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EA200700555A1 - INDOL DERIVATIVES AS AN INHIBITORS OF SOLUBLE ADENYLATE CYCLASE - Google Patents

INDOL DERIVATIVES AS AN INHIBITORS OF SOLUBLE ADENYLATE CYCLASE

Info

Publication number
EA200700555A1
EA200700555A1 EA200700555A EA200700555A EA200700555A1 EA 200700555 A1 EA200700555 A1 EA 200700555A1 EA 200700555 A EA200700555 A EA 200700555A EA 200700555 A EA200700555 A EA 200700555A EA 200700555 A1 EA200700555 A1 EA 200700555A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
adenylate cyclase
soluble adenylate
indol derivatives
indol
Prior art date
Application number
EA200700555A
Other languages
Russian (ru)
Inventor
Дуй Нгуен
Анне Менгель
Мартин Фрич
Гернот Лангер
Ульф Бёмер
Сок-Кё Ким
Кнут Айс
Бернд Менценбах
Бернд Бухманн
Original Assignee
Байер Шеринг Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004047272A external-priority patent/DE102004047272A1/en
Application filed by Байер Шеринг Фарма Акциенгезельшафт filed Critical Байер Шеринг Фарма Акциенгезельшафт
Publication of EA200700555A1 publication Critical patent/EA200700555A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Изобретение относится к соединениям общей формулы I, а также к их получению и применению в качестве лекарственного средства.The invention relates to compounds of the general formula I, as well as to their preparation and use as a medicine.

EA200700555A 2004-09-24 2005-09-23 INDOL DERIVATIVES AS AN INHIBITORS OF SOLUBLE ADENYLATE CYCLASE EA200700555A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004047272A DE102004047272A1 (en) 2004-09-24 2004-09-24 Inhibitors of soluble adenylate cyclase
PCT/EP2005/010629 WO2006032541A1 (en) 2004-09-24 2005-09-23 Indol derivatives as inhibitors of soluble adenylyl cyclase

Publications (1)

Publication Number Publication Date
EA200700555A1 true EA200700555A1 (en) 2007-10-26

Family

ID=37600950

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700555A EA200700555A1 (en) 2004-09-24 2005-09-23 INDOL DERIVATIVES AS AN INHIBITORS OF SOLUBLE ADENYLATE CYCLASE

Country Status (24)

Country Link
US (1) US20080004268A1 (en)
EP (1) EP1802572B1 (en)
JP (1) JP2008514572A (en)
KR (1) KR20070054685A (en)
CN (1) CN101084189A (en)
AR (1) AR051300A1 (en)
AT (1) ATE429419T1 (en)
AU (1) AU2005287481A1 (en)
BR (1) BRPI0516057A (en)
CA (1) CA2581492A1 (en)
CR (1) CR9058A (en)
DE (1) DE502005007158D1 (en)
EA (1) EA200700555A1 (en)
GT (1) GT200500268A (en)
IL (1) IL181739A0 (en)
MX (1) MX2007003287A (en)
MY (1) MY142839A (en)
NO (1) NO20072078L (en)
PA (1) PA8646301A1 (en)
PE (1) PE20060696A1 (en)
SV (1) SV2006002238A (en)
TW (1) TW200615260A (en)
UY (1) UY29141A1 (en)
ZA (1) ZA200703307B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070225284A1 (en) * 2006-03-23 2007-09-27 Bernd Buchmann Inhibitors of soluble adenylate cyclase
CN102262159B (en) 2010-05-27 2014-03-26 李建远 Method for detecting 305 kinds of semen positioning protein of human testicle and epididymis expression related to procreation
WO2017190050A1 (en) * 2016-04-28 2017-11-02 Cornell University Inhibitors of soluble adenylyl cyclase
WO2019046465A2 (en) * 2017-08-29 2019-03-07 Rutgers, The State University Of New Jersey Therapeutic indoles
CN111479805B (en) 2017-08-29 2024-08-13 罗格斯新泽西州立大学 Therapeutic indazoles
CN108096244B (en) * 2018-01-25 2020-11-24 昆明医科大学 Application of 1-hydrogen-2-indolone-3-benzyl/substituted benzyl-3-formate compounds
EP3851853A1 (en) * 2020-01-17 2021-07-21 Biotechnologicky Ustav AV CR, v.v.i. Method for separation of sperm with undamaged intact heads from sperm with damaged heads and somatic cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1614678B1 (en) * 1998-07-08 2014-01-01 Sanofi-Aventis Deutschland GmbH Sulfur substituted sulfonylaminocarboxylic acid N-heteroarylamides, their preparation, their use and pharmaceutical preparations comprising them
US7442805B2 (en) * 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7417066B2 (en) * 2005-06-08 2008-08-26 Schering Ag Inhibitors of soluble adenylate cyclase
US20070225284A1 (en) * 2006-03-23 2007-09-27 Bernd Buchmann Inhibitors of soluble adenylate cyclase

Also Published As

Publication number Publication date
IL181739A0 (en) 2007-07-04
DE502005007158D1 (en) 2009-06-04
TW200615260A (en) 2006-05-16
AU2005287481A1 (en) 2006-03-30
NO20072078L (en) 2007-05-31
ZA200703307B (en) 2009-05-27
KR20070054685A (en) 2007-05-29
EP1802572A1 (en) 2007-07-04
UY29141A1 (en) 2006-04-28
PE20060696A1 (en) 2006-08-01
JP2008514572A (en) 2008-05-08
AR051300A1 (en) 2007-01-03
BRPI0516057A (en) 2008-08-19
ATE429419T1 (en) 2009-05-15
SV2006002238A (en) 2006-06-26
CN101084189A (en) 2007-12-05
CA2581492A1 (en) 2006-03-30
MX2007003287A (en) 2007-10-11
GT200500268A (en) 2006-10-10
MY142839A (en) 2011-01-14
EP1802572B1 (en) 2009-04-22
PA8646301A1 (en) 2006-09-08
US20080004268A1 (en) 2008-01-03
CR9058A (en) 2007-10-04

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