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EA201070651A1 - Стабильная кристаллическая соль 1-азабицикло[2.2.2]окт-3-илового сложного эфира (r)-3-фторфенил-3,4,5-трифторбензилкарбаминовой кислоты - Google Patents

Стабильная кристаллическая соль 1-азабицикло[2.2.2]окт-3-илового сложного эфира (r)-3-фторфенил-3,4,5-трифторбензилкарбаминовой кислоты

Info

Publication number
EA201070651A1
EA201070651A1 EA201070651A EA201070651A EA201070651A1 EA 201070651 A1 EA201070651 A1 EA 201070651A1 EA 201070651 A EA201070651 A EA 201070651A EA 201070651 A EA201070651 A EA 201070651A EA 201070651 A1 EA201070651 A1 EA 201070651A1
Authority
EA
Eurasian Patent Office
Prior art keywords
azabicyclo
oct
acid
triftorobenzylkarbaminic
ftorphenyl
Prior art date
Application number
EA201070651A
Other languages
English (en)
Other versions
EA017483B1 (ru
Inventor
Хуан Лоренсо Катена Руис
Хосе Идальго Родригес
Мария Дель Кармен Серра Комас
Исабель Масип Масип
Original Assignee
Лабораториос Салват, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лабораториос Салват, С.А. filed Critical Лабораториос Салват, С.А.
Publication of EA201070651A1 publication Critical patent/EA201070651A1/ru
Publication of EA017483B1 publication Critical patent/EA017483B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к стабильной кристаллической соли 1-азабицикло[2.2.2]окт-3-илового сложного эфира (R)-3-фторфенил-3,4,5-трифторбензилкарбаминовой кислоты формулы (I) и к ее применению в качестве лекарственного средства, в частности, для лечения недержания мочи и других заболеваний, связанных с мочеполовыми расстройствами.
EA201070651A 2007-11-28 2008-11-26 Стабильная кристаллическая соль 1-азабицикло[2.2.2]окт-3-илового сложного эфира (r)-3-фторфенил-3,4,5-трифторбензилкарбаминовой кислоты EA017483B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07384038A EP2065385A1 (en) 2007-11-28 2007-11-28 Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester
PCT/EP2008/010012 WO2009068253A2 (en) 2007-11-28 2008-11-26 Stable crystalline salt of (r)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo [2.2.2]oct-yl ester

Publications (2)

Publication Number Publication Date
EA201070651A1 true EA201070651A1 (ru) 2010-12-30
EA017483B1 EA017483B1 (ru) 2012-12-28

Family

ID=39401152

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070651A EA017483B1 (ru) 2007-11-28 2008-11-26 Стабильная кристаллическая соль 1-азабицикло[2.2.2]окт-3-илового сложного эфира (r)-3-фторфенил-3,4,5-трифторбензилкарбаминовой кислоты

Country Status (19)

Country Link
US (2) US8492402B2 (ru)
EP (2) EP2065385A1 (ru)
JP (1) JP5336509B2 (ru)
KR (1) KR101557832B1 (ru)
CN (1) CN101925600B (ru)
AU (1) AU2008329181B2 (ru)
BR (1) BRPI0819607A2 (ru)
CA (1) CA2706565C (ru)
DK (1) DK2220082T3 (ru)
EA (1) EA017483B1 (ru)
ES (1) ES2498819T3 (ru)
HK (1) HK1144192A1 (ru)
IL (1) IL206032A (ru)
MX (1) MX2010005850A (ru)
NZ (1) NZ585833A (ru)
PL (1) PL2220082T3 (ru)
UA (1) UA102083C2 (ru)
WO (1) WO2009068253A2 (ru)
ZA (1) ZA201003718B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ301323B6 (cs) 2000-12-22 2010-01-13 Laboratorios Almirall, S.A. Chinuklidinkarbamátové deriváty a lécivé kompozice je obsahující
PT3150610T (pt) 2010-02-12 2019-11-11 Pfizer Sais e polrmorfos de 8-fluor0-2-{4- [(metilamino}metil]fenil}-1,3,4,5-tetrahidr0-6hazepin0[ 5,4,3-cd]indol-6-0na
KR101978364B1 (ko) * 2017-06-15 2019-05-14 크리스탈지노믹스(주) 알킬카바모일 나프탈렌일옥시 옥테노일 하이드록시아마이드 또는 그 유도체의 약학적으로 허용 가능한 염 및 그 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE510305C2 (sv) * 1997-05-30 1999-05-10 Astra Ab Nytt salt
CZ294251B6 (cs) * 2000-06-27 2004-11-10 Laboratorios S. A. L. V. A. T., S. A. Karbamáty a jejich použití pro výrobu farmaceutického prostředku
CZ301323B6 (cs) * 2000-12-22 2010-01-13 Laboratorios Almirall, S.A. Chinuklidinkarbamátové deriváty a lécivé kompozice je obsahující
GEP20063958B (en) * 2001-12-20 2006-11-10 Chiesi Farma Spa 1-alkyl-1-azoniabicyclo [2.2.2] octane carbamate derivatives and their use as muscarinic receptor antagonists
ES2203327B1 (es) * 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2246170B1 (es) * 2004-07-29 2007-04-01 Almirall Prodesfarma, S.A. Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.

Also Published As

Publication number Publication date
EP2220082B1 (en) 2014-06-25
CA2706565A1 (en) 2009-06-04
WO2009068253A3 (en) 2009-08-13
EP2065385A1 (en) 2009-06-03
AU2008329181B2 (en) 2012-03-29
JP2011504890A (ja) 2011-02-17
EP2220082A2 (en) 2010-08-25
DK2220082T3 (da) 2014-10-06
US8492402B2 (en) 2013-07-23
US20140051721A1 (en) 2014-02-20
IL206032A (en) 2014-07-31
KR101557832B1 (ko) 2015-10-06
US20110207769A1 (en) 2011-08-25
PL2220082T3 (pl) 2014-12-31
NZ585833A (en) 2011-05-27
AU2008329181A1 (en) 2009-06-04
BRPI0819607A2 (pt) 2015-10-13
CN101925600A (zh) 2010-12-22
CN101925600B (zh) 2013-01-09
HK1144192A1 (en) 2011-02-02
JP5336509B2 (ja) 2013-11-06
CA2706565C (en) 2015-04-28
IL206032A0 (en) 2010-11-30
EA017483B1 (ru) 2012-12-28
KR20100103532A (ko) 2010-09-27
ES2498819T3 (es) 2014-09-25
ZA201003718B (en) 2011-08-31
MX2010005850A (es) 2010-09-03
WO2009068253A2 (en) 2009-06-04
US8871787B2 (en) 2014-10-28
UA102083C2 (ru) 2013-06-10

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU