1 (ru) | Производные пиразола в качестве ингибиторов jak | |
| EA201500953A1 (ru) | 3-ацетиламино-1-(фенилгетероариламинокарбонил или фенилгетероарилкарбониламино)бензольные производные для лечения гиперпролиферативных нарушений | |
| UA106875C2 (uk) | Тіадіазолілоксифеніламідини та їх застосування як фунгіцидів | |
| EA200900397A1 (ru) | Новые соединения диосметина, способ их получения и фармацевтические композиции, которые их содержат | |
| EA201071224A1 (ru) | Ингибиторы limk2, композиции, содержащие их, и способы их применения | |
| EA201490438A1 (ru) | Антибактериальные 3,4-дигидро-1н-[1,8]нафтиридиноны, замещенные циклопента[c]пирролом |