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EA200901598A1 - Способ получения триазолонов - Google Patents

Способ получения триазолонов

Info

Publication number
EA200901598A1
EA200901598A1 EA200901598A EA200901598A EA200901598A1 EA 200901598 A1 EA200901598 A1 EA 200901598A1 EA 200901598 A EA200901598 A EA 200901598A EA 200901598 A EA200901598 A EA 200901598A EA 200901598 A1 EA200901598 A1 EA 200901598A1
Authority
EA
Eurasian Patent Office
Prior art keywords
triazolones
producing
preparation
alkylsulfanyl
application describes
Prior art date
Application number
EA200901598A
Other languages
English (en)
Other versions
EA016913B1 (ru
Inventor
Умберто Бартоломе Арзено
Гэри М. Ли
Майкл Мартин
Кешаб Сарма
Цзян Чжу
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of EA200901598A1 publication Critical patent/EA200901598A1/ru
Publication of EA016913B1 publication Critical patent/EA016913B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/18—Preparation of halogenated hydrocarbons by replacement by halogens of oxygen atoms of carbonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

В заявке описан улучшенный способ получения алкилсульфанилзамещенных триазолов 2, которые являются полезными промежуточными продуктами в новом способе получения триазолонов 20.
EA200901598A 2007-05-30 2008-05-20 Способ получения триазолонов EA016913B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93221607P 2007-05-30 2007-05-30
PCT/EP2008/056166 WO2008145563A2 (en) 2007-05-30 2008-05-20 Process for preparing triazolones

Publications (2)

Publication Number Publication Date
EA200901598A1 true EA200901598A1 (ru) 2010-06-30
EA016913B1 EA016913B1 (ru) 2012-08-30

Family

ID=39645556

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901598A EA016913B1 (ru) 2007-05-30 2008-05-20 Способ получения триазолонов

Country Status (13)

Country Link
US (2) US7745634B2 (ru)
EP (1) EP2164835B1 (ru)
JP (1) JP5341881B2 (ru)
KR (1) KR101541929B1 (ru)
CN (1) CN101679320B (ru)
AU (1) AU2008257772B2 (ru)
BR (2) BRPI0811988B1 (ru)
CA (2) CA2912224C (ru)
EA (1) EA016913B1 (ru)
ES (1) ES2401037T3 (ru)
IL (1) IL202142A (ru)
MX (1) MX2009012706A (ru)
WO (1) WO2008145563A2 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2803103A1 (en) * 2010-07-15 2012-01-19 Albemarle Corporation Processes for producing 4-bromo-2-methoxybenzaldehyde
US9039765B2 (en) 2011-01-21 2015-05-26 Warsaw Orhtopedic, Inc. Implant system and method for stabilization of a sacro-iliac joint
CN102584689A (zh) * 2012-01-13 2012-07-18 江苏中邦制药有限公司 一种2-氯-3-氟吡啶的制备方法
EP2900240B1 (en) * 2012-09-26 2020-01-08 Merck Sharp & Dohme Corp. Crystalline form of a reverse transcriptase inhibitor
SG11202010907VA (en) * 2018-05-04 2020-12-30 Inflazome Ltd Novel compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200505441A (en) * 2003-03-24 2005-02-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitorsⅠ
CN1942449A (zh) 2004-04-15 2007-04-04 弗·哈夫曼-拉罗切有限公司 制备哒嗪酮化合物的方法
US7686803B2 (en) * 2004-05-14 2010-03-30 Cardima, Inc. Ablation probe with stabilizing member
ES2391461T3 (es) * 2004-07-27 2012-11-27 F. Hoffmann-La Roche Ag Compuestos de benciltriazolona utilizados como inhibidores no nucleósidos de transcriptasa inversa
EP2142520A1 (en) * 2007-03-29 2010-01-13 F. Hoffmann-Roche AG Non-nucleoside reverse transcriptase inhibitors

Also Published As

Publication number Publication date
WO2008145563A2 (en) 2008-12-04
CN101679320B (zh) 2013-01-23
EP2164835B1 (en) 2012-12-12
MX2009012706A (es) 2009-12-08
IL202142A (en) 2015-06-30
EA016913B1 (ru) 2012-08-30
AU2008257772A1 (en) 2008-12-04
US20090012304A1 (en) 2009-01-08
CA2912224A1 (en) 2008-12-04
JP5341881B2 (ja) 2013-11-13
ES2401037T3 (es) 2013-04-16
BRPI0811988B1 (pt) 2021-05-25
CA2687770C (en) 2016-03-08
CA2912224C (en) 2018-04-24
US7893276B2 (en) 2011-02-22
KR20100023010A (ko) 2010-03-03
IL202142A0 (en) 2010-06-16
JP2010528084A (ja) 2010-08-19
EP2164835A2 (en) 2010-03-24
US7745634B2 (en) 2010-06-29
KR101541929B1 (ko) 2015-08-04
BRPI0811988A2 (pt) 2020-08-18
BR122021006634B1 (pt) 2022-03-29
CA2687770A1 (en) 2008-12-04
WO2008145563A3 (en) 2009-04-09
AU2008257772B2 (en) 2013-06-20
US20100280256A1 (en) 2010-11-04
CN101679320A (zh) 2010-03-24

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM