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EA200601562A1 - Сокристаллы госсипола и их применение - Google Patents

Сокристаллы госсипола и их применение

Info

Publication number
EA200601562A1
EA200601562A1 EA200601562A EA200601562A EA200601562A1 EA 200601562 A1 EA200601562 A1 EA 200601562A1 EA 200601562 A EA200601562 A EA 200601562A EA 200601562 A EA200601562 A EA 200601562A EA 200601562 A1 EA200601562 A1 EA 200601562A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sossicles
application
state
gossypol
relates
Prior art date
Application number
EA200601562A
Other languages
English (en)
Other versions
EA011218B1 (ru
Inventor
Шаомэн Ван
Дажон Ян
Original Assignee
Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган
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Application filed by Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган filed Critical Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган
Publication of EA200601562A1 publication Critical patent/EA200601562A1/ru
Publication of EA011218B1 publication Critical patent/EA011218B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P33/00—Antiparasitic agents
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Данное изобретение относится к композициям, содержащим сокристаллы (-)-госсипола с C-карбоновой кислотой или C-сульфоновой кислотой, которые применимы в качестве ингибиторов белков семейства Bcl-2. Изобретение также относится к применению сокристаллов (-)-госсипола с С-карбоновой кислотой или C-сульфоновой кислотой для индукции апоптоза в клетках и для сенсибилизации клеток к индукции апоптотической клеточной гибели.
EA200601562A 2004-03-25 2005-03-24 Сокристаллы госсипола и их применение EA011218B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55624904P 2004-03-25 2004-03-25
PCT/US2005/009673 WO2005094804A1 (en) 2004-03-25 2005-03-24 Gossypol co-crystals and the use thereof

Publications (2)

Publication Number Publication Date
EA200601562A1 true EA200601562A1 (ru) 2007-02-27
EA011218B1 EA011218B1 (ru) 2009-02-27

Family

ID=35063489

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601562A EA011218B1 (ru) 2004-03-25 2005-03-24 Сокристаллы госсипола и их применение

Country Status (15)

Country Link
US (3) US7342046B2 (ru)
EP (1) EP1732529A4 (ru)
JP (1) JP2007530568A (ru)
KR (2) KR20080097496A (ru)
CN (1) CN1960719B (ru)
AU (2) AU2005228998B2 (ru)
BR (1) BRPI0509182A (ru)
CA (1) CA2561303C (ru)
EA (1) EA011218B1 (ru)
IL (1) IL178286A0 (ru)
MX (1) MXPA06010938A (ru)
NO (1) NO20064829L (ru)
SG (1) SG151299A1 (ru)
WO (1) WO2005094804A1 (ru)
ZA (1) ZA200607956B (ru)

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KR101579371B1 (ko) * 2014-02-27 2015-12-22 국립암센터 고시폴 및 펜포르민을 유효성분으로 함유하는 암 치료용 약제학적 조성물
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EA011218B1 (ru) * 2004-03-25 2009-02-27 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Сокристаллы госсипола и их применение

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US7432300B2 (en) 2008-10-07
ZA200607956B (en) 2008-02-27
IL178286A0 (en) 2007-03-08
KR20070026473A (ko) 2007-03-08
US20090082445A1 (en) 2009-03-26
BRPI0509182A (pt) 2007-09-18
EA011218B1 (ru) 2009-02-27
JP2007530568A (ja) 2007-11-01
US20050234135A1 (en) 2005-10-20
WO2005094804A1 (en) 2005-10-13
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KR100906843B1 (ko) 2009-07-08
US20070293585A1 (en) 2007-12-20
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US7342046B2 (en) 2008-03-11
CA2561303C (en) 2011-01-18
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CA2561303A1 (en) 2005-10-13

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