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EA200601846A1 - Содержащие бензоксазины лекарственные комбинации для лечения заболеваний дыхательных путей - Google Patents

Содержащие бензоксазины лекарственные комбинации для лечения заболеваний дыхательных путей

Info

Publication number
EA200601846A1
EA200601846A1 EA200601846A EA200601846A EA200601846A1 EA 200601846 A1 EA200601846 A1 EA 200601846A1 EA 200601846 A EA200601846 A EA 200601846A EA 200601846 A EA200601846 A EA 200601846A EA 200601846 A1 EA200601846 A1 EA 200601846A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzoxasins
diseases
treatment
respiratory tracks
medicinal combinations
Prior art date
Application number
EA200601846A
Other languages
English (en)
Other versions
EA013157B1 (ru
Inventor
Тьерри Буиссу
Инго Конетцки
Забине Пестель
Андреас Шнапп
Кристоф Хёнке
Филипп Лустенбергер
Клаус Рудольф
Михаэль П. Пипер
Мишель Пере
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966478&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200601846(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE102004019540A external-priority patent/DE102004019540A1/de
Priority claimed from DE102004052987A external-priority patent/DE102004052987A1/de
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200601846A1 publication Critical patent/EA200601846A1/ru
Publication of EA013157B1 publication Critical patent/EA013157B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

В заявке описаны новые лекарственные комбинации, которые наряду с одним или несколькими соединениями, предпочтительно одним соединением, общей формулы (1)в которой остатки R, Rи Rмогут иметь указанные в формуле изобретения и в описании значения, содержат по меньшей мере одно другое действующее вещество 2, к способу их получения, а также к их применению в качестве лекарственных средств.
EA200601846A 2004-04-22 2005-04-18 Содержащие бензоксазины лекарственные комбинации для лечения заболеваний дыхательных путей EA013157B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102004019540A DE102004019540A1 (de) 2004-04-22 2004-04-22 Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen
DE102004052987A DE102004052987A1 (de) 2004-11-03 2004-11-03 Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen
EP05002496 2005-02-07
PCT/EP2005/004073 WO2005102349A1 (de) 2004-04-22 2005-04-18 Arzneinmittelkombinationen enthaltend benzoxazine zur behandlung von atemwegserkrankungen

Publications (2)

Publication Number Publication Date
EA200601846A1 true EA200601846A1 (ru) 2007-04-27
EA013157B1 EA013157B1 (ru) 2010-02-26

Family

ID=34966478

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601846A EA013157B1 (ru) 2004-04-22 2005-04-18 Содержащие бензоксазины лекарственные комбинации для лечения заболеваний дыхательных путей

Country Status (32)

Country Link
EP (2) EP2422786B1 (ru)
JP (1) JP2007533683A (ru)
KR (2) KR20130049840A (ru)
AR (1) AR049262A1 (ru)
AT (1) ATE539754T1 (ru)
AU (1) AU2005235419B2 (ru)
BE (1) BE2015C065I2 (ru)
BR (1) BRPI0510080B8 (ru)
CA (1) CA2559699C (ru)
CY (3) CY1113890T1 (ru)
DK (2) DK1781298T3 (ru)
EA (1) EA013157B1 (ru)
EC (1) ECSP066947A (ru)
ES (2) ES2523518T3 (ru)
FI (1) FIC20170005I1 (ru)
HU (1) HUS1500058I1 (ru)
IL (2) IL177685A (ru)
LT (1) LTC1781298I2 (ru)
LU (1) LU93066I2 (ru)
MY (1) MY148945A (ru)
NL (1) NL300779I2 (ru)
NO (2) NO337714B1 (ru)
NZ (1) NZ550797A (ru)
PE (1) PE20060462A1 (ru)
PL (2) PL1781298T4 (ru)
PT (2) PT1781298E (ru)
SG (1) SG152237A1 (ru)
SI (2) SI1781298T1 (ru)
TW (2) TWI374739B (ru)
UY (1) UY28861A1 (ru)
WO (1) WO2005102349A1 (ru)
ZA (1) ZA200606624B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE102004024452A1 (de) * 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation von Betaagonisten
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
US7923455B2 (en) * 2005-01-28 2011-04-12 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of heart failure comprising administration of an anticholinergic
JP2008530177A (ja) * 2005-02-16 2008-08-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用薬及びエチプレドノールを含有する医薬組成物
BRPI0614410A2 (pt) 2005-08-15 2011-03-29 Boehringer Ingelheim Int processo para preparação de betamiméticos
TWI396541B (zh) * 2005-10-10 2013-05-21 Boehringer Ingelheim Int 用於治療呼吸疾病之新穎藥物組合
TWI389692B (zh) * 2005-10-10 2013-03-21 Boehringer Ingelheim Int 用以吸入β-共效劑的氣溶膠調配物
ATE529399T1 (de) 2005-11-10 2011-11-15 Nicholas S Bodor Sanfte anticholinerge ester
WO2007093608A1 (de) * 2006-02-16 2007-08-23 Boehringer Ingelheim International Gmbh Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
ATE505193T1 (de) * 2006-08-07 2011-04-15 Boehringer Ingelheim Int Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
UY30543A1 (es) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int Formulacion de aerosol para la inhalacion de beta- agonistas
UY30542A1 (es) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int Formulacion de aerosol para la inhalacion de agonistas beta
EP2086641A2 (en) * 2006-10-26 2009-08-12 Boehringer Ingelheim International GmbH Egfr kinase inhibitor combinations for the treatment of respiratory and gastrointestinal disorders
EP1921070A1 (de) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
BRPI0907916A2 (pt) 2008-02-07 2015-07-28 Boehringer Ingelheim Int Heterociclos espirociclos, medicamentos contendo esses compostos, e processos para preparar os mesmos
CA2733153C (en) 2008-08-08 2016-11-08 Boehringer Ingelheim International Gmbh Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
EP2370053A1 (de) * 2008-11-27 2011-10-05 Boehringer Ingelheim International GmbH Neue pulverförmige kristalline arzneimittel zur inhalation
WO2014016548A2 (en) * 2012-07-27 2014-01-30 Cipla Limited Pharmaceutical composition
EP2906218B1 (en) 2012-10-09 2016-12-14 Boehringer Ingelheim International GmbH Beta-2-adrenoceptor agonist for the treatment of cough

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
IE59026B1 (en) 1985-07-30 1993-12-15 Glaxo Group Ltd Devices for administering medicaments to patients
SE453566B (sv) 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
CZ20023537A3 (cs) 2000-04-27 2003-02-12 Boehringer Ingelheim Pharma Kg Betamimetika, způsob jejich výroby a použití jako farmaceutický prostředek
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IL159238A0 (en) 2001-06-22 2004-06-01 Boehringer Ingelheim Pharma Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
DE10130371A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika
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DE10246374A1 (de) * 2002-10-04 2004-04-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika mit verlängerter Wirkungsdauer, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE10253282A1 (de) * 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung

Also Published As

Publication number Publication date
ES2523518T3 (es) 2014-11-26
TW201231055A (en) 2012-08-01
DK2422786T3 (da) 2014-11-17
ES2380370T3 (es) 2012-05-11
EA013157B1 (ru) 2010-02-26
BRPI0510080B1 (pt) 2020-08-18
HUS1500058I1 (hu) 2016-01-28
BE2015C065I2 (ru) 2024-08-08
ZA200606624B (en) 2008-01-08
PL1781298T3 (pl) 2012-06-29
WO2005102349A1 (de) 2005-11-03
SI1781298T1 (sl) 2012-04-30
NO337714B1 (no) 2016-06-06
KR20130049840A (ko) 2013-05-14
ATE539754T1 (de) 2012-01-15
EP2422786B1 (de) 2014-08-13
NO20065060L (no) 2006-11-21
NO2016022I2 (no) 2016-12-01
CY1115719T1 (el) 2017-01-25
TWI374739B (en) 2012-10-21
BRPI0510080A (pt) 2007-10-16
MY148945A (en) 2013-06-14
FIC20170005I1 (fi) 2017-01-13
KR20070015592A (ko) 2007-02-05
LU93066I2 (fr) 2016-07-11
NL300779I2 (nl) 2017-11-02
CA2559699C (en) 2012-06-19
LTC1781298I2 (lt) 2018-09-25
AU2005235419A1 (en) 2005-11-03
IL177685A (en) 2013-10-31
NO2016022I1 (no) 2016-12-01
CA2559699A1 (en) 2005-11-03
SG152237A1 (en) 2009-05-29
NZ550797A (en) 2010-08-27
IL226562A0 (en) 2013-06-27
PT1781298E (pt) 2012-02-03
PL2422786T3 (pl) 2015-02-27
ECSP066947A (es) 2007-01-26
TWI372056B (en) 2012-09-11
CY2017014I2 (el) 2017-11-14
IL177685A0 (en) 2006-12-31
EP2422786A1 (de) 2012-02-29
EP1781298A1 (de) 2007-05-09
SI2422786T1 (sl) 2014-12-31
JP2007533683A (ja) 2007-11-22
DK1781298T3 (da) 2012-05-07
CY1113890T1 (el) 2016-07-27
PL1781298T4 (pl) 2017-07-31
UY28861A1 (es) 2005-11-30
PT2422786E (pt) 2014-11-12
AU2005235419B2 (en) 2010-11-04
AR049262A1 (es) 2006-07-12
BRPI0510080B8 (pt) 2021-05-25
PE20060462A1 (es) 2006-06-19
KR101287460B1 (ko) 2013-07-23
EP1781298B1 (de) 2012-01-04
CY2017014I1 (el) 2017-11-14

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