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EA200601761A1 - Композиции в качестве адъювантов для усиления иммунных ответов на вакцины и способы их применения - Google Patents

Композиции в качестве адъювантов для усиления иммунных ответов на вакцины и способы их применения

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Publication number
EA200601761A1
EA200601761A1 EA200601761A EA200601761A EA200601761A1 EA 200601761 A1 EA200601761 A1 EA 200601761A1 EA 200601761 A EA200601761 A EA 200601761A EA 200601761 A EA200601761 A EA 200601761A EA 200601761 A1 EA200601761 A1 EA 200601761A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tim
compositions
targeting molecule
provides
methods
Prior art date
Application number
EA200601761A
Other languages
English (en)
Inventor
Уилльям Соо Хоо
Эрик Р. Дженсен
Томас Молль
Деннис Дж. Карло
Брайан К. Хелмич
Сунпинь Йей
Джаянт Тхатте
Original Assignee
Телос Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Телос Фармасьютикалз, Инк. filed Critical Телос Фармасьютикалз, Инк.
Publication of EA200601761A1 publication Critical patent/EA200601761A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)

Abstract

Изобретение представляет композиции, содержащие антиген и TIM-нацеливающую молекулу. Кроме того, изобретение обеспечивает конъюгат TIM-нацеливающей молекулы, например, TIM-нацеливающей молекулы, конъюгированной с терапевтическим или диагностическим фрагментом. Дополнительно изобретение предусматривает способы применения таких композиций. В одном воплощении, изобретение обеспечивает способ стимулирования иммунного ответа у индивидуума введением композиции, содержащей антиген и TIM-нацеливающую молекулу в фармацевтически приемлемом носителе. В другом воплощении, изобретение обеспечивает способ стимуляции иммунного ответа у индивидуума введением антигена и TIM-нацеливающей молекулы, которые можно вводить вместе в одной композиции или раздельно.
EA200601761A 2004-03-24 2005-03-22 Композиции в качестве адъювантов для усиления иммунных ответов на вакцины и способы их применения EA200601761A1 (ru)

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