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EA200901402A1 - Терапевтическое средство против глаукомы, содержащее в качестве активного ингредиента производное аденозина - Google Patents

Терапевтическое средство против глаукомы, содержащее в качестве активного ингредиента производное аденозина

Info

Publication number
EA200901402A1
EA200901402A1 EA200901402A EA200901402A EA200901402A1 EA 200901402 A1 EA200901402 A1 EA 200901402A1 EA 200901402 A EA200901402 A EA 200901402A EA 200901402 A EA200901402 A EA 200901402A EA 200901402 A1 EA200901402 A1 EA 200901402A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
cycloalkyl
glaucoma
hydrogen atom
therapeuticol
Prior art date
Application number
EA200901402A
Other languages
English (en)
Other versions
EA015971B1 (ru
Inventor
Ацуси Симазаки
Норико Кавабата
Томоко Кирихара
Джейсон М. Риджер
Роберт Д. Томпсон
Original Assignee
Сантен Фармасьютикал Ко., Лтд.
ПГэксХЕЛТ, ЛЛК
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сантен Фармасьютикал Ко., Лтд., ПГэксХЕЛТ, ЛЛК filed Critical Сантен Фармасьютикал Ко., Лтд.
Publication of EA200901402A1 publication Critical patent/EA200901402A1/ru
Publication of EA015971B1 publication Critical patent/EA015971B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к терапевтическому средству против глаукомы. Соединение общей формулы (1) или его соль обнаруживают превосходное понижающее действие на внутриглазное давление в испытании на снижение внутриглазного давления и применимы в качестве профилактического или терапевтического средства против глаукомы или глазной гипертензии.В указанной формуле Х представляет собой СН или N; Rпредставляет собой атом водорода, гидроксигруппу, атом галогена, алкильную группу, алкоксигруппу, циклоалкильную группу, циклоалкоксигруппу, (циклоалкил)алкоксигруппу илиRпредставляет собой атом водорода, алкильную группу, циклоалкильную группу, алкилкарбонильную группу или алкилоксикарбонильную группу; Rи Rявляются одинаковыми или различными и представляют собой атом водорода, гидроксигруппу, атом галогена, алкильную группу, алкоксигруппу, циклоалкильную группу или циклоалкоксигруппу.
EA200901402A 2007-04-16 2008-04-14 Терапевтическое средство против глаукомы, содержащее в качестве активного ингредиента производное аденозина EA015971B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007106915A JP2008266143A (ja) 2007-04-16 2007-04-16 アデノシン誘導体を有効成分として含有する緑内障治療剤
PCT/US2008/004770 WO2008130520A1 (en) 2007-04-16 2008-04-14 Therapeutic agent for glaucoma containing adenosine derivative as active ingredient

Publications (2)

Publication Number Publication Date
EA200901402A1 true EA200901402A1 (ru) 2010-04-30
EA015971B1 EA015971B1 (ru) 2012-01-30

Family

ID=39875791

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901402A EA015971B1 (ru) 2007-04-16 2008-04-14 Терапевтическое средство против глаукомы, содержащее в качестве активного ингредиента производное аденозина

Country Status (15)

Country Link
US (2) US20100093770A1 (ru)
EP (1) EP2134174A4 (ru)
JP (2) JP2008266143A (ru)
KR (1) KR20090128495A (ru)
CN (1) CN101677544A (ru)
AU (1) AU2008241496A1 (ru)
BR (1) BRPI0809953A2 (ru)
CA (1) CA2684866A1 (ru)
EA (1) EA015971B1 (ru)
IL (1) IL201418A0 (ru)
MX (1) MX2009011076A (ru)
NZ (1) NZ580165A (ru)
UA (1) UA100376C2 (ru)
WO (1) WO2008130520A1 (ru)
ZA (1) ZA200906989B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7985754B2 (en) * 2006-07-17 2011-07-26 Trovis Pharmaceuticals, Llc Selective antagonists of A2A adenosine receptors
PL2523669T3 (pl) 2010-01-11 2017-06-30 Inotek Pharmaceuticals Corporation Połączenie, zestaw i sposób obniżania ciśnienia wewnątrzgałkowego
WO2011119969A1 (en) 2010-03-26 2011-09-29 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
KR20130029049A (ko) * 2010-03-26 2013-03-21 이노텍 파마슈티컬스 코포레이션 아데노신 화합물 및 이의 용도
US20120058983A1 (en) 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
WO2012108489A1 (ja) * 2011-02-10 2012-08-16 参天製薬株式会社 親水性薬物の薬物移行性を改善した水性組成物
NZ627778A (en) 2012-01-26 2017-01-27 Inotek Pharmaceuticals Corp Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
AU2014239222A1 (en) 2013-03-15 2015-10-01 Inotek Pharmaceuticals Corporation Ophthalmic formulations
WO2017137528A1 (en) 2016-02-12 2017-08-17 Charité - Universitätsmedizin Berlin Adenosine a1 receptor agonist for use in treatment of status epilepticus
KR102007640B1 (ko) 2017-11-29 2019-08-07 퓨쳐메디신 주식회사 아데노신 유도체를 포함하는 망막 질환 또는 시신경 질환 예방 및 치료용 약학적 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7378400B2 (en) * 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US7427606B2 (en) * 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US6322771B1 (en) * 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
NZ532062A (en) * 2001-10-01 2006-09-29 Univ Virginia 2-propynyl adenosine analogues having A2 adenosine recepter agonist activity and compositions thereof to treat inflammatory responses
US20050058696A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
BRPI0414277A (pt) * 2003-09-12 2006-11-07 Allergan Inc métodos e composições para o tratamento de dor e outras condições mediadas adrenérgicas alfa 2
NZ553288A (en) * 2004-08-02 2010-12-24 Univ Virginia 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
US7368439B2 (en) * 2005-06-15 2008-05-06 Bar - Ilan University Dinucleoside poly(borano)phosphate derivatives and uses thereof
WO2008133129A1 (ja) * 2007-04-16 2008-11-06 Santen Pharmaceutical Co., Ltd. アデノシンａ２ａ受容体アゴニストを有効成分として含有する緑内障治療剤

Also Published As

Publication number Publication date
EP2134174A4 (en) 2011-05-25
CN101677544A (zh) 2010-03-24
ZA200906989B (en) 2010-06-30
US20130109646A1 (en) 2013-05-02
JP2008266143A (ja) 2008-11-06
WO2008130520A1 (en) 2008-10-30
CA2684866A1 (en) 2008-10-30
IL201418A0 (en) 2010-06-16
AU2008241496A1 (en) 2008-10-30
MX2009011076A (es) 2010-01-20
EP2134174A1 (en) 2009-12-23
UA100376C2 (en) 2012-12-25
BRPI0809953A2 (pt) 2014-09-23
EA015971B1 (ru) 2012-01-30
NZ580165A (en) 2012-07-27
JP2010524933A (ja) 2010-07-22
US20100093770A1 (en) 2010-04-15
KR20090128495A (ko) 2009-12-15
JP4923141B2 (ja) 2012-04-25

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU