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EA200701850A1 - Соединения трициклических нуклеозидов (варианты), фармацевтическая композиция на их основе и способ лечения или профилактики вирусных инфекций у млекопитающих - Google Patents

Соединения трициклических нуклеозидов (варианты), фармацевтическая композиция на их основе и способ лечения или профилактики вирусных инфекций у млекопитающих

Info

Publication number
EA200701850A1
EA200701850A1 EA200701850A EA200701850A EA200701850A1 EA 200701850 A1 EA200701850 A1 EA 200701850A1 EA 200701850 A EA200701850 A EA 200701850A EA 200701850 A EA200701850 A EA 200701850A EA 200701850 A1 EA200701850 A1 EA 200701850A1
Authority
EA
Eurasian Patent Office
Prior art keywords
viral infections
treating
mammalians
options
connections
Prior art date
Application number
EA200701850A
Other languages
English (en)
Inventor
Джесс Д. Кайхер
Кристофер Дон Робертс
Себастьян Йоганнес Райнхард Лир
Сяолин Чжен
Мария Прхавч
Вивек Кумар Раджванши
Рональд Конрад Гриффит
Чоун У. Ким
Original Assignee
Дженелабс Текнолоджис, Инк.
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дженелабс Текнолоджис, Инк., Джилид Сайэнс, Инк. filed Critical Дженелабс Текнолоджис, Инк.
Publication of EA200701850A1 publication Critical patent/EA200701850A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Предлагаются трициклические нуклеозидные соединения формулы (I), а также методы лечения с их помощью вирусных инфекций, обусловленных, по крайней мере частично, вирусом семейства Flaviviridae.
EA200701850A 2005-02-28 2006-02-28 Соединения трициклических нуклеозидов (варианты), фармацевтическая композиция на их основе и способ лечения или профилактики вирусных инфекций у млекопитающих EA200701850A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65746305P 2005-02-28 2005-02-28
PCT/US2006/007132 WO2006093987A1 (en) 2005-02-28 2006-02-28 Tricyclic-nucleoside compounds for treating viral infections

Publications (1)

Publication Number Publication Date
EA200701850A1 true EA200701850A1 (ru) 2008-02-28

Family

ID=36570903

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200701850A EA200701850A1 (ru) 2005-02-28 2006-02-28 Соединения трициклических нуклеозидов (варианты), фармацевтическая композиция на их основе и способ лечения или профилактики вирусных инфекций у млекопитающих
EA200701849A EA200701849A1 (ru) 2005-02-28 2006-02-28 Пролекарственные соединения трициклических нуклеозидов, фармацевтическая композиция на их основе и способ лечения и/или ингибирования вирусной инфекции у млекопитающего

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200701849A EA200701849A1 (ru) 2005-02-28 2006-02-28 Пролекарственные соединения трициклических нуклеозидов, фармацевтическая композиция на их основе и способ лечения и/или ингибирования вирусной инфекции у млекопитающего

Country Status (18)

Country Link
US (4) US7524825B2 (ru)
EP (2) EP1853617A1 (ru)
JP (2) JP2008531704A (ru)
KR (2) KR20070106781A (ru)
CN (2) CN101128474A (ru)
AP (2) AP2007004128A0 (ru)
AR (1) AR058419A1 (ru)
AU (2) AU2006218704A1 (ru)
BR (2) BRPI0607769A2 (ru)
CA (2) CA2597685A1 (ru)
EA (2) EA200701850A1 (ru)
HR (2) HRP20070436A2 (ru)
IL (2) IL184954A0 (ru)
MX (2) MX2007010463A (ru)
NO (2) NO20074613L (ru)
TW (1) TW200640474A (ru)
WO (2) WO2006093987A1 (ru)
ZA (1) ZA200707410B (ru)

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RU2654482C2 (ru) * 2012-04-18 2018-05-21 Байокрист Фармасьютикалз, Инк. Композиции и способы ингибирования вирусной полимеразы

Also Published As

Publication number Publication date
AU2006218705A1 (en) 2006-09-08
US20090208457A1 (en) 2009-08-20
HRP20070435A2 (en) 2008-02-29
BRPI0607770A2 (pt) 2009-06-13
US20060194749A1 (en) 2006-08-31
WO2006093987A1 (en) 2006-09-08
EA200701849A1 (ru) 2008-02-28
US7524825B2 (en) 2009-04-28
AP2007004118A0 (en) 2007-08-31
CN101142226A (zh) 2008-03-12
JP2008531703A (ja) 2008-08-14
US20090253648A1 (en) 2009-10-08
AP2007004128A0 (en) 2007-08-31
IL184955A0 (en) 2007-12-03
KR20070106767A (ko) 2007-11-05
MX2007010463A (es) 2007-11-08
US7534771B2 (en) 2009-05-19
CA2597685A1 (en) 2006-09-08
KR20070106781A (ko) 2007-11-05
CN101128474A (zh) 2008-02-20
AU2006218704A1 (en) 2006-09-08
JP2008531704A (ja) 2008-08-14
CA2597683A1 (en) 2006-09-08
WO2006093986A1 (en) 2006-09-08
IL184954A0 (en) 2007-12-03
TW200640474A (en) 2006-12-01
US20060252715A1 (en) 2006-11-09
ZA200707410B (en) 2008-10-29
BRPI0607769A2 (pt) 2009-10-06
HRP20070435A9 (en) 2008-09-30
NO20074613L (no) 2007-11-27
EP1853618A1 (en) 2007-11-14
HRP20070436A2 (en) 2008-02-29
MX2007010460A (es) 2007-11-08
NO20074915L (no) 2007-11-20
AR058419A1 (es) 2008-02-06
EP1853617A1 (en) 2007-11-14

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